scholarly journals DEVELOPMENT OF EFFERVESCENT TABLETS BASED ON RED GINGER (ZINGIBER OFFICINALE ROSC. VAR. RUBRUM) AND ROSELLA FLOWER (HIBISCUS SABDARIFFA L.)

2021 ◽  
Vol 9 (09) ◽  
pp. 720-727
Author(s):  
Suherman a ◽  
◽  
A.C. Kumoro ◽  
K. Anam ◽  
E.E. Susanto ◽  
...  
Keyword(s):  
Physical Properties ◽  
Hardness Test ◽  
Zingiber Officinale ◽  
Dissolution Time ◽  
Acid Mixture ◽  
Test Results ◽  
Uniformity Test ◽  
Acid And Base ◽  
Red Ginger

The COVID-19 virus is still spreading throughout the world, and many efforts are being made to combat the outbreak and develop vaccines. Several traditional plants such as ginger and rosella can increase endurance and ward off various diseases. In this research, effervescent tablets made from ginger and rosella have been developed. Five formulations of effervescent tablets with different concentrations of acid and base mixtures have been made to test their physical properties, both granules, and effervescent tablets. The granule physical properties test results showed that the variation of the mixture of acids and bases had no significant effect on the physical properties of the granules. The physical quality of the granule is following the applicable requirements. The same thing was also found in the weight uniformity test. In contrast, in the brittleness and hardness test, tablet formulation 5 (an acid mixture consisting only of tartaric acid) showed the best results. From the dissolution time test, it was found that the use of a mixture of citric acid and tartrate was able to accelerate the dissolving time compared to the use of one type of acid. From the test results, it can be concluded that formulation five tablets show the best quality of tablets. Further studies need to be done regarding the application of ginger and roselle effervescent tablets to increase the bodys immunity from COVID-19.

scholarly journals KUALITAS MINUMAN SARI BIJI NANGKA (Artocarpus heterophyllus)DENGAN PENAMBAHAN JAHE MERAH(Zingiber officinale varrubrum rhizoma)

2019 ◽  
Vol 5 ◽  
pp. 115
Author(s):  
Syahri Fadhila Al-Farid ◽  
Jamaluddin Jamaluddin ◽  
Andi Sukainah
Keyword(s):  
Protein Content ◽  
Water Content ◽  
Zingiber Officinale ◽  
Carbohydrate Content ◽  
Test Results ◽  
Artocarpus Heterophyllus ◽  
Randomized Design ◽  
Completely Randomized Design ◽  
Red Ginger

This study aims to determine the quality of jackfruit seed juice drinks with the addition of red ginger and to determine the level of acceptance of panelists on jackfruit seed juice drinks. Parameters observed included water content, protein content, carbohydrate content and organoleptic including color, taste, aroma and texture. This study used a Completely Randomized Design (CRD) consisting of one factor, namely the concentration of red ginger juice with four treatments, namely: 0%, 6%, 12%, 18%, each repeated three times. The results showed that jackfruit seed juice drink with the addition of 18% red ginger was the best treatment from the results of organoleptic tests. The proximate test results showed that the best treatment was 3.13% water content in 12% ginger treatment, 2.17% protein in 18% red ginger treatment and 95.61 carbohydrate in 18% red ginger treatment.

scholarly journals FORMULATION A CIPROFLOXACIN HYDROCHLORIDE EXTENDED-RELEASE TABLET WITH COMBINATION OF HYDROXYPROPYL METHYLCELLULOSE (HPMC) K100M AND HYDROXYPROPYL METHYLCELLULOSE (HPMC) K4M BY DIRECT COMPRESSION METHOD

2019 ◽  
pp. 25-30
Author(s):  
RESMI MUSTARICHIE ◽  
DOLIH GOZALI ◽  
YEDI HERDIANA
Keyword(s):  
Statistical Analysis ◽  
Extended Release ◽  
Hydroxypropyl Methylcellulose ◽  
Hardness Test ◽  
Dissolution Test ◽  
Test Results ◽  
Ciprofloxacin Hydrochloride ◽  
Uniformity Test ◽  
Size Uniformity ◽  
Release Tablet

