scholarly journals Relationship of secretor status in patients with oral cancers

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Sajid Jamil ◽  
Muhammad Tayyab ◽  
Muhammad Farooq
Keyword(s):  
Oral Cancer ◽  
Saliva Sample ◽  
Control Group ◽  
Healthy Controls ◽  
Oral Cancers ◽  
Secretor Status ◽  
Relationship Of

Present study was designed to find the association of secretor status with oral cancers. In this study 50 diagnosed cases of oral cancers and 50 healthy controls were selected. Secretor status on saliva sample was performed in all these subjects. 39 (78%) subjects were secretors and 11 (22%) were non secretors in control group. 28 (56%) patients with oral cancers were secretors and 22 (44%) were non secretors. Conclusions: Oral cancer was found to be associated with non-secretor status.

scholarly journals Evaluating the levels of D-dimer as a primary marker in oral cancers using immunoturbidimetric assay: The original research

2020 ◽  
Vol 5 ◽  
pp. 96-100
Author(s):  
Ashok K. Vikey ◽  
Rajkumar Parwani ◽  
Madhusudan Asteker ◽  
Deepali Gupta ◽  
Simran Parwani
Keyword(s):  
Oral Cancer ◽  
Cell Biology ◽  
Control Group ◽  
Original Research ◽  
Oral Cancers ◽  
Cancer Group ◽  
Tissue Factors ◽  
Dual Action ◽  
And Control ◽  
D Dimer

Objectives: Oral cancer is major health threat; with 90% mortality and ranks sixth among worldwide cancers. So to overcome this mortality; newer bio-markers are explored and one of such biomarker is D-dimer, which is end product of fibrinogen formed by plasmin. The raised levels of D-dimer play significant role in proliferation and progress of cancer cells. In cancers D-dimer is formed by dual action, where UPA (Urokinase type Plasminogen Activator) and Tissue factor play important role simultaneously. To understand correlation between D- dimer and oral cancers, by immunoturbidimetry; quantitative assay. Material and Methods: After obtaining consents of patients and Institutional ethical clearance, we randomly selected; age and sex matched; 216 samples. Further these samples were subdivides as oral cancer group and control group, consisting 108 samples in each group respectively. Results: Statistical analysis was done; using SPSS version 20, unpaired -T test, and one way ANOVA were applied. Plasma D-dimer levels were; 497.32±872.28μl/ml and 165.30±150.43 28μl/ml, among cancer and control groups respectively, (P≤ 0.0001), which was statistically highly significant. Conclusion: D-dimer is altered during carcinogenesis by activation of UPA and Tissue factors, and this distinguishes form routine levels of D-dimer. This suggests that, cancer cell biology is greatly affected by D-dimer levels during growth and spread of cancers. So raised levels of D-dimer can be considered during interventions of cancers, and incorporated as a biomarker. However for its scientific applications; there is need of further study, with collaborative approach and larger samples, to restrict cancer related mortalities.

scholarly journals Risk of depression in patients with oral cancer: a nationwide cohort study in Taiwan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ling-Yu Kung ◽  
Tsung-I Li ◽  
Chi-Hsiang Chung ◽  
Shiao-Pieng Lee ◽  
Gunng-Shinng Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Control Group ◽  
Research Database ◽  
Oral Cancers ◽  
Treatment Of Depression ◽  
Increased Risk ◽  
Oral Cancer Patients

AbstractThis study investigates an association between oral cancers and the risk of developing depression. We conducted a total of 3031 patients with newly diagnosed oral cancers and 9093 age-, sex-, and index year-matched controls (1:3) from 2000 to 2013 were selected from the National Health Insurance Research Database (NHIRD) of Taiwan. After adjusting for confounding factors, multivariate Cox proportional hazards analysis was used to compare the risk of depression over a 13-year follow-up. Of the patients with oral cancer, 69 (2.28%, or 288.57 per 105 person-years) developed depression compared to 150 (1.65%, 135.64 per 105 person-years) in the control group. The Cox proportional hazards regression analysis showed that the adjustment hazard ratio (HR) for subsequent depression in patients with oral cancer diagnosed was 2.224 (95% Confidence Interval [CI] 1.641–3.013, p < 0.001). It is noteworthy that in the sensitivity analysis is the adjusted HR in the group with depression diagnosis was 3.392 and in the oral cancer subgroup of “Tongue” was 2.539. This study shows oral cancer was associated with a significantly increased risk for developing subsequent depression and early identification and treatment of depression in oral cancer patients is crucial.

