scholarly journals Vitamin D Status and Parathyroid Hormone Levels in Girls With Central Precocious Puberty

2021 ◽  
Author(s):  
Teodoro Durá-Travé ◽  
Fidel Gallinas-Victoriano ◽  
Lotfi Ahmed-Mohamed ◽  
Paula Moreno-González ◽  
María Urretavizcaya-Martinez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Hypovitaminosis D ◽  
Bone Age ◽  
Control Group ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Endocrine Society ◽  
Prepubertal Girls

Abstract The objective of this study was to analyze the vitamin D status and PTH levels in 6- to 8-years-old girls with central precocious puberty. A cross-sectional clinical and blood testing (calcium, phosphorus, 25(OH)D and PTH) were carried out in 78 girls with central precocious puberty (CPP group), aged 6.1-7.9 years. A control group was recruited (157 prepubertal girls, aged 6.1-8.2 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. There were no significant differences in the vitamin D status between both groups. There were not significant differences in 25(OH)D levels between CPP (25.4±8.6 ng/mL) and control groups (28.2±7.4 ng/mL). In contrast, in CPP group PHT levels (44.8±16.3 pg/mL) were higher (p < 0.05) with respect to control group (31.0±11.9 ng/mL). In CPP group there was positive correlation (p < 0.05) between PTH levels and growth rate, bone age, basal estradiol, basal FSH, basal LH and LH peak. Conclusion: Vitamin D status in 6- to 8-years-old girls with CPP is similar to that in prepubertal girls. PTH levels were significantly higher in girls with CPP, and could be considered as a pubertal characteristic and, in this case, of pubertal precocity.

scholarly journals Vitamin D Status And Parathyroid Hormone Levels In Girls With Central Precocious Puberty

2021 ◽  
Author(s):  
Durá-Travé Teodoro ◽  
Gallinas-Victoriano Fidel ◽  
Ahmed-Mohamed Lotfi ◽  
Moreno-González Paula ◽  
Urretavizcaya-Martinez María ◽  
...  
Keyword(s):  
Vitamin D ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Hypovitaminosis D ◽  
Bone Age ◽  
Control Group ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Endocrine Society ◽  
Prepubertal Girls

Abstract Background. The presence of vitamin D receptor in both the pituitary gland and female reproductive tissue suggests that vitamin D could be involved in female fertility mechanisms as well as in the activation of the hypothalamic-pituitary-gonadal axis. The objective of this study was to analyze the vitamin D status and PTH levels in 6- to 8-years-old girls with central precocious puberty. Methods. A cross-sectional clinical and blood testing (calcium, phosphorus, 25(OH)D and PTH) were carried out in 78 girls with central precocious puberty (CPP group), aged 6.1-7.9 years. A control group was recruited (157 prepubertal girls, aged 6.1-8.2 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. Results. There were no significant differences in the vitamin D status between both groups. There were not significant differences in 25(OH)D levels between CPP (25.4±8.6 ng/mL) and control groups (28.2±7.4 ng/mL). In contrast, in CPP group PHT levels (44.8±16.3 pg/mL) were higher (p < 0.05) with respect to control group (31.0±11.9 ng/mL). In CPP group there was positive correlation (p < 0.05) between PTH levels and growth rate, bone age, basal estradiol, basal FSH, basal LH and LH peak. Conclusion: Vitamin D status in 6- to 8-years-old girls with CPP is similar to that in prepubertal girls. PTH levels were significantly higher in girls with CPP, and could be considered as a pubertal characteristic and, in this case, of pubertal precocity.

scholarly journals Age and Spinal Disease Correlate to Albumin and Vitamin D Status

2021 ◽  
pp. 219256822098256
Author(s):  
Anderson Gomes Marin ◽  
Raphael de Rezende Pratali ◽  
Samuel Machado Marin ◽  
Carlos Fernando Pereira da Silva Herrero
Keyword(s):  
Vitamin D ◽  
Nutritional Status ◽  
Age Groups ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Surgical Approaches ◽  
Albumin Concentration ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Epidemiological Profile

