scholarly journals Evaluation of the Relationship Between Celiac Disease and Refractory Epilepsy in Patients Referred to Imam Khomeini Hospital of Urmia

2021 ◽  
pp. 1-15
Author(s):  
Hanieh Mollazadeh ◽  
◽  
Surena Nazarbaghi ◽  
Mohammad Reza Pashaei ◽  
◽  
...  
Keyword(s):  
Celiac Disease ◽  
Serum Level ◽  
Refractory Epilepsy ◽  
Serum Levels ◽  
Control Group ◽  
Cross Sectional ◽  
Statistical Population ◽  
Significant Difference ◽  
The Mean ◽  
The Relationship

Objective: Celiac disease can be associated with other diseases, including neurological disorders. In this study, the relationship between celiac disease and refractory epilepsy was evaluated in patients referred to Imam Khomeini Hospital of Urmia. Material & Methods: In this cross-sectional study, patients with refractory epilepsy referred to the neurology clinic of Imam Khomeini Hospital of Urmia, during the second half of 2019 and controlled epilepsy were studied as a control group. The statistical population of the present study included 50 patients with refractory seizures and 50 patients with controlled seizures. The mean age of patients was 32.96 ± 11.35 years. Five ml blood samples were taken from the patients, and a serum anti-tTG test was performed using the ELISA kit. Then, in patients with positive anti-tTG, a duodenal biopsy sample was prepared using an endoscopy. Results: This study showed that the mean serum level of anti-tTG in patients with refractory epilepsy was higher than in patients with controlled epilepsy. Anti-tTG test results were positive in five of fifty patients with refractory epilepsy, and it was positive in two of fifty patients with controlled epilepsy. There was no significant difference between the two groups in terms of serum levels anti-tTG (p=0.14). Also, there was no significant relationship between serum level anti-tTG, age and genus (p>0.05). Biopsy results in three patients in the refractory epilepsy group and one patient in the controlled epilepsy group was in favor of a definitive diagnosis of the celiac disease. Patients in whom the celiac disease was confirmed by endoscopy had higher anti-tTG levels (p=0.006). Conclusion: There was no significant difference between the celiac disease in the group with refractory epilepsy and controlled epilepsy.

scholarly journals The effect of gamma radiation on plasma levels of zinc and selenium in nuclear medicine staff

2018 ◽  
Vol 21 (1) ◽  
pp. 51-56
Author(s):  
Mahdiyeh Mirnam Niha ◽  
Mehdi Salehi Barough
Keyword(s):  
Nuclear Medicine ◽  
Gamma Radiation ◽  
Graphite Furnace ◽  
Serum Zinc ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean

Background and aims: Gamma radiation is widely being used in medical-imaging centers. The aim of this study was to measure possible alterations in serum zinc and selenium levels among nuclear medicine staff. Methods: This cross-sectional study was carried out on 30 nuclear medicine staff as well as on 10 individuals as the control group. Blood samples (20 mL) were obtained from the participants and the serum specimens were isolated by centrifugation at 4000 rpm for 7 minutes. The samples were then used for measurement of zinc and selenium levels. Zinc and selenium levels were measured using atomic absorption spectroscopy (AAS) with a graphite furnace. The mean serum levels of zinc and selenium were compared using SPSS. Results: The mean level of zinc in the radiated group (70.91±14.46 μmol/L) was significantly lower than that in the control group (89.75±17.35 μmol/L) (P=0.002). A negative significant correlation was found between the duration of exposure to radiation and zinc levels (P=0.005). Furthermore, a negative significant relationship was observed between the mean radiation dose after 5 years and zinc concentration (P=0.019). Non-significant difference was found in the mean level of selenium between control (1.71±0.35 μmol/L) and radiation (2.13±1.12 μmol/L) groups. Furthermore, no significant correlation was found between selenium level and exposure time. Conclusion: Based on the results, declined level of zinc can be considered as one of the possible mechanisms caused by gamma radiation on cells which may be associated with oxidative damage. Therefore, zinc therapy can be helpful for those who work at medical radiation centers; however, it merits further studies.

