scholarly journals Acute insomnia: experience of treatment with doxylamine

2021 ◽  
pp. 267-273
Author(s):  
D. V. Romanov ◽  
P. G. Iuzbashian
Keyword(s):  
Clinical Observation ◽  
Transient State ◽  
Adjustment Disorder ◽  
Epidemiological Studies ◽  
Histamine Receptors ◽  
Spontaneous Resolution ◽  
Nonprescription Drugs ◽  
Therapeutic Approaches ◽  
Falling Asleep ◽  
The Subject

Insomnia is a common clinical condition characterized by difficulty initiating and/or maintaining sleep. According to most epidemiological studies, about a third of adults (30–36%) report at least one symptom of insomnia, such as having difficulty falling asleep or maintaining sleep. Insomnia interferes with the full-fledged social and professional functioning of patients, forcing them to visit doctors more often, take sick leave. While therapeutic approaches are actively developed and discussed in chronic insomnia, acute insomnia due to the transient state and the tendency (in some cases) to spontaneous resolution often remains the subject of underdiagnosis and undrtreatment. Antihistamines that are non-addictive and have a narrower side-effect profile and are nonprescription drugs are an alternative in the pharmacological treatment of insomnia, especially secondary and transient insomnia, which is widespread in the population. Donormil (doxylamine succinate) is a blocker of H1-histamine receptors from the ethanolamine group. Donormil (doxylamine succinate) is a blocker of H1-histamine receptors from the ethanolamine group. Doxylamine is successfully used in both psychiatric and general medical practice, including dermatology, allergology, and gynecology.This article presents the clinical observation of a patient with acute insomnia arising in adjustment disorder and was accompanied by anxiety and mild conversion symptoms.. Donormil therapy during two weeks allowed to reduce acute insomnia: the time to fall asleep and the number of night awakenings decreased, cognitive impairment, distraction, and asthenia associated with insomnia reduced. No significant side effects were observed.

scholarly journals The emerging role of mechanical and topographical factors in the development and treatment of nervous system disorders: dark and light sides of the force

2021 ◽  
Author(s):  
Natalia Bryniarska-Kubiak ◽  
Andrzej Kubiak ◽  
Małgorzata Lekka ◽  
Agnieszka Basta-Kaim
Keyword(s):  
Nervous System ◽  
Physical Factors ◽  
Nervous System Diseases ◽  
Therapeutic Approaches ◽  
System Disease ◽  
New Therapeutic Approaches ◽  
The Subject ◽  
Topographical Factors ◽  
New Treatment

AbstractNervous system diseases are the subject of intensive research due to their association with high mortality rates and their potential to cause irreversible disability. Most studies focus on targeting the biological factors related to disease pathogenesis, e.g. use of recombinant activator of plasminogen in the treatment of stroke. Nevertheless, multiple diseases such as Parkinson’s disease and Alzheimer’s disease still lack successful treatment. Recently, evidence has indicated that physical factors such as the mechanical properties of cells and tissue and topography play a crucial role in homeostasis as well as disease progression. This review aims to depict these factors’ roles in the progression of nervous system diseases and consequently discusses the possibility of new therapeutic approaches. The literature is reviewed to provide a deeper understanding of the roles played by physical factors in nervous system disease development to aid in the design of promising new treatment approaches. Graphic abstract

Selected studies of the Menopause

1973 ◽  
Vol 5 (4) ◽  
pp. 533-555 ◽  
Author(s):  
Sonja M. McKinlay ◽  
John B. McKinlay
Keyword(s):  
Clinical Trial ◽  
Clinical Observation ◽  
Annotated Bibliography ◽  
The Past ◽  
General Report ◽  
Methodological Problems ◽  
The Subject

SummaryLiterature on the subject of the menopause, primarily from the past three decades, is selectively reviewed in the form of an annotated bibliography. In order to highlight particular methodological problems, the review is presented in three sections, each preceded by a brief discussion, as follows: (a) the general report of clinical observation or experience, (b) the survey, and (c) the clinical trial. Several recommendations are also made for further research in this field.

