scholarly journals Evaluation of Corneal Endothelium in Middle-Aged Keratoconus Eyes

2021 ◽  
Author(s):  
Emine Doğan ◽  
Burçin Çakır ◽  
Nilgün Aksoy ◽  
Gürsoy Alagöz
Keyword(s):  
Endothelial Cell ◽  
Anterior Chamber Depth ◽  
Control Group ◽  
Specular Microscopy ◽  
Middle Aged ◽  
Cell Parameters ◽  
Cell Percentage ◽  
And Gender ◽  
Topographic Parameters ◽  
Healthy Eyes

Abstract Purpose To investigate the corneal endothelial cell parameters and to evaluate the correlation with corneal topographic parameters in middle-aged non-treated keratoconus (KC) patients. Materials and Methods Thirty-six eyes of 21 KC patients in the middle decade (4th-5th) and age-gender matched 36 healthy eyes were included. Topographic parameters [(K1, K2 Sim K, central, thinnest pachymetry, anterior chamber depth (ACD)] were obtained with Galillei double scheimpflug analyzer. Patients were divided into stages according to mean keratometric values ​​(Mild < 45D,Moderate 45-52D, Severe > 52D, Advanced > 62 D). Endothelial cell density (ECD), coefficient of variation (CV) of cell areas and hexagonal cell percentage (HCP) obtained with specular microscopy were recorded.Corneal topography and specular microscopy parameters were compared between KC and healthy eyes. The correlation between topographic and specular microscopy parameters were analyzed. Results The mean age of the patients was 38.6 ± 6.0 and 37.8 ± 4.2 years in the KC and control group, respectively. Age and gender were statistically similar between the groups. ECD was 2772 ± 17 in the KC group and 2741 ± 30 cells / mm2 in the control group, and there was no statistical difference between the groups (p: 0.621). HCP was 63.5 ± 7.2, 67.4 ± 5.2 in KC and healthy eyes, respectively (p: 0.014); CV was 30.7 ± 5.2 and 28.6 ± 3.4, respectively (p: 0.058). Specular microscopy parameters were not statistically different according to KC stage. K1,K2,SimK, CCT, ACD did not correlate with ECD in patients. Conclusion Our results showed that endothelial cell morphology is significantly affected in middle-aged KC patients who have not been treated.

scholarly journals Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

2020 ◽  
Author(s):  
Müge Özçelik Korkmaz ◽  
Bilgehan Çelik ◽  
Fatih Turan ◽  
Mehmet Güven ◽  
Ebru Güven
Keyword(s):  
Blood Cell ◽  
Patient Group ◽  
Control Group ◽  
Cell Parameters ◽  
Inflammatory Parameters ◽  
Significant Difference ◽  
Distribution Parameters ◽  
Predictive Role ◽  
Severity Of The Disease ◽  
And Gender

Abstract Introduction There are no definitive parameters to guide the etiology and severity of pediatric antrochoanal polyps. Objective The aim of our study is to compare the values of blood cell distribution parameters in cases of pediatric antrochoanal polyps (ACPs) with those of the control group. These values may be guiding parameters in determining the etiology of ACPs and evaluating the severity of the disease and the risk of recurrence. Methods Blood count values of patients operated for pediatric ACPs were retrospectively analyzed and compared with the data of the control group with the same age and gender distribution. The ACPs group was divided into subgroups in terms of inflammation, severity, and recurrence, and these subgroups were statistically compared as well. Results When the ACP patient group and the control group were compared, there was no statistically significant difference between the two groups. When we compared the patients considering the CT findings, there was a statistically significant difference between the stage III patients and the control group in terms of mean platelet volume (MPV) and platelet-to-lymphocyte ratio (PLR) values (p < 0.05 in both). Similarly, the MPV and PLR values were significantly higher in the recurrence patient group than in the control group. (p < 0.05 in both). Conclusion As a result of the data obtained, it can be suggested that inflammatory parameters in pediatric cases of ACPs vary in terms of recurrence and the severity of the disease.

scholarly journals Corneal thickness and endothelial cell density in diabetic and non- diabetic patients: a hospital based comparative study

2018 ◽  
Vol 5 (3) ◽  
pp. 694 ◽  
Author(s):  
Nagaraj G. ◽  
Anasuya Sangaraj Desai ◽  
Nagesh Jayaram
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Endothelial Cell Density ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Specular Microscopy ◽  
The Mean

