scholarly journals High Prevalence of viral and bacterial coinfections in malaria in Venezuela

Author(s):  
David Alberto Forero-Peña ◽  
Marisol Sandoval de Mora ◽  
Iván D. Amaya Rodríguez ◽  
Ángel F. Gamardo ◽  
Melynar Chavero ◽  
...  

Abstract Background Malaria remains a significant public health problem worldwide. Simultaneous infections with other pathogens complicate its diagnosis and can also change the clinical course of the disease. The similarities in the clinical presentation of malaria and other infections and the superimposed endemicity result in underdiagnosis of coinfections and increase mortality. No studies have focused on the presence of coinfections in patients with malaria in Venezuela. Methods Between June and November 2018, we conducted a cross-sectional study in patients with malaria who presented to any of the three reference medical centers in Ciudad Bolívar, Venezuela. A clinical and laboratory evaluation searching for coinfections with Dengue (DENV), Chikungunya (CHIKV), Viral Hepatitis (VH) (A, B, and C), and Leptospirosis (LEP) was performed using ELISA to test each patient. Results We studied a total of 161 patients of whom 106 (65.8%) presented P. vivax infection, 43 (26.7%) P. falciparum, and 12 (7.5%) had mixed malaria infections. Coinfections were found in 55/161 (34.2%) patients and were more frequent in patients with P. falciparum (48.8%) than in those with P. vivax (29.2%), or mixed infection (25%) [OR = 2.43; 95% CI = 1.39–4.25; p = 0.018]. The most prevalent coinfection was with DENV (14.9%), followed by HAV (11.8%), HBV (6.2%), CHIKV (5.5%), and LEP (3.7%). Coinfection with HCV was absent. Complicated malaria was significantly more frequent in coinfected individuals (56.4%) than those without coinfection (35.8%) [OR: 2.31; 95% CI = 1.18–4.92; p = 0.013]. Conclusion We found a high prevalence of coinfections in patients with malaria in this region, which was related to a worse outcome. Further prospective studies with samples at different points of infection and the use of molecular tools are needed.

2015 ◽  
Vol 129 (5) ◽  
pp. 425-429 ◽  
Author(s):  
S K Chadha ◽  
K Gulati ◽  
S Garg ◽  
A K Agarwal

AbstractObjective:This study aimed to assess the prevalence and profile of ear diseases in children from Delhi, India.Methods:A population-based cross-sectional door-to-door survey was carried out in two districts of Delhi, and involved children of all demographic sections of the region. A total of 4626 children aged between 18 days and 15 years underwent examinations including otoscopy, impedance audiometry and hearing screening.Results:In all, 14.8 per cent of the study sample was diagnosed with one or more ear morbidities, the most common being cerumen impaction (7.5 per cent) and chronic suppurative otitis media (3.6 per cent). There was clinical evidence of otitis media with effusion in 2 per cent of children, and 0.96 per cent had otitis externa (bacterial and fungal). The point prevalence of acute suppurative otitis media was 0.39 per cent. In all, 0.45 per cent of children were found to have an undiagnosed foreign body within the ear canal.Conclusion:The high prevalence of ear disease poses a significant public health problem in Delhi.


2017 ◽  
Vol 6 (04) ◽  
pp. 5340 ◽  
Author(s):  
Pavani Varma M.* ◽  
Prasad S.V.

Malnutrition continues to be a significant public health problem and is associated with many risk factors. To determine the association between prevalence of undernutrition, socio-demographic and maternal characteristics. It is a cross sectional study.400 children were examined for their weights and heights. Information is collected regarding the risk factors which are usually associated with undernutrition. The relevant information was recorded from each village of the mandal according to probability proportion to size. Significant association has been found with birth weight, birth interval and maternal occupation. Health education of parents regarding importance of ante-natal check-ups, proper birth spacing is essential.


2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Shweta R Singh ◽  
Bunsoth Mao ◽  
Konstantin Evdokimov ◽  
Pisey Tan ◽  
Phana Leab ◽  
...  