Objective: Ciprofloxacin hydrochloride tablets which are not extended-release will produce non-constant drug levels in the blood. This study aimed to overcome this problem by making ciprofloxacin hydrochloride extended-release tablets with a combination of hydroxypropyl methylcellulose (HPMC) K100M and hydroxypropyl methylcellulose (HPMC) K4M by a direct compression method. Methods: The method in this study consisted of preformulation, formula design, manufacture of ciprofloxacin hydrochloride tablets, tablet print mass testing, IPC (In-Process Control) slow-release tablet mass print, IPC (In-Process Control) quality of slow-release tablet preparation, dissolution test, and statistical analysis. Preformulation was carried out aiming to determine the physical and chemical properties of active-excipient substances based on a certificate of analysis. This was done using a Fourier Transform Infrared (FT-IR) and UV-Vis spectrophotometer. Five kinds of ciprofloxacin hydrochloride tablet formulations were made using the direct pressing method with variations in the concentration of HPMC K100M and HPMC K4M. The ratio of percentage of HPMC K100M and HPMC K4M were F1 0,5%: 1%, F2 1%: 0,5%, F3 0,75%: 0,75%, F4 1%: 0%, F5 0%: 3%. Evaluation of tablet preparations (IPC control) included weight uniformity test, size uniformity test, hardness test, and friability test. The dissolution test was carried out for 2 h by hydrochloride acid 0,1 N pH 1.2 as (pH of gastric acid). Statistical analysis using Perfect Block Random Design (PBRD) method and further testing using the Newman-Keuls test was applied for the data obtained. Results: The test results with FTIR showed that ciprofloxacin hydrochloride used compared to ciprofloxacin hydrochloride BPFI is equivalent and has a purity index of 0.992739. Determination of the level of the active ingredient ciprofloxacin hydrochloride was carried out by measuring the absorbance of a 5 ppm sample solution at a wavelength of 276 nm. The percentage of absorbance of the solution is then calculated and the result obtained is 98.87%. The range of levels that have been set is 98%-102%. These test results were under those listed on the certificate of analysis. The results of the IPC test in the form of weight uniformity test, size uniformity test, hardness test, friability test, and uniformity of ciprofloxacin hydrochloride levels in the preparation, showed all data obtained fulfilling the requirements set by USP 36 convention (2013). The result from dissolution tablet test on 30, 60, and 120 min showed the release of active substance on F1 56.00 %, 67.76 %, and 87.57 %. F2 were 53.42 %, 65.16 %, and 91.44 %. F3 were 59.18 %, 72.15 %, and 91.20 %. F4 were 50.51 %, 70.70 %, and 95.29 %. F5 were 53.75 %, 69.55 %, and 92.05 %. Statistical analysis was applied for the data obtained. Dissolution results illustrated the level of active substances dissolved in the dissolution medium for 2 h or in other words the dissolution test results indicated the number of active substances from tablets that were released and enter the digestive tract and came in contact with body fluids. Conclusion: The dissolution test results as a basis of extended-release tablets showed all of the formulae met dissolution requirements of the United States Pharmacopeia (USP) 36 convention.

ANALISIS PENGARUH JARAK KAMPUH HASIL PENGELASAN BAJA SS400 TERHADAP SIFAT MEKANIK MATERIAL MENGGUNAKAN METODE GMAW

2020 ◽  
Vol 8 (2) ◽  
pp. 57-66
Author(s):  
Novi Laura Indrayani ◽  
Herry Oktadinata ◽  
Ito Suteja
Keyword(s):  
Hardness Test ◽  
Butt Joint ◽  
Test Results ◽  
Destructive Test ◽  
Microstructure Observation ◽  
A Value ◽  
Welding Defects ◽  
Protective Gas ◽  
Non Destructive

Welding techniques have been used extensively in the construction field because welding techniques are a simpler method in the process of connecting steel than using bolts or rivets. Factors that influence the quality of welding results include distance of the seam. The seam distance can affect the increase in heat input value because the wider the seam distance the more filler metal will be used. The purpose of this study was to determine how the effect of variations in the distance of the seam to the mechanical properties of SS400 steel welding material using the GMAW method. SS400 steel welding welding position 2G with variations in the root gap distance of 0 mm, 2 mm and 4 mm using the GMAW method with a type of protective gas 82% Ar + 18% CO2 and ESAB ER70S-6 type welding wire. Single v butt joint type with a seam angle of 60o and 12 mm thick material. In this study several tests were conducted including distortion testing, non-destructive test, tensile, chemical composition, hardness and microstructure observation. The highest distortion test results obtained at a root gap of 4 mm seam, non-destructive test results showed no welding defects in the upper surface of the weld, the optimal tensile testing results were obtained on a sample root gap of 2 mm with a tensile strength value of 413 MPa and fractures that occurred in the base area metal. The highest hardness test results were obtained at a sample root gap  of 0 mm ap with a value of 235 HV and the lowest hardness obtained at a root gap of 4 mm with a value of 209 HV.

scholarly journals Effect of the change of firing temperature on microstructure and physical properties of clay bricks from Beruas (Malaysia)

