OncoArendi Therapeutics as Platform-based Polish Biotech Company – A Case Study

2020 ◽  
Vol 7 (1) ◽  
pp. 74-84
Author(s):  
Marcin Szumowski
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Private Investment ◽  
European Countries ◽  
Research Infrastructure ◽  
Clinical Validation ◽  
The Us ◽  
Novel Targets

OncoArendi Therapeutics SA (OAT) has been founded in 2012 as USstyle biotech operating in Poland. From the beginning, OAT has been focused on first-in-class or best-in-class programs involving interactions with novel targets with no clinical validation. The experienced group of founders thought that Poland offered an abundance of young talent and non-dilutive financing from European and national grants and subsidies, newly established research infrastructure and relatively little competition, as the biotech sector was still in its infancy. With strong proprietary IP, they thought, an experienced group of medicinal chemists could launch a competitive small molecule discovery business. Furthermore, the net cost of developing small molecules in Poland was several-fold lower than in the US or in western European countries. Based on these competitive factors, one could develop several programs in parallel with limited private investment, thus diversifying the high scientific and technological risk and increasing chances of long-term success. This case study shows how this strategy played out for OncoArendi over the last 7 years and how OncoArendi positions itself within the Polish biotech sector and on the increasingly competitive global biopharmaceutical scene.

Citizen Chen: a challenging test for bilateral diplomacy

2013 ◽  
Vol 3 (5) ◽  
pp. 1-9
Author(s):  
Barthélémy Michalon
Keyword(s):  
Legal Aspects ◽  
Subject Area ◽  
Chinese Government ◽  
Specific Situation ◽  
Content Type ◽  
The Us ◽  
The Usa ◽  
High Level

Subject area Diplomatic and consular policies; legal aspects of international relations and Asia regional scenario. Study level/applicability Undergraduate. Case overview In April 2012, high-level officials from China and the USA were about to meet in Beijing in the framework of the bilateral Strategic and Economic Dialogue, organized on a yearly basis. The event was always delicate, due to the ambiguous relationship existing between the two countries, which were at the same time rivals and dependent on one another. That time, the tension previous to the meeting increased significantly: a Chinese human rights activist had just sought and obtained diplomatic protection in the US Embassy in Beijing, thus creating an embarrassing situation for both States' foreign departments […] How could they possibly solve this contentious issue without affecting their already sensitive relationship? Expected learning outcomes Analytical: to be aware of the political nature of the current Chinese Government; to realize the concrete and practical implications of an Embassy's special status; to balance two contradictory objectives, in a specific situation where none of them can be fully discarded; to contrast and try to combine long-term goals (in this case, to maintain a functioning relationship between two main world powers) with short-term objectives (in this case, how to deal with a Chinese activist that required protection against his own country's security forces); to find a modus vivendi (conciliation) between values and interests; to get convinced that certain kinds of negotiations cannot be conceived through a “win or lose” approach: in this case, the only way out must be respectful of the two parties' core interests; and to take into account that image preservation (“face-saving”) must be included within any country's objectives in any situation involving diplomatic means. Conceptual: the purpose is to familiarize the students with specific concepts, such as: best alternative to a negotiated agreement (BATNA), which is to be mentioned as part of the discussion (it is not included in the case study itself); interdependence; (purported) Group of Two; asylum and refuge; Immunity; and sending state/receiving state. Supplementary materials Teaching notes are available for educators only. Please contact your library to gain login details or email [email protected] to request teaching notes.

scholarly journals Estimated Cancer Risks Associated with Nitrosamine Contamination in Commonly Used Medications

2021 ◽  
Vol 18 (18) ◽  
pp. 9465
Author(s):  
Kate Li ◽  
Karin Ricker ◽  
Feng C. Tsai ◽  
ChingYi J. Hsieh ◽  
Gwendolyn Osborne ◽  
...  
Keyword(s):  
Environmental Protection Agency ◽  
Animal Species ◽  
Protection Agency ◽  
Cancer Risks ◽  
The Us ◽  
Treatment Of Hypertension ◽  
Us Fda