scholarly journals Implicit assumptions and interpretation bias in youth with severe, chronic social phobia

2021 ◽  
Author(s):  
Lisa Krömer ◽  
Tomasz A. Jarczok ◽  
Heike Althen ◽  
Andreas M. Mühlherr ◽  
Vanessa Howland ◽  
...  
Keyword(s):  
Social Phobia ◽  
Interpretation Bias ◽  
Group Differences ◽  
Future Research ◽  
Control Group ◽  
Healthy Controls ◽  
Implicit Processing ◽  
Affective Stimuli ◽  
Affect Misattribution Procedure ◽  
Relationship Of

AbstractInterpretation bias and dysfunctional social assumptions are proposed to play a pivotal role in the development and maintenance of social phobia (SP), especially in youth. In this study, we aimed to investigate disorder-specific implicit assumptions of rejection and implicit interpretation bias in youth with severe, chronic SP and healthy controls (CG). Twenty-seven youth with SP in inpatient/day-care treatment (M age = 15.6 years, 74% female) and 24 healthy controls (M age = 15.7 years, 54% female) were included. The Implicit Association Test (IAT) and the Affect Misattribution Procedure (AMP) were completed to assess implicit assumptions and interpretation bias related to the processing of social and affective stimuli. No group differences were observed for the IAT controlling for depressive symptoms in the analyses. However, group differences were found regarding interpretation bias (p = .017, η2p = .137). Correlations between implicit scores and explicit questionnaire results were medium to large in the SP group (r =|.28| to |.54|, pall ≤ .05), but lower in the control group (r =|.04| to |.46|, pall ≤ .05). Our results confirm the finding of an interpretation bias in youth SP, especially regarding the implicit processing of faces, whereas implicit dysfunctional social assumptions of being rejected do not seem to be specific for SP. Future research should investigate the causal relationship of assumptions/interpretation bias and SP.

scholarly journals Evaluation of the Secretor Status of ABO Blood Group Antigens in Saliva using Absorption Inhibition Method

2021 ◽  
Author(s):  
M.L Avinash Tejasvi ◽  
Jaya Laksmi Bukkya ◽  
Pandu Ranga Rao ◽  
Harsha Bhayya
Keyword(s):  
Blood Group ◽  
Saliva Sample ◽  
Test Method ◽  
Control Group ◽  
Blood Group Antigens ◽  
Slide Agglutination ◽  
Secretor Status ◽  
Agglutination Method ◽  
Group 5 ◽  
And Control

Abstract Objectives While DNA profiling has become the principal technique for individualization of biological evidences, ABO blood grouping is still a useful test method in the initial stages of crime investigation. Objectives of the study were blood group determination using slide agglutination method, blood group determination from saliva using absorption inhibition method, and comparison of slide agglutination method with that of absorption inhibition method from saliva sample. Materials and Methods A total of 60 subjects were taken randomly with their age ranging from 20 to 60 years. Sixty subjects were divided in to two groups, study group and control group. 5 to 10 mL of unstimulated saliva was collected from 60 patients and Wieners agglutination test was performed to detect the secretor status of blood using absorption inhibition method and compared with that of slide agglutination method Results Out of 60 subjects, 52 subjects showed secretors of antigen in saliva with percentage value of 86.66% and eight subjects were nonsecretors (13.33%). Slightly higher percentage of secretor status was seen in males 84.6 and 88.2% in females. Conclusion Evaluation of secretor status of blood group antigen from saliva using absorption inhibition method can be useful method in identification of medicolegal cases.

scholarly journals Relationship of ABO blood groups in patients with oral cancers

