scholarly journals Corneal epithelial map after Photorefractive Keratectomy with and without mitomycin-C

2021 ◽  
Author(s):  
Shaabani Amirreza ◽  
Jabbarvand Mahmoud ◽  
Shahbazi Ahad
Keyword(s):  
Mitomycin C ◽  
Case Series ◽  
Photorefractive Keratectomy ◽  
Control Group ◽  
Data Set ◽  
Thickness Profile ◽  
Epithelial Thickness ◽  
Significant Difference ◽  
Before And After

Abstract Purpose: To compare epithelial thickness before and after photorefractive keratectomy (PRK) with and without mitomycin-C (MMC).Methods: Forty eyes treated with PRK for low myopia (less than -4.00 D) and low astigmatism (less than -2.00) were included in this interventional case series. The right eye of each patient assigned to receive intraoperative topical MMC% 0.02 for 15 to 30 seconds and other eye received equally balanced salt solution (control group). Epithelial thickness profile was analyzed before and 6 months postoperatively.Results: Epithelial thickness map was analyzed in superior and inferior of the cornea within central 7 mm diameter. Maximum and minimum thickness was measured and the data were compared before and after PRK. The Superior, the inferior and the maximum epithelial thickness were significantly increased after surgery in both groups (p<0.05). There was no significant difference in epithelial thickness profile between case and control group at baseline and 6-month post PRK. Final distance corrected visual acuity was similar in two groups. No case of corneal haze was observed during 6 months follow up visits.Conclusion: Intraoperative MMC% 0.02 in PRK for low myopia patients did not change the epithelial thickness profile and refractive results, when compared with matched control eyes in 6 months follow up. It seems that MMC doesn’t have a statistically significant impact in epithelial remodeling based on this data set.

Pyrocardan Scaphotrapeziotrapezoid Joint Arthroplasty for Isolated Osteoarthritis: Results after a Mean Follow-Up of 5 Years

2021 ◽  
Author(s):  
Martin Cholley-Roulleau ◽  
Yves Bouju ◽  
Flore-Anne Lecoq ◽  
Alexandre Fournier ◽  
Philippe Bellemère
Keyword(s):  
Case Series ◽  
Preoperative Assessment ◽  
Contralateral Side ◽  
High Rate ◽  
Significant Difference ◽  
Flexion Extension ◽  
Functional Scores ◽  
Before And After ◽  
The Mean

Abstract Background Isolated scaphotrapeziotrapezoid (STT) osteoarthritis (OA) mainly develops in women over 50 years of age in a bilateral manner. Many surgical treatments are available, including distal scaphoid resection with or without interposition, trapeziectomy, and STT arthrodesis. However, there is a controversy about which procedure is the most effective. Purposes The purpose of this study was to report the outcomes of the Pyrocardan implant for treating STT isolated OA at a mean follow-up of 5 years. Patients and Methods Consecutive patients who underwent STT arthroplasty using the Pyrocardan were reviewed retrospectively by an independent examiner who performed a clinical and radiological evaluation. Results The mean follow-up time was 5 years (range 3–8 years). Thirteen patients (76%) were followed for more than 5 years. Between the preoperative assessment and the last follow-up, pain levels decreased significantly. There was no significant difference in the mean Kapandji opposition score. Grip and pinch strengths were 88 and 91% of the contralateral side. The active range of motion in flexion–extension and radioulnar deviation was not significantly different to the contralateral side (119° vs. 121° and 58° vs. 52°, p > 0.1). Functional scores were improved significantly. No identifiable differences were found in the radioscaphoid, capitolunate, and scapholunate angles before and after surgery. In three cases, the preoperative dorsal intercalated scapholunate instability (DISI) failed to be corrected. In one case, DISI appeared after the procedure. There was one asymptomatic dislocation of the implant. Calcification around the trapezium and/or distal scaphoid was found in four cases. The survival rate of the implant without reoperation was 95%. Conclusions In the medium term, Pyrocardan implant is an effective treatment for STT OA as it reduces pain, increases grip strength, and maintains wrist mobility. This is consistent with the results of other published case series using pyrocarbon implants. It provides a high rate of patient satisfaction. Nevertheless, the surgical procedure must be done carefully to avoid STT ligament damage, periarticular calcifications, or dislocation.

