The performance of the human nose in odour measurement

2001 ◽  
Vol 44 (9) ◽  
pp. 1-7 ◽  
Author(s):  
J.C. Walker
Keyword(s):  
Olfactory System ◽  
Laboratory Data ◽  
Basic Research ◽  
The United States ◽  
Scientific Basis ◽  
Current State ◽  
Functional Aspects ◽  
Human Odour ◽  
Human Olfaction ◽  
Human Nose

Over the last 20 years or so, there has been steadily increasing activity in the area of applied human odour measurement. This has been especially true outside of the United States. Yet, for about 40 years, there has also been decreasing interest and activity, on the part of academic smell researchers, in rigorous quantitative measurement of the functional properties of the human olfactory system. There are some optimistic signs, however, that this situation may be improving. Applied meetings such as this one are reaching out to learn more about basic research in human olfaction and some research groups are venturing out to indoor air quality, environmental health, water quality and other applied areas. In this paper I hope to support and accelerate the increasingly fruitful interactions that are beginning. The paper aims to make four main points. First, some of the most important ways in which the laboratory differs from everyday life will be noted. Keeping these differences in mind lessens the risk that laboratory data will be used uncritically to make predictions of real-world responses to chemical stimuli. Next, the specific benefits that would accrue from more fruitful interactions between basic and applied researchers will be highlighted; this is perhaps best seen by noting problem areas resulting from too little cross-fertilisation. Third, the CEN standard for the measurement of odour thresholds will be discussed in light of what is known concerning both the functional aspects of the human olfactory system and the current state of knowledge concerning best methods for investigating this system. Finally, some recent work we have done that was designed to help characterise human odour responses and demonstrate improved methodology, will be briefly mentioned. The paper concludes with suggestions as to how the scientific basis of applied odour measurement may best be enhanced.

Integrative Approach in Law Understanding: the History of the Origin of Ideas and the Current State

2020 ◽  
Vol 2 (1) ◽  
pp. 115-130
Author(s):  
R. R. Palekha ◽  
Keyword(s):  
Central Place ◽  
Scientific Basis ◽  
Integrative Approach ◽  
Current State ◽  
History Of ◽  
Legal Thinking ◽  
Reliable Knowledge ◽  
The Right ◽  
Fat Formulation

Introduction. Right understanding is the most live, interesting and, at the same time, the uncertain and changeable area of researches which takes the central place as in the general theory of the right, and gains the increasing value in industry jurisprudence that is connected with its considerable teoretiko-methodological and applied potential which is shown in spheres of lawmaking and law-enforcement activity. Thus, right understanding represents research tools of the subject of knowledge which allow to study all range legal and, the based on them, state phenomena for the purpose of obtaining reliable knowledge of state and legal reality. In this regard integrative approach in right understanding which has rich history of the formation and development is of special interest, allows to perceive the right as integrally complete phenomenon, as much as possible retrieves its regulatory abilities and, provides achievement of criteria of scientific research: comprehensiveness, objectivity, historicism. Materials and Methods. In article an attempt of the analysis of integrative approach in right understanding from a position of history of origin of his ideas and assessment of the current state is made. A result of studying of scientific literature, generalization and comparison of the different points of view fat formulation of author’s determination of category “right understanding” and submission of the evidence-based integrative theory of right understanding which as much as possible conforms to requirements of time and has essential regulatory and guarding potential. Results. In article the category right understanding is comprehensively considered, different integrative theories of right understanding from a position of their origin and development are submitted, the value of modern integrative approach in right understanding is shown, perspectives of its further development are evaluated. Discussion and Conclusion. The author comes to the conclusion about the theoretical and methodological consistency and inevitability of the integrative approach in law understanding, which acts as a scientifically grounded type of legal thinking capable of comprehending the law on a truly scientific basis.

scholarly journals Ice-Breaking Fleets of the United States and Canada: Assessing the Current State of Affairs and Future Plans

