Recent Patent based perspective on diagnostic and therapeutic interventions in Malignant Mesothelioma: Is Drug Repositioning knocking the door?

2021 ◽  
Vol 16 ◽  
Author(s):  
Vikas Yadav ◽  
Roghaiyeh Safari
Keyword(s):  
Malignant Mesothelioma ◽  
Drug Repositioning ◽  
Gene Signature ◽  
Therapeutic Interventions ◽  
Clinical Settings ◽  
Global Epidemic ◽  
Diagnosis And Therapy ◽  
Pubmed Database ◽  
Search Data ◽  
Novel Biomarkers

Background: Malignant Mesothelioma (MM), an orphan but aggressive malignancy of the mesothelial membrane, is a fatal tumor. Global epidemic related to malignant pleural mesothelioma is on the rise, so there is a need to explore novel biomarkers and ingenious therapeutic approaches to stalk this silent killer. Objective: The main aim of the present review is to provide a consolidated overview of the recent active patents related to diagnosis and therapy in MM that will affect its future management. Method: A search of existing literature was conducted from a PubMed database search. Recent patent information was fetched out from online accessible open-access databases. For related clinical trials, www.clinicaltrial.gov was searched. Results: Patent search data showed 72 active patents related to diagnosis and therapy in the field of MM, which we classified into eight broad categories. Of these, a maximum of 17 patents was attributed to immunotherapy, and 13 each were attributed to “Drug Repositioning” and “Biological / synthetic” based candidates. The remaining 17 patents were distributed amongst virotherapy and various miscellaneous categories. A relatively low number of patents accounts for gene signature (7), epigenetics (3), and microRNA (2) based diagnosis and therapy. Furthermore, our clinical trial-based investigation revealed the futuristic impact of listed patents in MM patient management. Conclusion: This review article has provided an overview of patent-based advancement in MM, which might become the apex in clinical settings in the future. Interestingly, immunotherapy and “drug repositioning” based therapy seems to be the front-runners in the race to provide relief.

Chemogenomics Mapping of Potential Drugs and Targets for Treatment of Multiple Myeloma

2021 ◽  
Author(s):  
Shifan Ma ◽  
Xiang-Qun Xie
Keyword(s):  
Multiple Myeloma ◽  
Gene Signature ◽  
Therapeutic Interventions ◽  
Data Sets ◽  
Diagnostic Biomarkers ◽  
Risk Of Death ◽  
Pathological Mechanism ◽  
Search Data ◽  
Drug Reposition

Abstract Multiple myeloma (MM) is the second common hematological malignancy affecting about 352,000 worldwide. Some subgroups of MM patients still cannot benefit from the currently available anti-MM drugs and therefore are at high risk of death. The pathological mechanism of MM remains to be unraveled. The identification of a global gene signature for MM might lead toward development of novel diagnostics and therapeutic interventions. Here, we identified common differentially expressed genes (DEGs) shared by 30 MM microarray data sets and compared the common DEGs with those induced by genetic or chemical perturbations. We found some potential therapeutic targets for MM treatment, for example RARA, FGFR1, PML, ROR1, SLAMF7, MTDH and Daxx. as modulating them can reverse the MM-induced gene signature. Based on our analysis results, we also predicted and validated some drug reposition, such as Imatinib, Decitabine, Dexamethasone, Vincristine, Paclitaxel, as well as Bortezomib plus Bafilomycin A1 combination for MM treatment by a literature search, data mining, and in vitro bioassays. This study could provide guidance and indications for the development of MM specific diagnostic biomarkers, indication predictors and therapeutic treatment.

scholarly journals Therapeutic Strategies for Diabetic Kidney Disease

Diabetology ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 31-35
Author(s):  
Keiichiro Matoba
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Intensive Therapy ◽  
Therapeutic Strategies ◽  
Therapeutic Interventions ◽  
Hemodynamic Changes ◽  
Diabetic Kidney ◽  
Global Epidemic ◽  
Stage Renal Disease ◽  
End Stage

Diabetic kidney disease (DKD) is a global epidemic leading to end-stage renal disease (ESRD) and susceptibility to cardiovascular disease, with few therapeutic interventions. A hallmark of DKD is the activation of the renin-angiotensin-aldosterone system and hemodynamic changes in glomerulus. Although intensive therapy with agents that targets those abnormalities lowers the risk of DKD progression, it does not completely abolish the risk of ESRD and cardiovascular events. Recent studies have illustrated the importance of renal inflammation, oxidative stress, and activated Rho-associated protein kinase (ROCK) signaling as essential pathogenesis for the development of DKD. In this commentary, these topics will be discussed.

scholarly journals Differential Interactome Based Drug Repositioning Unraveled Abacavir, Exemestane, Nortriptyline Hydrochloride, and Tolcapone as Potential Therapeutics for Colorectal Cancers

