Awareness, treatment and control of hyperliidaemia in middle-aged men in France and Northern Ireland in 1991-1993

2002 ◽  
Vol 57 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Pedro MARQUES-VIDAL ◽  
Dominique ARVEILER ◽  
Alun EVANS ◽  
Philippe AMOUYEL ◽  
Jean FERRIÈRES ◽  
...  
Keyword(s):  
Northern Ireland ◽  
Middle Aged ◽  
And Control

scholarly journals Spatio-temporal evolution and influencing mechanism of the COVID-19 epidemic in Shandong province, China

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinlong Shi ◽  
Xing Gao ◽  
Shuyan Xue ◽  
Fengqing Li ◽  
Qifan Nie ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Temporal Evolution ◽  
Geographical Location ◽  
Shandong Province ◽  
Control Measures ◽  
Middle Aged ◽  
Health Crisis ◽  
Aged People ◽  
Spatio Temporal ◽  
And Control

AbstractThe novel coronavirus pneumonia (COVID-19) outbreak that emerged in late 2019 has posed a severe threat to human health and social and economic development, and thus has become a major public health crisis affecting the world. The spread of COVID-19 in population and regions is a typical geographical process, which is worth discussing from the geographical perspective. This paper focuses on Shandong province, which has a high incidence, though the first Chinese confirmed case was reported from Hubei province. Based on the data of reported confirmed cases and the detailed information of cases collected manually, we used text analysis, mathematical statistics and spatial analysis to reveal the demographic characteristics of confirmed cases and the spatio-temporal evolution process of the epidemic, and to explore the comprehensive mechanism of epidemic evolution and prevention and control. The results show that: (1) the incidence rate of COVID-19 in Shandong is 0.76/100,000. The majority of confirmed cases are old and middle-aged people who are infected by the intra-province diffusion, followed by young and middle-aged people who are infected outside the province. (2) Up to February 5, the number of daily confirmed cases shows a trend of “rapid increase before slowing down”, among which, the changes of age and gender are closely related to population migration, epidemic characteristics and intervention measures. (3) Affected by the regional economy and population, the spatial distribution of the confirmed cases is obviously unbalanced, with the cluster pattern of “high–low” and “low–high”. (4) The evolution of the migration pattern, affected by the geographical location of Wuhan and Chinese traditional culture, is dominated by “cross-provincial” and “intra-provincial” direct flow, and generally shows the trend of “southwest → northeast”. Finally, combined with the targeted countermeasures of “source-flow-sink”, the comprehensive mechanism of COVID-19 epidemic evolution and prevention and control in Shandong is revealed. External and internal prevention and control measures are also figured out.

Computer Aided Dynamical System Analysis and Control for Undergraduate Courses

1977 ◽  
Vol 10 (2) ◽  
pp. 44-50 ◽  
Author(s):  
C. McCorkell ◽  
N. Wilson
Keyword(s):  
Dynamical System ◽  
Northern Ireland ◽  
System Analysis ◽  
Computer Usage ◽  
Synthesis Techniques ◽  
Initial Stage ◽  
Control Options ◽  
Computer Aided ◽  
Computational Requirement ◽  
And Control

Dynamical system analysis is included in undergraduate courses in the Northern Ireland Polytechnic, as part of a presentation of general engineering methodology and more particularly, accompanied by synthesis techniques, in control options at final year honours level. Such is the extent of the computational requirement, necessary for a non-trivial treatment, that steps have been taken to introduce computer usage where possible. Included is information on the initial stage of a project undertaken to provide for the computational needs of undergraduates involved in dynamical problems in the laboratory.

Abstract 18787: Hypertension Treatment and Control Rates in United States Adults by Risk Group

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Kunal N Karmali ◽  
Hongyan Ning ◽  
Donald M Lloyd-Jones
Keyword(s):  
Older Adults ◽  
High Risk ◽  
Kidney Disease ◽  
Risk Group ◽  
Intensive Therapy ◽  
Risk Groups ◽  
Middle Aged ◽  
Ascvd Risk ◽  
Middle Aged Adults ◽  
And Control