Abstract Background The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries. Methods We conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage. Results Forty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts. Conclusions The high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread.


BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e041609
Author(s):  
Emmanuel Nii-Boye Quarshie ◽  
Farag Shuweihdi ◽  
Mitch Waterman ◽  
Allan House

ObjectivesTo identify the prevalence, methods, associations and reported reasons for self-harm among in-school and street-connected adolescents in Ghana.DesignA cross-sectional survey. We applied multi-level regression models and model-based cluster analysis to the data.SettingThree contexts in the Greater Accra region were used: second cycle schools, facilities of charity organisations and street census enumeration areas (sleeping places of street-connected adolescents, street corners, quiet spots of restaurants, markets, train and bus stations, and lorry and car parks).ParticipantsA regionally representative sample of 2107 (1723 in-school and 384 street-connected) adolescents aged 13–21 years.Outcome measuresParticipants responded to a structured self-report anonymous questionnaire describing their experience of self-harm and eliciting demographic information and social and personal adversities.ResultsThe lifetime prevalence of self-harm was 20.2% (95% CI 19.0% to 22.0%), 12-month prevalence was 16.6% (95% CI 15.0% to 18.0%) and 1-month prevalence was 3.1% (95% CI 2.0% to 4.0%). Self-injury alone accounted for 54.5% episodes and self-poisoning alone for 16.2% episodes, with more than one method used in 26% of episodes. Self-cutting (38.7%) was the most common form of self-injury, whereas alcohol (39.2%) and medications (27.7%) were the most commonly reported means of self-poisoning. The factors associated with self-harm were interpersonal: conflict with parents (adjusted OR (aOR)=1.87, 95% CI 1.24 to 2.81), physical abuse victimisation (aOR=1.69, 95% CI 1.16 to 2.47), difficulty in making and keeping friends (aOR=1.24, 95% CI 0.85 to 1.80), sexual abuse victimisation (aOR=1.21, 95% CI 0.78 to 1.87) and conflict between parents (aOR=1.07, 95% CI 0.73 to 1.56).ConclusionsSelf-harm is a significant public health problem among in-school and street-connected adolescents in the Greater Accra region of Ghana. Its origins are very largely in social and familial adversity, and therefore prevention and treatment measures need to be focused in these areas.


Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 327
Author(s):  
Silvia Portero de la Cruz ◽  
Jesús Cebrino

Influenza is a significant public health problem and the elderly are at a greater risk of contracting the disease. The vaccination coverage of the elderly is below the Spanish target of 65% for each influenza season. The aims of this study were to report the coverage of influenza vaccination in Spain among the population aged ≥65 years and high-risk groups for suffering chronic diseases, to analyze the time trends from 2006 to 2017 and to identify the factors which affect vaccination coverage. A nationwide cross-sectional study was conducted including 20,753 non-institutionalized individuals aged ≥65 years who had participated in the Spanish National Health Surveys in 2006, 2011/2012, and 2017. Sociodemographic, health-related variables, and influenza vaccination data were used. A logistic regression analysis was performed to determine the variables associated with influenza vaccination. Influenza vaccination coverage was 60%. By chronic condition, older people with high cholesterol levels and cancer had the lowest vaccination coverage (62.41% and 60.73%, respectively). This coverage declined from 2006 to 2017 in both groups. Higher influenza vaccination was associated with males, Spanish nationality, normal social support perceived, polypharmacy, worse perceived health, participation in other preventive measures, and increasing age and the number of chronic diseases.