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Sajid Jamil ◽  
Naveed Akhtar Saleem ◽  
Syed Ikhlaq Amjad ◽  
Anjum Rashid Butt ◽  
Muhammad Tayyab ◽  
...  
Keyword(s):  
Blood Groups ◽  
Healthy Controls ◽  
Abo Blood Groups ◽  
Oral Cancers ◽  
Blood Group A ◽  
Group A ◽  
Group B ◽  
Relationship Of ◽  
Abo Blood Grouping ◽  
Blood Grouping

Present study was designed to find the association of ABO blood groups with oral cancers. In this study 50 diagnosed cases of oral cancers and 50 healthy controls were selected. ABO blood grouping, complete blood examination was performed in all these subjects. Out of 50 patients 16 were blood group A, 11 group `B`, 8 group `AB` and 15 belong to group `O` as compared to controls who were, 14, 15, 3, 18 for blood groups A, B, AB and O respectively. Conclusions: No relationship is found between Oral Cancers and ABO Blood groups.

scholarly journals Effect of Chemo-radiotherapy on Salivary Flora of Oral Cancer Patients

2021 ◽  
Author(s):  
Reeta Maurya ◽  
Madhup Rastogi ◽  
Manodeep Sen ◽  
Ajai Kumar Singh ◽  
Somali Sanyal
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Bacterial Colonization ◽  
Control Group ◽  
Oral Flora ◽  
Oral Cancers ◽  
Oral Cancer Patients ◽  
Post Radiation ◽  
Oropharyngeal Flora ◽  
And Control

Management of cancers of oral cancers has remained a major challenge in India and globally. Radiotherapy and chemotherapy are mostly employed for treatment which inflicts changes in oral mucosa and makes it vulnerable for bacterial colonization and eventual infections. This study aims at evaluating the changes in oropharyngeal flora (bacteria and yeast) in oral cancer patients treated by a combination of chemo-radiotherapy with the control groups comprising of non-cancerous patients living in the same environment. This prospective evaluation included Seventy seven patients with oral squamous cell carcinomas in the study group. Whereas the control group comprised of twenty five non-cancerous patients. Saliva samples were collected from patients with oral carcinomas and those of the control group for bacteriological examination, and were transported within 2 hours to the laboratory and immediately inoculated and incubated. The oral microflora samples collected were evaluated for the presence of bacteria in saliva in both study and control group of patients. We evaluated the change in salivary oral flora during chemo-radiotherapy treatment. A statistically significant increase in growth of normal as well as abnormal oral flora was observed post-radiation. Escherichia coli showed a significant decrease in post-RT and also near to significant in control. Various changes in salivary oral flora were observed during the course of chemo-radiotherapy in study and controls groups. This shows that there are some sensitive spots in the oral cavity where the occurrence of oral cancer is more.

scholarly journals Association of Cathepsin B a Salivary Biomarkers in Different Histological Grades of Oral Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Alveena Shabbir ◽  
Humera Waheed ◽  
Shaheen Ahmed ◽  
Sabhita Shabir Shaikh
Keyword(s):  
Survival Rate ◽  
Oral Cancer ◽  
Cathepsin B ◽  
Biological Fluids ◽  
Saliva Sample ◽  
Control Group ◽  
Major Public Health Problem ◽  
Salivary Biomarkers ◽  
Poorly Differentiated ◽  
Well Differentiated

Abstract Background:Oral cancer is considered a major public health problem due to its high mortality and morbidity rates. Survival rate of OSCC can be significantly improved by using non -invasive tool such as salivary biomarkers for detection of OSCC which is considered a promising approach. Cathepsin B is a lysosomal cysteine protein, which is present in abundant quantities in lysosome of cells, tissues and different biological fluids. Increased expression of Cathepsin B is observed in many malignancies including oral cancer. The present study was designed to determine the salivary levels of Cathepsin B in different histological grades of OSCC.Method:In this study total no of 80 research participants were enrolled which were divided into four groups. Each group comprises 20 participants. Groups 1 comprises 20 patients of OSCC (Well differentiated), Group 2 comprises 20 patients of OSCC (moderately differentiated), Group 3 comprises 20 patients of OSCC (poorly differentiated|) and Group 4 comprises 20 healthy controls. Saliva sample was collected from all the four study group and salivary Cathepsin B levels were analyzed by ELISA sandwich technique in duplicate.Results:Salivary levels of Cathepsin B are significantly increased with p- value (<0.001) in patients of OSCC in comparison to control group. We observed highest mean Cathepsin B levels in well differentiated OSCC followed by poorly differentiated OSCC and moderately differentiated OSCC.Conclusion:Results of the present study suggests that Cathepsin B has a great value as a salivary biomarker for diagnosis and monitoring of OSCS in different histological grades of OSCC. It could increase the survival rate and further improve the prognosis of OSCC.

