scholarly journals A Prospective Study of Feto-Maternal Outcome Among Covid-19 Positive Women Delivered in a Level III Covid Hospital at Moradabad, Western UP

2021 ◽  
Author(s):  
Nupur Nandi ◽  
Ritika Agarwal ◽  
Garima Bajpai
Keyword(s):  
Pregnant Women ◽  
Vertical Transmission ◽  
Ventilatory Support ◽  
Late Pregnancy ◽  
Maternal Outcome ◽  
Data Availability ◽  
Research Centre ◽  
Care Hospital ◽  
Rt Pcr ◽  
Pcr Test

Abstract Background: The ongoing pandemic situation by a highly infective Covid-19 virus is a global health threat. Pregnancy related physiological changes of cardio- respiratory system and relative immunosuppression might cause more infectivity and worsening complications of this novel respiratory virus infection. Limited data availability on feto -maternal outcome of Covid 19 positive pregnant women necessitates the current study.Methodology: A prospective cohort study was conducted in a government designated level III Covid care hospital at Teerthankar Mahaveer Medical College & Research Centre to assess the feto-maternal outcome in Covid 19 RT- PCR test positive pregnant women delivered between April 2020 to September 2020. Mothers were evaluated in terms of asymptomatic status or predominant symptoms (fever, cough, sore throat, and breathlessness), complication if any including need for ventilatory support for extensive pneumonia, or mortality. Neonates were tested for presence of infection by RT-PCR test on day 2 & 5 of delivery, and also looked for any symptoms of the disease or it’s complication.Results: Total 33 women with Covid19 positivity delivered at term pregnancy in the said period of 6 months. The most frequent (45.45%) age group was 26 to 30 years. Asymptomatic Covid 19 positive cases were more (57.58%) prevailing over symptomatic patients. Fever was most frequent (33.33%) physical symptom. Emotional quotient was significantly affected by presence of anxiety amongst 36.36%. Caesarean delivery conducted maintaining all protocol in 60.6% women, but all were indicated for other obstetric reason. None of the mother had developed significant pneumonia or other complication. One case of maternal mortality noted, but was not related to Covid 19 infection. Vertical transmission was nil in our study and no neonate was affected by any complication.Conclusion: Course of disease was not different in pregnant women infected by Covid 19 virus in late pregnancy in comparison to non-pregnant adults. No case of vertical transmission noted, neither any neonatal morbidity nor mortality in present study, shows the importance of following optimum protocol. All pregnant women should be screened for Covid 19 infection in current scenario.

scholarly journals Frequency and Fetomaternal Outcome in COVID 19 Positive Pregnant Women

2021 ◽  
pp. 200-205
Author(s):  
Mehwish Younus ◽  
Urooj Naz ◽  
Aruna Kumari Hira ◽  
Sana Shahmir ◽  
Uroosa Naz ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Tertiary Care ◽  
Maternal Outcome ◽  
Premature Delivery ◽  
Care Hospital ◽  
Observational Cohort ◽  
The Mean ◽  
Adverse Pregnancy ◽  
Antenatal Visits ◽  
High Chance

Objective: To determine the frequency and outcome in pregnant women with COVID-19 infection. Study Design: This is a observational cohort study. Setting: Study carried out at Department of Obstetrics & Gynecology, Civil Hospital, Dow University of health sciences Karachi, from July 2020 to November 2021. Materials & Methods:  The study was conducted in a tertiary care hospital in Karachi. Women having COVID-19 positive status during any stage of their pregnancy having antenatal visits in our hospital were included in our study. Maternal demographics, race, maternal outcome, and neonatal complications were noted on a self-made Performa. Statistical analysis was done by SPSS version 21 and descriptive statistics with frequencies were mainly calculated. Results: During the defined time of 14 months, we had 143 women visiting antenatal outpatient department and were tested positive for COVID-19. Majority of the women were tested for COVID-19 due to symptoms like fever, flu, cough and diarrhea. The mean age of women in our study was found to be 30 ± 6.7 years. The most frequent maternal outcome with SARSCOV-2 was preterm delivery. Out of 143, 27 cases had emergency lower segment C-section.PCR testing of neonates was carried out and 8.39% (n=12) neonates tested positive for SARSCOV-2.  Conclusion: Infection with Covid-19 during pregnancy is associated with adverse pregnancy outcomes. Covid-19  infection can be transmitted to the fetus during pregnancy or childbirth. Neonatal has a high chance of being admitted to the ICU, and women also faces other complications of Covid 19, such as the risk of miscarriage and premature delivery.