2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Marina Aferiba Tandoh ◽  
Abigail Owusuaa Appiah ◽  
Anthony Kwaku Edusei

Anemia among adolescent females is a major worldwide public health problem which should be given appropriate attention. Half of all anemic cases are caused by iron deficiency. In addition to anemia, poor nutrition is also a challenge in sub-Saharan Africa. This study determined the prevalence of anemia and undernutrition among adolescent females in school. A cross-sectional study was conducted among 151 adolescent females in four basic schools in the Ahafo region of Ghana. The hemoglobin level and anthropometry measures of participants were taken to determine their anemic and nutritional status. The prevalence of anemia among adolescent females in school was 50.3%. Out of the 151 participants, 6.6%, 19.9%, and 23.8% were severely anemic, moderately anemic, or mildly anemic, respectively. Only 2% of the participants were underweight, but the rate of stunting was 26.5%. The notable high prevalence of anemia that was found among adolescent females was correlated with other health and wellness concerns. Anemia and under nutrition negatively affect academic performance, productivity, and general wellbeing of adolescents; therefore, effective measures should be put in place to correct and eradicate these nutritional problems.


2019 ◽  
Vol 7 (1) ◽  
pp. 140
Author(s):  
Bharatkumar Balkrishna Pandya ◽  
Upendrakumar Rameshbhai Chaudhari ◽  
Avirat A. Bhatt ◽  
Nilesh Thakor

Background: Adolescence period is very crucial in the life of an individual, when major physical, psychological and behavioral changes take place. Tobacco and Areca nut use among school going adolescent is becoming a major public health problem. Objective of this study was to determine the prevalence and pattern of smokeless tobacco and betel nut use among school going adolescents.Methods: The study was a cross sectional study. After taking the permission of principal of Government high schools of Vadodara and Surat city of Gujarat and consent of the parents of adolescents, 1107 adolescents were interviewed during March-April 2017. A self-administered questionnaire was used for data collection. Thus collected data was analyzed using SPSS 17 (Trial Version).Results: Age of the study students (total 1107) ranged from 10-19 years. (Mean age=14.61±2.85 years). Out of 1107 children 389 (35.1%) children had addiction. Prevalence of any type of addiction in girls and boys was 14.3% and 20.7% respectively. Tobacco prevalence was 13.4% and betel nut prevalence was 21.6%. Type of addiction and its association with gender was highly significant. All children addicted to tobacco using chewing form (gutkha) of tobacco. The mean age group of children who consume tobacco and betel nut was 16.13±1.32 years and 16.01±1.21 years respectively. Most common reasons among adolescents for starting addiction of tobacco and betel nut was to look mature (93.8%) followed by to look good (63.2%) and to refresh breathe (48.6%).Conclusions: High prevalence of tobacco and betel nut use among adolescents needs attention of parents, teachers and health officials.


1991 ◽  
Vol 107 (3) ◽  
pp. 685-691 ◽  
Author(s):  
R. Eitrem ◽  
M. Stylianou ◽  
B. Niklasson

SUMMARYNeutralizing antibodies to sandfly fever Naples, sandfly fever Sicilian and Toscana viruses were investigated among 479 sera collected from a normal human population in Cyprus. Antibody prevalence rates of 57%, 32% and 20% were found to Naples, Sicilian and Toscana viruses, respectively. The observed frequency of dual and triple infections was higher than would be expected with a random chance of infection. Antibody prevalence rates were similar for men and women for all three viruses tested, but one of two study sites had significantly higher antibody prevalence to Naples and Sicilian viruses than the other. Individuals with antibodies to both Naples and Toscana viruses had higher antibody levels to Naples virus than those with antibodies to Naples virus only. If the antibody prevalence rates found in this study reflect a history of clinical disease as described in the literature, sandfly fever poses a significant public health problem in Cyprus.


2020 ◽  
Author(s):  
Nicole Kravitz-Wirtz ◽  
Amanda Aubel ◽  
Julia Schleimer ◽  
Rocco Pallin ◽  
Garen Wintemute

