scholarly journals Metal Nanodelivery Systems for Improved Efficacy of Herbal Drugs

2019 ◽  
Vol 16 (2) ◽  
pp. 251-261 ◽  
Author(s):  
Sonu Ambwani ◽  
Roopali Tandon ◽  
Tanuj Kumar Ambwani
Keyword(s):  
Release Site ◽  
The Body ◽  
Herbal Drugs ◽  
Sustained Drug Release ◽  
Dose Administration ◽  
Site Of Action ◽  
Ancient Times ◽  
Solvent Systems ◽  
Specific Tissue ◽  
Herbal Formulations

Herbal drugs have been used since ancient times in various parts of the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Mostly, the herbal drugs are either in dried powder form or in crude extract form prepared in different solvent systems. These preparations generally need large dose administration and also could be less effective in the form of conventional formulations. Moreover, these herbal formulations cannot be targeted to specific tissue in case of different chronic diseases. Oral consumed herbal formulations display reduced bioavailability as these are subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using “Nano Delivery Systems” (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient’s compliance. Nanometal based herbal drugs can be used for targeted drug delivery in the body which improves their safety, effectiveness and reduces need of frequent large doses. Metal Nanocarriers loaded with herbal drugs can carry the optimal amount of the drug to their site of action avoiding different obstructions such as low pH in the stomach, metabolism by liver so that the drug can circulate into the blood for a longer period of time. Herbal drugs with NDS thus would be helpful in enhancing their efficacy.

Nano Phytomedicine Based Delivery System for CNS Disease

2020 ◽  
Vol 21 (9) ◽  
pp. 661-673 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Chettupalli Anand ◽  
Abdul Muheem ◽  
Sadaf Jamal Gilani ◽  
Mohamad Taleuzzaman ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Low Cost ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Widespread Acceptance ◽  
The Central Nervous System ◽  
Low Toxicity ◽  
Ancient Times ◽  
Plant Sources ◽  
Herbal Formulations

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.

An ayurvedic tablet formulation for ulcer protection

2020 ◽  
Vol 10 (4) ◽  
pp. 35-38
Author(s):  
Shiva Kumar K ◽  
Purushothaman M ◽  
Soujanya H ◽  
Jagadeeshwari S
Keyword(s):  
Pharmacological Activity ◽  
The Body ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Herbal Drugs ◽  
Human Beings ◽  
Synthetic Drugs ◽  
Scientific Investigations ◽  
System A ◽  
The World

Gastric ulcers or the peptic ulcer is the primary disease that affects the gastrointestinal system. A large extent of the population in the world are suffering from the disease, and the age group of people those who suffer from ulcers are 20-55years. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs. Practitioners have been using the herbal material to treat the ulcers successfully, and the same had been reported scientifically. Numerous publications have been made that proves the antiulcer activity of the plants around the world. The tablets were investigated for the antiulcer activity in two doses 200 and 400mg/kg in albino Wistar rats in the artificial ulcer those are induced by the ethanol. The prepared tablets showed a better activity compared to the standard synthetic drug and the marketed ayurvedic formulation. The tablets showed a dose-dependent activity in ulcer prevention and treatment. Many synthetic drugs are available for the ulcer treatment, and the drugs pose the other problems in the body by showing the side effects and some other reactions. This limits the use of synthetic drugs to treat ulcers effectively. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs.

Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease

2020 ◽  
Vol 10 (3) ◽  
pp. 228-247
Author(s):  
Niloufar Choubdar ◽  
Sara Avizheh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Polymeric Nanoparticles ◽  
Biological Fluids ◽  
Delivery Systems ◽  
Original Research ◽  
Sustained Drug Release ◽  
The Past ◽  
Site Of Action ◽  
Therapeutic Compound

Alzheimer’s Disease (AD) is one of the most common forms of dementia affecting over 46 million people, according to AD International. Over the past few decades, there has been considerable interest in developing nanomedicines. Using nanocarriers, the therapeutic compound could be delivered to the site of action where it gets accumulated. This accumulation, therefore, reduces the required doses for therapy. Alternatively, using nanocarriers decreases the side effects. Nanotechnology has had a great contribution in developing Drug Delivery Systems (DDS). These DDS could function as reservoirs for sustained drug release or control the pharmacokinetics and biodistribution of the drugs. In the current review, we have collected 38 original research articles using nanotechnology as DDS for the clinically used cholinesterase inhibitor drugs donepezil (DPZ), Rivastigmine (Riv), and galantamine (Gal) used for AD treatment from 2002 to 2017 from Scopus and PubMed databases. Regarding DDS used for DPZ, most of the research in recent years dealt with polymeric nanoparticles (NPs) including Poly-D, L-Lactide-Co-Glycolide (PLGA), and chitosans (CHs), then Liposomes (LPs), nanogels, and natural products, respectively. In terms of Riv most of the research performed was focused on polymeric NPs including PLGA, polylactic acid (PLA), Poly-Ε-Caprolactone (PCL), poly-alkyl-cyanoacrylates, CH, gelatin and then LPs. The highest application of NPs in regard to Gal was related to modified LPs and polymeric NPs. Polymeric NPs demonstrate safety, higher stability in biological fluids and against enzymatic metabolism, biocompatibility, bioavailability, and improved encapsulation efficacy. LPs, another major delivery system used, demonstrate biocompatibility, ease of surface modification, and amphiphilic nature.

