Versatile Impact of Serum Proteins on Ruthenium(II) Polypyridyl Complexes Properties - Opportunities and Obstacles

2019 ◽  
Vol 20 (11) ◽  
pp. 1052-1059 ◽  
Author(s):  
Olga Mazuryk ◽  
Przemysław Gajda-Morszewski ◽  
Małgorzata Brindell
Keyword(s):  
Anticancer Agents ◽  
Serum Proteins ◽  
Biological Effects ◽  
Photophysical Properties ◽  
Intravenous Route ◽  
Polypyridyl Complexes ◽  
The Past ◽  
Ru Complexes ◽  
Further Development

Ruthenium(II) polypyridyl complexes have been extensively studied for the past few decades as promising anticancer agents. Despite the expected intravenous route of administration, the interaction between Ru(II) polypyridyl compounds and serum proteins is not well characterized and vast majority of the available literature data concerns determination of the binding constant. Ru-protein adducts can modify the biological effects of the Ru complexes influencing their cytotoxic and antimicrobial activity as well as introduce significant changes in their photophysical properties. More extensive research on the interaction between serum proteins and Ru(II) polypyridyl complexes is important for further development of Ru(II) polypyridyl compounds towards their application in anticancer therapy and diagnostics and can open new opportunities for already developed complexes.

Cucurbitacins as Anticancer Agents: A Patent Review

2019 ◽  
Vol 14 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Hidayat Hussain ◽  
Ivan R. Green ◽  
Muhammad Saleem ◽  
Khanzadi F. Khattak ◽  
Muhammad Irshad ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Wide Spectrum ◽  
Biological Effects ◽  
Therapeutic Effects ◽  
Cytotoxic Effects ◽  
Natural Sources ◽  
Oh Groups ◽  
Drug Candidates ◽  
The Past ◽  
Wide Range

Background: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its cytotoxic effects. Objective: his review covers patents on the therapeutic effects of natural cucurbitacins and their synthetic analogs published during the past decade. By far, the majority of patents published are related to cancer and Structure-Activity Relationships (SAR) of these compounds are included to lend gravitas to this important class of natural products. Methods: The date about the published patents was downloaded via online open access patent databases. Results: Cucurbitacins display significant cytotoxic properties, in particular cucurbitacins B and D which possess very potent effects towards a number of cancer cells. Numerous cucurbitacins isolated from natural sources have been derivatized through chemical modification at the C(2)-OH and C(25)- OH groups. Most importantly, an acyl ester of the C(25)-OH and, iso-propyl, n-propyl and ethyl ether groups of the C(2)-OH demonstrated the most increased cytotoxic activity. Conclusion: The significant cytotoxic effects of natural and semi-synthetic cucurbitacins make them attractive as new drug candidates. Moreover, cucurbitacins have the capability to form conjugates with other anticancer drugs which will synergistically enhance their anticancer effects. The authors believe that in order to get lead compounds, there should be a greater focus on the synthesis of homodimers, heterodimers, and halo derivatives of cucurbitacins. In the opinion of the authors the analysis of the published patents on the cucurbitacins indicates that these compounds can be developed into a regimen to treat a wide spectrum of cancers.

scholarly journals PROFILING OF ISLAMIC CALLIGRAPHY SCRIPTS USED FOR ARCHITECTURAL DECORATION OF MASJID IN PENINSULAR MALAYSIA

2020 ◽  
Vol 18 (14) ◽  
Author(s):  
Zumahiran Kamarudin ◽  
Ziad Baydoun ◽  
Nik Ahmed Mazlan Nik Mahidin
Keyword(s):  
Peninsular Malaysia ◽  
Kuala Lumpur ◽  
Face To Face ◽  
Decorative Art ◽  
The Past ◽  
Analytical Review ◽  
Architecture Style ◽  
The Relationship ◽  
Further Development

In Malaysia, the introduction of the Islamic calligraphy, especially after the spread of Islam in the 14th century has impacted on the further development of decorative art in the built environment. While Islamic calligraphy has witnessed significant developments in the past decades, it still lacks a profiling classification system of calligraphy scripts that give impact to the contemporary mosque. The objectives of the study are to analyse the visual qualities of the calligraphy scripts in the mosque components and its compositional categories and to determine the relationship between the calligraphy placement and the mosque architecture within the interior and exterior fabrics of the buildings. This research involved an analytical review of the Islamic calligraphy found in the 10 selected mosques in Selangor and Kuala Lumpur, Malaysia and their depiction in various components. Face-to-face interviews with the mosque authorities and local calligraphers on the types and styles of scripts used in the mosque components were conducted as a complementary measure to the analytical method. The analysis reveals the application of cursive and angular style of scripts, fabricated in specified shapes, sizes and dimensions of the mosque components. Selection and depiction of calligraphy, especially in Thuluth and Kufi scripts suggest their strong preference to the traditional major styles ranging from its composition to the determination of its positional layout regardless of differences in the mosque architecture style.