Background: Diabetes mellitus is associated with structural changes in corneal endothelial cells and their thickness. The present study was done to compare the endothelial cell density (ECD), central corneal thickness (CCT) and morphology in diabetic and non-diabetic patients.Methods: A cross-sectional study was conducted at Minto Ophthalmic hospital, BMC and RI Bangalore for a period of 20 months (October 2013 - May 2015). A total of 200 study subjects, 100 diabetics and 100 non-diabetic age matched controls were selected, and complete timed ophthalmic evaluation was performed. Specular microscopy was performed on all patients for endothelial cell count assessment and corneal thickness was measured by Pachymeter. The data was analyzed and represented using descriptive statistics. ‘t’ test was used for comparing the two groups.Results: The mean endothelial cell density in diabetic group was significantly lower (2438.73±250.23cells/mm2) compared to non-diabetic group (2599.88±168.16cells/mm2) (p<0.0001). The mean Central corneal thickness in diabetic group was significantly higher (518.40±28.13 μm) compared to control group (490.14±24.31 μm) (p<0.001). The Co-efficient of variation percentage of the diabetics was higher than the non-diabetics but this difference was not statistically significant (P>0.05). The hexagonality percentage was significantly lower in diabetic group compared to the controls suggesting less pleomorphism in the diabetic group.Conclusions: The study concludes that the endothelial cell density was lower and central corneal thickness was higher in diabetic patients compared with the non-diabetics. The altered endothelial morphology was significantly seen in the form of pleomorphism (hexagonality) but polymegathism was not significantly altered.

scholarly journals Overestimation of corneal endothelial cell density by automated method in glaucomatous eyes with impaired corneal endothelial cells

2021 ◽  
Author(s):  
Mayumi Minami ◽  
Etsuo Chihara
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Close Correlation ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Specular Microscopy ◽  
Cell Parameters ◽  
Automated Method ◽  
Corneal Endothelial Cell Density ◽  
Automated Methods

Abstract Purpose To determine between-method differences in corneal endothelial cell parameters using center and automated methods of non-contact specular microscopy (CellCheck software of Konan, Inc.) in glaucomatous eyes. Methods We analyzed the central corneal endothelial cell density (ECD) of 245 glaucomatous eyes using center (ECD-Ce) and automated methods (ECD-Au). Based on the ECD-Ce, we allocated subjects to Groups 1 to 10 (at 250 cells/mm2 intervals) and evaluated the ECD, coefficient of variation in cell area (CV), and percentage of hexagonal cells (HEX). Results There was a close correlation (r = 0.91) between the ECD values measured using both methods. However, ECD-Au were significantly higher than those measured by the center method when ECD-Ce was less than 2500 (in Groups 1 to 8; P < 0.001 to P = 0.006). The regression equation of (ECD-Au—ECD-Ce) = 1028–0.397*ECD-Ce shows greater deviation in eyes with lower ECD, and this difference became 0 when ECD -Ce was 2593 cells/mm2. None of the 44 subjects with an ECD-Ce of < 1000 cells/mm2 recorded an ECD-Au < 1000 cells/mm2. Compared with the center method, the automated method had higher and lower median CV and HEX values, respectively (P < 0.001). The between-method differences in both CV and HEX were negatively correlated with ECD-Ce (r = −0.49, P < 0.001 and r = −0.25, P < 0.001, respectively). Conclusion The automated method of the CellCheck software overestimates ECD in eyes with lower ECD values and may overlook risk of corneal decompensation.

Laser Peripheral Iridotomy Changes Anterior Chamber Architecture

2016 ◽  
Vol 27 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Christian Theinert ◽  
Peter Wiedemann ◽  
Jan D. Unterlauft
Keyword(s):  
Anterior Chamber ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Angle Closure ◽  
Control Group ◽  
Threshold Values ◽  
Characteristic Analysis ◽  
Laser Peripheral Iridotomy ◽  
Peripheral Iridotomy ◽  
Healthy Eyes