Plasma Levels of Lipoprotein(a) Are Elevated in Patients with the Antiphospholipid Antibody Syndrome

1994 ◽  
Vol 71 (04) ◽  
pp. 424-427 ◽  
Author(s):  
Masahide Yamazaki ◽  
Hidesaku Asakura ◽  
Hiroshi Jokaji ◽  
Masanori Saito ◽  
Chika Uotani ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Active Form ◽  
Plasminogen Activator Inhibitor ◽  
Arterial System ◽  
Control Group ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Lipoprotein A ◽  
Soluble Thrombomodulin ◽  
Relationship Of

SummaryThe mechanisms underlying clinical abnormalities associated with the antiphospholipid antibody syndrome (APAS) have not been elucidated. We measured plasma levels of lipoprotein(a) [Lp(a)], the active form of plasminogen activator inhibitor (active PAI), thrombin-antithrombin III complex (TAT) and soluble thrombomodulin (TM), to investigate the relationship of these factors to thrombotic events in APAS. Mean plasma levels of Lp(a), TAT, active PAI and TM were all significantly higher in patients with aPL than in a control group of subjects. Plasma levels of Lp(a) and active PAI were significantly higher in patients with aPL and arterial thromboses than in patients with aPL but only venous thromboses. There was a significant correlation between plasma levels of Lp(a) and active PAI in patients with aPL. These findings suggest that patients with aPL are in hypercoagulable state. High levels of Lp(a) in plasma may impair the fibrinolytic system resulting in thromboses, especially in the arterial system.

A Common Thrombomodulin Amino Acid Dimorphism Is Associated with Myocardial Infarction

1997 ◽  
Vol 77 (02) ◽  
pp. 248-251 ◽  
Author(s):  
Lena Norlund ◽  
Johan Holm ◽  
Bengt Zöller ◽  
Ann-Kristin Öhlin
Keyword(s):  
Myocardial Infarction ◽  
Amino Acid ◽  
Plasma Concentration ◽  
Acute Coronary Syndromes ◽  
Protein C ◽  
Integral Membrane Protein ◽  
Control Group ◽  
Healthy Controls ◽  
Coronary Syndromes ◽  
Premature Myocardial Infarction

SummaryEndothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) for development of premature myocardial infarction (MI). The C/T dimorphism predicts an Ala455 to Val replacement in the sixth EGF-like domain of TM. The dimorphism was investigated in 97 MI survivors and 159 healthy controls. The C allele was significantly more frequent among patients than controls (p = 0.035). The allele frequency for the C allele was 0.82 in the patients and 0.72 in the control group. The plasma concentration of TM was investigated among healthy controls but was not related to the C/T dimorphism. In conclusion, the association of the C allele with premature MI, suggests that the TM gene and the C/T dimorphism may be aetiological factors involved in the pathogenesis of MI. Possibly, the Ala455 to Val replacement may affect the function of the TM molecule and the activation of the protein C anticoagulant pathway.

Relationship of HLA-DRB1 Alleles and Rheumatoid Arthritis in West South of Iran

2017 ◽  
Vol 9 (03) ◽  
Author(s):  
Karim Mowla ◽  
Elham Rajaee M. D. ◽  
Mehrdad Dargahi-MalAmir M. D. ◽  
Neda Yousefinezhad ◽  
Maryam Jamali Hondori
Keyword(s):  
Rheumatoid Arthritis ◽  
Environmental Factors ◽  
Rheumatoid Factor ◽  
Dna Extraction ◽  
Wrist Joint ◽  
Blood Sampling ◽  
Healthy Controls ◽  
Relationship Of ◽  
Synovial Pannus

Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1 *04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025).

Sign in / Sign up

Export Citation Format

Share Document