scholarly journals Toxic Effects of Metallopharmaceuticals

2017 ◽  
Vol 18 (3) ◽  
pp. 191-194 ◽  
Author(s):  
Slobodan Novokmet ◽  
Isidora Stojic ◽  
Katarina Radonjic ◽  
Maja Savic ◽  
Jovana Jeremic
Keyword(s):  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Rational Design ◽  
Current Knowledge ◽  
The Past ◽  
Ru Complexes ◽  
Key Features

Abstract Discovery of the metallopharmaceutical cisplatin and its use in antitumour therapy has initiated the rational design and screening of metal-based anticancer agents as potential chemotherapeutics. In addition to the achievements of cisplatin and its therapeutic analogues, there are significant drawbacks to its use: resistance and toxicity. Over the past four decades, numerous transition metal complexes have been synthesized and investigated in vitro and in vivo. The most studied metals among these complexes are platinum and ruthenium. The key features of these investigations is to find novel metal complexes that could potentially exert less toxicity and equal or higher antitumour potency and to overcome other pharmacological deficiencies. Ru complexes have a different mode of action than cisplatin does, some of which are under clinical trials for treating metastatic or cisplatin-resistant tumours. This review consists of the current knowledge, published and unpublished, related to the toxicity of metallopharmaceuticals, and special attention is given to platinum [Pt(II) and Pt(IV)] and ruthenium [Ru(II) and Ru(III)] complexes.

scholarly journals Bottoms-up! Rejecting Top-down Human-centered Approaches in Comparative Psychology

2018 ◽  
Vol 31 ◽  
Author(s):  
Taryn Eaton ◽  
Robert Hutton ◽  
Jessica Leete ◽  
Jennifer Lieb ◽  
Audrey Robeson ◽  
...  
Keyword(s):  
Comparative Psychology ◽  
Top Down ◽  
Bottom Up ◽  
New Approach ◽  
The Past ◽  
And Behaviors ◽  
Species Specific ◽  
Further Development

Although comparative psychologists have made considerable strides in the past several decades, expanding the breadth of species and questions examined, the field still suffers from an overemphasis on top-down approaches that begin and end with a focus on humans. This top-down perspective leads to biases and oversights that hamper the further development of the field. A bottom-up approach that considers species-specific abilities and behaviors in the context of theoretically relevant comparisons will be most useful in advancing knowledge of species-specific and shared abilities. This will allow a better determination of the extent to which continuities and discontinuities exist as a function of different ecological forces. In addition, a bottom-up approach will facilitate a shift in focus from using animals to better understand humans, to understanding animals themselves. This new approach will allow for an appreciation of how humans can benefit other species.

scholarly journals Семь десятилетий ойратоведения в КНР (1949‒2019 гг.)

2020 ◽  
Vol 13 (6) ◽  
pp. 1524-1536
Author(s):  
Na. Alatengaoqier ◽  
◽  
Baazr A. Bicheev ◽  
Keyword(s):  
Inner Mongolia ◽  
Scientific Journal ◽  
Historical Science ◽  
Main Research ◽  
The Past ◽  
Scientific Analysis ◽  
The Status ◽  
Development Methods ◽  
Further Development

Introduction. Historically, the Oirats of China mainly live in the territory of Xinjiang, in the provinces of Qinghai, Gansu, and in the Western part of Inner Mongolia. Some of the Olets (descendants of Dzungars) live in the steppe part of the Emin Gol of the Hulun Buir Aimag of Inner Mongolia, in Fuyu County of Heilongjiang Province, and in Chengdu, Hebei Province. In the modern historical science of China, until the mid-20th century the Oirats were not distinguished from the bulk of China’s Mongols, and, consequently, their history, culture and language were not subjects of individual studies. Only after its formation in 1949, Chinese Oirat studies started gaining visible features as an important part of Mongolian studies and the historical science of China as a whole. At the same time, Oirat studies as a historical direction were created by several generations of scientists of different nationalities (Han Chinese, Mongols, and Oirats themselves). Goals. The article aims to provide a general overview and scientific analysis of the formation and development of Oirat studies in China over the past seven decades (1949–2019), and to identify the historical paradigm of conducted researches and prospects of further development. Methods. The main research method is historical and chronological analysis. Despite Oirat studies have been existing as an integral part of Mongolian science for seven decades, no analysis of its historical development was ever carried out. Results. This work fills the gap and highlights the most important achievements in the study of China-based Oirats’ history and culture. A prominent attention in this study is given to the materials of ten scientific conferences that have the status of ‘all-China’ ones and were devoted to the study of the history and culture of the Oirats, as well as the scientific journal ‘Barayun mongyol sudul’ (‘Journal of Western Mongolian Studies’), which plays an important role in the development and determination of promising areas of Oirat studies. Conclusion. The analysis of Oiratological research over the past seven decades has revealed the historical paradigm of Oirat studies and prospects for their further development.