2010 ◽  
Vol 42 (2) ◽  
pp. 245-254 ◽  
Author(s):  
I. Johari ◽  
S. Said ◽  
B. Hisham ◽  
A. Bakar ◽  
Z.A. Ahmad
Keyword(s):  
Physical Properties ◽  
Firing Temperature ◽  
Phase Changes ◽  
Test Results ◽  
Clay Brick ◽  
Soaking Time ◽  
Clay Bricks ◽  
Optimum Firing ◽  
Optimum Firing Temperature

This study is focused on the behaviour of fired-clay brick from the area around Beruas (Malaysia) that is known for it brick industries. The firing temperatures were set from 800?C to 1250?C and soaking time was fixed for an hour. The effects of firing temperature on the phase changes, microstructure, compressive strength, water absorption and porosity of the bricks were investigated. Test results indicate that the optimum firing temperature was found to be 1200?C. The percentage of porosity significantly reduces from 39.33% to 5.87% when sintered from 1000?C to 1250?C. Bricks sintered at 1200?C exhibited the highest strength of 89.5 N/mm2. The effect of firing temperature significantly improved the microstructure in terms of porosity and the quality of physical properties of fired-clay bricks.

scholarly journals EFFECT OF RED GINGER EXTRACT (Zingiber officinale Var Rubrum) ON CHEMICAL AND ORGANOLEPTICS QUALITY OF AMBON CURUP BANANA WET “SALE”

2019 ◽  
Vol 9 (1) ◽  
pp. 28-36
Author(s):  
Wuri Marsigit ◽  
Laili Susanti ◽  
Lia Marzalena
Keyword(s):  
Immersion Time ◽  
Consumer Preference ◽  
Zingiber Officinale ◽  
Ash Content ◽  
Chemical Quality ◽  
Ginger Extract ◽  
Average Value ◽  
Randomized Design ◽  
Red Ginger

ABSTRACTQuality improvement  of sale banana ambon curup was necessary to increase chemical and organoleptics quality and consumer preference. The  purpose  of  this  study  was  to  determine  the  effect  of  variations  in  theconcentration   of   red   ginger   juice   and   the   length   of   immersion   on  chemical   quality, microbiology and organoleptic wet sale of banana ambon curup. By using (RAL) 2 factorial randomized design, the concentration of red ginger juice was 5%, 10% and 15% with a time of immersion for 20 and 10 minutes. The analytical method used was ANOVA. The results of the study found that sucrose levels were 37.56% to 57.54 %, the water content was 36.66% and 38.33%, ash content was 1.47 % to 1.87 %.  The  panelists  preferred  the  average  value  of  the  whole (texture, aroma, and tate)  was  found  in  the  P1T1 sample  with  a  treatment  of  red  ginger  concentration  of  0.05%  and  immersion  time  for  10 minut  

scholarly journals Formulation of Orally Disintegrating Tablet from Nifedipin-β-siklodekstrin Inclusion Complex using Kneading Method

2019 ◽  
Vol 15 (1) ◽  
pp. 22
Author(s):  
Nur Aini Purnamasari ◽  
Pratama Anggi Saputra
Keyword(s):  
Inclusion Complex ◽  
Physical Properties ◽  
Bitter Taste ◽  
Dissolution Time ◽  
Test Results ◽  
Pressing Method ◽  
Orally Disintegrating Tablet ◽  
Cyclodextrin Inclusion ◽  
Kneading Method ◽  
Cyclodextrin Inclusion Complex

Nifedipine is widely used for managing hypertension. The challenges of developing nifedipine oral preparation are its low solubility and unpleasant taste. The purpose of developing the Oral Disintegrating Tablet (ODT) dosage form from the Nifedipine-β-cyclodextrin inclusion complex is to increase the solubility of nifedipine and mask the unpleasant taste of the drug. Specific target: use of a superdisintegrant combination to increase the solubility of nifedipine and mask the bitter taste. The method used in the formation of Nifedipine inclusion complex with β-cyclodextrin was kneading method. Making ODT was done by direct pressing method. Characterization of nifedipine-β-cyclodextrin inclusion complex was analyzed by FTIR and DSC. ODT was tested for the physical properties of the tablet and its solution. Test results for ODT physical properties were analyzed and compared with the literature. Data obtained from the dissolution test results calculated the concentration of the active substance dissolved at 20 minutes (Q20). The results showed that the formation of the Nifedipine-β-cyclodextrin inclusion complex increased solubility and masked the bitter taste. The combination of superdisintegrant Ac-Di-Sol-Crosspovidon accelerated the disintegration and dissolution time and improve the taste of Nifedipine ODT.

