scholarly journals The next-generation combination drugs as part of the comprehensive therapy for inflammatory diseases of the pharynx

2018 ◽  
pp. 55-57
Author(s):  
S. V. Ryazantsev ◽  
D. D. Kalyapin
Keyword(s):  
Lower Respiratory Tract ◽  
Inflammatory Diseases ◽  
Epidemiological Data ◽  
Pharmacological Agents ◽  
Main Symptom ◽  
Comprehensive Therapy ◽  
Combination Drugs ◽  
Common Etiology ◽  
Combination Preparation ◽  
Respiratory Tract Inflammation

Inflammatory diseases of the pharynx constitute one of the most significant nosologies groups in the ENT organ diseases profile. According to modern epidemiological data, acute and chronic tonsillopharyngitis are inferior only to influenza and other forms of ARVI with predominantly nasal and paranasal sinuses, as well as the lower respiratory tract inflammation in prevalence among the population. Infectious pathogens are the most common etiology of inflammatory diseases of the pharynx. Accordingly, the pharmacological agents should be selected among the drugs having pronounced antimicrobial activity against both bacterial and other organisms - viral and fungal, and an analgesic effect, as sore throat is the main symptom of tonsillofingitis. The combination preparation Septolete® total is one of such drugs.

scholarly journals The CONFINE (Comorbidities and Outcome iN patients with chronic heart Failure: a study in INternal mEdicine units) study: a new epidemiologic observational study on heart failure in the internal medicine departments in Italy

2013 ◽  
pp. 57-64
Author(s):  
P. Biagi
Keyword(s):  
Internal Medicine ◽  
Heart Failure ◽  
Observational Study ◽  
Inflammatory Diseases ◽  
Correct Diagnosis ◽  
Cognitive Disorders ◽  
Epidemiological Data ◽  
Chronic Kidney Failure ◽  
Chronic Obstructive ◽  
Quality Life

BACKGROUND The burden of heart failure (HF) is enormous and its prevalence increases sharply with age. It has been estimated that heart failure affects up to 3% of the general population and 10% of the elderly. It contributes to hospital admission for most of them, mainly elder adults (admitted in internal medicine units) with more than one comorbidity, cognitive disorders, impairment and so on. Despite the increasing prevalence of heart failure, its exact incidence and prevalence remain largely unknown and probably underestimated due to a lack of accurate epidemiological data and difficulties associated with comorbidities and correct diagnosis: over 40% of recurrent hospitalization causes, either cardiac or extracardiac, cannot be determined due to the lack of data. AIM OF THE STUDY The objective of this study estimated the prevalence and the primary care burden associated with comorbidities in internal medicine units. METHOD The design: a longitudinal multicentric observational study using spot analysis three data sheets were filled in during the hospital stay according to three crucial moments: enrolment (“the index day”), admission and discharge. Will be analyzed the following primary outcomes: total and cardiovascular mortality, intensive unit care admission, recurrent cardiovascular disorders, length of stay, hospital readmission, changes in activities of daily living, need for care. Second outcomes: clinical, therapeutic, instrumental and laboratory changes during the admission process. Deep analysis of the following comorbidities will be also taken into account: acute and chronic kidney failure, anaemia, chronic obstructive pulmonary disease, muscle loss, nutritional status, cirrhosis of the liver, neoplasms, blood cell disorders, chronic inflammatory diseases. Further evalutation items: cognitive impairment, self-sufficiency and perception of quality life.

scholarly journals Characteristics of the etiological structure of infection associated with the provision of medical care in a multi-specialty hospital

2020 ◽  
Vol 22 (1) ◽  
pp. 7-11
Author(s):  
B N Kotiv ◽  
B Yu Gumilevsky ◽  
E N Kolosovskaya ◽  
L A Kaftyreva ◽  
E S Orlova ◽  
...  
Keyword(s):  
Medical Care ◽  
Antibacterial Therapy ◽  
Lower Respiratory Tract ◽  
Surgical Intervention ◽  
Epidemiological Data ◽  
Epidemic Process ◽  
The Past ◽  
Surgical Infections ◽  
Klebsiella Spp ◽  
Russian Association