Transmission Electron Microscopy of Protein Macromolecules

1971 ◽  
Vol 29 ◽  
pp. 424-425
Author(s):  
Henry S. Slayter
Keyword(s):  
Biological Systems ◽  
Metal Vapor ◽  
Resolving Power ◽  
Electron Microscopic ◽  
Chemical Methods ◽  
Molecular Weights ◽  
The Past ◽  
Physical Chemical ◽  
Transmission Electron

Electron microscopic methods have been applied increasingly during the past fifteen years, to problems in structural molecular biology. Used in conjunction with physical chemical methods and/or Fourier methods of analysis, they constitute powerful tools for determining sizes, shapes and modes of aggregation of biopolymers with molecular weights greater than 50, 000. However, the application of the e.m. to the determination of very fine structure approaching the limit of instrumental resolving power in biological systems has not been productive, due to various difficulties such as the destructive effects of dehydration, damage to the specimen by the electron beam, and lack of adequate and specific contrast. One of the most satisfactory methods for contrasting individual macromolecules involves the deposition of heavy metal vapor upon the specimen. We have investigated this process, and present here what we believe to be the more important considerations for optimizing it. Results of the application of these methods to several biological systems including muscle proteins, fibrinogen, ribosomes and chromatin will be discussed.

Perceived Burden of Informal Caregivers of a Chronically Ill Older Family Member

GeroPsych ◽  
2011 ◽  
Vol 24 (3) ◽  
pp. 143-154 ◽  
Author(s):  
Elmar Gräßel ◽  
Raffaela Adabbo
Keyword(s):  
Family Member ◽  
Informal Caregiver ◽  
Chronically Ill ◽  
Stress Model ◽  
The Past ◽  
Perceived Burden ◽  
Hypothetical Construct ◽  
Care Situation ◽  
The Impact ◽  
Further Development

The burden of caregivers has been intensively researched for the past 30 years and has resulted in a multitude of individual findings. This review illustrates the significance of the hypothetical construct of perceived burden for the further development and design of the homecare situation. Following explanations regarding the term informal caregiver, we derive the construct burden from its conceptual association with the transactional stress model of Lazarus and Folkman. Once the extent and characteristics of burden have been set forth, we then present the impact of perceived burden as the care situation. The question of predictors of burden will lead into the last section from which implications can be derived for homecare and relief of caregivers.

Commonwealth of Independent States: The First 20 Years

2011 ◽  
pp. 90-101 ◽  
Author(s):  
N. Shumsky
Keyword(s):  
Commonwealth Of Independent States ◽  
The Past ◽  
Independent States ◽  
Further Development

The article assesses the effectiveness and outcomes of cooperation of the Commonwealth participating states over the past 20 years. It reviews perspectives and directions for further development of the CIS taking into account the conditions and characteristics of integration processes of the post-Soviet states, implementation of the principles of multilevel and multispeed integration of the Commonwealth participating states.

Therapeutic Perspectives of Food Bioactive Peptides: A Mini Review

2019 ◽  
Vol 26 (9) ◽  
pp. 664-675
Author(s):  
Sulochana Priya
Keyword(s):  
Bioactive Peptides ◽  
Marine Organism ◽  
Biological Effects ◽  
Amide Bond ◽  
Therapeutic Effects ◽  
Specific Sequence ◽  
The Past ◽  
Cancer Immunity ◽  
Microbial Infections ◽  
Diverse Origin

Bioactive peptides are short chain of amino acids (usually 2-20) that are linked by amide bond in a specific sequence which have some biological effects in animals or humans. These can be of diverse origin like plant, animal, fish, microbe, marine organism or even synthetic. They are successfully used in the management of many diseases. In recent years increased attention has been raised for its effects and mechanism of action in various disease conditions like cancer, immunity, cardiovascular disease, hypertension, inflammation, diabetes, microbial infections etc. Bioactive peptides are more bioavailable and less allergenic when compared to total proteins. Food derived bioactive peptides have health benefits and its demand has increased tremendously over the past decade. This review gives a view on last two years research on potential bioactive peptides derived from food which have significant therapeutic effects.

Biological Activity of Trans-Membrane Anion Carriers

2018 ◽  
Vol 25 (30) ◽  
pp. 3560-3576 ◽  
Author(s):  
Massimo Tosolini ◽  
Paolo Pengo ◽  
Paolo Tecilla
Keyword(s):  
Biological Activity ◽  
Membrane Transport ◽  
Anticancer Agents ◽  
Biological Effects ◽  
Structure Activity Relationship ◽  
New Drugs ◽  
Activity Relationship ◽  
Anion Channels ◽  
Cellular Homeostasis ◽  
Structure Activity

Natural and synthetic anionophores promote the trans-membrane transport of anions such as chloride and bicarbonate. This process may alter cellular homeostasis with possible effects on internal ions concentration and pH levels triggering several and diverse biological effects. In this article, an overview of the recent results on the study of aniontransporters, mainly acting with a carrier-type mechanism, is given with emphasis on the structure/activity relationship and on their biological activity as antibiotic and anticancer agents and in the development of new drugs for treating conditions derived from dysregulation of natural anion channels.

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