scholarly journals The Endocannabinoid System May Modulate Sleep Disorders in Aging

2020 ◽  
Vol 18 (2) ◽  
pp. 97-108
Author(s):  
Eric Murillo-Rodríguez ◽  
Henning Budde ◽  
André Barciela Veras ◽  
Nuno Barbosa Rocha ◽  
Diogo Telles-Correia ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Endocannabinoid System ◽  
The Elderly ◽  
Therapeutic Approaches ◽  
Beneficial Effects ◽  
Demographic Projections ◽  
Age Related ◽  
Therapeutic Tools

Aging is an inevitable process that involves changes across life in multiple neurochemical, neuroanatomical, hormonal systems, and many others. In addition, these biological modifications lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative disorders, and sleep disturbances, among others that affect activities of daily life. Demographic projections have demonstrated that aging will increase its worldwide rate in the coming years. The research on chronic diseases of the elderly is important to gain insights into this growing global burden. Novel therapeutic approaches aimed for treatment of age-related pathologies have included the endocannabinoid system as an effective tool since this biological system shows beneficial effects in preclinical models. However, and despite these advances, little has been addressed in the arena of the endocannabinoid system as an option for treating sleep disorders in aging since experimental evidence suggests that some elements of the endocannabinoid system modulate the sleep-wake cycle. This article addresses this less-studied field, focusing on the likely perspective of the implication of the endocannabinoid system in the regulation of sleep problems reported in the aged. We conclude that beneficial effects regarding the putative efficacy of the endocannabinoid system as therapeutic tools in aging is either inconclusive or still missing.

Sleep and Sleep Disorders in Tourette Syndrome: What is Known and What is Still Unknown

2020 ◽  
Vol 15 (2) ◽  
pp. 124-131 ◽  
Author(s):  
Arie Oksenberg
Keyword(s):  
Sleep Disorders ◽  
Sleep Disorder ◽  
Tourette Syndrome ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Life Quality ◽  
Sleep Stages ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Impaired Sleep

Background: Most of the patients with Tourette Syndrome (TS) present additional comorbidities. Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are the most common. Sleep Disorder has been suggested also as common comorbidity. Objective: To review the literature on sleep characteristics and sleep disorder in patients with Tourette Syndrome (TS), with emphasis on the contribution of specific co-morbidities to the severity of impaired sleep and life quality of the patients. Results: In general, sleep problems are not frequent at the age when tics appear which are estimated to affect about 10 % of these children. In severe cases, tics appear in all sleep stages. In a large study, the prevalence of sleep problems was 17.8% but was 12 % in “TS-only” (9.4% in children and 7.5 in adults) compared to 22% in children and 18% in adults with TS+ADHD. Unfortunately, in most of the studies, the characteristics of these “sleep problems” are not defined. In spite of the scarcity of data, the two main sleep disorders in TS patients are insomnia and parasomnias. Although much more data is needed, many TS subjects are sleep deprived (which exacerbate the tics) and may suffer from excessive daytime sleepiness, which negatively affects normal functioning. Conclusions: Although the literature is not conclusive, children and adolescents with TS appear to suffer more from sleep disturbances and sleep disorders than age-matched controls. Not all patients have tics during sleep, but in severe cases, tics may appear in all sleep stages. It is clear that when patients present both TS and ADHD, (a very common condition), the sleep difficulties are related mainly to ADHD. Much more research is warranted in all aspects of sleep and sleep disorders in TS.

scholarly journals Sleep Problems in Pregnancy—A Cross-Sectional Study in over 7000 Pregnant Women in Poland

2020 ◽  
Vol 17 (15) ◽  
pp. 5306
Author(s):  
Magdalena Smyka ◽  
Katarzyna Kosińska-Kaczyńska ◽  
Nicole Sochacki-Wójcicka ◽  
Magdalena Zgliczyńska ◽  
Mirosław Wielgoś
Keyword(s):  
Pregnant Women ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Sleep Onset ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Physical Symptoms ◽  
Sleep Patterns ◽  
Cross Sectional

The aim was to characterize sleep patterns in pregnant women in Poland and to analyze the relation between sociodemographic factors, pregnancy-related physical symptoms and sleep problems. A self-composed questionnaire, containing questions in Polish language, was distributed online via web pages and Facebook groups designed for pregnant women. The questionnaire included questions regarding sociodemographic data and information on the current pregnancy and sleep patterns over the past four weeks. Exactly 7207 respondents were included to the study. 77.09% reported sleep problems: nocturnal awakening (52.77%), sleep onset insomnia (20.23%), awakening too early (18.56%) and believed their sleep was too shallow (9.82%). Sleep onset insomnia (26.38%) and frequent awakening (62.88%) were most often reported in 3rd trimester, while daytime drowsiness (86.35%) and naps impeding daytime function (27.18%) in the 1st trimester of pregnancy. The analyzed demographic, socioeconomic and psychological issues had a small but significant influence on sleep problems occurrence (aOR 0.81–1.24). Time to conceive from 6 to 12 months of trying increased the risk of developing sleep problems during pregnancy (aOR 1.31). Pregnancy ailments increased the risk of sleep disturbances (aOR 1.53–2.59). Sleep disorders are prevalent among pregnant women in Poland. The evaluation of risk factors is essential in proper screening for sleep disorders in pregnant women.