scholarly journals Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

2006 ◽  
Vol 5 (7) ◽  
pp. 1091-1103 ◽  
Author(s):  
William J. Steinbach ◽  
Robert A. Cramer ◽  
B. Zachary Perfect ◽  
Yohannes G. Asfaw ◽  
Theodor C. Sauer ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Clinical Observation ◽  
Immunocompromised Patient ◽  
Fungal Growth ◽  
Pathogenic Fungi ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Growth Morphology ◽  
Different Types ◽  
Hyphal Morphology

ABSTRACT Calcineurin is implicated in a myriad of human diseases as well as homeostasis and virulence in several major human pathogenic microorganisms. The fungus Aspergillus fumigatus is a leading cause of infectious death in the rapidly expanding immunocompromised patient population. Current antifungal treatments for invasive aspergillosis are often ineffective, and novel therapeutic approaches are urgently needed. We demonstrate that a mutant of A. fumigatus lacking the calcineurin A (cnaA) catalytic subunit exhibited defective hyphal morphology related to apical extension and polarized growth, which resulted in drastically decreased filamentation. The ΔcnaA mutant lacked the extensive lattice of invading hyphae seen with the wild-type and complemented strains. Sporulation was also affected in the ΔcnaA mutant, including morphological conidial defects with the absence of surface rodlets and the added presence of disjunctors creating long conidial chains. Infection with the ΔcnaA mutant in several distinct animal models with different types of immunosuppression and inoculum delivery led to a profound attenuation of pathogenicity compared to infection with the wild-type and complemented strains. Lung tissue from animals infected with the ΔcnaA mutant showed a complete absence of hyphae, in contrast to tissue from animals infected with the wild-type and complemented strains. Quantitative fungal burden and pulmonary infarct scoring confirmed these findings. Our results support the clinical observation that substantially decreasing fungal growth can prevent disease establishment and decrease mortality. Our findings reveal that calcineurin appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention.

scholarly journals SARS-CoV-2 and Acute Cerebrovascular Events: An Overview

2021 ◽  
Vol 10 (15) ◽  
pp. 3349
Author(s):  
Mehdi Ghasemi ◽  
Raffaella Pizzolato Umeton ◽  
Kiandokht Keyhanian ◽  
Babak Mohit ◽  
Nasrin Rahimian ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Case Reports ◽  
Critical Role ◽  
Epidemiological Studies ◽  
Therapeutic Approaches ◽  
Angiotensin Converting Enzyme 2 ◽  
Cerebrovascular Complications ◽  
Current State ◽  
Cerebrovascular Events ◽  
Brain Homeostasis

Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19’s general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. In this review, we discuss the current state of knowledge of the possible mechanisms underlying the acute cerebrovascular events in patients with COVID-19, and we review the current epidemiological studies and case reports of neurovascular complications in association with SARS-CoV-2, as well as the relevant therapeutic approaches that have been considered worldwide. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients.

Speaking Fundamental Frequency Characteristics of Five- and Six-Year-Old Children with Mongolism

1970 ◽  
Vol 13 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Bernd Weinberg ◽  
Marsha Zlatin
Keyword(s):  
Fundamental Frequency ◽  
Trisomy 21 ◽  
Clinical Observation ◽  
Control Sample ◽  
Frequency Standard ◽  
Normal Children ◽  
The Subject ◽  
The Mean ◽  
Voice Fundamental Frequency ◽  
Speaking Fundamental Frequency

Spontaneous speech samples of 27 children with trisomy-21 type Down’s syndrome and 66 normal children were tape-recorded and analyzed for mean fundamental frequency, standard deviation, and range. Results indicate that the mean speaking fundamental frequency (SFF) level for the sample of children with mongolism was significantly higher than the mean SFF level for the control sample. Approximately 50% of the children with mongolism had mean SFF levels exceeding the highest mean SFF level of their matched controls. In only two cases did the mean SFF for a child with mongolism fall below the mean SFF level for control children of the same age and sex. No child with mongolism exhibited a mean SFF level below the lowest mean SFF for any control subject. The subject in question is the clinical observation that children with mongolism typically have low voice fundamental frequency levels.

scholarly journals Severe idiopathic pulmonary fibrosis: what can be done?