scholarly journals Vertical Transmission of COVID-19 to the Neonate

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Sindy C. Moreno ◽  
Justin To ◽  
Hajoon Chun ◽  
Ivan M. Ngai
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Medical Centre ◽  
Test Results ◽  
Third Trimester ◽  
The Third ◽  
Hospital Medical ◽  
Pcr Test

Objective. To estimate the incidence rate of vertical transmission of coronavirus disease 2019 (COVID-19) to the neonate during the third trimester. Study Design. We conducted a retrospective observational study of pregnant women diagnosed with COVID-19 during the third trimester, who delivered at Flushing Hospital Medical Centre (FHMC) or Jamaica Hospital Medical Centre (JHMC) between March 20, 2020, and April 30, 2020. The study participants were symptomatic pregnant women diagnosed with COVID-19 via positive SARS-CoV-2 RNA, real-time reverse transcription-polymerase chain reaction (SARS-CoV-2 rRT-PCR) test. Evidence of vertical transmission was assessed in the neonate via a SARS-CoV-2 rRT-PCR test, with nasopharyngeal swab samples collected on the neonates after 24 hours of birth. The exclusion criteria for this study were maternal or neonate records without SARS-CoV-2 rRT-PCR test results, neonates not delivered at FHMC or JHMC, and foetuses with suspected foetal anomalies or incomplete medical records. Results. We identified 19 symptomatic pregnant women diagnosed with COVID-19, including two women with twin pregnancies. Seven patients (36.8%) were delivered via cesarean. 12 patients (63.1%) presented in spontaneous labour, and 8 (38.1%) had preterm delivery. No maternal intensive care unit admission, maternal sepsis, or maternal mortality was observed. Twenty-one neonates were evaluated for COVID-19 after birth. SARS-CoV-2 rRT-PCR test results were negative in 100% of the neonates. Thirteen neonates (61.9%) were admitted to the neonatal intensive care unit. Prematurity was the most common cause of NICU admission 6 (46.1%), with a length of stay of 5.5 ± 6.4 days. No invasive mechanical ventilation, neonatal sepsis, or neonatal mortality was observed. Conclusion. In our cohort, symptomatic COVID-19 during the third trimester of pregnancy was not associated with vertical transmission to the neonate.

scholarly journals Maternal and Perinatal Outcomes in Patients with Suspected COVID-19 and Their Relationship with a Negative RT-PCR Result

2020 ◽  
Vol 9 (11) ◽  
pp. 3552 ◽  
Author(s):  
Yolanda Cuñarro-López ◽  
Óscar Cano-Valderrama ◽  
Pilar Pintado-Recarte ◽  
Ignacio Cueto-Hernández ◽  
Blanca González-Garzón ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Oxygen Therapy ◽  
Perinatal Outcomes ◽  
Tertiary Hospital ◽  
Monocyte Count ◽  
Rt Pcr ◽  
Negative Test ◽  
Negative Test Result ◽  
Test Result ◽  
Pcr Test