2021 ◽  
Vol 13 (2) ◽  
pp. 703
Author(s):  
Megan Drewniak ◽  
Dimitrios Dalaklis ◽  
Anastasia Christodoulou ◽  
Rebecca Sheehan
Keyword(s):  
United States ◽  
The United States ◽  
Maritime Transportation ◽  
The Arctic ◽  
Polar Ice ◽  
Northwest Passage ◽  
Ice Cap ◽  
Ice Coverage ◽  
Current State ◽  
State Of Affairs

In recent years, a continuous decline of ice-coverage in the Arctic has been recorded, but these high latitudes are still dominated by earth’s polar ice cap. Therefore, safe and sustainable shipping operations in this still frozen region have as a precondition the availability of ice-breaking support. The analysis in hand provides an assessment of the United States’ and Canada’s polar ice-breaking program with the purpose of examining to what extent these countries’ relevant resources are able to meet the facilitated growth of industrial interests in the High North. This assessment will specifically focus on the maritime transportation sector along the Northwest Passage and consists of four main sections. The first provides a very brief description of the main Arctic passages. The second section specifically explores the current situation of the Northwest Passage, including the relevant navigational challenges, lack of infrastructure, available routes that may be used for transit, potential choke points, and current state of vessel activity along these routes. The third one examines the economic viability of the Northwest Passage compared to that of the Panama Canal; the fourth and final section is investigating the current and future capabilities of the United States’ and Canada’s ice-breaking fleet. Unfortunately, both countries were found to be lacking the necessary assets with ice-breaking capabilities and will need to accelerate their efforts in order to effectively respond to the growing needs of the Arctic. The total number of available ice-breaking assets is impacting negatively the level of support by the marine transportation system of both the United States and Canada; these two countries are facing the possibility to be unable to effectively meet the expected future needs because of the lengthy acquisition and production process required for new ice-breaking fleets.

Biosurveillance: A Modern Look

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
James Lee Brooks
Keyword(s):  
United States ◽  
Homeland Security ◽  
The United States ◽  
First Century ◽  
Direct Result ◽  
Current State ◽  
Twenty First Century ◽  
Security Operations

AbstractThe early part of the twenty-first century saw a revolution in the field of Homeland Security. The 9/11 attacks, shortly followed thereafter by the Anthrax Attacks, served as a wakeup call to the United States and showed the inadequacy of the current state of the nation’s Homeland Security operations. Biodefense, and as a direct result Biosurveillance, changed dramatically after these tragedies, planting the seeds of fear in the minds of Americans. They were shown that not only could the United States be attacked at any time, but the weapon could be an invisible disease-causing agent.

scholarly journals How Are Residents Trained in Neuropathology? A Survey of Neurology Program Directors in the United States

2020 ◽  
Vol 79 (11) ◽  
pp. 1218-1222
Author(s):  
Appaji Rayi ◽  
Kiran Rajneesh ◽  
Vineet Punia ◽  
Amanda R Start
Keyword(s):  
Descriptive Analysis ◽  
Program Directors ◽  
The United States ◽  
Categorical Variables ◽  
Training Methods ◽  
Child Neurology ◽  
Alternative Evaluation ◽  
Current State ◽  
Service Training ◽  
Program Characteristics

Abstract To understand the current state of neurology residents training in neuropathology, we electronically distributed a 16-item survey to 150 adult and 70 child neurology program directors (PDs). The survey inquired about their program characteristics, neuropathology curriculum and assessment methods, trainee performance, and attitudes. Descriptive analysis was used to summarize categorical variables as frequencies and percentages and continuous as means and standard deviations. We conducted a series of Mann-Whitney U and Fisher’s exact tests to evaluate differences between various program characteristics. Sixty-four (29%) PDs responded to the survey, including 45 (30%) adult and 19 (27%) child neurology PDs. Thirty-one programs required a dedicated neuropathology rotation. The majority (92%) used the Residency In-Service Training Examination (RITE) to assess trainee’s knowledge. Approximately 86% of the PDs agreed that neuropathology is essential and a defined curriculum is necessary during residency training. There was no difference in the RITE scores between programs. We conclude that a neuropathology rotation was felt to be essential even though the RITE scores did not differ between programs with and without a dedicated rotation. Alternative evaluation and training methods may need consideration. A future survey of all the stakeholders may be required to thoroughly understand and disseminate the neuropathology education well.