The relationship between workload and adherence to professional codes of ethics among a sample of Iranian nurses

2021 ◽  
pp. 147775092110401
Author(s):  
Mahsa Dadkhah-Tehrani ◽  
Mohsen Adib-Hajbaghery
Keyword(s):  
Personal Characteristics ◽  
Codes Of Ethics ◽  
Spearman Correlation ◽  
Cross Sectional ◽  
Significant Difference ◽  
Perceived Workload ◽  
Professional Codes ◽  
The Mean ◽  
Professional Codes Of Ethics ◽  
The Relationship

Background Many studies have investigated the adherence to professional codes of ethics by nurses. However, no study has explicitly examined the relationship between workload and adherence to professional codes of ethics among Iranian nurses. Objective This study aimed to explore the relationships between workload and adherence to professional codes of ethics among a sample of Iranian nurses. Materials and Methods A cross-sectional descriptive study was conducted on 213 nurses who were randomly selected from the different wards of Shahid Beheshti Hospital of Kashan, Iran. Data collection instruments included a personal characteristics questionnaire, the Nursing Ethics Questionnaire, and the National Aeronautics and Space Administration Task Load Index. The Chi-square, the Spearman correlation coefficient, the Kruskal–Wallis, and Mann–Whitney U tests were used to analyze the data. Results A majority of nurses were females (77.5%), married (79.3%), and permanently employed (55.4%). The mean of the overall perceived workload and adherence to professional codes of ethics were 76.36 ± 13.64 and 13.98 ± 2.58, that were at high and moderated level, respectively. Spearman correlation test showed no significant correlation between perceived workload and adherence to professional codes of ethics ( r = 0.03, P = 0.6). A significant difference was found between the mean scores of adherence to professional codes of ethics in nurses working in different departments ( P < 0.001). Conclusion Participating nurses perceived high levels of workload but their mean adherence to professional codes of ethics was at a moderate level. The perceived workload was indirectly correlated with adherence to professional codes of ethics.

scholarly journals Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

2016 ◽  
Vol 9 (5) ◽  
pp. 234
Author(s):  
Zahra Heidari ◽  
Zahra Sepehri ◽  
Aleme Doostdar
Keyword(s):  
Type 2 Diabetes ◽  
Serum Level ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Incidence ◽  
Serum Selenium ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
The Mean

<p>In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P&lt;0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.</p>

scholarly journals Comparing Executive Functions in Normal and Diabetic Children in the City of Isfahan

2020 ◽  
Author(s):  
Niloofar Sadat Shokrekhodaei ◽  
Zahra Yousefi
Keyword(s):  
Executive Functions ◽  
Healthy Children ◽  
Cross Sectional ◽  
Statistical Population ◽  
Social And Emotional ◽  
Significant Difference ◽  
Diabetic Children ◽  
The Mean ◽  
Sick Children ◽  
The City

Background: The emergence of chronic physiologic diseases such as diabetes damages the children's psychological, cognitive, communicational, social and emotional processes. Therefore, the present study was aimed to compare executive functions in normal and diabetic children. Methods: The research method was cross-sectional. The statistical population included healthy and sick children in 2019 in Isfahan. The statistical population of the study included diabetic children and 150 healthy children who were selected through convenient sampling method. The applied questionnaires were the executive functions. The data from the study were analyzed through t method. Results: There is a significant difference between diabetic children and healthy ones in the variable of executive functions (p < 0.001). In a way that diabetic children got lower mean scores in executive functions. The mean scores of executive functions of children with diabetes were 233.63 and the mean scores of non-children with diabetes were 192.64. Conclusion: According to the findings of the present study it can be concluded that diabetes causes the decrease of executive functions due to being chronic and this process emphasizes the necessity of applying child-oriented psychological interventions for these people.

scholarly journals Assessment Of Tumour Necrosis Factor-Alpha (Tnf- Α) And Creatinine Levels In Echis Ocellatus Bite Victims In Jos Metropolis, Nigeria