2017 ◽  
Vol 26 (145) ◽  
pp. 170047 ◽  
Author(s):  
Antonella Caminati ◽  
Roberto Cassandro ◽  
Olga Torre ◽  
Sergio Harari
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Clinical Observation ◽  
Anxiety And Depression ◽  
Neoplastic Disease ◽  
Therapeutic Approaches ◽  
Slow Disease Progression ◽  
Open Label ◽  
Number Of Patients

Idiopathic pulmonary fibrosis (IPF) remains a challenging disease to manage. Two drugs are now available that can slow disease progression in patients with mild-to-moderate IPF. This means that early diagnosis is mandatory, because there are no proven effective therapies for severe IPF. This lack of proven therapies may be at least partially due to the fact that severe IPF patients are usually not enrolled in randomised, prospective, multicentre, international trials. Clinical observation experiences and preliminary results of long-term, open-label extensions of clinical trials suggest that both pirfenidone and nintedanib may also slow or decrease progression in patients with severe IPF. However, data are sparse and obtained from a relatively small number of patients. Lung transplantation should be taken into account early and discussed with patients, when indicated. Rehabilitative strategies are important and effective supportive therapies. The needs of patients with severe IPF are similar to those of patients with an advanced neoplastic disease. Palliative care and psychological support play an important role in the relief of symptoms of anxiety and depression. Accordingly, these therapeutic approaches should start early in IPF patients.

scholarly journals Cross-sectional evaluation of clinical parameters to select high prevalence populations for periodontal disease: the site comparative severity methodology

2004 ◽  
Vol 15 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Sérgio Luís Scombatti de Souza ◽  
Mario Taba Jr.
Keyword(s):  
Periodontal Disease ◽  
Age Groups ◽  
Computer Software ◽  
Epidemiological Studies ◽  
Age Group ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Attachment Loss ◽  
Calculated Parameter ◽  
The Subject

Epidemiological studies have shown strong evidence that periodontal disease does not affect all subjects in the same manner. There are subjects and sites with higher risk for disease progression. This study tested parameters to select "a priori" sites and subjects potentially at risk. The data from periodontal clinical examinations of 2273 subjects was used. The clinical loss of attachment was measured in 6 sites per tooth. Using computer software, the patients were distributed into 14 age groups, with intervals of 5 years, from 11 years to greater than 75 years of age. The measure of each site was compared with the average and the median values of the subject age group, with the results indicating site comparative severity (SCS). Three global parameters were calculated: parameter 1 (P1) - percentage of sites with clinical attachment loss > 4 mm; parameter 2 (P2) - percentage of sites with clinical attachment loss > 7 mm; parameter 3 (P3) - percentage of sites with clinical attachment loss surpassing the median value for the age group by 100% or more. There were 1466 (65%) females and 807 (35%) males. Most subjects had P1, P2 and P3 values less than 30%. Parameter 3 allowed a division of the sample similar to that of Parameters 1 and 2, with the advantage of analyzing the subject in relation to his/her age group. It was suggested that the methodology of SCS is useful for selecting a population with a high disease prevalence, and that cut-off lines between 10% and 20% would be appropriate for using Parameter 3.

scholarly journals Epidemiologia nowotworu płuc w Polsce

2018 ◽  
Vol 15 (2) ◽  
pp. 71-77
Author(s):  
Paulina Irena Szlitkus
Keyword(s):  
Lung Cancer ◽  
Epidemiological Studies ◽  
Influential Factor ◽  
The European Union ◽  
Respiratory Epithelial Cells ◽  
Lung Cancers ◽  
Long Time ◽  
The Subject ◽  
Diagnosis Of Lung Cancer ◽  
Respiratory Epithelial