The Effect of Mindfulness Training on Athletes’ Flow: An Initial Investigation

2011 ◽  
Vol 25 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Cian Aherne ◽  
Aidan P. Moran ◽  
Chris Lonsdale
Keyword(s):  
Significant Interaction ◽  
Performance Enhancement ◽  
Training Session ◽  
Mindfulness Training ◽  
Control Group ◽  
Flow State ◽  
Significant Difference ◽  
Before And After ◽  
Flow Experiences

This study investigated the relationship between mindfulness training (a nonjudgmental attentional training technique) and flow experiences in athletes. Participants were 13 university athletes (M = 21 years), assigned either to a control group or an experimental group. Flow experiences were assessed before and after the intervention. ANOVA (group x time) of global scores on the Flow State Scale-2 (FSS-2; Jackson & Eklund, 2004) showed a significant interaction (F = 11.49, p < .05). Follow-up t tests indicated no significant difference (p > .05) between the experimental and control groups’ FSS-2 global scores at the baseline training session, but a large difference (p < .05, d = 1.66) at a follow-up training session. Significant interaction effects were also observed for FSS-2 subscales scores for the flow dimensions of “Clear Goals” (F =18.73, p < .05) and “Sense of Control” (F = 14.61, p < .05). Following an evaluation of the strengths and weaknesses of this study, the theoretical significance of the results is assessed and the promise for the application of mindfulness training in performance enhancement is discussed.

scholarly journals Oxytocin Administration in High-Intensity Focused Ultrasound Treatment of Myomata

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Tomasz Lozinski ◽  
Justyna Filipowska ◽  
Piotr Krol ◽  
Anna Kubaty ◽  
Piotr Wegrzyn
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Uterine Fibroids ◽  
Volume Ratio ◽  
High Intensity Focused Ultrasound ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
Registration Number

Objectives. The aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin. Methods. 156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy. Before and after the procedure we performed MR and measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR). The follow-up was up to 15 months to assess efficacy of treatment and relief of symptoms. Results. Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). The remaining parameters did not show significant difference between both groups. Conclusion. Oxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. This study’ clinical registration number is DRKS00014794.

Supplementing Lecture with Simulations in Developmental Disabilities: SIDD Software

2001 ◽  
Vol 28 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Marcie N. Desrochers ◽  
Anna M. House ◽  
Puja Seth
Keyword(s):  
Developmental Disabilities ◽  
Behavioral Assessment ◽  
Control Group ◽  
Clinical Knowledge ◽  
Multimedia Software ◽  
Significant Difference ◽  
Before And After ◽  
Assessment And Treatment ◽  
Experimental Group

We evaluated Simulations in Developmental Disabilities (SIDD), a multimedia software program that provides students with practice in behavioral assessment and treatment decisions for persons with developmental disabilities. Following a lecture on clinical strategies, students in an experimental group received instruction with SIDD whereas students in the control group did not. We collected assessments of students' clinical knowledge before and after the lecture, immediately after training, and several weeks later. The lecture had no immediate impact on clinical knowledge; however, there was a significant difference in test scores between the experimental group and the control group following exposure to SIDD training, which remained at follow-up.

scholarly journals Subconjunctival Bevacizumab Injection in Glaucoma Filtering Surgery: A Case Control Series

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Jing Wang ◽  
Paul Harasymowycz
Keyword(s):  
Case Series ◽  
Glaucoma Surgery ◽  
Operative Management ◽  
Control Group ◽  
Filtering Surgery ◽  
Control Series ◽  
Vein Occlusion ◽  
Significant Difference ◽  
Control Group Group