Purpose The pressure gradient between anterior and posterior chamber in acute angle closure (AAC) and primary angle closure suspects is balanced by a sufficient laser peripheral iridotomy (LPI). The anterior chamber changes induced by LPI in patients with unilateral AAC were examined and compared to healthy eyes to define threshold values, which may help to discriminate between healthy and diseased eyes. Methods Using Scheimpflug photography, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and central corneal thickness (CCT) were measured before and after LPI in both eyes of unilateral AAC cases. These measurements were compared to a group of healthy control eyes to determine threshold values for ACD, ACV, and ACA. Results The ACD, ACV, and ACA increased significantly in the 25 AAC eyes after LPI. The ACD, ACV, ACA, and CCT values in the AAC eyes obtained before LPI were compared to a control group of 59 healthy eyes with wide open chamber angles. The cutoff values revealed by receiver operating characteristic analysis were 2.1 mm for ACD, 90.5 mm2 for ACV, and 27.25° for ACA. Conclusions Our results confirm the significant changes of the anterior segments architecture induced by LPI in AAC eyes. The found threshold values for ACD, ACV, and ACA may help in daily clinical routine to discriminate between healthy eyes and those in need for a prophylactic LPI.

scholarly journals Evaluation of the Endothelial Cell Density and the Central Corneal Thickness in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Bożydar T. Tomaszewski ◽  
Renata Zalewska ◽  
Zofia Mariak
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Endothelial Cell Density ◽  
Pseudoexfoliation Syndrome ◽  
Control Group ◽  
Specular Microscopy ◽  
Pseudoexfoliation Glaucoma ◽  
And Control

Purpose.Evaluation of central corneal thickness (CCT) and endothelial cell density (ECD) in patients with senile cataract and coexisting pseudoexfoliation (PEX) syndrome with glaucoma (PEXG) and without glaucoma using specular microscopy.Participants and Methods.The study included 122 patients (217 eyes). In this group of patients we identified 133 eyes with PEX syndrome (65 with glaucoma, 68 without glaucoma) and 84 eyes without PEX syndrome. ECD and CCT were measured in each eye by specular microscopy.Results.ECD in eyes with PEX syndrome without glaucoma (2297 ± 359 cell/mm2) and in eyes with PEXG (2241 ± 363 cell/mm2) was lower than in the control group (2503 ± 262 cell/mm2) (P<0.001). CCT in eyes with PEXG (508.2 ± 32.6 μm) was thinner than in eyes with PEX syndrome without glaucoma (529.7 ± 30.3 μm) and control group (527.7 ± 29.4 μm) (P<0.001).Conclusions.This research shows that in eyes with PEX syndrome, both with and without glaucoma, ECD was statistically significantly lower than in the control group. In patients with PEXG, CCT was statistically significantly thinner than in the PEX syndrome and control group.

scholarly journals The corneal effects of intravitreal dexamethasone implantation

2020 ◽  
Vol 12 ◽  
pp. 251584142094754
Author(s):  
Alper Halil Bayat ◽  
Gamze Karataş ◽  
Muhammet Mustafa Kurt ◽  
Mustafa Nuri Elçioğlu
Keyword(s):  
Endothelial Cell ◽  
Cell Structure ◽  
Glycosylated Hemoglobin ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Corneal Topography ◽  
Specular Microscopy ◽  
The Mean ◽  
Intravitreal Dexamethasone

Objectives: To evaluate the corneal effects of the intravitreal dexamethasone implantation using corneal topography and specular microscopy. Material and methods: 27 eyes of the 27 patients who received a single intravitreal dexamethasone implantation dose for diabetic macular edema were enrolled in this study. Sirius topography and EM-3000 specular microscopic examinations were performed at the initial examination (baseline), and then on the first day, during the first week, and 1 month after IDI. Changes in corneal parameters were investigated. Results: The mean age was 58.66 ± 6.59 years. 15 patients were men, and 12 were women. The mean disease duration was 12.2 ± 2.4 months, and mean glycosylated hemoglobin (HbA1c) was 7.2 ± 1.1. After dexamethasone injection, the mean central corneal thickness, endothelial cell density, and coefficient variation of cell area presented a statistically significant decrease ( p < 0.05). Anterior segment parameters, such as anterior chamber depth, iridocorneal angle, sim K1 and K2 keratometry, pupillary diameter, horizontal visible iris diameter, and corneal astigmatism did not change ( p > 0.05). Conclusion: Intravitreal dexamethasone implantation affects corneal endothelial cell structure but does not appear to affect corneal topography parameters.

