scholarly journals Comparative analysis of anatomic parameters of the eyeball in children with ametropia, congenital glaucoma, aphakia and artiphakia

2019 ◽  
Vol 12 (3) ◽  
pp. 38-42
Author(s):  
L. S. Khamraeva ◽  
L. Yu. Bobokha ◽  
Ch. K. Abdurakhmanova ◽  
Z. A. Makhmudova
Keyword(s):  
Comparative Analysis ◽  
Axial Length ◽  
High Myopia ◽  
Clinical Course ◽  
Axial Direction ◽  
Congenital Glaucoma ◽  
Advanced Stage ◽  
Anatomical Parameters ◽  
Vertical Size ◽  
High Hyperopia

Purpose. To conduct a comparative analysis of the anatomical parameters of the eyeball in children with ametropia, congenital glaucoma, aphakia and artiphakia.Material and methods. The study involved 73 patients (146 eyes) aged 5 to 12 years with ametropia, congenital glaucoma, aphakia and artiphakia and was carried out on an ultrasonic device STRONG 6000 T in the A-scan mode with the 10 MHz sensor set for three points.Results. A significant increase in the size of axial length of the eyeball in moderate and high myopia and in the vertical size in high myopia were revealed. In high hyperopia, sagittal dimensions were reduced while the transverse dimensions were a bit greater than the sagittal ones. In far-advanced stage of congenital glaucoma, a significant increase in eyeball dimensions was noted both in the axial direction and in the transverse — horizontal direction. No significant differences in sagittal and transverse dimensions were noted in aphakia and artiphakia. Conclusion. For a comprehensive assessment of the clinical course of the disease, in particular as concerns the condition of the fibrous capsule of the eye in children with ametropia, congenital glaucoma, aphakia and artiphakia, echobiometric indicators characterizing sagittal and transverse (vertical and horizontal) sizes of the eyeball should be taken into account. 

scholarly journals 8806 Russian patients demonstrate T cell count as better marker of COVID-19 clinical course severity than SARS-CoV-2 viral load

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Konstantin S. Sharov
Keyword(s):  
Viral Load ◽  
Comparative Analysis ◽  
T Cell ◽  
Cell Count ◽  
T Lymphocyte ◽  
Clinical Course ◽  
Time Interval ◽  
Early Prediction ◽  
Disease Prognosis ◽  
Respiratory Index

AbstractThe article presents a comparative analysis of SARS-CoV-2 viral load (VL), T lymphocyte count and respiratory index PaO2:FiO2 ratio as prospective markers of COVID-19 course severity and prognosis. 8806 patients and asymptomatic carriers were investigated in time interval 15 March–19 December 2020. T cell count demonstrated better applicability as a marker of aggravating COVID-19 clinical course and unfavourable disease prognosis than SARS-CoV-2 VL or PaO2:FiO2 ratio taken alone. Using T cell count in clinical practice may provide an opportunity of early prediction of deteriorating a patient’s state.

Choroidal vascularity index in leptochoroid: A comparative analysis between reticular pseudodrusen and high myopia

Eye ◽  
2022 ◽  
Author(s):  
Riccardo Sacconi ◽  
Enrico Borrelli ◽  
Siva Balasubramanian ◽  
Giovanna Vella ◽  
Marco Battista ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
High Myopia ◽  
Reticular Pseudodrusen

Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma

2015 ◽  
Vol 94 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Jost B. Jonas ◽  
Leonard Holbach ◽  
Songhomitra Panda-Jonas
Keyword(s):  
High Myopia ◽  
Congenital Glaucoma

scholarly journals Endothelin-1 Serum Concentration is Lower in Children and Adolescents with High Myopia, a Preliminary Study

2020 ◽  
Vol 9 (5) ◽  
pp. 1327
Author(s):  
Katarzyna Powierza ◽  
Beata Żelazowska-Rutkowska ◽  
Jolanta Sawicka-Powierza ◽  
Bożena Mikołuć ◽  
Beata Urban ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Axial Length ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Concentrations ◽  
Myopia Progression ◽  
Cross Sectional ◽  
Weak Negative Correlation ◽  
Preliminary Study