Study Design: Cross-sectional study. Objectives: Thus, this study aimed to assess the epidemiological profile of a patient sample that underwent spinal surgery regarding their nutritional and vitamin D status. Methods: Serum albumin and vitamin D (25-hydroxyvitamin D) levels were measured in patients with different spinal surgical approaches and various pathologies at a single institution. 112 patients were retrospectively identified for inclusion and stratified by age into 4 age groups and by pathology. The nutritional status of the patients was classified in vitamin D inadequacy (< 30ng/mL), vitamin D deficiency (<20ng/mL), and hypoalbuminemia (<3.5g/dL). Data was analyzed comparing vitamin D, and albumin means considering gender, age group, and pathologies. Results: Twenty-eight (25.2%) patients had hypoalbuminemia. There was no difference between gender (p = 0.988); there was a significant decrease in albumin concentration increasing the age (p < 0.001). The prevalence of hypoalbuminemia was significantly higher in patients with trauma, tumor and infection than in those patients with degenerative and deformity diseases (p = 0.003). The prevalence of vitamin D inadequacy was 33.7%, and that of deficiency was 62.2%, while severe deficiency (< 10 ng/mL) in 16.3%. The vitamin D concentration was significantly different among the pathologies (P = 0.047), the lower concentration occurring in patients with tumor. Conclusion: Older patients, as well as patients with tumor and infectious pathologies, seem to have a higher prevalence of hypoalbuminemia, inferring malnutrition. There was a low epidemic level of vitamin D concentration, almost all patients presenting some degree of hypovitaminosis D, independent of age, gender and nutritional status.

scholarly journals Differences in vitamin D status and calcium metabolism in Saudi Arabian boys and girls aged 6 to 18 years: effects of age, gender, extent of veiling and physical activity with concomitant implications for bone health

2012 ◽  
Vol 15 (10) ◽  
pp. 1845-1853 ◽  
Author(s):  
Maryam A Al-Ghamdi ◽  
Susan A Lanham-New ◽  
Jalal A Kahn
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Parathyroid Hormone ◽  
Bone Health ◽  
Age Groups ◽  
Hypovitaminosis D ◽  
Vitamin D Status ◽  
Kingdom Of Saudi Arabia ◽  
Cross Sectional

AbstractObjectiveFew data exist looking at vitamin D status and bone health in school-aged boys and girls from Saudi Arabia. The present study aimed to determine the extent of poor vitamin D status in school boys and girls aged 6–18 years and to examine if there was any difference in status with age, physical activity and veiling and concomitant effects on bone.DesignCross-sectional study.SettingJeddah, Kingdom of Saudi Arabia.SubjectsA total of 150 boys (7–16 years) and 150 girls (6–18 years) from local schools were divided into age categories: 6–9 years (elementary school); 10–12 years (secondary school); 13–14 years (middle years); 15–18 years (high school).ResultsVitamin D status was significantly lower in girls than boys in all age groups (P < 0·01), with the 15–18-year-old girls having the lowest level (22·0 (sd 9·4) nmol/l) in comparison to the 15–18-year-old boys (39·3 (sd 14·0) nmol/l) and the 6–9-year-old girls (41·2 (sd 9·3) nmol/l). Parathyroid hormone status was highest in the 15–18-year-old girls in comparison to boys of the same age. A total of 64 % of 15–18-year-old girls had 25-hydroxyvitamin D (25OHD) status <25 nmol/l in comparison to 31 % in the 13–14 years age category, 26 % in the 10–12 years category and 2·5 % in the 6–9 years category. No boys had 25OHD status <25 nmol/l. Fully veiled girls had lower 25OHD status than partly veiled or unveiled girls (P < 0·05). Low 25OHD and high parathyroid hormone was associated with lower bone mass in the 6–9 years and 13–14 years age groups (P < 0·05).ConclusionsThese data suggest significant hypovitaminosis D in older adolescent females, which is a cause for concern given that there is currently no public health policy for vitamin D in the Kingdom of Saudi Arabia.

Vitamin D status and its associations with components of metabolic syndrome in healthy children

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Ali Awsat Mellati ◽  
Faranak Sharifi ◽  
Soghrat Faghihzade ◽  
Seyed Akbar Mousaviviri ◽  
Hosain Chiti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Resistance Index ◽  
Sun Exposure ◽  
Hypovitaminosis D ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Low Serum

AbstractHigh prevalence of vitamin D insufficiency/deficiency has been reported in populations of different countries. The aim of this cross-sectional study was to determine the prevalence and association of vitamin D status with components of metabolic syndrome.Lipid profile indices, anthropometric indices [body mass index and waist circumference (WC)], insulin resistance index (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), C-reactive protein, intact parathyroid hormone (iPTH), and serum 25-hydroxyvitamin D [25(OH)D] concentration were evaluated in 297 healthy schoolchildren aged 7–11 years. Multivariate linear regression was used to determine independent predictors associated with low serum 25(OH)D concentrations.The mean serum 25(OH)D concentration was 14.12±8.20 ng/mL (35.3±20.5 nmol/L); 96% of children had low serum 25(OH)D levels, 31.0% were deficient, and 65.0% had insufficient levels of 25(OH)D. Vitamin D deficiency was higher in girls (χThe prevalence of low vitamin D level in the studied healthy children was high and it is correlated with some components of metabolic syndrome. Outdoor activity for optimum sun exposure and additional studies are needed to evaluate the underlying metabolic syndrome components and hypovitaminosis D complications.