scholarly journals The United States’ Regulatory Environment Is Evolving to Accommodate a Coming Boom in Gene Therapy Research

2019 ◽  
Vol 24 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Daniel Eisenman
Keyword(s):  
United States ◽  
Gene Therapy ◽  
Clinical Trials ◽  
The United States ◽  
Regulatory Environment ◽  
Evidence Based ◽  
Regulatory Structure ◽  
Regulatory Changes ◽  
Current State ◽  
Therapy Field

Introduction: A dramatic increase in the number of clinical trials involving gene-modified cell therapy and gene therapy is taking place. The field is on the verge of a boom, and the regulatory environment is evolving to accommodate the growth. Discussion: This commentary summarizes the current state of the field, including an overview of the growth. The United States (US) regulatory structure for gene therapy will be summarized, and the evolution of the oversight structure will be explained. Conclusion: The gene therapy field has recently produced its first FDA-approved therapeutics and has a pipeline of other investigational products in the final stages of clinical trials before they can be evaluated by the FDA as safe and effective therapeutics. As research continues to evolve, so must the oversight structure. Biosafety professionals and IBCs have always played key roles in contributing to the safe, evidence-based advancement of gene therapy research. With the recent regulatory changes and current surge in gene therapy research, the importance of those roles has increased dramatically.

scholarly journals The Trending Academic Library Job Market: An Analysis of Library Position Announcements from 2011 with Comparisons to 1996 and 1988

2015 ◽  
Vol 76 (6) ◽  
pp. 716-739 ◽  
Author(s):  
Therese F. Triumph ◽  
Penny M. Beile
Keyword(s):  
Work Experience ◽  
Academic Library ◽  
The United States ◽  
Primary Objective ◽  
Job Market ◽  
Current State ◽  
Emerging Trends ◽  
Job Advertisements ◽  
Salary Information ◽  
Over Time

The primary objective of the study was to describe the number, types and titles, requested qualifications and skills, salary information, and locations of positions advertised in 2011 on the ALA JobLIST and ARL Job Announcements websites and in the print version of the Chronicle of Higher Education for purposes of determining the current state of the academic library job market in the United States. To investigate changes in the academic library job market and identify emerging trends over a 23-year period, results also were compared to studies that analyzed position announcements from 1996 and 1988. Content analysis of 957 unique academic library job advertisements revealed relative stasis in the market regarding the number of positions advertised, presence of administrative duties, geographic distribution of positions, and, to some extent, educational requirements. However, other comparisons were more dynamic. Specifically, there has been a decline in foreign language skills and prior work experience requirements over time while computer skills are increasingly sought. Perhaps most striking is the proliferation of new position titles that have emerged over time, which serves as an indication that library positions are becoming increasingly specialized.

Does History Matter in Business?

2009 ◽  
Vol 10 (4) ◽  
pp. 816-830 ◽  
Author(s):  
Paul Tiffany
Keyword(s):  
Management Training ◽  
The United States ◽  
American Business ◽  
Hard Drives ◽  
Current State ◽  
Current Events ◽  
History Matter ◽  
State Of Affairs ◽  
Current Reality ◽  
Management Scholarship