The article deals with the problem of lung and pleural cancer. In order to understand the subject properly, it is important to start with how important the lungs are - they are a part of the system through which we can breathe. Unfortunately, the majority of lung tumors are malignant and are caused by mutations of respiratory epithelial cells. There are many factors that contribute to lung cancer. The most known and influential factor is smoking. In the European Union countries, one in five lung cancers is caused by smoking. Lung cancer is very specific because it can develop for a very long time without giving any symptoms and it's usually diagnosed at a late stage of the disease's advancement. The lack of early symptoms is the reason why screening for lung cancer is not carried out even though it is one of the most common tumors.Only epidemiological studies allow to broaden the scope of knowledge about cancers. It is thanks to them that many factors can be distinguished and understood as to which are responsible for the formation of all kinds of tumors. The incidence of lung cancer in Poland is very high, especially among men. Duration of survival after diagnosis of lung cancer varies according to gender. However, survival ratehas in creased in recent years.

scholarly journals Evaluating the role of formulation in counselling psychology: A systematic literature review

2018 ◽  
Vol 7 (1) ◽  
pp. 47-68
Author(s):  
Harriet Challoner ◽  
Fani Papayianni
Keyword(s):  
Systematic Review ◽  
Clinical Practice ◽  
Literature Review ◽  
Therapeutic Approaches ◽  
Regulatory Bodies ◽  
The Subject ◽  
Training Institutions ◽  
Shed Light ◽  
Counselling Psychology

Despite the importance placed upon the concept and act of formulation across multiple therapeutic approaches, there is a lack of literature from within the profession of counselling psychology directly on the role, use and practice of formulation, with existing literature predominantly emanating from the related yet distinct therapeutic fields of counselling, psychotherapy, clinical psychology or psychiatry. This, in conjunction with the controversies and lack of consensus on the subject, as well as the demands of the professional and regulatory bodies, have led to this paper. Our aim is to shed light on the role that formulation plays within the profession under the lens of counselling psychology’s philosophical underpinnings. More specifically, this systematic review investigates whether formulation may be considered as fact or opinion; whether formulations across therapeutic approaches may be cohesive or divisive within counselling psychology practice; whether formulations should be undertaken inclusively with clients and other professionals or exclusively by the practitioner. Such exploration uncovers key areas of debate and potential considerations for the profession regarding how formulation is approached, utilised in clinical practice and, taught by training institutions.

scholarly journals Osobennosti adaptatsii novorozhdennykh u materey s ozhireniem

2008 ◽  
Vol 5 (2) ◽  
pp. 23-26
Author(s):  
L Yu Zernova ◽  
T V Kovalenko ◽  
N N Popova ◽  
N S Strelkov
Keyword(s):  
Distress Syndrome ◽  
Adjustment Disorder ◽  
Perinatal Period ◽  
Postnatal Period ◽  
Reproductive Disorders ◽  
High Incidence ◽  
Neonatal Adaptation ◽  
The Subject ◽  
Postnatal Adaptation ◽  
Available Information

According to various authors, obesity among pregnant recorded at a frequency of 15.5 to 26.9%. There is strong evidence that obesity contributes to complications of pregnancy, childbirth and the postpartum period, provoking the development of gestosis, placental insufficiency, abnormalities of labor, bleeding, et al., Which suggests the possibility of adjustment disorder in the neonatal period in infants of obese mothers. It should be recognized, however, that the available information on the subject are scarce and fragmentary. The purpose of this study was to investigate the features of postnatal adaptation of newborns of mothers with obesity. According to the study found that obesity in women is associated with a high incidence of reproductive disorders, gestational complications and pathological course of labor, resulting in abnormalities in the neonatal adaptation in the postnatal period. Disadaptation syndrome is manifested by the development of jaundice sustained over, edema, transient changes of the cardiovascular system, hypoglycemia. Violations in health are detected in the majority of infants (83.3%) born to mothers with obesity. The most significant pathologies are infections specific to the perinatal period (40.5%), respiratory distress syndrome (3.6%), diabetic fetopathy (4.8%), congenital malformations (2.4%).

Sign in / Sign up

Export Citation Format

Share Document