Sleep Disorders and Depression

2014 ◽  
Author(s):  
Colleen E. Carney ◽  
Taryn G. Moss
Keyword(s):  
Sleep Disorders ◽  
Sleep Disorder ◽  
Clinical Management ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Clinical Care ◽  
Major Depressive ◽  
Bidirectional Relationship ◽  
Assessment And Treatment ◽  
Almost All

Major depressive disorder (MDD) commonly occurs with several sleep disorders, including hypersomnia, breathing or limb-related sleep disturbances, and most notably chronic insomnia. A bidirectional relationship exists between sleep and mood problems, and both issues often warrant timely clinical management. However, there are several assessment- and treatment-related complexities that complicate the clinical management of such patients. For example, there are several overlapping symptoms for MDD and both insomnia and hypersomnia, and the two sleep conditions are both listed as possible symptoms in the diagnostic criteria for MDD. This has led to a well-documented problem of underrecognizing and undertreating these significant disorders in the context of MDD. Moreover, certain effective depression treatments can actually worsen the coexisting sleep disorder. Understanding and treating both disorders (i.e., MDD and the co-occurring sleep disorder) is imperative for effective clinical care. Almost all (i.e., up to 90%) of those with depression report sleep problems. This chapter provides an overview of the etiologic, assessment, and treatment issues inherent in this very large, highly prevalent group.

Melatonin Rhythm Abnormalities and Sleep Disorders in the Elderly

CNS Spectrums ◽  
2001 ◽  
Vol 6 (6) ◽  
pp. 502-506 ◽  
Author(s):  
Iris Haimov
Keyword(s):  
Sleep Disorders ◽  
Old Age ◽  
Matched Control ◽  
Sleep Problems ◽  
The Elderly ◽  
Biological Aging ◽  
Age Group ◽  
Melatonin Secretion ◽  
Daytime Drowsiness ◽  
Melatonin Treatment

AbstractBiological aging is often associated with sleep problems and daytime napping. Complaints of difficulty in initiating and maintaining sleep, as well as daytime drowsiness, are more common in the elderly than in any other age group. This report reviews evidence that impaired melatonin secretion is associated with sleep disorders in old age. Circulating melatonin levels have been found to be significantly lower and onset and peak times have been delayed in elderly insomniacs as compared to age-matched control subjects. In view of these findings, we investigated the effects of melatonin treatment on melatonin-deficient insomnia in the elderly. From the results of our study, it seems likely that melatonin replacement therapy may be beneficial in the initiation and maintenance of sleep in this population.

scholarly journals Diminished Melatonin Secretion in the Elderly Caused by Insufficient Environmental Illumination1

2001 ◽  
Vol 86 (1) ◽  
pp. 129-134 ◽  
Author(s):  
K. Mishima ◽  
M. Okawa ◽  
T. Shimizu ◽  
Y. Hishikawa
Keyword(s):  
Sleep Disturbances ◽  
Bright Light ◽  
Close Relation ◽  
The Elderly ◽  
Control Group ◽  
Elderly Persons ◽  
Melatonin Secretion ◽  
Young Control ◽  
Environmental Light ◽  
Age Related

The pineal hormone melatonin has some circadian regulatory effects and is assumed to have a close relation with sleep initiation and maintenance. Many previous reports have described age-related decreases in melatonin levels, especially in elderly insomniacs (EIs), which may act as causal or exacerbating factors in sleep disturbances in the elderly. Ten elderly residents with psychophysiological insomnia (mean age, 74.2 yr), 10 healthy residents of the same home [elderly control (EC) group; mean age, 72.7 yr], and 10 healthy young control subjects (mean age, 20.9 yr) living at home participated in this study. The elderly persons, especially the EIs, were exposed to significantly less environmental light and simultaneously suffered from significantly diminished nocturnal melatonin secretion. Supplementary exposure to 4 h (1000 to 1200 h, 1400 to 1600 h) of midday bright light in the EI group significantly increased melatonin secretion to levels similar to those in the young control group without circadian phase-shifting. There was a tendency for the magnitude of the increase in nocturnal melatonin secretion stimulated by bright light to parallel amelioration of sleep disturbances in these subjects. The present findings suggest that we need to pay attention to elderly individuals who suffer under conditions of poor environmental light resulting in disorganized circadian rhythms, including the sleep-wake cycle.

