scholarly journals Diabetic neuropathy

2018 ◽  
pp. 68-75
Author(s):  
N. V. Pizova
Keyword(s):  
Diabetic Neuropathy ◽  
Genetic Factors ◽  
Clinical Manifestations ◽  
Nerve Fibers ◽  
Emergency Situations ◽  
Wide Range ◽  
The World ◽  
Modern Classification

Diabetes mellitus is one of the emergency situations worldwide. DM is the most common cause of neuropathy throughout the world that create a wide range of conditions associated with the damage of various nerves and various pathological mechanisms. The article considers the main pathogenetic mechanisms of neuropathy - the role of metabolic, vascular and genetic factors. It presents the main clinical manifestations, depending on what type of nerve fibers are affected. A modern classification of diabetic neuropathy is provided. The most common form - diabetic distal symmetric polyneuropathy is considered in detail. The authors describe the main drugs used for the treatment of diabetic neuropathy, which were proposed by the International Diabetic Federation (2017) in 2017. Lipoic acid supplements are examined in more details.

scholarly journals Prevention of Imported Infectious Diseases in Travelers

2018 ◽  
Vol 17 (5) ◽  
pp. 89-95 ◽  
Author(s):  
A. A. Erovichenkov ◽  
N. N. Zvereva ◽  
M. A. Sayfullin ◽  
N. V. Okolot
Keyword(s):  
Infectious Diseases ◽  
International Travel ◽  
Urgent Problem ◽  
Foreign Countries ◽  
The World ◽  
Modern Classification ◽  
Imported Infections ◽  
Study Development

In modern conditions, the study, development of methods for the prevention of imported infections after international travel is an urgent problem in many countries of the world. In 2017, the world has committed more than 1322 million international trips, in Russia – 39.6 million trips abroad. The factors influencing the growth in the number of international trips made are singled out. The structure of imported infectious diseases in 380 children and 1580 adult patients hospitalized in Moscow's Infectious Clinical Hospital № 1 between 2009 and 2016 after arriving from foreign countries is given. Objective: to analyze some modern approaches to the prevention of imported infectious diseases. The modern classification of categories of travelers is given. Examples of studies conducted in different countries indicate the important role of pre-travel consultations for the prevention of imported infections. The analysis of the risks of development of certain infectious diseases in travelers has been carried out. Modern algorithms of vaccination before journeys are considered. Attention is drawn to the need to develop centers for medicine in Russia, which will help provide practical health care in the prevention of imported infections.

scholarly journals Hyaluronan and the Fascial Frontier

2021 ◽  
Vol 22 (13) ◽  
pp. 6845
Author(s):  
Rebecca L. Pratt
Keyword(s):  
Nerve Fibers ◽  
The Body ◽  
Water Volume ◽  
Cell Behavior ◽  
Connective Tissues ◽  
Wide Range ◽  
The World ◽  
Extracellular Microenvironment ◽  
The Impact ◽  
The Relationship

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body’s fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.

Balanoposthitis: issues of classification, diagnosis and approaches to therapy

2021 ◽  
pp. 39-44
Author(s):  
A. V. Ignatovsky
Keyword(s):  
Therapeutic Index ◽  
Therapy Options ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Choice Of Treatment ◽  
High Therapeutic Index ◽  
Modern Classification ◽  
Aerobic And Anaerobic

Objective. To present a variant of the modern classification of the processes occurring with lesions of the genitals, to draw specialists’ attention to the peculiarities and variety of causes leading to inflammation of the glans and foreskin, as well as to discuss topical issues of external therapy of balanopostitis.Material and methods. Data from modern studies and clinical guidelines were used in the preparation of the publication.Results. The variety of variants of lesions of the glans and foreskin can be due to a number of reasons and can be either an independent local process or a fragment of dermatosis, where it is possible to be affected in the form of balanoposthitis. Also, when examining and selecting therapy options, it is important to consider the possible role of microorganisms, whose spectrum as a cause of balanoposthitis varies from aerobic and anaerobic, to viral and fungal microflora. Treatment approaches are determined by the etiological factors.Conclusions. Balanoposthitis is a heterogeneous group of nosologies. The choice of treatment is based on the identified cause or empirically when possible. External therapy and hygiene constitute an essential part of treatment. When choosing drugs for topical glucocorticosteroids, preferenceshould be given to drugs with a high therapeutic index and low atrophogenic potential. Dysplastic processes of the penis are associated with human papillomavirus infection, the treatment of which can be both conservative and destructive.

scholarly journals THE CLASSIFICA ASSIFICATION OF PHRASEOL TION OF PHRASEOLOGICAL UNI OGICAL UNITS WITH ONOMASTIC COMPONENTS