This study was designed to examine maternal-perinatal outcomes in pregnant women with suspected coronavirus disease 2019 (COVID-19) according to the result of a real-time reverse transcription polymerase chain reaction (RT-PCR) test and to investigate possible variables that could be useful for predicting a negative RT-PCR result. Participants of this retrospective cohort study were obstetrics patients with suspected COVID-19 who underwent an RT-PCR test in a tertiary hospital in Madrid, Spain. Maternal-perinatal features were analysed according to the results of this test. Clinical, radiological and analytical characteristics that could be associated with a negative result were also explored. In a final subgroup analysis, patients were included if they had pneumonia and a negative test result for the virus. Out of the 111 obstetric patients with suspected COVID-19 that were enrolled, 38.7% returned a negative result. In this RT-PCR-negative group, we recorded lower rates of pneumonia (21.4% vs. 45.6%, p = 0.009), severe or critical clinical features (4.7% vs. 11.8% and 0.0% vs. 5.9%, p = 0.02, respectively), lower lactate dehydrogenase (LDH) levels (168 UI/L vs. 224.5 UI/L, p = 0.003), a greater need for maternal treatment (60.3% vs 24.4%, p < 0.001), a reduced need for oxygen therapy (2.4% vs 28.8%, p < 0.001) and a lower rate of intensive care unit admission (0.0% vs. 3.7%, p = 0.046) than the RT-PCR-positive group. While no differences were found in other variables, the monocyte count was higher (946.2/μL vs. 518.8/μL, p = 0.022) in this group. The predictive model for a negative test result included the monocyte count, LDH level and no need for oxygen therapy. This model was able to identify 73.5% of patients with a negative RT-PCR result. Only 11% of the patients with pneumonia testing negative for the virus had IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The proportion of pregnant women with suspected COVID-19 and a negative RT-PCR result was nearly 39%. In these patients, the symptoms were mild and the systemic severity of the disease was lower. The monocyte count, LDH level and no need for oxygen therapy were the factors that were more related to a negative test result in this group. These variables could be used to guide the management of patients with suspected COVID-19, mainly while waiting for RT-PCR results or in settings where this test is not available.

scholarly journals Study of mode of delivery and maternal morbidity in preterm and term COVID-19 positive pregnant women

2021 ◽  
Vol 10 (12) ◽  
pp. 4383
Author(s):  
Saksha Dholakiya ◽  
Pooja S. Singh ◽  
Jaishree Bamniya ◽  
Haresh U. Doshi
Keyword(s):  
Pregnant Women ◽  
Mode Of Delivery ◽  
Initial Assessment ◽  
High Risk Population ◽  
Cesarean Sections ◽  
Rt Pcr ◽  
Third Trimester ◽  
The Third ◽  
Obstetrics And Gynaecology ◽  
Pcr Test

Background: Pregnant women are likely to represent a high-risk population during current coronavirus 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2. The aim and objective of this study was to evaluate how COVID-19 pandemic has affected the mode of delivery and whether complications of the disease and mortality rate are higher in pregnant women than in non‐pregnant women.Methods: This ambispective observational study was conducted in department of obstetrics and gynaecology of our institute. Pregnant women diagnosed with positive for COVID-19 via the SARS-CoV-2 RT-PCR test in the third trimester and all neonates with complete COVID-19 testing and delivery data. This data was analysed.Results: Out of total 66 cases studied, 48 patients (72.7%) were asymptomatic, while 13 (19.7%) had mild respiratory or gastro intestinal symptoms on initial assessment at admission, including cough, sore throat, fever, weakness or diarrhoea. Cesarean sections were performed in 57.6% of cases. There were no cases of maternal or neonatal mortality.Conclusions: The study revealed that COVID-19 positive pregnant women are usually asymptomatic or mild-moderately symptomatic, similar to COVID-19 positive non-pregnant women. There was a noted rise in the rate of caesarean sections as a mode of delivery. 

scholarly journals Significance of placental swab in diagnosing vertical transmission in SARS-CoV-2 positive mothers.

2020 ◽  
Author(s):  
Isabelle Sweeney ◽  
Rizwan Khan ◽  
Niazy Al Assaf
Keyword(s):  
Literature Review ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Neonatal Outcome ◽  
Placental Tissue ◽  
Vaginal Fluid ◽  
Second Trimester ◽  
Rt Pcr ◽  
Search Terms ◽  
Expectant Mothers