In 2008 Professor Eric Godelier published a provocative essay in which he concluded that a positive dialogue between business historians and both management scientists and business management practitioners was possible. While the divide between these camps was not trivial, he nevertheless wrote that current events and scholarship was bringing them together, at least as he could observe these trends in the context of emerging French scholarship. In this current review, my own conclusion is the opposite. Management scholarship, in fact, continues to move away from the “soft” approach of the historian and more towards the “rigorous” and quantitatively biased methodology of the management sciences. My essay reviews the background of this development in terms of American business practice and scholarship, as it seeks to demonstrate how the evolution of management training in the United States brought us to the current state of affairs where “hard” drives out soft in almost every encounter. However, while I conclude that this is indeed the current reality, I do not imply any endorsement of this outcome. Rather, I end with a hope that some forms of rapprochement might be possible-yet with an acknowledgement that we will have no definitive answers to this question anytime soon.

scholarly journals Human Coinfection withBorrelia burgdorferiandBabesia microtiin the United States

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Kristen L. Knapp ◽  
Nancy A. Rice
Keyword(s):  
United States ◽  
Lyme Disease ◽  
Causative Agent ◽  
Ixodes Scapularis ◽  
Immunological Response ◽  
The United States ◽  
Babesia Microti ◽  
Current State ◽  
Tick Borne Disease ◽  
Multiple Pathogens

Borrelia burgdorferi, the causative agent of Lyme disease, andBabesia microti, a causative agent of babesiosis, are increasingly implicated in the growing tick-borne disease burden in the northeastern United States. These pathogens are transmitted via the bite of an infected tick vector,Ixodes scapularis, which is capable of harboring and inoculating a host with multiple pathogens simultaneously. Clinical presentation of the diseases is heterogeneous and ranges from mild flu-like symptoms to near-fatal cardiac arrhythmias. While the reason for the variability is not known, the possibility exists that concomitant infection with bothB. burgdorferiandB. microtimay synergistically increase disease severity. In an effort to clarify the current state of understanding regarding coinfection withB. burgdorferiandB. microti, in this review, we discuss the geographical distribution and pathogenesis of Lyme disease and babesiosis in the United States, the immunological response of humans toB. burgdorferiorB. microtiinfection, the existing knowledge regarding coinfection disease pathology, and critical factors that have led to ambiguity in the literature regarding coinfection, in order to eliminate confusion in future experimental design and investigation.

Epistemic and Aleatory Uncertainty in Recommended, Generic Rock Kd Values used in Performance Assessment Studies

2006 ◽  
Vol 932 ◽  
Author(s):  
James Crawford ◽  
Ivars Neretnieks ◽  
Luis Moreno
Keyword(s):  
Performance Assessment ◽  
Laboratory Data ◽  
Scientific Basis ◽  
Performance Assessments ◽  
Aleatory Uncertainty ◽  
Transport Modelling ◽  
Natural Systems ◽  
Rock Types ◽  
Kd Values ◽  
Experimental Laboratory

ABSTRACTOver the past decade or so there has been an explosion in the number of sorption modelling approaches and applications of sorption modelling for understanding and predicting solute transport in natural systems. The most widely used and simplest of all models, however, is that employing a constant distribution coefficient (Kd) relating the sorbed concentration of a solute on a mineral surface and its aqueous concentration.There are a number of reasons why a constant partitioning coefficient is attractive to environmental modellers for predicting radionuclide retardation, and in spite of all the shortcomings and pitfalls associated with such an approach, it remains the leitmotif of most performance assessment transport modelling.This paper examines the scientific basis underpinning the Kd-approach and its broad defensibility in a performance assessment framework. It also examines sources of epistemic and aleatory uncertainty that undermine confidence in Kd-values reported in the open literature. The paper focuses particularly upon the use of so-called “generic” data for generalised rock types that may not necessarily capture the full material property characteristics of site-specific materials.From the examination of recent literature data, it appears that there are still a number of outstanding issues concerning interpretation of experimental laboratory data that need to be considered in greater detail before concluding that the recommended values used in performance assessments are indeed conservative.

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