2016 ◽  
Vol 12 (21) ◽  
pp. 70
Author(s):  
Manafa P.O. ◽  
Osmond E.O. ◽  
Onyenekwe C.C. ◽  
Okeke C.O. ◽  
Chukwuma G.O. ◽  
...  
Keyword(s):  
Serum Level ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Significant Difference ◽  
Factor Alpha ◽  
The Mean ◽  
Necrosis Factor

This study was designed to assess tumour necrosis factor-alpha and creatinine levels in Echis ocellatus bite victims. A total of 50 subjects were recruited. Out of this number, 40 were victims of E. ocellatus bite and the remaining 10 were non-victims of snake bite who served as the control group. Blood samples were collected from the victims within 24 hours of the snake bite and EchiTAb-G antivenom administered within the same period. Another batch of blood sample was collected 48 hours post-administration of the anti-venom. Tumour necrosis factor-alpha (TNF-alpha) levels were estimated by the Enzyme Linked Immunosorbent Assay technique while creatinine levels were determined using kinetic-spectrophotometric procedure. The mean serum levels of tumour necrosis factor-alpha and creatinine were significantly increased in E. ocellatus bite victims compared with the control group (P<0.05). Furthermore, the mean serum level of TNFalpha was significantly lower in E. ocellatus bite victims, post-administration of anti-venom, compared with the pre-administration of anti-venom (P<0.05). In contrast, no significant difference was observed in the mean serum level of creatinine in E. ocellatus bite victims, post-administration of anti-venom, compared with the pre-administration of anti-venom (P>0.05). Moreover, the mean serum level of creatinine was found to be significantly increased in E. ocellatus bite victims, post-administration of anti-venom, compared with the control group (P<0.05), while no significant difference was observed in the mean serum level of tumour necrosis factor-alpha in E. ocellatus bite victims, post-administration of anti-venom, compared with the control group(P>0.05). A positive correlation existed between tumour necrosis factor-alpha and creatinine levels in E. ocellatus bite subjects (r= 0.782). Echis ocellatus bite is a risk factor for renal damage indicated by an elevated serum creatinine, thus health authorities should make EchiTAb-G anti-venom freely available in health facilities and administered as quickly as possible to reduce the risk of renal damage in Echis ocellatus bite-prone areas.

scholarly journals THE PREVALENCE OF CELIAC DISEASE AMONG PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

2015 ◽  
Vol 52 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Sedat IŞIKAY ◽  
Nurgül IŞIKAY ◽  
Halil KOCAMAZ
Keyword(s):  
Celiac Disease ◽  
Familial Mediterranean Fever ◽  
Tissue Transglutaminase ◽  
Control Group ◽  
Marsh Type ◽  
Significant Difference ◽  
Healthy Control ◽  
Mediterranean Fever ◽  
Relationship Of ◽  
The Relationship

Background Familial Mediterranean Fever and celiac disease are both related to auto-inflammation and/or auto-immunity and they share some common clinical features such as abdominal pain, diarrhea, bloating and flatulence. Objectives We aimed to determine the association of these two diseases, if present. Methods Totally 112 patients diagnosed with Familial Mediterranean Fever and 32 cases as healthy control were included in the study. All participants were examined for the evidence of celiac disease, with serum tissue transglutaminase IgA levels (tTG IgA). Results Totally 144 cases, 112 with Familial Mediterranean Fever and 32 healthy control cases were included in the study. tTG IgA positivity was determined in three cases with Familial Mediterranean Fever and in one case in control group. In that aspect there was no significant difference regarding the tTG IgA positivity between groups (P=0.81). Duodenum biopsy was performed to the tTG IgA positive cases and revealed Marsh Type 3b in two Familial Mediterranean Fever cases and Marsh Type 3c in the other one while the biopsy results were of the only tTG IgA positive case in control group was Marsh Type 3b. In HLA evaluation of the celiac cases; HLA DQ2 was present in two celiac cases of the Familial Mediterranean Fever group and in the only celiac case of the control group while HLA DQ8 was present in one celiac case of the Familial Mediterranean Fever group. Conclusions We did not determine an association of Familial Mediterranean Fever with celiac disease. Larger studies with subgroup analysis are warranted to determine the relationship of these two diseases.