Preparation of Tablet from Naagdon Plant by Wet Granulation Method for Treatment of Excessive Bleeding in Piles

2021 ◽  
Vol 9 (12) ◽  
pp. 1654-1665
Author(s):  
Sushma Kamble
Keyword(s):  
The Body ◽  
Wet Granulation ◽  
Herbal Drugs ◽  
Excessive Bleeding ◽  
In Vitro Drug Release ◽  
Acceptable Range ◽  
Weight Variation ◽  
Natural Drugs ◽  
Evaluation Parameters

Abstract: The objective of present study was to formulate and evaluate the tablets for piles with different combination of herbal drugs. Material and Method: The tablet for piles containing lactose and mannitol as diluent and containing natural drugs like naagdon which was prepared by wet granulation method. The wet and compressed formulations were subject to several evaluation parameters like appearance, thickness, weight variation, hardness and friability. Results: The results of all evaluation parameters of piles tablet were within the acceptable limit. Pre-compression studies of piles tablet show satisfactory results. The thickness, hardness, weight variation, and friability of pilestablet were found to in acceptable range. The in-vitro drug release of eugenol from optimised for treatment piles formulation was found to be 90.23%. Significant results were obtained from present study. Discussion: The finding of current investigation clearly found that the health promotion of the body could be done by piles

WESTERN NOMADIC DISCOURSE AND THE DISCOVERY OF THE OTHER

2021 ◽  
Vol 3 (4) ◽  
pp. 244-252
Author(s):  
Brahim BOUKHALFA
Keyword(s):  
Middle Ages ◽  
Travel Literature ◽  
Arab Countries ◽  
The Body ◽  
The Other ◽  
The Political ◽  
Human Sciences ◽  
Political Consciousness ◽  
Ancient Times ◽  
Nineteenth And Twentieth Centuries

The yearning for a journey towards the places of strangers, the longing to mingle with them and immerse themselves in their lives, and to record everything that is strange and wondrous about their lifestyle, their ways of thinking, their customs and traditions, that is the nature that characterizes man, since ancient times. The lives of the prophets, may blessings and peace be upon them, were frenetic migrations, and a constant movement, length and breadth, in search of a place of intimacy, a comfortable life, and a bright truth. Western poets, writers, philosophers and travelers have also been fond of the journey to the Naked and Islamic East, from the Middle Ages to the present day; The desire to get to know the Easterners closely, to mix with them, and then to dominate them, was evident in the so-called travel literature. It is the writing emanating from the experiences of travelers in the eastern "One Thousand and One Nights". However, these travelers have always hidden the true intentions that drove them on the journey, which, as we will present in the body of this study, are colonial motives deposited in the political consciousness of Western governments that stand behind the colonial phenomenon. It is from this perspective in the research that urgent questions come to the surface, which we are trying to answer. What are the real motives for the trip for Western writers in the nineteenth and twentieth centuries? What is their relationship with the Western governments that were colonizing large areas of the Arab countries? What are the representations of Arabs and Muslims in so-called travel literature? The answer to these questions is to reveal to us the colonial nature of the modern West, and the extent of its contempt for non-Westerners, which is supported by myths of racial superiority and self-centeredness in that. It is a belief that has not been affected by the tremendous development in the field of human sciences that our time has witnesse

Simultaneous estimation of simvstatin and piperine in its formulation by UV spectrophotometric method

2021 ◽  
Vol 11 (1) ◽  
pp. 1-4
Author(s):  
Vijayamma G ◽  
Panneerselvam P ◽  
Siddeswari T ◽  
Nithya Kalyani K ◽  
Jeslin ◽  
...  
Keyword(s):  
Spectrophotometric Method ◽  
Black Pepper ◽  
The Body ◽  
Simultaneous Estimation ◽  
Chemical Release ◽  
Standard Solution ◽  
Experimental Findings ◽  
The Brain ◽  
Herbal Formulations ◽  
Validation Experiments

The active ingredient, called piperine, is present in black pepper. The ions are very small so they are easily consumed by the tissue and nervous system, causing the chemical release within the brain. Piperine has been shown to help ease gastrointestinal ailments, help with vomiting, and has the ability to help with inflammation of the body. This explains to us how simvastatin can help expedite piperine in the body. The new, clear, effective, quick, accurate ultraviolet spectrophotometric method has to be validated and developed for the study of simvastatin and piperine in bulk and poly-herbal formulations. Data from validation experiments was tested using methodological techniques. Since processing at a wavelength of 285nm, the standard solution appeared to have a far higher absorbance than at other wavelengths. Normal simvastatin and piperine have been measured in varying amounts, and they make spectrums of overlays. In Beer Law, the concentration (C) of a solvent is plotted against the absorbance (A) from a calibration curve, as a result. A linearity range of between 14and 39μg/mL was observed. The sample was tested by prorating the standard deviation and standard error of the approximate means with the sample size, demonstrating the accuracy and the precision of the methods used in the analysis. Based on the experimental findings, it can be easily inferred that for UV spectrometry estimation of simvastatin and piperine from pharmaceutical intravenous liquid formulation, the proposed method is very simple, fast, accurate, precise, economical and reproducible.