2021 ◽  
Vol 1 ◽  
Author(s):  
Hande Beklen ◽  
Sema Arslan ◽  
Gizem Gulfidan ◽  
Beste Turanli ◽  
Pemra Ozbek ◽  
...  
Keyword(s):  
Drug Repositioning ◽  
Positive Control ◽  
Drug Candidates ◽  
Novel Biomarkers ◽  
Critical Requirement ◽  
Nortriptyline Hydrochloride ◽  
In Silico Molecular Docking ◽  
Prognostic Power ◽  
Potential Therapeutics

There is a critical requirement for alternative strategies to provide the better treatment in colorectal cancer (CRC). Hence, our goal was to propose novel biomarkers as well as drug candidates for its treatment through differential interactome based drug repositioning. Differentially interacting proteins and their modules were identified, and their prognostic power were estimated through survival analyses. Drug repositioning was carried out for significant target proteins, and candidate drugs were analyzed via in silico molecular docking prior to in vitro cell viability assays in CRC cell lines. Six modules (mAPEX1, mCCT7, mHSD17B10, mMYC, mPSMB5, mRAN) were highlighted considering their prognostic performance. Drug repositioning resulted in eight drugs (abacavir, ribociclib, exemestane, voriconazole, nortriptyline hydrochloride, theophylline, bromocriptine mesylate, and tolcapone). Moreover, significant in vitro inhibition profiles were obtained in abacavir, nortriptyline hydrochloride, exemestane, tolcapone, and theophylline (positive control). Our findings may provide new and complementary strategies for the treatment of CRC.

scholarly journals Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer

2021 ◽  
Vol 22 (18) ◽  
pp. 9953
Author(s):  
Mai Tanaka ◽  
Dietmar W. Siemann
Keyword(s):  
Signaling Pathway ◽  
Receptor Tyrosine Kinase ◽  
Therapeutic Agents ◽  
Therapeutic Interventions ◽  
Therapeutic Resistance ◽  
Clinical Settings ◽  
Affinity Ligand ◽  
Current State ◽  
Cancer Types ◽  
High Affinity Ligand

Many signaling pathways are dysregulated in cancer cells and the host tumor microenvironment. Aberrant receptor tyrosine kinase (RTK) pathways promote cancer development, progression, and metastasis. Hence, numerous therapeutic interventions targeting RTKs have been actively pursued. Axl is an RTK that belongs to the Tyro3, Axl, MerTK (TAM) subfamily. Axl binds to a high affinity ligand growth arrest specific 6 (Gas6) that belongs to the vitamin K-dependent family of proteins. The Gas6/Axl signaling pathway has been implicated to promote progression, metastasis, immune evasion, and therapeutic resistance in many cancer types. Therapeutic agents targeting Gas6 and Axl have been developed, and promising results have been observed in both preclinical and clinical settings when such agents are used alone or in combination therapy. This review examines the current state of therapeutics targeting the Gas6/Axl pathway in cancer and discusses Gas6- and Axl-targeting agents that have been evaluated preclinically and clinically.

CircRNAs in lung adenocarcinoma: diagnosis and therapy

2021 ◽  
Vol 21 ◽  
Author(s):  
Lijia Su ◽  
Jinying Zhao ◽  
Huahua Su ◽  
Yanhua Wang ◽  
Wenfeng Huang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Biomedical Application ◽  
Small Cell Lung Carcinoma ◽  
Disease Diagnosis ◽  
Circular Rnas ◽  
Cell Lung Carcinoma ◽  
Diagnosis And Therapy ◽  
Diagnosis And Prognosis ◽  
Novel Biomarkers ◽  
New Biomarkers

: Lung adenocarcinoma (LUAD) is the common histological subtype of non-small-cell lung carcinoma (NSCLC). Circular RNAs (circRNAs) represent a new class of non-coding RNAs (ncRNAs) involved in the development of cancer. Accumulating evidence indicated that a large number of circular RNAs were found to be involved in many biological processes, including tumor initiation, proliferation and progression. These circRNAs present great potentials as new biomarkers and vital targets for disease diagnosis and prognosis. In this review, we mainly focus on the differentially expressed circRNAs and their functions in the pathogenesis of LUAD, which makes it possible for the utility of circRNAs as novel biomarkers for early diagnosis and therapy. Especially, it is helpful to develop circRNAs as crucial therapeutic targets, thus providing a promising biomedical application in the field of cancer gene therapy.