Abstract AimsCurrently, there is limited date on the effects of COVID-19 on pregnancy and neonatal outcome. This literature review aims to investigate the possibility of fetal vertical transmission in COVID-19 positive pregnant mothers by diagnosing through placental swabs.MethodsThe search terms ‘pregnant COVID-19 positive mothers’, ‘fetal vertical transmission’ and ‘placental swabs’ were used. 11 papers were selected for this review.ResultsThis literature review comprises 45 COVID-19 positive pregnant women whose placentas and neonates were also analysed by RT-PCR for the presence of SARS-CoV-2. 43 neonates were successfully delivered primarily via caesarean section out of 45 expectant mothers (96%). 2 mothers did not deliver due to severe preeclampsia and a miscarriage both occurring in the second trimester. 3 neonates tested positive for SARS-CoV-2 (7%). We report no neonatal mortality after birth and no maternal mortality. 8 female’s placentas tested positive for SARS-CoV-2 out of a total of 45 tested (18%). Of these 8, 2 cases of SARS-CoV-2 were identified in the maternal, neonatal and placental tissue.ConclusionAfter reviewing multiple studies and investigating the nature of placental physiology in SARS-CoV-2 positive mothers we conclude that there is no concrete evidence of vertical transmission occurring between mother and infant. However, there are inconsistencies across the different papers used for this review and further research investigating the effects of COVID-19 on pregnant women by using RT-PCR to test the mother, placenta, vaginal fluid, breast milk and infant for SARS-CoV-2 at various stages of transmission is urgently needed.

scholarly journals Diagnosis Challenges, Management, and Outcome of Infants Born to Mothers With COVID 19

2020 ◽  
Author(s):  
Gabriela Zaharie ◽  
Monica Hasmasanu ◽  
Daniel Muresan ◽  
Tunde Kovacs ◽  
Melinda Matyas
Keyword(s):  
Hospital Stay ◽  
Pregnant Women ◽  
Distress Syndrome ◽  
Laboratory Data ◽  
Perinatal Transmission ◽  
Risk Category ◽  
Rt Pcr ◽  
Medical Assistance ◽  
High Risk Category ◽  
Pcr Test

Abstract Background: Severe acute respiratory distress syndrome with Coronavirus 2 (SARS-CoV-2) infection affected the pregnant women during the pandemics. Immunological particularity of this population and the increased need for medical assistance put this population in a high-risk category for SARS-Cov-2 infection.Because of high contamination risk and limited studies about vertical transmission, the labor and delivery of positive women require special conditions. Cesarean section is probably the best option for delivery of infants to reduce the risk of infection during birth.Aim: Our study aims to present the management and outcome of infants born to mothers confirmed with coronavirus disease 2019 (COVID19) before delivery.Material and methods: This is longitudinal, retrospective study, analyzing demographics, laboratory data and management of neonates born of mothers with diagnosis of SARS-Cov -2 infection.Results: 5 neonates were born of SARS-Cov-2 positive mothers , all by C- section and had negative real time –PCR ( RT-PCR) test. None of them was breastfed during hospital stay. The negative RT-PCR test allowed us to reduce the hospital stay of infants and care them in non –isolated area.Conclusion: In our study, vertical or perinatal transmission of the infection was not present. The testing of the pregnant women, their isolation and delivery in safe conditions for the medical staff were possible, using adequate protection equipment to limit their infection and the risk for the newborns.

scholarly journals Transmission of SARS-CoV-2 infection mother to the newborn

2020 ◽  
Vol 7 (10) ◽  
pp. 2086
Author(s):  
Bonifacio Caballero ◽  
Daniel Caballero
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Intrauterine Infection ◽  
Late Pregnancy ◽  
Hubei Province ◽  
Capital City ◽  
Third Trimester ◽  
The Third ◽  
The World

The emergence of the new corona virus infection that occurred in Wuhan, the capital city of China's Hubei province in December 2019 initially labeled 2019-nCoV and later named SARS-CoV-2, has spread in several countries around the world and subsequently raised concerns about the possibility of vertical transmission from the mother to the fetus, producing its disease named COVID-19. Around 12 articles about pregnant women infected with COVID-19 and their newborns have been published between February 10 and April 4, 2020. So far, there are few reports on newborns. There is currently evidence of vertical transmission from pregnant women with COVID-19 infection during the third trimester. The results of this report suggest that currently there is evidence of intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia and die in late pregnancy. However, most of these newborns have been asymptomatic or mildly symptomatic, but as the outbreak and information are changing rapidly, it is recommended to continue to check for updates.

scholarly journals Vertical transmission and clinical outcome of the neonates born to SARS-CoV-2-positive mothers: a tertiary care hospital-based observational study