AbstractIMPORTANCEViolence is a significant public health problem that has become entwined with the coronavirus pandemic. Conditions that contribute to violence—poverty, unemployment, lack of available resources, isolation, hopelessness, and loss—have intensified and are further compounded by the recent surge in firearm sales, which is itself a risk factor for firearm-related harm.OBJECTIVETo describe individuals’ worry about violence for themselves and others in the context of the pandemic, pandemic-related unfair treatment, as well as the prevalence of and reasons for firearm acquisition and changes in firearm storage practices due to the pandemic. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the California Safety and Wellbeing Survey, a statewide Internet survey of 2,870 California adults (18 years of age and older) conducted from July 14 to July 27, 2020. Responses were weighted to be representative of the state population of adults.MAIN OUTCOMES AND MEASURESSurvey topics for this study included: changes in worry about violence happening to oneself, by type of violence and location, before and during the pandemic; concern someone else might physically hurt another person or themselves on purpose due to a pandemic-related loss; experiences of unfair treatment related to the pandemic; firearm and ammunition acquisition and changes in firearm storage practices due to the pandemic; and participation in civic and political activities “in response to gun violence” during the pandemic.RESULTSWorry about violence significantly increased during the pandemic for all violence types except mass shootings. More than 1 in 10 respondents were concerned that someone they know might intentionally harm another person (12.2%) or themselves (13.1%). Of those concerned about self-harm for someone else, 7.5% said it was because the person had suffered a pandemic-related loss. An estimated 110,000 individuals acquired a firearm in response to the pandemic (2.4% of current firearm owners), including 47,000 new owners. Approximately 55,000 individuals (1.2% of owners) who currently store at least one firearm loaded and not locked up said they had adopted this unsecure storage practice in response to the pandemic.CONCLUSIONS AND RELEVANCEGiven the impulsive nature of many types of violence, short-term crisis interventions, such as options for temporary firearm storage outside the home, extreme risk protection orders, and efforts involving community-based violence intervention workers, may be critical for reducing violence-related harm now and following other societal shocks.Key PointsQUESTIONSHas the coronavirus pandemic modified (1) individuals’ worry about violence for themselves or others, (2) the prevalence of and reasons for firearm and ammunition acquisition, and (3) firearm storage practices?FINDINGSIn this cross-sectional, population-representative survey of 2,870 adults in California, worry about multiple types of violence for oneself increased during the pandemic; pandemic-related loss contributed to concern that someone else might physically harm themselves on purpose; an estimated 110,000 people acquired firearms due to the pandemic (2.4% of firearm owners in the state), including approximately 47,000 new owners; and 6.7% of owners who currently store firearms loaded and not locked up adopted this unsecure storage practice in response to the pandemic.MEANINGViolence is a significant public health problem that touches the lives of far more people than is typically recognized. The coronavirus pandemic and efforts to lessen its spread have compounded this burden.


2020 ◽  
Vol 7 (1) ◽  
pp. 11-21
Author(s):  
Faheem Ullah ◽  
Naheed Mahsood ◽  
Waqas Mohyuddin ◽  
Saadullah Afridi ◽  
Zia Ur Rehman

OBJECTIVES: Refractive errors and strabismus continue to remain a significant public health problem. Among school children it has an impact on child development. The aim of the study was to determine the prevalence and pattern of refractive error and strabismus among primary school children. METHODOLOGY: It was a cross-sectional study. Stratified random sampling technique was used to select the school children. Data was collected in November-December 2013. Visual impairment was defined as, presenting VA of < 6/12. A total of 2288 children (1746 boys and 542 girls) were screened from 26 randomly selected schools. Stratified sampling technique was used. Data were collected on pre-designed questionnaires and entered and analyzed by SPSS software version 16. RESULTS: The mean age of children was 8.10 + 2.3 years. About 4% children were found visually impaired. The prevalence of refractive error was found to be 5.4%, of which 88.6% was uncorrected refractive error. The prevalence of refractive error was found higher in girls than boys, 6.8% and 5.0% respectively. Among types of refractive error, myopia prevalence was 2.3%, hypermetropia prevalence was 2.0% and astigmatism prevalence was 1.1%. The prevalence of strabismus was 1.3%. Refractive error was found as a main cause of visual impairment in school children. Prevalence of strabismus among this study population is relatively low as compared to the global prevalence of 2% to 5%. CONCLUSION: It is recommended that more study to determine the extent of the problem and possible factors for development of refractive error and strabismus types are needed to mitigate these conditions.


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