scholarly journals Insitu Opthalmic Drug Delivery Systems

2020 ◽  
Vol 11 (4) ◽  
pp. 5315-5320
Author(s):  
Mani Dineshkumar ◽  
Vyshnavi Tallapaneni ◽  
Veera Venkata Satyanarayana Reddy Karri
Keyword(s):  
Control Release ◽  
Ionic Concentration ◽  
The Body ◽  
Anatomy And Physiology ◽  
Site Of Action ◽  
Successful Control ◽  
Adequate Quantity ◽  
Gel Preparation ◽  
Bio Compatibility ◽  
Systemic Drug

Eyes are considered as one of the most important organs of the body. The main hurdle for achieving effective ocular treatment is the maintenance of adequate quantity of drug at the site of action within the eye. Maintaining the concentration of drug in the eye is a difficult task as the anatomy and physiology of the eye leads to the draining of the drug from the eye. This leads to poor ocular bio availability and there by poor ocular therapy. The ocular bio availability can be improved by increasing the ocular retention time of the formulation. Insitu gel formation technology is a promising technique to prevent the lacrimal drainage of the drug rapidly from the eyes. Insitu gel preparation will be in liquid from when prepared, they are administered into the Cul-de-sac of the eye. Due to the environmental characteristics of the eye such as temperature, pH, Ionic concentration etc. the liquid formulation changes to gel form. This will increase the residence time and contact time of the drug with the mucosa of the eye. Insitu gels can increase the ocular bioavailability of the drug .The primary requirement of a successful control release product focuses on increasing patient compliance, good stability and bio compatibility. Insitu gels are used now a days as vehicles for both local and systemic drug therapies. This review deals with the study of a novel insitu gel approaches as a means to localize and prolong drug activity at its site of action.

Into the Icehouse

2012 ◽  
Author(s):  
Jan Zalasiewicz ◽  
Mark Williams
Keyword(s):  
The Body ◽  
Ice Age ◽  
Polar Regions ◽  
Earth System ◽  
The North ◽  
The World ◽  
The Face ◽  
Ancient Times ◽  
Almost All ◽  
Popular Image

The frozen lands of the north are an unforgiving place for humans to live. The Inuit view of the cosmos is that it is ruled by no one, with no gods to create wind and sun and ice, or to provide punishment or forgiveness, or to act as Earth Mother or Father. Amid those harsh landscapes, belief is superfluous, and only fear can be relied on as a guide. How could such a world begin, and end? In Nordic mythology, in ancient times there used to be a yet greater kingdom of ice, ruled by the ice giant, Ymir Aurgelmir. To make a world fit for humans, Ymir was killed by three brothers—Odin, Vilje, and Ve. The blood of the dying giant drowned his own children, and formed the seas, while the body of the dead giant became the land. To keep out other ice giants that yet lived in the far north, Odin and his brothers made a wall out of Ymir’s eyebrows. One may see, fancifully, those eyebrows still, in the form of the massive, curved lines of morainic hills that run across Sweden and Finland. We now have a popular image of Ymir’s domain—the past ‘Ice Age’—as snowy landscapes of a recent past, populated by mammoths and woolly rhinos and fur-clad humans (who would have been beginning to create such legends to explain the precarious world on which they lived). This image, as we have seen, represents a peculiarly northern perspective. The current ice age is geologically ancient, for the bulk of the world’s land-ice had already grown to cover almost all Antarctica, more than thirty million years ago. Nevertheless, a mere two and a half million years ago, there was a significant transition in Earth history—an intensification of the Earth’s icehouse state that spread more or less permanent ice widely across the northern polar regions of the world. This intensification— via those fiendishly complex teleconnections that characterize the Earth system—changed the face of the entire globe. The changes can be detected in the sedimentary strata that were then being deposited around the world.

Pharmacokinetics and Pharmacodynamics of Antimicrobials

2012 ◽  
pp. 3-13
Author(s):  
Lynn L. Estes
Keyword(s):  
Protein Binding ◽  
Antimicrobial Therapy ◽  
Drug Concentration ◽  
Drug Exposure ◽  
The Body ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Site Of Action ◽  
Pharmacologic Effect ◽  
Over Time

Pharmacokinetics is the disposition of drugs in the body (how the body acts on the drug); it incorporates terms such as absorption, bioavailability, distribution, protein binding, metabolism, and elimination. Pharmacodynamics is the interaction between the drug concentration at the site of action over time (drug exposure) and the pharmacologic effect, which, in the case of antimicrobials, is eradication of microorganisms. Pharmacokinetics and pharmacodynamics are interrelated. Both need to be taken into account to optimize antimicrobial therapy.

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