Plasma kisspeptin and ghrelin levels in puberty variant cases

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Premature Thelarche ◽  
Premature Adrenarche ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

The Role of sFas in the Immune Escape Mechanism and Progression of Cancer Larynx

2009 ◽  
Vol 2 ◽  
pp. CMENT.S2565
Author(s):  
Amr A El Badry ◽  
Ismail Elmofty ◽  
Amira Helmy
Keyword(s):  
Serum Level ◽  
Buffy Coat ◽  
Control Group ◽  
Group Iii ◽  
Soluble Fas ◽  
Group I ◽  
Significant Difference ◽  
Cancer Larynx ◽  
The Mean ◽  
Group Ii

This work assess serum levels of soluble Fas form (sFas) in patients with different stages of laryngeal squamous cell carcinoma(LSCC) to investigate its prognostic significance. We correlate its levels with the morphological changes of peripheral blood cells via buffy coat examinatin. The study population included 70 patients clinically diagnosed and pathohistologically confirmed LSCC in addition to 20 healthy controls. According to TNM classification 33(47.1%) patients were in stage I (group I) and 24(34.3%) in stage II (group II), 13(18.5%) in stage III (group III). The results revealed that the mean serum level of sFas (pg/ml) in the control group was 51.2, in group I was 66.33, in group II was 81.33 and in group III was 112.45. Statistical analysis of the mean of sFas by ELISA test in the patients' groups in comparison to the control revealed a significant increase of both group II and III in comparison to the control group (P < 0.01) but there was no significant difference (P > 0.05) between group I in comparison to either the control or group II. There was a significant difference (P < 0.05) between group I in comparison to group III. LM examination revealed massive extent of the apoptotic cells in group III when compared to both group I and group II. EM examination of the buffy coat revealed apoptotic changes, mainly in the peripheral blood mononuclear cells (PBMNCs), represented by surface membrane ruffles and blebs with clumped nuclear chromatin and vacuolated cytoplasm. In conclusion, this study may help us to better understand one of the escape mechanisms in cancer larynx. This mechanism is represented by the significant increase in both the serum level of sFas and the morphological apoptotic changes that detected in PBMNCs. Soluble Fas may contribute to the progression of laryngeal cancer. It can be used as an attractive target for anticancer therapy and may be considered as a marker of disease progression and poor prognosis in laryngeal cancer.

scholarly journals Comparing the Lifestyle of Veteran and Non-Veteran Families in Tehran

2020 ◽  
Author(s):  
Seyed Alireza Afshani ◽  
Seyed Mostajad Hosseini-motlagh
Keyword(s):  
Health Literacy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Members ◽  
Cross Sectional ◽  
Statistical Population ◽  
Significant Difference ◽  
Lifestyle Questionnaire ◽  
The Mean ◽  
Descriptive Level

Introduction: Lifestyle of a community members  should be investiagted, especially in the devotees and their families. The present research aimed at measuring and comparing the lifestyle status of veteran and non-veteran families in Iran. Methods: In this cross-sectional study, the statistical population included the veteran and non-veteran families in Tehran City and the sample size included 360 people. The research instruments were Lali, Abedi, and Kajbaf’s Lifestyle Questionnaire (LSQ) (2012), and All Aspects of Health Literacy Scale (AAHLS, 2013). The data were analyzed by SPSS v.24. At the descriptive level, graphing was performed and at the inferential level, Pearson, t-test, Friedman, and analysis of variance tests were run. Results: A significant difference was observed between the mean scores of lifestyle in two groups of Veteran and Non-Veteran in Tehran. No significant difference was found between the lifestyle scores of men and women in the Non-Veteran group as well as between the mean scores of the single and married lifestyle in the Veteran and Non-Veteran group (P<0/05). However, a significant relationship was found between health literacy and lifestyle of the veteran and non-veteran participants (p<0/05). Conclusion: The results showed that lifestyle should be considerd as a set of observable behaviors and health literacy should be investiagted as predicting variables in promoting lifestyle in the Veteran and Non-Veteran groups.