Sleep disorders in neurodegenerative diseases other than Parkinson disease and multiple system atrophy

2017 ◽  
Author(s):  
Raffaele Manni ◽  
Michele Terzaghi
Keyword(s):  
Neurodegenerative Diseases ◽  
Sleep Disorders ◽  
Neurodegenerative Disorders ◽  
Sleep Problems ◽  
Lewy Bodies ◽  
Corticobasal Degeneration ◽  
Spinocerebellar Ataxias ◽  
Age Related ◽  
Key Points ◽  
Sleep Alterations

This chapter examines sleep–wake disturbances occurring in the most common neurodegenerative disorders. It reviews sleep alterations in Alzheimer disease and dementia with Lewy bodies. It also discusses sleep problems in progressive supranuclear palsy, corticobasal degeneration, Huntington disease, and spinocerebellar ataxias. Status dissociatus as an extreme form of sleep alteration in advanced neurodegenerative diseases is also considered. The chapter reviews the key points for the treatment of disrupted sleep in neurodegenerative disorders, with a focus on pharmacological and nonpharmacological interventions to improve sleep continuity. It also summarizes paraphysiological age-related changes in sleep patterns and discusses indications and procedures for clinical and instrumental assessment of sleep disorders in neurodegenerative disorders.

scholarly journals Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?

2020 ◽  
Vol 50 (6) ◽  
pp. 1504-1512
Author(s):  
Güler ÖZTÜRK ◽  
Kazime Gonca AKBULUT ◽  
Şevin GÜNEY
Keyword(s):  
Aging Process ◽  
Biological Process ◽  
The Elderly ◽  
The Body ◽  
Biological Processes ◽  
Therapeutic Approaches ◽  
Free Radical Reactions ◽  
Age Related ◽  
The Relationship ◽  
Age Related Changes

The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions.Melatoninrhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline is associated with several age-related diseases. Aging is closely associated with oxidative damage and mitochondrial dysfunction. Free radical reactions initiated by the mitochondria constitute the inherent aging process. Melatonin plays a pivotal role in preventing age-related oxidative stress. Coronavirus disease 2019 (COVID-19) fatality rates increase with chronic diseases and age, where melatonin levels decrease. For this reason, melatonin supplementation in elderly could be beneficial in COVID-19 treatment. Therefore, studies on the usage of melatonin in COVID-19 treatment are needed.

scholarly journals 1171 Commonly Encountered Yet Not Confident: Graduate Psychology Students’ Experience and Confidence Managing Sleep Disturbances

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A447-A447
Author(s):  
H Meaklim ◽  
M Monfries ◽  
I C Rehm ◽  
M Junge ◽  
L J Meltzer ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Sleep Disorders ◽  
Clinical Training ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Psychology Students ◽  
Empirically Supported ◽  
Graduate Psychology Students ◽  
Psychology Training Programs ◽  
Strongly Agree

Abstract Introduction Trainee psychologists receive minimal sleep education during graduate psychology training programs, despite the frequent co-occurrence of sleep disturbances in mental health conditions. This study aimed to explore graduate psychology students’ experience working with sleep disturbances and their perceived skills and confidence to assess and treat sleep problems in clinical practice. Methods Australian graduate psychology students (N = 163) completed a novel survey developed specifically for the study, inquiring about their experience, skills and confidence to manage sleep disturbances in clinical practice. Students perceived skills to manage sleep disturbances were recorded on a 7-point Likert scale, where 1 = ‘strongly disagree’ and 7 = ‘strongly agree’. Students’ confidence to treat specific sleep disorders was also recorded. Results Sixty-eight percent of students reported having already worked with a client who experienced a sleep disturbance as part of their training. However, students’ perceived skills to assess and treat sleep disturbances were low. Only 14.9% ‘agreed’ or ‘strongly agreed’ that they had the skills to assess and diagnose common sleep disorders (M = 3.22, SD = 1.75). Similarly, less than a quarter of students ‘agreed’ or ‘strongly agreed’ that they felt comfortable using common sleep-related assessments (23.7%; M = 3.56, SD = 1.96) or empirically-supported interventions for sleep disturbances (22.6%; M = 3.71, SD = 1.83). The majority of students reported they were ‘not confident at all’ to treat parasomnias (80.3%); hypersomnias (77.9%); OSA (71.3%); circadian rhythm disorders (50%) or insomnia (41%). Conclusion Graduate psychology students report low levels of confidence in assessing and managing sleep disturbances in clinical practice, despite over two-thirds of students already working with clients experiencing sleep difficulties. Clinical training in the management of sleep disturbances is required for graduate psychology students. Support N/A

Sleep Disorders and Activities in Long Term Care Facilities —a Vicious Cycle?

