Preparation and Antitubercular Activities of Palindromic Hydrazinecarbothioamides and Carbonothioic Dihydrazides

2019 ◽  
Vol 16 (11) ◽  
pp. 1202-1210 ◽  
Author(s):  
Michael Joseps Hearn ◽  
Gwendolyn Towers ◽  
Michael Henry Cynamon
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Virulent Strain ◽  
Chemotherapeutic Agents ◽  
Disc Diffusion ◽  
Global Public Health ◽  
Health Crisis ◽  
Chemical Structures ◽  
Public Health Crisis ◽  
Zones Of Inhibition ◽  
Diffusion Assay

Background:With approximately one-third of the world’s population infected, tuberculosis continues to be a global public health crisis. The rise of strains that are unusually virulent or highly resistant to current drugs is a cause of special concern, prompting research into new classes of compounds, as well as the re-evaluation of known chemotherapeutic agents.Objectives:The antimycobacterial activities associated with some recently-reported thiocarbonyl compounds kindled our interest in the synthesis of substituted hydrazinecarbothioamides (3) and carbonothioic dihydrazides (4), with the aim of investigating their potential in antitubercular drug design and discovery.Methods:In the present study, the title compounds 3 and 4 were prepared by the condensation of hydrazines with isothiocyanates in reactions readily controlled by stoichiometry, temperature and solvent. The compounds were assessed against Mycobacterium bovis BCG in Kirby-Bauer disc diffusion, and minimum inhibitory concentrations were determined against the virulent strain M. tuberculosis Erdman.Results:The chemical structures of these thermally stable compounds were determined by IR, 1HNMR, 13C-NMR, high-resolution mass spectrometry and elemental analysis. In the Kirby-Bauer disc diffusion assay, some of the compounds showed substantial diameters of inhibition against BCG. In some cases, the zones of inhibition were so large that no growth at all was observed on the assay plates. Against M. tuberculosis Erdman, several of the compounds showed significant activities. Compound 3h was the most active, demonstrating a minimum inhibitory concentration of 0.5 µg/mL.Conclusion:We found that the title compounds may be prepared conveniently in excellent purity and good yields. They are readily identified on the basis of their characteristic spectra. Some members of this class showed significant activities against mycobacteria. We conclude that further work will be warranted in exploring the antitubercular properties of these compounds.

scholarly journals A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Guo ◽  
Lisu Huang ◽  
Guangshun Zhang ◽  
Yanfeng Yao ◽  
He Zhou ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Complex Structure ◽  
Neutralizing Antibody ◽  
Economic Consequences ◽  
Binding Motif ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Monkey Model ◽  
Therapeutic Outcomes

AbstractCOVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can provide an important treatment option to fight COVID-19, especially for the most vulnerable populations. In this work, potent antibodies binding to SARS-CoV-2 Spike protein were identified from COVID-19 convalescent patients. Among them, P4A1 interacts directly with and covers majority of the Receptor Binding Motif of the Spike Receptor-Binding Domain, shown by high-resolution complex structure analysis. We further demonstrate the binding and neutralizing activities of P4A1 against wild type and mutant Spike proteins or pseudoviruses. P4A1 was subsequently engineered to reduce the potential risk for Antibody-Dependent Enhancement of infection and to extend its half-life. The engineered antibody exhibits an optimized pharmacokinetic and safety profile, and it results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection. These data suggest its potential against SARS-CoV-2 related diseases.

scholarly journals The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

Diseases ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 46
Author(s):  
Feng Xu ◽  
Yawei Wen ◽  
Xinge Hu ◽  
Tiannan Wang ◽  
Guoxun Chen
Keyword(s):  
Vitamin C ◽  
Distress Syndrome ◽  
Kidney Injury ◽  
Mortality Rates ◽  
Protective Effects ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Renal Functions ◽  
Potential Use

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

Synergising International Public Health Law and International Disaster Law

2020 ◽  
pp. 1-11
Author(s):  
Pratik DIXIT
Keyword(s):  
Public Health ◽  
International Health ◽  
Health Law ◽  
Global Public Health ◽  
Public Health Law ◽  
Health Crisis ◽  
Response Strategies ◽  
Public Health Crisis ◽  
International Public Health ◽  
Health Regulations