2020 ◽  
Vol 4 (6) ◽  
pp. 139-147
Author(s):  
Marjona Akhmadovna Radjabova ◽  
Keyword(s):  
Cultural Values ◽  
Daily Life ◽  
National Character ◽  
Ancient History ◽  
The Past ◽  
The World

Abstract. The following article discusses the role of onomastic components in phraseological units and their meaning as well as giving a classification of onomastic components in phraseological units based on the materials of different structural languages. Through examples the author proves that the presence of names in the ancient rich phraseological layer of non-fraternal English, Russian and Uzbek languages is related to the national and cultural values, customs, ancient history, folklore and daily life of the peoples who speak this language. Besides, in the process of study of onomastic components it is also determined that names, along with forming their national character, are a factor giving information about the past of a particular nation. Background. In the world linguistics there have been carried out a series of researches in the field of the study of phraseological units with onomastic components in comparative-typological aspect revaling their national and cultural peculiarities, analyzing and classifying their content structurally and semantically

scholarly journals A Review on Epilepsy and its Management

2020 ◽  
Vol 10 (3) ◽  
pp. 273-279
Author(s):  
V.V. Potnis ◽  
Ketan G. Albhar ◽  
Pritamsinh Arjun Nanaware ◽  
Vishal S. Pote
Keyword(s):  
Developing Countries ◽  
Neurological Disorders ◽  
Genetic Factors ◽  
Future Trends ◽  
Brain Infection ◽  
The World ◽  
Different Types ◽  
Patients With Epilepsy ◽  
The Brain

Today, people face various types of stress in everyday fast life and most people in the world suffer from various neurological disorder. Epilepsy is one of the most common neurological disorders of the brain, affecting about 50 million people around the world, and 90% of them are coming from developing countries. Genetic factors and brain infection, stroke, tumors and epilepsy cause high fever. It imposes a great economic burden on the health systems of countries associated with stigma and discrimination against the patient and also his family in the community, in the workplace, school and home. Many patients with epilepsy suffer from severe emotional stress, behavioral disorders and extreme social isolation. There are many different types of seizure and mechanisms by which the brain generates seizures. The two features of generating seizures are hyperexcitability of neurons and a hyper synchronousneural circuits. A variety of mechanisms alters the balance between excitation and inhibition in predisposing brain local or generalized hyperexcitability region and a hypersynchronia. Purpose of the review is to discuss the history, epidemiology, etiology, pathophysiology, classification of epilepsy, symtomps, diagnosis, management of epilepsy and future trends. Keywords: Anti-epileptic drugs, pathophysiology, seizures, epidemiology, hypersynchrony

scholarly journals Cycling Pathways

2021 ◽  
Author(s):  
Henk-Jan Dekker
Keyword(s):  
Climate Change ◽  
The Netherlands ◽  
Political Struggle ◽  
The Road ◽  
Wide Range ◽  
The World ◽  
Road Space ◽  
History Of ◽  
On The Road

In an effort to fight climate change, many cities try to boost their cycling levels. They often look towards the Dutch for guidance. However, historians have only begun to uncover how and why the Netherlands became the premier cycling country of the world. Why were Dutch cyclists so successful in their fight for a place on the road? Cycling Pathways: The Politics and Governance of Dutch Cycling Infrastructure, 1920-2020 explores the long political struggle that culminated in today’s high cycling levels. Delving into the archives, it uncovers the important role of social movements and shows in detail how these interacted with national, provincial, and urban engineers and policymakers to govern the distribution of road space and construction of cycling infrastructure. It discusses a wide range of topics, ranging from activists to engineering committees, from urban commuters to recreational cyclists and from the early 1900s to today in order to uncover the long and all-but-forgotten history of Dutch cycling governance.

scholarly journals Genome-Wide Heritability Estimates for Family Life Course Complexity

Demography ◽  
2021 ◽  
Author(s):  
Zachary Van Winkle ◽  
Dalton Conley
Keyword(s):  
Life Course ◽  
Family Life ◽  
Genetic Factors ◽  
Methodological Approach ◽  
Age At First Birth ◽  
Genetic Contribution ◽  
Sequence Complexity ◽  
Wide Range ◽  
Family Trajectories