2010 ◽  
Vol 15 (5) ◽  
pp. 744-754 ◽  
Author(s):  
Vjenka Garms-Homolovà ◽  
Uwe Flick ◽  
Gundula Röhnsch
Keyword(s):  
Sleep Disorders ◽  
Social Engagement ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Nursing Home Residents ◽  
Term Care ◽  
Low Levels ◽  
The Relationship ◽  
Multiple Morbidities

Sleep disorders are symptoms of many diseases. Persons suffering from multiple morbidities are affected most. We investigated the relationship between sleep and activities using assessment data of 2577 German nursing home residents. In total, 37.3 percent were affected by insomnia, 29.6 percent by non-restful sleep. We used SEM to analyze the relationship between sleep disorders and activities. Residents with sleep problems exhibited low levels of activities and social engagement and high levels of communication impairment and interpersonal conflicts. They received less activation than persons without sleep disorders. We found significant evidence that sleep disturbances and lack of activities influence each other negatively.

scholarly journals Efektivitas Baby Massage Dan Baby Gym Terhadap Kualitas Tidur Bayi Usia 3-6 Bulan

2021 ◽  
Vol 8 (1) ◽  
pp. 6
Author(s):  
Rose Nurhudariani ◽  
Yeni Dwi Ratnasari ◽  
Sonhaji Sonhaji ◽  
Siti Nur Umariyah Febriyanti
Keyword(s):  
Sleep Quality ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
P Value ◽  
Test Design ◽  
Quality Of Sleep ◽  
Post Test ◽  
A Minor

Baby massage dan baby gym adalah upaya untuk meningkatkan kualitas tidur pada bayi.  Masalah tidur pada bayi di Indonesia cukup banyak, yaitu sekitar 44,2% bayi mengalami gangguan tidur seperti sering terbangun di malam hari. Namun lebih dari 72% orang tua menganggap gangguan tidur bukan suatu masalah atau hanya masalah kecil, hal tersebut diungkapkan oleh sebuah penelitian pada tahun 2014-2015 yang dilaksanakan di lima kota besar di Indonesia Berdasarkan data awal terdapat 20 bayi yang datang ke posyandu dan ditemukan 17 bayi yang mengalami gangguan tidur. Tujuan penelitian untuk mengetahui efektivitas baby massage dan baby gym terhadap kualitas tidur bayi usia 3-6 bulan di Desa Talang Tegal. Jenis penelitian adalah kuantitatif dengan two group pre and post test  design. Sampel sebanyak 34 bayi yang diberikan perlakuan baby massage dan baby gym dilakukan selama 2 minggu 3x seminggu, untuk baby massage 15 menit sedangkan untuk baby gym 5 menit. Terdapat pengaruh baby massage terhadap kualitas tidur bayi usia 3-6 bulan dengan  p value 0.000. Terdapat pengaruh baby gym terhadap kualitas tidur bayi usia 3-6 bulan dengan  p value 0,001. Tidak terdapat perbedaan efektivitas baby massage dan baby gym terhadap kualitas tidur bayi usia 3 – 6 bulan. Kata kunci : baby gym; baby massage; kualitas tidur bayi  The Effectiveness of Baby Massage And Baby Gym on Sleep Quality of 3-6 Months Baby ABSTRACT  Baby massage and baby gym are efforts to improve the quality of sleep in babies. There are quite a number of sleep problems in infants in Indonesia, which is around 44.2% of infants experiencing sleep disorders such as frequent awakenings at night. However, more than 72% of parents consider sleep disturbances not a problem or just a minor problem, this was revealed by a 2014-2015 study conducted in five major cities in Indonesia. Based on initial data there were 20 babies who came to the Integrated Healthcare Centre and found 17 babies with sleep disorders. The purpose of the study was to determine the effectiveness of baby massage and baby gym on the sleep quality of baby aged 3-6 months in Talang Tegal Village. This type of research was quantitative with two groups pre-post test design. A sample of 34 babies who were given baby massage and baby gym treatment was carried out for 2 weeks 3 time each week, for baby massage 15 minutes while for baby gym 5 minutes. There is an effect of baby massage on the sleep quality of babies aged 3-6 months with a p value of 0.000. There is an effect of baby gym on the sleep quality of babies aged 3-6 months with a p value of 0.001. There is no difference in the effectiveness of baby massage and baby gym on the sleep quality of babies aged 3-6 months. Keywords: baby gym; baby massages; sleep quality of baby

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