Introduction: Ten-year cardiovascular disease (CVD) risk and absolute benefit from antihypertensive therapy vary at any given BP based on associated risk factor levels. Thus, implications of treatment and control rates at a particular BP vary substantially in different risk groups. Objectives: We examined the prevalence, treatment, and control of hypertension (HTN) by risk group in US adults without prevalent CVD. Methods: We used data from the National Health and Nutrition Examination Survey 2005 to 2010 for adults age 40-79 years without prevalent CVD (n=4,066). We estimated 10-year risk for an atherosclerotic CVD (ASCVD) event using the ACC/AHA 2013 Pooled Cohort risk equations. We examined HTN treatment and control rates according to current guidelines in middle-aged (40-59 years) and older (60-79 years) adults with: 10-year ASCVD risk <7.5% (no diabetes/kidney disease); 10-year ASCVD risk ≥7.5% (no diabetes/kidney disease); and either diabetes or kidney disease. Results: The proportion of adults with treatment-eligible HTN was 39.3% for those with 10-year ASCVD risk <7.5%, 32.2% for those with 10-year ASCVD risk ≥7.5%, and 28.4% for those with either diabetes or kidney disease (see Table 1). Treatment rates across the risk groups varied from 51.5% to 79.0% for middle-aged adults and 81.8% to 90.2% for older adults. HTN control rates were highest (87.7%) in older adults with 10-year ASCVD risk <7.5% but were lowest (29.3%) in middle-aged individuals with 10-year ASCVD risk ≥7.5%. Conclusions: US HTN guidelines, based solely on BP thresholds, identify a higher proportion of low-risk adults and a lower proportion of high-risk adults as being eligible for treatment. Control rates remain suboptimal in high-risk individuals, particularly middle-aged adults. Future guidelines should consider pre-treatment risk stratification to identify those at increased pretreatment ASCVD risk who would benefit most from more intensive therapy.

scholarly journals The values of AHCY and CBS promoter methylation on the diagnosis of cerebral infarction in Chinese Han population

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiaodong Li ◽  
Shufang Bu ◽  
Ran Ran Pan ◽  
Cong Zhou ◽  
Kun Qu ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Promoter Methylation ◽  
Methylation Level ◽  
Young Group ◽  
Control Group ◽  
Case Group ◽  
Middle Aged ◽  
Aged Group ◽  
Significant Difference ◽  
And Control

Abstract Background The goal of our study is to investigate whether the methylation levels of AHCY and CBS promoters are related to the risk of cerebral infarction by detecting the methylation level of AHCY and CBS genes. Methods We extracted peripheral venous blood from 152 patients with cerebral infarction and 152 gender- and age-matched healthy controls, and determined methylation levels of AHCY and CBS promoters using quantitative methylation-specific polymerase chain reaction. We used the percentage of methylation reference (PMR) to indicate gene methylation level. Results We compared the promoter methylation levels of two genes (AHCY and CBS) in peripheral blood DNA between the cerebral infarction case group and the control group. Our study showed no significant difference in AHCY promoter methylation between case and control. Subgroup analysis by gender showed that the methylation level of AHCY in males in the case group was lower than that in the control group, but the difference was not statistically significant in females. In a subgroup analysis by age, there was no significant difference in the AHCY methylation level between the case and control in the young group (≤44 years old). However, the level of AHCY gene methylation in the middle-aged group (45–59 years old) was significantly higher and the aged group (≥60 years old) was significantly lower than that in the control groups. However, CBS promoter methylation levels were significantly lower in the case group than in the control group (median PMR: 70.20% vs 104.10%, P = 3.71E-10). In addition, the CBS methylation levels of males and females in the case group were significantly lower than those in the control group (male: 64.33% vs 105%, P = 2.667E-08; female: 78.05% vs 102.8%, P = 0.003). We also found that the CBS levels in the young (23–44), middle-aged (45–59), and older (60–90) groups were significantly lower than those in the control group (young group: 69.97% vs 114.71%; P = 0.015; middle-aged group: 56.04% vs 91.71%; P = 6.744E-06; older group: 81.6% vs 119.35%; P = 2.644E-04). Our ROC curve analysis of CBS hypomethylation showed an area under the curve of 0.713, a sensitivity of 67.4%, and a specificity of 74.0%. Conclusion Our study suggests that hypomethylation of the CBS promoter may be closely related to the risk of cerebral infarction and may be used as a non-invasive diagnostic biomarker for cerebral infarction.