Epidemiological data on infections associated with medical care in surgical hospitals are presented. The features of the epidemic process of infections associated with Klebsiella spp. were studied among the patients of surgical profile. The study of the etiological structure in hemocultures in 33% of cases revealed the predominance of Klebsiella spp. In patients with a surgical profile, the incidence of Klebsiella spp. has increased over the past 10 years in wound content from 0,4 to 8,3% and in 7,7% of cases - in hemocultures. Significant resistance of Klebsiella spp. strains was detected currently used in the clinical practice of surgical hospitals antibacterial drugs. The highest sensitivity among Klebsiella spp. strains antimicrobial resistance was detected in the group of carbapenems. The structure of the epidemic process of infections caused by Klebsiella spp. is considered among patients of surgical clinics in 2018. In 32% of cases, the infectious process was localized in the lower respiratory tract, in 25% of cases - in the urinary tract, in 22% of cases - in the blood and in 21% of cases - in the area of surgical intervention. The results obtained do not differ significantly from the data obtained in other medical organizations in the country. The need for a comprehensive approach to microbiological monitoring and the appointment of antibacterial therapy for infections associated with the provision of medical care in surgical hospitals has been established. For example, the «Strategy for controlling antibacterial therapy» developed by the Russian Association of specialists in surgical infections, which is well-established in several dozen large hospitals in the country, is being more widely introduced into medical practice.

scholarly journals Doxycycline in the current clinical practice

2020 ◽  
Vol 22 (1) ◽  
pp. 21-28
Author(s):  
Sergey K. Zyryanov ◽  
Alexey V. Golub ◽  
Roman S. Kozlov
Keyword(s):  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Inflammatory Diseases ◽  
Skin Infections ◽  
Current Clinical Practice ◽  
Lower Respiratory Tract Infections ◽  
Sexually Transmitted ◽  
Prevention And Treatment ◽  
Vector Borne ◽  
Tract Infections

This paper reviews clinical and pharmacological characteristics of doxycycline which is currently indicated for the treatment of some common sexually transmitted infections, pelvic inflammatory diseases, lower respiratory tract infections, several skin infections and periodontitis. This antimicrobial agent still plays an important role in the prevention and treatment of certain vector-borne and particularly dangerous infections.

scholarly journals Association between eczema and major cardiovascular outcomes in population-based studies: a systematic review protocol

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017979 ◽  
Author(s):  
Anna Ascott ◽  
Ashley M Yu ◽  
Morten Schmidt ◽  
Katrina Abuabara ◽  
Liam Smeeth ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Data Extraction ◽  
Meta Analysis ◽  
Epidemiological Data ◽  
Epidemiological Studies ◽  
Cardiovascular Death ◽  
Population Based ◽  
Cardiovascular Outcomes ◽  
Cross Sectional

IntroductionChronic inflammatory diseases such as eczema (also known as atopic dermatitis) have been inconsistently linked to cardiovascular disease and stroke in both mechanistic and epidemiological studies. There is a need to review the existing epidemiological data examining the association between eczema and major cardiovascular outcomes, including angina, myocardial infarction, coronary revascularisation, heart failure, cardiac arrhythmias, stroke and cardiovascular death, in order to improve our understanding of the comorbidities of eczema.Methods and analysisWe will systematically review population-based studies, including cohort, case–control and cross-sectional studies, reporting on the association between eczema and cardiovascular outcomes. We will search Medline, Embase and Global Health, from their date of inception to April 2017, using a comprehensive search strategy formulated with the help of a librarian. Two reviewers will independently screen titles and abstracts in duplicate, followed by independent data extraction and quality assessment. We will group studies by the cardiovascular outcome under study and synthesise them narratively. If sufficient numbers of homogeneous studies are returned, we will perform meta-analyses to obtain pooled effect estimates. Preferred Reporting Items for Systematic Review and Meta-Analysis will be used to inform the reporting of this study.Trial registration numberCRD42017060359.

scholarly journals Activation of HIF-1α does not increase intestinal tumorigenesis

2014 ◽  
Vol 307 (2) ◽  
pp. G187-G195 ◽  
Author(s):  
Xiang Xue ◽  
Sadeesh K. Ramakrishnan ◽  
Yatrik M. Shah
Keyword(s):  
Colon Cancer ◽  
Transcription Factors ◽  
Cancer Progression ◽  
Intestinal Inflammation ◽  
Inflammatory Diseases ◽  
Cell Metabolism ◽  
Tumor Biology ◽  
Hypoxia Inducible Factor ◽  
Pharmacological Agents ◽  
Epithelial Barrier Function

The hypoxic response is mediated by two transcription factors, hypoxia-inducible factor (HIF)-1α and HIF-2α. These highly homologous transcription factors are induced in hypoxic foci and regulate cell metabolism, angiogenesis, cell proliferation, and cell survival. HIF-1α and HIF-2α are activated early in cancer progression and are important in several aspects of tumor biology. HIF-1α and HIF-2α have overlapping and distinct functions. In the intestine, activation of HIF-2α increases inflammation and colon carcinogenesis in mouse models. Interestingly, in ischemic and inflammatory diseases of the intestine, activation of HIF-1α is beneficial and can reduce intestinal inflammation. HIF-1α is a critical transcription factor regulating epithelial barrier function following inflammation. The beneficial value of pharmacological agents that chronically activate HIF-1α is decreased due to the tumorigenic potential of HIFs. The present study tested the hypothesis that chronic activation of HIF-1α may enhance colon tumorigenesis. Two models of colon cancer were assessed, a sporadic and a colitis-associated colon cancer model. Activation of HIF-1α in intestinal epithelial cells does not increase carcinogenesis or progression of colon cancer. Together, the data provide proof of principle that pharmacological activation of HIF-1α could be a safe therapeutic strategy for inflammatory bowel disease.

scholarly journals Clinical and microbiological peculiarities of nose pathology and paranasal sinuses in patients with non-hospital pneumonia.