2021 ◽  
Vol 5 (1) ◽  
pp. e001193
Author(s):  
Pradeep Kumar ◽  
Fadila ◽  
Arun Prasad ◽  
Ambrin Akhtar ◽  
Bhabesh Kant Chaudhary ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Observational Study ◽  
Vertical Transmission ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Stable Condition ◽  
Nasopharyngeal Swab ◽  
Care Hospital ◽  
Rt Pcr

BackgroundNeonatal transmission of SARS-CoV-2 from positive mothers to their babies has been a real concern, opening the arena of research in this area.ObjectiveTo detect the possibility of vertical transmission of SARS-CoV-2 from COVID-19-positive mothers to their neonates and the clinicopathological outcome in them.DesignA single-centre, prospective, observational study involving 47 COVID-19-positive mothers and their neonates.SettingA tertiary care hospital in Eastern India.ParticipantsNeonates born to SARS-CoV-2-infected mothers.Main outcome measuresWe investigated the SARS-CoV-2 positivity rate by real-time reverse transcriptase-PCR (RT-PCR) done twice (on admission and after 24 hours of admission) in neonates born to SARS-CoV-2-positive mothers, who tested RT-PCR positive for this virus in their nasopharyngeal swab. Clinical outcome was also assessed in these neonates during their hospital stay.ResultsOut of 47 neonates born to SARS-CoV-2-positive mothers, four were SARS-CoV-2 positive by RT-PCR. All the neonates in our study were discharged home in stable condition after management of acute complications. None of them required readmission.ConclusionVertical transmission occurs in neonates born to COVID-19-positive mothers; however, the risk is small. Majority of the neonates remain asymptomatic with good clinical outcome.

scholarly journals Covid-19 Infection in Pregnant Women in Dubai: A Case-control Study

2021 ◽  
Author(s):  
Komal Hazari ◽  
Rasha Abdeldayem ◽  
Litty Paulose ◽  
Nimmi Kurien ◽  
Zukaa Almahloul ◽  
...  
Keyword(s):  
Pregnant Women ◽  
United Arab Emirates ◽  
Vertical Transmission ◽  
Case Control Study ◽  
Late Pregnancy ◽  
Case Control ◽  
Icu Admission ◽  
Risk Pregnancy ◽  
The Impact ◽  
Control Study

Abstract Background: Whilst the impact of Covid-19 infection in pregnant women has been examined, there is a scarcity of data on pregnant women in the Middle East. Thus, the aim of this study was to examine the impact of Covid-19 infection on pregnant women in the United Arab Emirates population. Methods: A case-control study was carried out to compare the clinical course and outcome of pregnancy in 79 pregnant women with Covid-19 and 85 non-pregnant women with Covid-19 admitted to Latifa Hospital in Dubai between March and June 2020. Results: On admission, most pregnant women (69/79; 87%) were either asymptomatic or suffered mild respiratory symptoms, much like non-pregnant women. The main symptoms, observed in both groups, were fever, cough, headache, runny nose and myalgia. In early pregnancy four women had spontaneous miscarriages. However, severe Covid-19 illness, ICU admission, intubation and complications were observed in late pregnancy in 10/79 (13%) women with prior comorbidities. During the study period, 31/79 women delivered: 22 (70%) had a lower segment Caesarean section, 16 for obstetric reasons and 6 for severe Covid-19 pneumonia; and 12 had a preterm delivery. Postoperatively, none showed significant improvement on account of early delivery. Sepsis, acute renal failure and acute respiratory distress syndrome were the most common complications observed. The neonatal outcome was comparable to that of the general obstetric population, even though 12/31 (38%) were preterm and had to be admitted to the neonatal ICU. Two neonates, born by vaginal delivery, tested positive for Covid-19 after delivery. Both were asymptomatic and tests were negative within 72 hours. It was not possible to ascertain whether vertical transmission occurred in utero.Conclusions: Severe Covid-19 illness, ICU admission, intubation, complications and preterm deliveries were observed in late pregnancy in women with comorbidities. Pregnancy with Covid-19 infection, could, therefore, be categorised as high-risk pregnancy. It was not possible to confirm whether vertical transmission of Covid-19 had occurred during the third trimester of pregnancy.

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