scholarly journals Potential Factors of Corneal Endothelial Cells for Progression in Children with Uveitis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xu Chen ◽  
Yi Shao ◽  
Shi-Nan Wu ◽  
Shan-Bi Zhou
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Morphological Changes ◽  
Corneal Endothelial Cell ◽  
Control Group ◽  
Cell Area ◽  
Corneal Endothelial Cells ◽  
Cell Parameters ◽  
Corneal Endothelial Cell Density ◽  
The Difference

Objective. To observe the morphological changes and abnormal structure of corneal endothelial cells in children with uveitis, to analyze the related factors affecting the morphological changes of corneal endothelial cells, and to explore the clinical application of a corneal endothelial microscope in children with uveitis. Methods. The corneal endothelial cells of 70 patients with uveitis were photographed with the Topcon SP-3000 noncontact corneal endothelial microscope, and the corneal endothelial cell density (CD), average cell area (AVE), coefficient of variation of the cell area (CV), and percentage of hexagonal cells (PHC) were measured with the IMAGEnet system. Twenty-eight patients (56 eyes) with monocular uveitis were selected, with the affected eyes (28 eyes) as the experimental group and the contralateral healthy eyes (28 eyes) as the control group. The corneal endothelial cell parameters between the two groups were statistically analyzed. The parameters of corneal endothelial cells in 70 children with uveitis were compared, and the effects of the course of the disease, inflammatory cells in the anterior chamber, and posterior corneal deposition (KP) on the parameters of corneal endothelial cells were analyzed. Results. There are four abnormal forms of the corneal endothelium in children with uveitis: enlarged cell area gap, irregular cell shape, blurred intercellular space, and cell loss. KP showed irregular high reflective white spots in the corneal endothelial microscope images, surrounded by dark areas, and existed in all the eyes with dusty KP found in slit lamp examination and a small number of eyes without obvious KP. Comparing the corneal endothelial cell parameters between the experimental group and the control group, it was found that the corneal endothelial CD and PHC of the former were lower than those of the latter, and the difference was statistically significant ( P < 0.001 and P = 0.018 , respectively). The AVE and CA of the former were higher than those of the latter ( P = 0.013 and P = 0.046 , respectively). The corneal endothelial cell density of the eyes with a course of the disease of more than 1 year was lower than that of the eyes with a course of the disease less than 1 year, the coefficient of variation of the corneal endothelial cell area of the eyes with KP was higher than that of the eyes without KP, and the difference was statistically significant ( P = 0.003 and P = 0.030 , respectively). Conclusion. Corneal endothelial microscopy is one of the important methods for the detection of uveitis with high sensitivity. The change of morphological parameters of corneal endothelial cells is one of the important indexes to assist in the diagnosis of uveitis and can be further promoted in ophthalmological examination.

scholarly journals Correlation between ocular biometric parameters and corneal endothelium in a sample of young Egyptian adults

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Mohamed N. Hamza ◽  
Maged Maher Roshdy ◽  
Mouamen M. Seleet ◽  
Tamer M. El Raggal
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Central Zone ◽  
Peripheral Zone ◽  
Cross Sectional Study ◽  
Normative Values ◽  
Specular Microscopy ◽  
Cross Sectional ◽  
Cell Parameters ◽  
Cellular Density

Background: To evaluate the normative values of corneal endothelial cell parameters within a group of healthy young Egyptian adults using specular microscopy and to examine any correlations between endothelial parameters and refractive or biometric parameters.Methods: In this cross-sectional study, specular microscopy was used to study the right eyes of 150 healthy young volunteers and evaluated endothelial cell parameters, including cellular density, hexagonality (HEX), and coefficient of variation (CV) at 15 different points on the back corneal surface, which were later grouped into the central zone and either four quadrants or three annular zones. The same eyes underwent refractive and biometric assessments.Results: Hundred fifty healthy adults were examined, and the age ranged from 20 to 30 years, with a median of 23 (interquartile range, 21?27) years. The mean ± standard deviation of central cell density was 2902.7 ± 270.7 cells/mm2. The superior paracentral area had the lowest mean density (2895.8 cells/mm2), but the highest mean HEX (67.7%), while the inferior peripheral area had the highest mean density (3100.5 cells/ mm2) but the lowest mean HEX (64%). The difference in cell density among the three annular zones was not statistically significant (P = 0.365). However, HEX and CV in the central and paracentral zones differed statistically significantly from those of the peripheral zone (P < 0.001 and P = 0.014, respectively). Weak but non-significant correlations were detected between endothelial cell density and all measured refractive and biometric parameters.Conclusions: The findings of this study provided useful normative biometric and specular data in a specific age group and a specific population, and could be useful in planning intraocular surgery in young Egyptian adults. However, future longitudinal studies with a larger sample could refine more endothelial cell parameter specifications over time.