Effects of crossbred ewe genotype and ram genotype on ewe prolificacy, lamb viability and lamb output in the lowland sector

2002 ◽  
Vol 139 (2) ◽  
pp. 169-181 ◽  
Author(s):  
L. E. R. DAWSON ◽  
A. F. CARSON
Keyword(s):  
Growth Rate ◽  
Northern Ireland ◽  
Growth Rates ◽  
Genetic Improvement ◽  
Live Weight ◽  
Growth Index ◽  
The Other ◽  
Lean Growth ◽  
And Control ◽  
Lamb Growth

A study was carried out on five lowland farms in Northern Ireland over 3 years to investigate the effect of crossbred ewe and ram genotype on ewe prolificacy, lamb viability and weaned lamb output. Four crossbred ewe genotypes were sourced from six hill farms involved in a previous study – Bluefaced Leicester×Blackface (BLXB), Texel×Blackface (TXB), Suffolk×Cheviot (SXCH) and Texel×Cheviot (TXCH). On each farm, groups of 20–30 of each crossbred ewe genotype were mated with Suffolk or Texel rams. Throughout the 3 years of the study, the ewe genotypes lambed at 1, 2 and 3 years of age. Within each of the ram breeds, high lean growth index rams sourced from UK sire reference schemes were compared with rams sourced from flocks not involved in objective genetic improvement programmes (control). BLXB ewes were the most prolific of the four ewe genotypes producing 1.73 lambs per ewe lambed compared with 1.47 for TXB, 1.46 for SXCH and 1.41 for TXCH (P<0.001). Lamb mortality was similar for the four ewe genotypes, thus number of lambs weaned was greatest for the BLXB ewes (P<0.001) with the other three crosses producing similar numbers of lambs. A greater proportion (P<0.05) of SXCH ewes lambed without assistance compared with BLXB and TXB ewes and a greater proportion of TXCH ewes had abundant supplies of colostrum compared with the other crosses (P<0.10). Output of weaned lamb per ewe lambed and per ewe metabolic live weight (P<0.001) was greatest in the BLXB ewes. Ewe productivity, prolificacy, number of lambs weaned and the proportion of ewes lambing without assistance increased with ewe age (P<0.001). Lamb growth rate from birth to 6 weeks and from birth to weaning increased with ewe age (P<0.05). Crossbred ewes lambing at 3 years old had a greater output of weaned lamb compared with ewes lambing at 1 and 2 years old (P<0.001). Ram genotype had no effect on ewe prolificacy, lamb viability or pre-weaning growth rates, although Texel-sired lambs had lower birth weights than Suffolk-sired lambs and control-sired lambs had lower birth weights than high lean index-sired lambs (P<0.05).

Community-based screening intervention for depression affects suicide rates among middle-aged Japanese adults

2017 ◽  
Vol 47 (8) ◽  
pp. 1500-1509 ◽  
Author(s):  
H. Oyama ◽  
T. Sakashita
Keyword(s):  
Negative Binomial ◽  
Intervention Group ◽  
Depression Screening ◽  
Sensitivity Analyses ◽  
Control Group ◽  
Middle Aged ◽  
Community Based ◽  
Suicide Rates ◽  
Implementation Period ◽  
And Control

BackgroundIt has been suggested that screening interventions may be effective for suicide prevention. Few studies, however, have reported their effects on outcome measures, including death by suicide among middle-aged adults.MethodWe used a quasi-experimental parallel cluster design with matched community-based intervention and control municipalities (total eligible population: 90 000) in Japan. At-risk residents within the intervention area were invited for universal depression screening and subsequent care/support. We compared changes in suicide incidence of adults aged 40–64 years for the 4-year pre- and post-implementation periods in the intervention group with the control group and the whole country. Incidence rate ratios (IRRs) of the outcomes were adjusted for age group, gender and interaction terms, using mixed-effects negative binomial regression models. Suicide rates among intervention and control subgroups were compared.ResultsThe screening procedure was offered to 52% of the intervention group, and 61% of those contacted responded over the implementation period. Suicide rates decreased more in the intervention group [IRR 0.57, 95% (CI) 0.41–0.78; F1,36 = 12.52, p = 0.001] than the control group (IRR proportion 1.63, 95% CI 1.06–2.48; F1,82 = 5.20, p = 0.025) or the whole country (IRR proportion 1.64, 95% CI 1.16–2.34; F1,42 = 8.21, p = 0.006). Sensitivity analyses confirmed the results from the primary analysis. There were lower suicide rates among both respondents and non-respondents to the screening than in the control group during the implementation period.ConclusionsPrevention efforts involved in the depression screening intervention were probably successful in reducing suicide rates.

Effect of hypertension and risk factors on diameters of abdominal aorta and common iliac and femoral arteries in middle-aged hypertensive and control subjects

2000 ◽  
Vol 153 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Markku J. Päivänsalo ◽  
Jukka Merikanto ◽  
Tapani Jerkkola ◽  
Markku J. Savolainen ◽  
Asko O. Rantala ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Aorta ◽  
Middle Aged ◽  
Femoral Arteries ◽  
Control Subjects ◽  
And Control
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