Avatars and Digital Technology Literacy Applied in Psychology

2019 ◽  
pp. 402-420
Author(s):  
Judy Joohye Lee ◽  
Laura Dryjanska
Keyword(s):  
Media Literacy ◽  
Digital Technology ◽  
Autism Spectrum ◽  
Therapeutic Interventions ◽  
Technology Literacy ◽  
Clinical Settings ◽  
Diverse Populations ◽  
Virtual Technology ◽  
Technological Advances ◽  
Clinical Methods

Technological advances have led to a variety of positive outcomes and benefits. This chapter aims to discuss the different kinds of therapeutic interventions, clinical methods, and approaches in the field of psychology that have resulted from the advance in digital and virtual technology. In particular, this chapter focuses on avatars and virtual technology as a component of media literacy. Additionally, the chapter explores, in detail, how avatars are used across various clinical settings with diverse populations such as individuals with autism spectrum disorder, individuals with schizophrenia, prison settings, and the criminal justice system. Furthermore, the chapter highlights the significant implications avatars have in regards to education. Lastly, controversies and challenges are discussed regarding the efficacy of digital technology within clinical settings (e.g., telepsychology).

scholarly journals Untangling Species-Level Composition of Complex Bacterial Communities through a Novel Metagenomic Approach

mSystems ◽  
2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Christian Milani ◽  
Giulia Alessandri ◽  
Marta Mangifesta ◽  
Leonardo Mancabelli ◽  
Gabriele Andrea Lugli ◽  
...  
Keyword(s):  
Bacterial Communities ◽  
Internal Transcribed Spacer ◽  
Its Region ◽  
Cost Effective ◽  
Species Level ◽  
Clinical Settings ◽  
Mucosal Biopsy ◽  
Environmental Matrices ◽  
Novel Biomarkers ◽  
Bacterial Profiling

ABSTRACT 16S small-subunit (SSU) rRNA gene-based bacterial profiling is the gold standard for cost-effective taxonomic reconstruction of complex bacterial populations down to the genus level. However, it has been proven ineffective in clinical and research settings requiring higher taxonomic resolution. We therefore developed a bacterial profiling method based on the internal transcribed spacer (ITS) region employing optimized primers and a comprehensive ITS database for accurate cataloguing of bacterial communities at (sub)species resolution. Performance of the microbial ITS profiling pipeline was tested through analysis of host-associated, food, and environmental matrices, while its efficacy in clinical settings was assessed through analysis of mucosal biopsy specimens of colorectal cancer, leading to the identification of putative novel biomarkers. The data collected indicate that the proposed pipeline represents a major step forward in cost-effective identification and screening of microbial biomarkers at (sub)species level, with relevant impact in research, industrial, and clinical settings. IMPORTANCE We developed a novel method for accurate cataloguing of bacterial communities at (sub)species level involving amplification of the internal transcribed spacer (ITS) region through optimized primers, followed by next-generation sequencing and taxonomic classification of amplicons by means of a comprehensive database of bacterial ITS sequences. Host-associated, food, and environmental matrices were employed to test the performance of the microbial ITS profiling pipeline. Moreover, mucosal biopsy samples from colorectal cancer patients were analyzed to demonstrate the scientific relevance of this profiling approach in a clinical setting through identification of putative novel biomarkers. The results indicate that the ITS-based profiling pipeline proposed here represents a key metagenomic tool with major relevance for research, industrial, and clinical settings.

Non-coherent optical radiation sources

2015 ◽  
Author(s):  
David K Taylor
Keyword(s):  
Clinical Practice ◽  
Optical Radiation ◽  
Clinical Settings ◽  
Diagnosis And Therapy ◽  
Radiation Sources ◽  
Laser Sources

Optical radiation is ubiquitous, and intense artificial sources find many applications in clinical practice, including zone illumination, diagnosis, and therapy. Its effects on humans are strongly wavelength-dependent, its hazards sometimes overlooked due to familiarity or masking by other wavelengths. This chapter examines non-laser sources of ultraviolet, visible, and infrared radiations, the risks likely to be encountered in clinical settings, the calculations needed to assess commonly encountered optical radiation sources, and the measures that can be taken to minimize the hazards to workers and patients, in compliance with the requirements of the Artificial Optical Radiation directive.

scholarly journals Radiation-induced intestinal damage: latest molecular and clinical developments

2019 ◽  
Vol 15 (35) ◽  
pp. 4105-4118 ◽  
Author(s):  
Lina Lu ◽  
Wenjun Li ◽  
Lihua Chen ◽  
Qiong Su ◽  
Yanbin Wang ◽  
...  
Keyword(s):  
Relevant Literature ◽  
Therapeutic Interventions ◽  
In Vivo Studies ◽  
Publication Date ◽  
Intestinal Damage ◽  
Chronic Radiation ◽  
Pubmed Database ◽  
Radiation Induced ◽  
Meta Analyses

Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancer patients receiving radiotherapy. Materials & methods: A literature search was conducted in the PubMed database using various search terms, including ‘radiation enteritis’, ‘radiation enteropathy’, ‘radiation-induced intestinal disease’, ‘radiation-induced intestinal damage’ and ‘radiation mucositis’. The search was limited to in vivo studies, clinical trials and meta-analyses published in English with no limitation on publication date. Other relevant literature was identified based on the reference lists of selected studies. Results: The pathogenesis of acute and chronic radiation-induced intestinal damage as well as the prevention and treatment approaches were reviewed. Conclusion: There is inadequate evidence to strongly support the use of a particular strategy to reduce radiation-induced intestinal damage. More high-quality randomized controlled trials are required for interventions with limited evidence suggestive of potential benefits.

Sign in / Sign up

Export Citation Format

Share Document