scholarly journals Genotype-phenotype correlations in central precocious puberty caused by MKRN3 mutations

2020 ◽  
Author(s):  
Carlos Eduardo Seraphim ◽  
Ana Pinheiro Machado Canton ◽  
Luciana Montenegro ◽  
Maiara Ribeiro Piovesan ◽  
Delanie B Macedo ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Genetic Defect ◽  
Ring Finger ◽  
Central Precocious Puberty ◽  
Bone Age ◽  
Control Group ◽  
Missense Mutations ◽  
Loss Of Function ◽  
Reproductive Axis ◽  
Time Of Presentation

Abstract Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most common monogenic cause of familial central precocious puberty (CPP). Objective To describe the clinical and hormonal features of a large cohort of patients with CPP due to MKRN3 mutations and compare the characteristics of different types of genetic defects. Patients/methods Multiethnic cohort of 716 patients with familial or idiopathic CPP screened for MKRN3 mutations using Sanger sequencing. A group of 156 Brazilian girls with idiopathic CPP (ICPP) was used as control group. Results Seventy-one patients (45 girls and 26 boys from 36 families) had 18 different loss-of-function MKRN3 mutations. Eight mutations were classified as severe (70% of patients). Among the 71 patients, first pubertal signs occurred at 6.2 ± 1.2 years in girls and 7.1 ± 1.5 years in boys. Girls with MKRN3 mutations had a shorter delay between puberty onset and first evaluation and higher FSH levels compared to ICPP. Patients with severe MKRN3 mutations had a greater bone age advancement compared to patients with missense mutations (2·3 ± 1·6 vs. 1·6 ± 1·4 years, p = 0.048), and had higher basal LH levels (2·2 ± 1·8 vs. 1·1 ± 1·1 UI/L, p=0.018) at the time of presentation. Computational protein modeling revealed that 60% of the missense mutations were predicted to cause protein destabilization. Conclusions Inherited premature activation of the reproductive axis caused by loss-of-function mutations of MKRN3 is clinically indistinct from ICPP. However, the type of genetic defect may affect bone age maturation and gonadotropin levels.

scholarly journals Vitamin D status and prevalence of hypovitaminosis D in different genders throughout life stages: A Brazilian cross-sectional study

Clinics ◽  
2021 ◽  
Vol 76 ◽  
Author(s):  
Lenora M. Camarate S.M. Leão ◽  
Bernardo Campos Rodrigues ◽  
Paulo Telles Pires Dias ◽  
Bárbara Gehrke ◽  
Thiago da Silva Pereira de Souza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Life Stages ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional

The relation of urinary bisphenol A with kisspeptin in girls diagnosed with central precocious puberty and premature thelarche

2016 ◽  
Vol 29 (3) ◽  
Author(s):  
İlker Tolga Özgen ◽  
Emel Torun ◽  
Bilge Bayraktar-Tanyeri ◽  
Erdem Durmaz ◽  
Elif Kılıç ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Precocious Puberty ◽  
Endocrine Disruptor ◽  
Statistical Difference ◽  
Daily Life ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Control Group ◽  
Premature Thelarche ◽  
Prepubertal Girls

AbstractBisphenol A (BPA) is known as an endocrine disruptor and it is supposed to have a role on the development of central precocious puberty (CPP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of gonadotropin releasing hormone and it has an important role on regulation of the onset of puberty. The BPA levels in girls with CPP and premature thelarche (PT) and its relation with kisspeptin levels were investigated.Twenty-eight girls with CPP, 28 girls with PT and 22 prepubertal girls as a control group were enrolled to the study. Urinary BPA and serum kisspeptin levels were compared in the groups. Bivariate correlations were performed to evaluate the relations of BPA with kisspeptin and estradiol.There was no statistical difference between groups regarding BPA levels. Serum kisspeptin levels were higher in CPP group than controls [306.56 (interquartile range (IQR), 175.63–504.66) vs. 157.62 (IQR, 55.61–285.00) p: 0.008]. There were no correlations between BPA and kisspeptin levels (r: 0.088, p: 0.391) and between BPA and estradiol (r: –0.171, p: 0.144).The BPA levels did not differentiate between groups and it seems that the exposed amount of BPA in daily life did not affect kisspeptin levels in girls with CPP and PT.