scholarly journals Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes with Exudative Circumscribed Choroidal Haemangioma : An Optical Coherence Tomography Angiography Study

2020 ◽  
Author(s):  
Kunbei Lai ◽  
Chuangxin Huang ◽  
Yali Zhang ◽  
Faobao Xu ◽  
Xiaojing Zhong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Evaluation ◽  
Optical Coherence Tomography Angiography ◽  
Statistical Significance ◽  
Trial Registration ◽  
Control Group ◽  
Optical Coherence ◽  
Age And Gender ◽  
And Gender ◽  
Healthy Eyes

Abstract Background: To quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma (CCH) compared with age- and gender-controlled healthy eyes.Methods: This was a cross-sectional, case-control study. 82 eyes of eighty-two subjects including 41 eyes of forty-one subjects in the exudative CCH group and 41 eyes of forty-one subjects in the age- and gender-controlled healthy eye group were enrolled in this study. Optical coherence tomography angiography (OCTA) was performed in each subject, and the capillary density (CD) of superficial plexus, deep capillary plexus, and the choriocapillaris as well as the area of foveal avascular zone (FAZ) were noted and analyzed between two groups.Results: The CD of the superficial plexus (44.51 ± 3.58 % vs 47.93 ± 2.94%) and deep plexus (47.75 ± 5.60% vs 52.66 ± 5.04%) of retina as well as the vessel density of choriocapillaris (54.42 ± 6.36% vs 61.83 ± 3.65%) significantly decreased in eyes with exudative CCH compared with age- and gender-controlled healthy eyes (all P < 0.001). Although we found that the FAZ areas in the exudative CCH group was larger than that of the healthy eye control group (0.30 ± 0.11mm2 vs 0.27 ± 0.87mm2), however, no statistical significance was found between two groups (P = 0.164).Conclusions: OCTA is a rapid, non-invasive, high-resolution procedure with which could monitor the parafoveal microvasculature changes in eyes with exudative CCH. We found that not only the CD of the superficial plexus and deep plexus but also the CD of choriocapillaris significantly decreased in eyes with exudative CCH compared with age- and gender-controlled healthy eye group.Trial registration: This study was registered on the https://www.clinicaltrials.gov (trial registration number: NCT04449900)

HUBUNGAN TUNGAU DEBU RUMAH, PAPARAN ASAP ROKOK DAN RIWAYAT PENYAKIT KELUARGA TERHADAP KEJADIAN ASMA BRONKIAL PADA ANAK USIA 5 – 10 TAHUN DI WILAYAH KERJA PUSKESMAS LEMPAKE KOTA SAMARINDA TAHUN 2016

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Sri Evi New Yearsi Pangadongan ◽  
Agustina Rahyu ◽  
Selvy Pasulu
Keyword(s):  
Cigarette Smoke ◽  
Bronchial Asthma ◽  
Sampling Technique ◽  
Total Sample ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
History Of ◽  
Weather Changes ◽  
And Gender

Bronchial Asthma generally starts from childhood which is condition where respiration channel experiences constriction because of hyperactivity with some specific stimulation which cause inflammation. Some risk factors are smoking exposure of cigarette smoke, weather changes, mite on house dirt, pet and history of family sickness. The purpose of this research is to know Relation of mite on house dirt, exposure of cigarette smoke  and history of family sickness with bronchial asthma incident to child 5 – 10  years old on working area of Puskesmas Lempake Samarinda City in 2016. Method which used was analytic survey with Case Control approaching. The total sample was 36 children which consisted of 18 case group and 18 control group with matching by using age and gender which submitted with Purposive Sampling technique. Data Analysis used Chi Square with wrong degree α = 0,005. The result showed that there was relation of mite of house dirt (p = 0,006), history of family sickness (p = 0,001) and no relation with exposure of cigarette smoke (p = 0,370) with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016.

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