There is no time more opportune to review the workings of the International Health Regulations (IHR) than the present COVID-19 crisis. This article analyses the theoretical and practical aspects of international public health law (IPHL), particularly the IHR, to argue that it is woefully unprepared to protect human rights in times of a global public health crisis. To rectify this, the article argues that the IHR should design effective risk reduction and response strategies by incorporating concepts from international disaster law (IDL). Along similar lines, this article suggests that IDL also has a lot to learn from IPHL in terms of greater internationalisation and institutionalisation. Institutionalisation of IDL on par with IPHL will provide it with greater legitimacy, transparency and accountability. This article argues that greater cross-pollination of ideas between IDL and IPHL is necessary in order to make these disciplines more relevant for the future.

scholarly journals Psychometric properties of the Fear of COVID-19 Scale amongst black South African university students

2021 ◽  
Vol 3 ◽  
Author(s):  
Malose Makhubela ◽  
Solomon Mashegoane
Keyword(s):  
University Students ◽  
South African ◽  
Discriminant Validity ◽  
Global Public Health ◽  
Infection Rates ◽  
Health Crisis ◽  
Black South African ◽  
Public Health Crisis ◽  
Life Threatening ◽  
Acceptable Internal Consistency

Coronavirus disease 2019 (COVID-19) has spread widely leading to a global public health crisis of a pandemic proportion. Whilst infection rates tend to fluctuate in South Africa, COVID-19 remains a life-threatening disease with the capacity to wreak fear and concern. The present study evaluated the psychometric qualities of the Fear of COVID-19 Scale (FCV-19S) amongst black South African university students (N = 433; Female: 58%; Mage = 23.51 [SD = 4.18]). The FCV-19S demonstrated a unidimensional factor structure and acceptable internal consistency (α = 0.87), Omega (ω = 0.88) and the greatest lower bound (GLB = 0.90) reliabilities. In addition, discriminant validity was demonstrated when FCV-19S items loaded separately from ordinary fear. The FCV-19S can be used as a measure of COVID-19-related fear amongst black South African university students.

An Essay on the Political Economy Effects of the COVID-19 Pandemic as Twin Crises

2022 ◽  
pp. 1-18
Author(s):  
Irfan Kalaycı
Keyword(s):  
Economic Crisis ◽  
Global Public Health ◽  
Health Crisis ◽  
Global Epidemic ◽  
Public Health Crisis ◽  
Political Approach ◽  
New Type ◽  
The Subject ◽  
Twin Crises ◽  
Trade Education

The subject and purpose of this study is to examine the new type of coronavirus disease (COVID-19), which has turned into a global epidemic, with an economic-political approach. There are twin crises in the form of a health crisis (high human deaths) and an economic crisis (recession). Trillion-dollar aid packages from governments and international financial organizations also show that this global public health crisis has created an economic crisis. In the context of these crises, G-20 countries that did not intervene in their transmission channels in a timely manner showed the worst situations. This epidemic, calculated with the SIR model, is global, but the measures are local. What makes a clean, masked, and socially distant life obligatory against the risk of contamination is that this epidemic locks or restricts the whole economy, especially trade, education, and tourism. Measures called “new normalization” have started to relax in order to prevent further increase in unemployment and poverty.

scholarly journals Coronavirus Pandemic: a major public health crisis for the developed and developing world

2021 ◽  
Vol 15 (03) ◽  
pp. 366-369
Author(s):  
Rooh Ullah ◽  
Muhammad Suleman Rana ◽  
Mehmood Qadir ◽  
Muhammad Usman ◽  
Niaz Ahmed
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Day By Day

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. The risk from this epidemic depends on the nature of the virus, including how well it transmits from person to person, and the complications resulting from this current illness. The novel coronavirus has killed thousands of people in China and other countries as well; its rate of mortality is increasing day by day. There is an urgent need to control the virus by developing vaccine or any other antiviral drugs to save the world from this deadly viral infection.

scholarly journals Comparing with other countries the spread of COVID-19 within the first 120 days of its outbreak in Nigeria