scholarly journals Hubungan Kadar LDL dan HDL Serum Ibu Hamil Aterm dengan Berat Lahir Bayi

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Oktalia Sabrida ◽  
Hariadi Hariadi ◽  
Eny Yantri
Keyword(s):  
Birth Weight ◽  
Serum Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Term Pregnancy ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
The Mean ◽  
Infant Birth

AbstrakAda anyak penelitian yang membuktikan transfer kolesterol dari ibu ke janin melalui lapisan trofoblas yang membawa partikel LDL (Low Density Lipoprotein) dan HDL (High Density Lipoprotein). Pengambilan dan pemanfaatan LDL oleh plasenta merupakan mekanisme alternatif oleh janin untuk memperoleh asam lemak dan asam amino esensial. Tujuan penelitian ini untuk mengetahui hubungan kadar LDL dan HDL serum ibu hamil aterm dengan berat lahir bayi. Penelitian ini merupakan studi observasional dengan rancangan cross sectional. Dilakukan pemeriksaan kadar LDL dan HDL serum terhadap 31 sampel ibu hamil aterm yang dipilih secara consecutive sampling, kemudiaan saat bayi dari sampel lahir dilakukan penimbangan berat lahir bayi dalam 1 jam setelah lahir dengan keadaan tanpa pakaian. Data dianalisis menggunakan uji korelasi Pearson dilanjutkan dengan uji regresi linier sederhana, nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL serum ibu hamil aterm 138,52±37,86 mg/dl dengan 7 sampel (22,60%) kadar LDL <101 mg/dl. Rerata kadar HDL serum ibu hamil aterm 53,32±17,39 mg/dl dengan 13 sampel (41,90%) kadar HDL <48 mg/dl. Rerata berat lahir bayi 3150,00±489,89 gram dengan 2 sampel (6,50%) memiliki bayi dengan berat<2500 gram. Terdapat hubungan positif antara kadar LDL serum ibu hamil aterm dengan berat lahir bayi, kekuatan hubungan lemah (r=0,258), secara statistik tidak bermakna (p=0,161). Terdapat hubungan positif antara kadar HDL serum ibu hamil aterm, kekuatan hubungan sangat lemah (r=0,035), secara statistik tidak bermakna (p=0,850). Kesimpulan penelitian tidak terdapat hubungan kadar LDL dan HDL serum ibu hamil dengan berat lahir bayi.Kata kunci: kadar LDL serum, kadar HDL serum, ibu hamil aterm, berat lahir bayiAbstractMany studies proved that the transferring of cholesterol from mother to fetus through the trophoblastic layer carried LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein) particles. Uptake and usage of LDL by placenta to the fetus is an alternative mechanism to obtain fatty acids and essential amino acids. The objective of this study was to determine whether there is a relationship between LDL and HDL serum level of pregnant women at term with infant birth weight. This study was an observational study with cross sectional design. Examination of LDL and HDL serum level to 31 term pregnancy sample choose by consecutive sampling, and then infant’s birth weight was counted within 1 hour after birth without clothes. The data analyzed with Pearson correlation statistical test followed by simple linier regression statistical test. The mean of LDL serum level term pregnancy was 138,52±37,86mg/dlwith7 samples(22.60%) in LDL levels<101 mg/dl. The mean of HDL serum level at term pregnancy was 53,32±17,39 mg/dlwith 13 samples (41,90%) in HDL levels<48 mg/dl. The mean of infant birth weight was 3150,00±489,89 grams with 2 samples (6,50%) had infants weighing < 2500 grams. There is a positive relationship between LDL serum levels term pregnancy with birth weight infants, the strength of the relationship is weak (r =0,258), were not significant statistically (p=0,161). There is a positive relationship between HDL serum levels at term pregnancy with birth weight infants, the strength ofthe relationshipis veryweak(r =0,035), were not significant statistically (p=0,850). In conclusion there was no correlation of serum levels of LDL and HDL at term pregnant with birth weight.

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