Aims. To describe the use of subconjunctival bevacizumab (SCB) injection in the combined cataract and glaucoma filtering surgery (GFS). Methods. Retrospective comparative case series. Thirty eyes of twenty-eight patients who had GFS followed by SCB injection as part of post-operative management were included (Group SCB). The types of GFS included trabeculectomy and non-penetrating glaucoma surgery (NPGS) with mitomycin-C. Outcome measures included the reduction of intraocular pressure (IOP) and medications. Age-matched patients who had the same types of surgery without SCB were selected as a control group (Group C). Results. The types of GFS were: combined cataract surgery and NPGS (SCB: 20; C: 24), phacotrabeculectomy (SCB: 6; C: 3), NPGS (SCB: 3; C: 2) and trabeculectomy alone (SCB: 1; C: 1). The average follow-up time was 16.9 (±8.2) months in the SCB group and 19.6 (±11.5) months in the controls. 1.25 mg of bevacizumab was injected on average 14.1 (range: 3–42) days post-GFS. The mean IOP decreased from 21.9 (±9.8) to 11.9 (±4.7) mmHg in the controls and from 19.6 (±8.9) to 14.0 (±4.7) mmHg in the SCB group. There was no statistically significant difference between the two groups (P=0.11). Complications included three cases of branch vein occlusion in the SCB group. Conclusions. SCB did not result in better outcome in term of IOP reduction. Clinicians should monitor its side effects in glaucoma patients.

THE ASSOCIATION OF SCAPHO-TRAPEZIO-TRAPEZOID OSTEOARTHROSIS AND SCAPHOLUNATE DISSOCIATION

Hand Surgery ◽  
2006 ◽  
Vol 11 (03) ◽  
pp. 135-141 ◽  
Author(s):  
C. Roberts ◽  
M. Porter ◽  
A. P. Wines ◽  
B. Shadbolt
Keyword(s):  
Temporal Relationship ◽  
Clinical Manifestations ◽  
Case Series ◽  
Control Group ◽  
Scapholunate Dissociation ◽  
Radiographic Evidence ◽  
Clinical Assessments ◽  
Significant Difference ◽  
Over Time

There are two parts to this paper. In the first part we report 18 cases of bilateral scapho-trapezio-trapezoid osteoarthrosis associated with uni- or bilateral scapholunate dissociation. This case series was followed prospectively using repeat clinical assessments and radiographs. We were able to document the progression of both the clinical manifestations and radiographic features of the scapholunate dissociation in these patients. In the second part of the paper we compared the radiographic indices of scapholunate dissociation seen in our series, that is, the scapholunate angle and interval, with those of a control group over time, to determine if there was a significant difference. The control group differed from our series principally by being devoid of any clinical or radiographic evidence of scapho-trapezio-trapezoid osteoarthrosis. We found that our case series already had some radiographic evidence of scapholunate attrition at presentation and that at follow-up the scapholunate dissociation became more pronounced both clinically and radiographically relative to the controls. The authors propose a theory to explain the association and temporal relationship between the two conditions.

Melatih Kepemimpinan Perangkat Desa Kebonharjo Kulonprogo: Membangun Sikap Anti Korupsi

2018 ◽  
Vol 1 ◽  
pp. 107
Author(s):  
Adi Heryadi ◽  
Evianawati Evianawati
Keyword(s):  
Transformational Leadership ◽  
Data Collection ◽  
Paired Samples ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
Sample Test ◽  
Corruption Perception ◽  
Measuring Tool

This study aims to prove whether transformational leadership training is effective for building anti-corruption attitudes of villages in Kebonharjo village, subdistrict Samigaluh Kulonprogo. This research is an experimental research with one group pre and posttest design.Subject design is 17 people from village of 21 candidates registered. Measuring tool used in this research is the scale of anti-corruption perception made by the researcher referring to the 9 anti-corruption values with the value of reliability coefficient of 0.871. The module used as an intervention made by the researcher refers to the transformational leadership dimension (Bass, 1990). The data collected is analyzed by statistical analysis of different test Paired Sample Test. Initial data collection results obtained sign value of 0.770 which means> 0.05 or no significant difference between anti-corruption perception score between before and after training. After a period of less than 1 (one) month then conducted again the measurement of follow-up of the study subjects in the measurement again using the scale of anti-corruption perception. The results of the second data collection were analysed with Paired Samples Test and obtained the value of 0.623 sign meaning p> 0.05 or no significant difference between post test data with follow-up data so that the hypothesis of this study was rejected.