scholarly journals Hypovitaminosis D and Its Associated Factors in North Algerian Postmenopausal Women: Results of a Cross-Sectional Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
S. Oussedik-Lehtihet ◽  
C. Haouichat ◽  
N. Hammoumraoui ◽  
E. Ducros ◽  
C. Gouhier-Kodas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Postmenopausal Women ◽  
Statistical Power ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Sample Population ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional

Purpose. As the vitamin D status of Algerian postmenopausal women was poorly described, this cross-sectional study investigated the prevalence of low vitamin D status in a sample population. Secondarily, predictive factors of this hypovitaminosis D were explored.Methods. All the 336 selected women ≥ 45 years from Douera were interviewed to get anthropometric and lifestyle data, reproductive and medical history, medications, and calcium/vitamin D intakes. A blood sample was collected to measure 25-hydroxyvitamin D (25(OH)D) concentrations.Results. Approximately 86% of subjects had low vitamin D status (<20 ng/mL). Mean 25(OH)D level was 14.4 ± 5.3 ng/mL with a clear seasonal dynamic and a significant negative correlation with PTH levels (r  = −0.15,p=0.006). A multiple regression analysis using the 25(OH)D cutoff value of 17 ng/mL instead of the generally admitted level of 20 ng/mL was performed to increase statistical power. Other seasons than summer (OR 4.159 and 95% CI 2.456–7.043), obesity (≥30 kg/m2, OR 1.826, 95% CI 1.081–3.083), and veiling (OR 3.526, 95% CI 1.090–11.400) were significantly associated with 25(OH)D concentrations <17 ng/mL.Conclusions. In North Algeria, the abundant sunlight appears insufficient to fully offset hypovitaminosis D risk factors in postmenopausal women, especially obesity and veiling. It suggests the major need to increase vitamin D supplementation in this subpopulation.

scholarly journals Vitamin D and PTH: data from a cross-sectional study in an equatorial population

2020 ◽  
Vol 9 (7) ◽  
pp. 667-675
Author(s):  
Natércia Neves Marques de Queiroz ◽  
Franciane Trindade Cunha de Melo ◽  
Fabrício de Souza Resende ◽  
Luísa Corrêa Janaú ◽  
Norberto Jorge Kzan de Souza Neto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Institute Of Medicine ◽  
Sectional Study ◽  
Cross Sectional ◽  
Endocrine Society

Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria. Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL. Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.

scholarly journals Assessment of vitamin D, calcium, inorganic phosphate, alkaline phosphatase and parathormone in juvenile idiopathic arthritis patients

2020 ◽  
Vol 43 (3) ◽  
pp. 145-151
Author(s):  
Sufia Khatun Sumi ◽  
Shahana A Rahman ◽  
Mohammad Imnul Islam ◽  
Mohammad Mahbubul Islam ◽  
Manik Kumar Talukder
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Biochemical Parameters ◽  
Inorganic Phosphate ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Control Group ◽  
Osteoporotic Bone ◽  
Cross Sectional ◽  
The Status

Background: Decrease in bone mass in JIA patients is multifactorial. By assessing the level of vitamin D and other associated parameters we can identify the deficiency earlier and can predict the risk of osteoporotic bone fracture & give appropriate supplements. Objective: To determine the status of serum 25(OH)D, calcium, inorganic phosphate, alkaline phosphatase and parathormone in patients with JIA. Materials and methods: It was a cross sectional study. Thirty newly diagnosed cases of JIA attending the pediatric rheumatology clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from October 2015 to September 2016 were included. Thirty age and sex matched control were also selected. Serum 25(OH)D, calcium, inorganic phosphate, alkaline phosphatase & parathormone were assesed in both cases and controls. Results: Hypovitaminosis D was present in 60% of JIA and 33% of controls. In JIA group the mean level of all biochemical parameters were significantly lower than control group except serum 25 (OH) D. Level of calcium, inorganic phosphate and alkaline phosphatase was decreased with the decrease of 25 (OH) D levels and there was no change of parathyroid hormone level. Conclusion: More than half of JIA patients had hypovitaminosis D. There was positive relationship between 25(OH)D level and other biochemical parameters except PTH. Bangladesh J Child Health 2019; VOL 43 (3) :145-151

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