2020 ◽  
Author(s):  
Ayo Stephen Adebowale ◽  
Adeniyi Francis Fagbamigbe ◽  
Joshua Odunayo Akinyemi ◽  
Olalekan K Obisesan ◽  
Emmanuel J Awosanya ◽  
...  
Keyword(s):  
Control Measures ◽  
Global Public Health ◽  
Linear Quadratic ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Exponential Growth Model ◽  
Strict Compliance ◽  
Cubic Polynomial ◽  
Exponential Methods ◽  
Best Fit

Abstract Background: COVID-19 is an emerging global public health crisis. The increase in the daily COVID-19 confirmed cases in Nigeria is worrisome vis-a-vis its large and dense population. This study aims at assessing the first 120 days of COVID-19 case confirmation in Nigeria.Methods: Data extracted from the World Bank’s website were used for the descriptive assessment and modelling of COVID-19 disease using the first 120 days of the index case in Nigeria and seven other countries. Linear, quadratic, cubic and exponential methods of regression model were used to fit the data (α=0.05).Results: The COVID-19 growth pattern in Nigeria was similar to that of Egypt, Ghana and Cameroun; Nigeria COVID-19's daily death distribution was comparable to six of the other seven countries considered. There was an increasing trend in the daily COVID-19 confirmed cases in Nigeria. During the lockdown, the growth rate of COVID-19 in Nigeria was 5.85 (R2=0.728, p<0.001); however, it was 8.42 (R2=0.625, p<0.001) after the lockdown’s relaxation. Across all the countries investigated, the cubic polynomial model (CPM) provided the best fit for predicting COVID-19 cumulative cases and there was a clear deviation from the exponential growth model. Using the CPM, all things being equal, a 3-month (30 September 2020) prediction of COVID-19 cases in Nigeria was 155,467 (95% CI:151,111-159,824, p<0.001).Conclusions: An improvement in COVID-19 control measures and strict compliance with the COVID-19 recommended protocols are essential. A contingency plan is needed to provide care for the active cases in case the predicted target is realised.

scholarly journals Renal Transplants In Covid-19 Pandemic

2020 ◽  
Vol 6 (2) ◽  
pp. 1-4
Author(s):  
Keyword(s):  
Public Health ◽  
Kidney Transplant ◽  
Global Public Health ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Renal Transplants ◽  
Health Crisis ◽  
Public Health Crisis

Coronavirus Disease 2019 (COVID-19) is a global public health crisis and a pandemic of international concern. The delivery of transplant care worldwide is severely challenged by the COVID-19 pandemic. Along with the inherent risks of immunosuppression, kidney transplant recipients are also at higher risk of getting infected with the coronavirus.

scholarly journals Nonstructural protein 7 and 8 complexes of SARS-CoV-2

2020 ◽  
Author(s):  
Changhui Zhang ◽  
Li Li ◽  
Jun He ◽  
Cheng Chen ◽  
Dan Su
Keyword(s):  
Nonstructural Protein ◽  
Genome Replication ◽  
Global Public Health ◽  
Host Proteins ◽  
Health Crisis ◽  
Public Health Crisis ◽  
C Terminus ◽  
Viral Genome Replication ◽  
Replicase Complex ◽  
Viral Replicase

Abstract The pandemic outbreak of coronavirus disease 2019 (COVID-19) across the world has led to millions of infection cases and caused a global public health crisis. Current research suggests that SARS-CoV-2 is a highly contagious coronavirus that spreads rapidly through communities. To understand the mechanisms of viral replication, it is imperative to observe coronavirus viral replicase, a huge protein complex comprising up to 16 viral nonstructural and associated host proteins, which is the most promising antiviral target for inhibiting viral genome replication and transcription. Recently, several components of the viral replicase complex in SARS-CoV-2 have been solved to provide a basis for the design of new antiviral therapeutics. Here, we report the crystal structure of the SARS-CoV2 nsp7-8 tetramer, which comprises two copies of each protein representing nsp7’s full-length and the C-terminus of nsp8 owing to N-terminus proteolysis during the process of crystallization. We also identified a long helical extension and highly flexible N-terminal domain of nsp8, which is preferred for interacting with single-stranded nucleic acids.

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