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

2019 ◽  
pp. 18-20
Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

scholarly journals Effectiveness of Text Messaging as an Incentive to Maintain Physical Activity after Cardiac Rehabilitation: A Randomized Controlled Pilot Study

2021 ◽  
Vol 18 (12) ◽  
pp. 6645
Author(s):  
Giulia Foccardi ◽  
Marco Vecchiato ◽  
Daniel Neunhaeuserer ◽  
Michele Mezzaro ◽  
Giulia Quinto ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiac Rehabilitation ◽  
Exercise Testing ◽  
Text Messages ◽  
Control Group ◽  
Stand Test ◽  
Randomized Controlled ◽  
Sit To Stand ◽  
Significant Difference

Although the efficacy of cardiac rehabilitation (CR) is proven, the need to improve patients’ adherence has emerged. There are only a few studies that have investigated the effect of sending text messages after a CR period to stimulate subjects’ ongoing engagement in regular physical activity (PA). A randomized controlled pilot trial was conducted after CR, sending a daily PA text message reminder to an intervention group (IG), which was compared with a usual care control group (CG) during three months of follow-up. Thirty-two subjects were assessed pre- and post-study intervention with GPAQ, submaximal iso-watt exercise testing, a 30 s sit-to-stand test, a bilateral arm curl test, and a final survey on a seven-point Likert scale. A statistically significant difference in the increase of moderate PA time (Δ 244.7 (95% CI 189.1, 300.4) minutes, p < 0.001) and in the reduction of sedentary behavior time (Δ −77.5 (95% CI 104.9, −50.1) minutes, p = 0.004) was shown when the IG was compared with the CG. This was associated with an improvement in heart rate, blood pressure, and patients’ Borg rating on the category ratio scale 10 (CR10) in iso-watt exercise testing (all p < 0.05). Furthermore, only the IG did not show a worsening of the strength parameters in the follow-up leading to a change of the 30 s sit-to-stand test with a difference of +2.2 (95% CI 1.23, 3.17) repetitions compared to CG (p = 0.03). The telemedical intervention has been appreciated by the IG, whose willingness to continue with regular PA emerged to be superior compared to the CG. Text messages are an effective and inexpensive adjuvant after phase 2 CR that improves adherence to regular PA. Further studies are needed to confirm these results in a larger patient population and in the long term.

scholarly journals Intracameral Bevacizumab Versus Sub-Tenon’s Mitomycin C as Adjuncts to Trabeculectomy: 3-Year Results of a Prospective Randomized Study

2021 ◽  
Vol 10 (10) ◽  
pp. 2054
Author(s):  
Gerasimos Kopsinis ◽  
Dimitrios Tsoukanas ◽  
Dimitra Kopsini ◽  
Theodoros Filippopoulos
Keyword(s):  
Mitomycin C ◽  
Primary Outcome ◽  
Randomized Study ◽  
Primary Outcome Measure ◽  
Complication Rates ◽  
Filtration Surgery ◽  
Significant Difference ◽  
Exfoliative Glaucoma

Conjunctival wound healing determines success after filtration surgery and the quest for better antifibrotic agents remains active. This study compares intracameral bevacizumab to sub-Tenon’s mitomycin C (MMC) in trabeculectomy. Primary open-angle or exfoliative glaucoma patients were randomized to either bevacizumab (n = 50 eyes) or MMC (n = 50 eyes). The primary outcome measure was complete success, defined as Intraocular Pressure (IOP) > 5 mmHg and ≤ 21 mmHg with a minimum 20% reduction from baseline without medications. Average IOP and glaucoma medications decreased significantly in both groups at all follow-up points compared to baseline (p < 0.001), without significant difference between groups at 3 years (IOP: bevacizumab group from 29 ± 9.4 to 15 ± 3.4 mmHg, MMC group from 28.3 ± 8.7 to 15.4 ± 3.8 mmHg, p = 0.60; Medications: bevacizumab group from 3.5 ± 0.9 to 0.5 ± 1, MMC group from 3.6 ± 0.7 to 0.6 ± 1.1, p = 0.70). Complete success, although similar between groups at 3 years (66% vs. 64%), was significantly higher for bevacizumab at months 6 and 12 (96% vs. 82%, p = 0.03; 88% vs. 72%, p = 0.04, respectively) with fewer patients requiring medications at months 6, 9 and 12 (4% vs. 18%, p = 0.03; 6% vs. 20%, p = 0.04; 8% vs. 24%, p = 0.03, respectively). Complication rates were similar between groups. In conclusion, intracameral bevacizumab appears to provide similar long-term efficacy and safety results as sub-Tenon’s MMC after trabeculectomy.

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