scholarly journals Effect of Red Ginger Essential Oil (Zingiber officinale Var. Rubrum) Addition on Chitosan Based Edible Coating towards Organoleptic Characteristics Pempek

2021 ◽  
pp. 1-9
Author(s):  
Nabila Ayu Pratiwi ◽  
Iis Rostini ◽  
Ayi Yustiati ◽  
Rusky Intan Pratama
Keyword(s):  
Essential Oil ◽  
Moisture Content ◽  
Shelf Life ◽  
Zingiber Officinale ◽  
Fat Content ◽  
Edible Coating ◽  
Organoleptic Characteristics ◽  
Parametric Statistics ◽  
Red Ginger

This study aims to determine the best concentration of red ginger essential oil addition (Zingiber officinale var. Rubrum) edible coating to chitosan on the organoleptic quality of pempek. The research method was experimental which consisted of 5 treatments, namely control, addition of red ginger essential oil with concentrations of 0%, 0.5%, 1%, and 1.5% with 20 panelists as replicates. Parameters observed included organoleptic characteristics (appearance, texture, aroma, taste, tooth test, and folding test) based on the panelists' preference level using hedonic tests and chemical analysis (moisture content and fat content) and the shelf life of pempek. The data from the water content and fat content tests were analyzed descriptively, while the organoleptic test results were analyzed using non-parametric statistics with the test Friedman, if the test Friedman gave a rejection, multiple comparisons were performed and test was performed Bayes for decision making. The results showed that the best treatment in extending the shelf life of pempek was treatment D with the addition of 1% red ginger essential oil with a moisture content of 55.30% on the first day and 55.31% on the fourth day. While the fat content on the first day was 1.42% and on the fourth day it rose to 2.72% with the characteristics of appearance, texture, aroma, and taste still favored by the panelists.

scholarly journals Formulation Of Effervescent Tablet Of Temulawak Extract (Curcuma xanthorrhiza Roxb.) With Variation Of Stevia As Sweetener

2018 ◽  
Vol 9 (2) ◽  
pp. 72-82
Author(s):  
Cessa Lynatra ◽  
Wardiyah Wardiyah ◽  
Yetri Elisya
Keyword(s):  
Hardness Test ◽  
Wet Granulation ◽  
Test Results ◽  
Physical Test ◽  
Solubility Test ◽  
Uniformity Test ◽  
Curcuma Xanthorrhiza ◽  
The Difference ◽  
Effervescent Tablet ◽  
Made In

The effervescent tablet containing extract of temulawak (Curcuma xanthorrhiza Roxb.) with variation of stevia sweetener has been formulated using wet granulation method. This research aims to find the formulation of effervescent tablet of temulawak extract (Curcuma xanthorrhiza Roxb.) with the variation of stevia sweetener that meets the requirements of physical tablet test. The effervescent tablet formula was made in three formulas with the difference in the stevia content. Tests conducted include visual tests, uniformity test, hardness test, friability test, pH test and solubility test. Based on the test results on the physical properties of tablets, it is known that all the formula meets the physical test of tablets and the preferred formula is formula 3 with 4% of stevia.

scholarly journals Physical changes of low quality of clay bricks due to sandy-soil mixture under combustion performance

2021 ◽  
Vol 331 ◽  
pp. 03010
Author(s):  
Muhammad Ridwan ◽  
Ade Indra ◽  
Annisa Febiana Yunera ◽  
Rudy Kurniawan
Keyword(s):  
Physical Properties ◽  
Sandy Soil ◽  
Fire Exposure ◽  
Test Results ◽  
Soil Mixture ◽  
Combustion Performance ◽  
Clay Bricks ◽  
Home Industries ◽  
Physical Changes

This research studies the physical properties of the low quality of bricks mixed with sandy -soil in home industries located in Gunung Sarik of Padang City. The ratio mixture of the brick making material in the home industries was not measured with the proper measurement; as a result the quality of the brick was poor. The research used 5 x 5 x 5 cm and 180 cubes of bricks to see the physical changes. The ratio of mixed materials between sandy soil and clay are 0.11.025, 0.43,0.67,1.0, and 1.50. The procedure for making bricks was the same as a factory without changing the factory method. The process of burning bricks for three days and two nights using wood. From the test results, the density of the bricks did not change significantly between direct and indirect fire exposure but decreased in proportion to the addition of sandy soil. The addition of sandy soil reduces the percentage of damage and physical changes. The acceptable ratio of sandy -soil mixture is a range of 0.43.-0.6.

Sign in / Sign up

Export Citation Format

Share Document