The aim of this study is to evaluate the levels of enothelin-1 (ET-1) in children and adolescents with high myopia and its association with the axial length of the eye and the presence of myopic retinal degeneration. The cross-sectional study was carried out in 57 patients with high myopia and 29 control subjects. Serum concentrations of ET-1 were measured using enzyme-linked immunosorbent assay (ELISA) kit. A significantly lower concentration of ET-1 in highly myopic patients compared to controls was found (1.47 (0.91; 1.87) vs. 1.94 (1.1; 2.69) pg/mL, p = 0.005). In patients with high myopia, a weak negative correlation between ET-1 concentration and the longest axial length out of the two eyes was found (r = −0.255, p = 0.0558). Further analysis revealed statistically significant differences in ET-1 concentration between patients with the axial length of the eye > 26 and ≤ 26 mm (p < 0.041) and patients with the axial length of the eye > 26 mm and controls (p < 0.001). ET-1 expression is disturbed in highly myopic children and adolescents. Lower ET-1 concentration in patients with the axial length of the eye > 26 mm may co-occur with high myopia and should be considered a risk factor in the pathophysiology of high myopia progression.

Dome-shaped macula: a potential protective factor for visual acuity after cataract surgery in patients with high myopia

2019 ◽  
Vol 103 (11) ◽  
pp. 1566-1570 ◽  
Author(s):  
Xiangjia Zhu ◽  
Wenwen He ◽  
Shaohua Zhang ◽  
Xianfang Rong ◽  
Qi Fan ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Axial Length ◽  
High Myopia ◽  
Protective Factor ◽  
Choroidal Neovascularisation ◽  
Postoperative Visual Acuity ◽  
Younger Age ◽  
Male Sex ◽  
Central Fovea

PurposeTo evaluate whether the presence of dome-shaped macula (DSM) is a protective factor for visual acuity after cataract surgery in patients with high myopia.MethodsIncluded were 891 highly myopic cataract eyes (600 patients) that were examined by optical coherence tomography (OCT) through the central fovea and underwent cataract surgery in our hospital. DSM was defined as an inward bulge >50 µm in horizontal or vertical OCT sections. The incidences of various maculopathies were compared between eyes with and those without DSM. The influences of age, sex, eye laterality, axial length and DSM on postoperative visual acuity were evaluated by multivariate linear regression.ResultsOf the 891 eyes, 123 (13.8%) had DSM. There was a greater association of DSM with extrafoveal retinoschisis (RS) than with other vision-threatening complications such as foveal RS and choroidal neovascularisation. In addition to axial length and age, sex was associated with the presence of DSM (p=0.016). In bilateral high myopia, the incidence of DSM increased with the degree of anisometropia and was more common in the longer eye of patients with anisometropia. Younger age, male sex, shorter axial length and the presence of DSM were associated with better postoperative visual acuity in highly myopic cataract eyes (β=0.124, p=0.002; β=0.142, p<0.001; β=0.275, p<0.001 and β=−0.088, p=0.038, respectively).ConclusionAssociated with fewer visual threatening macular complications, presence of DSM may be a protective factor for visual function after cataract surgery in highly myopic eyes.

scholarly journals The Association between Macular Thickness and Axial Length in Myopic Eyes

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Yeon Woong Chung ◽  
Moon Young Choi ◽  
Jung-sub Kim ◽  
Jin-woo Kwon
Keyword(s):  
Optical Coherence Tomography ◽  
Axial Length ◽  
High Myopia ◽  
Polynomial Regression ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Regression Analyses ◽  
Foveal Thickness ◽  
P Values ◽  
The Relationship