2021 ◽  
Vol 1 (1) ◽  
pp. 011-015
Author(s):  
Daulet Azadbek Ugli Jumanov ◽  
Shakhlo Khamidullaevna Bakieva ◽  
Jamolbek Abdukakharovich Djuraev ◽  
Islambek Abdinasirovich Kudiyarov ◽  
Navruz Noryigitovich Djabbarov
Keyword(s):  
Respiratory Tract ◽  
Paranasal Sinuses ◽  
Lower Respiratory Tract ◽  
Inflammatory Diseases ◽  
Community Acquired Pneumonia ◽  
Microbial Colonization ◽  
Microbiological Analysis ◽  
Microbiological Study ◽  
Significant Difference ◽  
Nose And Paranasal Sinuses

This article presents the results of a comprehensive otorhinolaryngological and microbiological study of diseases of the nose and paranasal sinuses in patients with community-acquired pneumonia. These diseases are closely interconnected, since the upper and lower respiratory tract are a single whole, have structures and functions and mechanisms for the development of pathological conditions. The etiopathogenesis of bacterial inflammatory diseases of the upper and lower respiratory tract is based on the violation of the integrity of epithelial cells under the influence of respiratory viruses. Under the influence of the general toxic effect of the virus, phagocytosis is inhibited, immunological protection is disrupted, as a result, favorable conditions are created for microbial colonization in the nasopharynx and the further spread of infections to the paranasal sinuses and lower respiratory tract. As a result of a clinical and microbiological study, it was revealed that in community-acquired pneumonia, inflammatory diseases of the nose and paranasal sinuses such as acute and chronic rhinosinusitis, allergic and vasomotor rhinitis, curvature of the nasal septum were often encountered. To determine the nature of the microbial landsURTe of the upper and lower respiratory tract, a comparative microbiological analysis was performed from the nose and sputum. Analyzes showed that there was no significant difference in pathogenic microflora between the upper and lower respiratory tract. The main pathogen in both diseases was Streptococcus pneumoniae. Correspondence of the pathogenic microflora of the nasal cavity and lower respiratory tract when rhinosinusitis is detected in patients with community-acquired pneumonia confirms the pathogenetic relationship of inflammatory processes in these organs, as well as the need for parallel diagnosis, treatment, prevention.

scholarly journals The study of clinical and echocardiographic assessment of patients with atrial fibrillation

2019 ◽  
Vol 6 (4) ◽  
pp. 1041
Author(s):  
Gurinder Mohan ◽  
Sukhvir Kaur ◽  
Ranjeet Kaur ◽  
Aakash Aggarwal
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Hospital Admissions ◽  
Hypertensive Heart Disease ◽  
Epidemiological Data ◽  
Elderly Age ◽  
Early Management ◽  
Global Epidemic ◽  
Male Predominance ◽  
Common Etiology

Background: Atrial Fibrillation is the most common arrhythmia encountered in our clinical practice accounting for 1/3rd of the total hospital admissions for cardiac rhythm disturbances. Recent worldwide epidemiological data have reaffirmed that AF is a global epidemic and has adverse effects on long term morbidity and mortality. This study is aimed to assess the clinical profile and etiology along with Echocardiographic evaluation of patients presenting with Atrial Fibrillation.Methods: Total of 100 patients of Atrial Fibrillation were enrolled for the study, who got admitted in hospital from March 2017 to June 2018. These patients were evaluated clinically, and detailed Cardiovascular, Neurological examination was done to evaluate etiology and for any evidence of thromboembolism. Echocardiography was also done.Results: Mean Age of the patients enrolled was 67.02±12.50 yrs. There was male predominance. The presenting complaints were dyspnea, palpitations, chest pain & pedal edema. On Echocardiography, Hypertensive Heart Disease was found to be the most common etiology. Mean LA size was 46.18±9.49 mm. LA clot was present in 4% patients. Most common complication was congestive cardiac failure followed by stroke. CHA2DS2- VASc score was ≥2 in 86% patients.Conclusions: Increasing age and hypertension are associated with occurrence of AF. Hypertensive heart disease was the most common etiology in elderly age group. Presence of LVH or left atrial enlargement in patients with hypertensive heart disease requires early management to improve the outcomes.

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