Abstract Sequence analysis is an established method used to study the complexity of family life courses. Although individual and societal characteristics have been linked with the complexity of family trajectories, social scientists have neglected the potential role of genetic factors in explaining variation in family transitions and events across the life course. We estimate the genetic contribution to sequence complexity and a wide range of family demographic behaviors using genomic relatedness–based, restricted maximum likelihood models with data from the U.S. Health and Retirement Study. This innovative methodological approach allows us to provide the first estimates of the heritability of composite life course outcomes—that is, sequence complexity. We demonstrate that a number of family demographic indicators (e.g., the age at first birth and first marriage) are heritable and provide evidence that composite metrics can be influenced by genetic factors. For example, our results show that 11% of the total variation in the complexity of differentiated family sequences is attributable to genetic influences. Moreover, we test whether this genetic contribution varies by social environment as indexed by birth cohort over a period of rapid changes in family norms during the twentieth century. Interestingly, we find evidence that the complexity of fertility and differentiated family trajectories decreased across cohorts, but we find no evidence that the heritability of the complexity of partnership trajectories changed across cohorts. Therefore, our results do not substantiate claims that lower normative constraints on family demographic behavior increase the role of genes.

scholarly journals On the Cognitive Foundation of Lexical Classification of the Subject World

2020 ◽  
pp. 59-75
Author(s):  
Alexey D. Koshelev ◽  
Keyword(s):  
Human Cognition ◽  
Language Of Thought ◽  
Human Species ◽  
Specific Level ◽  
Human Ability ◽  
The World ◽  
The Subject ◽  
Lexical Classification

The paper presents a language of thought (a set of cognitive units and relations) used to provide non-verbal definitions for the following five concepts: ARMCHAIR, MUG, RAVINE, LAKE, TREE. These definitions make it possible to describe concepts on two levels of specificity. On the first level, a concept is presented as a holistic cognitive unit. On the second, more specific, level, the same concept is viewed as a partitive system, i.e. a hierarchical system of its parts, the latter being smaller concepts into which the original holistic unit is decomposed. A hypothesis is advanced that such structure is inherent to all visible objects. The partitive system is argued to play a major role in human cognition. It, first, provides for an in-depth understanding of the perceived objects through understanding the role of their parts, and, second, underlies the formation of the hierarchy of concepts with respect to their generality. Besides, it can be considered as one of the defining properties of the human species as it accounts for the human ability to purposefully change the world.

scholarly journals Рукописное наследие татарских ученых в фондах Института востоковедения Академии Наук Республики Узбекистан

Islamology ◽  
2019 ◽  
Vol 9 (1-2) ◽  
pp. 195
Author(s):  
Saidakbar Mukhammadaminov
Keyword(s):  
Wide Range ◽  
The World ◽  
The Creation ◽  
Oriental Studies ◽  
Academy Of Sciences

The article is dedicated to the manuscript heritage of Tatar scholars held in Abu Rayhan Beruni Institute of Oriental Studies of the Academy of Sciences of Uzbekistan, one of the richest manuscript repositories in the world. Works of manuscripts of Tatar theologians such as Abdurahim Utyz-Imyani, Abu al-Nasr Qursawi, Shihabaddin Mardjani, and Hisam al-Din b. Sharaf al- Din al-Bulgari, Kamal al-Din b. Siraj al-Din al-Uribfori al-Kazani, ̒Ayn al-Din b. Jalal al-Din al-Kazani, Abu al-Sharaf Husain b. Abu Umar al- Bulgari, Muhammad Latif b. Abdulislam al-Bulgari are analyzed. Based on a review of the manuscripts, it is established that some of them have not yet been catalogued. It is argued that the works of Tatar scholars were mainly devoted to religious subjects. The role of Tatar scholars in the creation of commentaries and works on legal, medical and Sufi terms is analyzed in order to make the works accessible to a wide range of people seeking knowledge.

Chief Digital Officers and Their Roles, Agendas, and Competencies

2021 ◽  
pp. 1929-1940
Author(s):  
Vladimir Korovkin
Keyword(s):  
Digital Transformation ◽  
Important Condition ◽  
New Era ◽  
Managerial Skills ◽  
Profound Knowledge ◽  
Wide Range ◽  
The World ◽  
Strategic Role ◽  
Chief Digital Officer

Digital transformation of business is an increasingly pressing issue for top management of the companies across the world. Appointing dedicated executive is a popular measure undertaken to respond to the challenges of the new era. Many view the role of CDO (Chief Digital Officer) to be “the most exciting strategic role in the coming decade”. There is a wide range of views on the CDO's role, agenda, and competencies. Depending on the nature and the environment of a given business, there are three possible strategic approaches to the digital transformation: “fully digital”, “digitally wrapped”, and “digitally spiced”. Each of these requires a CDO, the digital transformation-focused executive, as an important condition for success, yet the range of tasks such a manager handles is profoundly different in each case. The role of CDO is defined by a diverse and demanding set of requirements; the perfect CDO is a manager with a variety of functions who actively interacts with other executives and has profound knowledge and strong managerial skills.

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