Purpose. To investigate the relationship between macular thickness and axial length (AL) in myopic eyes. Methods. We included 441 myopic eyes in this study and measured macular thickness at the fovea and in other macular regions, using optical coherence tomography. We got thickness difference indices (TDIs) which by definition are the values of thickness difference obtained by subtracting the foveal thickness from that of each macula sector to evaluate macular contour. We then analyzed the relationships between AL and foveal thickness and AL and the TDIs of each macular sector. Results. In polynomial regression analyses, foveal thickness slope was relatively flat up to an AL of 25.5 mm and began to rise from 25.5–26.0 mm. The TDIs were also relatively flat up to AL of 25.5mm and started to show steepened negative slopes from around AL of 25.5 mm. When grouping myopia participants as high myopia or non-high myopia based on AL of 25.5mm, all macular indices of the high myopia group showed significant correlation with AL (all p values <0.01). But all indices of non-high myopia group had no significant correlation with AL. Conclusions. Average macular thickness profiles showed that appreciable changes started at an AL of 25.5mm.

The Relationship Between Axial Length and Choroidal Thickness in Eyes With High Myopia

2013 ◽  
Vol 155 (2) ◽  
pp. 314-319.e1 ◽  
Author(s):  
Ignacio Flores-Moreno ◽  
Francisco Lugo ◽  
Jay S. Duker ◽  
José M. Ruiz-Moreno
Keyword(s):  
Axial Length ◽  
High Myopia ◽  
Choroidal Thickness ◽  
The Relationship

scholarly journals Morphologic and functional changes in the retina and sclera induced by form deprivation high myopia in guinea pigs

2019 ◽  
Author(s):  
yingxin zi ◽  
Yu Deng ◽  
Jingru Zhao ◽  
Meiqi Ji ◽  
Yali Qin ◽  
...  
Keyword(s):  
Axial Length ◽  
Guinea Pigs ◽  
High Myopia ◽  
Light And Electron Microscopy ◽  
Anterior Chamber Depth ◽  
Control Group ◽  
Group Iii ◽  
Functional Changes ◽  
Group I ◽  
Group Ii

Abstract Background Our aim was to study the morphologic and functional changes in the retina and sclera induced by form deprivation high myopia (FDHM) in guinea pigs and explore the possible mechanisms FDHM formation. Methods Forty 3-weeks-old guinea pigs were randomized into the blank control (Group I, 20 cases) and model groups (20 cases). In the model group, the right eyes of the guinea pigs were sutured 8 weeks to induce FDHM (Group II) and the left eyes were considered a self-control group (Group III). The diopters were measured with retinoscopy. The anterior chamber depth (AC), lens thickness (L), vitreous depth (V) and axial length (AL) were measured using ultrasonometry A. Retinal and scleral morphology and ultrastructural features were observed with light and electron microscopy. The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the retina and sclera were detected with a chemical colorimetric assay. Results After remaining stitched for eight weeks, the diopters of Group II changed from (+3.59±0.33) D to (-7.96±0.55) D, and these values were significantly higher than those of Group I (+0.89±0.32) D and Group III (-0.55±0.49) D. The vitreous chamber depth (4.12±0.13) mm and axial length (8.93±0.22) mm of Group II were significantly longer than that of Group I [(3.71±0.23) mm and (7.95±0.37) mm, respectively] and Group III [(3.93±0.04) mm and (8.01±0.15) mm, respectively] (P < 0.05). With the prolongation of form deprivation, the retina and scleral tissue became thinner, the ganglion cell and inner and outer nuclear layers of the retina became decreased, and the arrangement was disordered. In Group II, the activity of SOD was significantly lower than that in Group I and Group III, and the content of MDA was significantly higher in Group II than in Group I and Group III. The differences were statistically significant (P < 0.05). Conclusions These findings suggested that in the FDHM guinea pigs model, the diopter, the vitreous chamber depth, and axial length increased significantly with prolongation of monocular FD time, and morphological structural changes in the retina and sclera were observed. Oxygen free radicals might participate in the formation of FDHM.

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