Many nitrosamines are potent carcinogens, with more than 30 listed under California’s Proposition 65. Recently, nitrosamine contamination of commonly used drugs for treatment of hypertension, heartburn, and type 2 diabetes has prompted numerous Food and Drug Administration (FDA) recalls in the US. These contaminants include the carcinogens NDMA (N-nitrosodimethylamine) and NDEA (N-nitrosodiethylamine) and the animal tumorigen NMBA (N-nitroso-N-methyl-4-aminobutyric acid). NMBA and NDEA are metabolically and/or structurally related to NDMA, an N-nitrosomethyl-n-alkylamine (NMA), and 12 other carcinogenic NMAs. These nitrosamines exhibit common genotoxic and tumorigenic activities, with shared target tumor sites amongst chemicals and within a given laboratory animal species. We use the drug valsartan as a case study to estimate the additional cancer risks associated with NDMA and NDEA contamination, based on nitrosamine levels reported by the US FDA, cancer potencies developed by California’s Proposition 65 program and the US Environmental Protection Agency (EPA), and specific exposure scenarios. These estimates suggest that nitrosamine contamination in drugs that are used long-term can increase cancer risks and pose a serious concern to public health.

scholarly journals AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

2021 ◽  
Author(s):  
Frances M Potjewyd ◽  
Joel K Annor-Gyamfi ◽  
Jeffrey Aube ◽  
Shaoyou Chu ◽  
Ivie L Conlon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Molecules ◽  
Small Molecule ◽  
Positive Control ◽  
Target Validation ◽  
Protein Targets ◽  
Novel Targets ◽  
Chemical Tools ◽  
Small Molecule Modulators

Introduction: The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the AMP-AD program. Methods: A cheminformatics-driven effort enabled identification of existing small molecule modulators for many protein targets nominated by AMP-AD and suitable positive control compounds to be included in the set. Results: We have built an annotated set of 171 small molecule modulators, including mostly inhibitors, targeting 98 unique proteins that have been nominated by AMP-AD consortium members as novel targets for AD treatment. These small molecules vary in their quality and should be considered chemical tools that can be used in efforts to validate therapeutic hypotheses, but which would require further optimization. A physical copy of the AD Informer Set can be ordered via the AD Knowledge Portal. Discussion: Small molecule tools that enable target validation are important tools for the translation of novel hypotheses into viable therapeutic strategies for AD.

A Cruel Innovation: Israeli Experiments on Gaza’s Great March of Return

2020 ◽  
Vol 8 (2) ◽  
pp. 175-198
Author(s):  
Tariq Dana
Keyword(s):  
Settler Colonialism ◽  
Private Investment ◽  
The United States ◽  
High Tech ◽  
War Economy ◽  
Palestinian Territories ◽  
The Us ◽  
Military Security ◽  
The Relationship

This article sheds light on the relationship between Israeli high-tech innovation and military/security production in the framework of settler-colonialism and the prolonged occupation of the Palestinian territories. It analyzes the global rise of Israel in military and security innovation as a result of decades-long colonial ventures and regional wars, which have been a key variable for dynamic and extensive innovation and productivity. Moreover, the article argues that Israeli military and security would not have been attainable without the extraordinary official assistance and private investment from the United States, especially since the aftermath of the 1967 war. Besides the structural dependency on the US, this article highlights other characteristics that define Israel’s military and security production, such as the vicious nature of these innovations, complicity in global atrocities, and profitability of innovation to Israel’s war economy. Finally, the article presents Gaza’s Great March of Return (gmr) as a case study to present evidence on the ways in which Israeli military forces and security companies are jointly involved in experimentation, using new weapons and unmanned devices on the Palestinian civilians.

BUDGET DEFICITS AND INTEREST RATES: THE US EVIDENCE SINCE 1946

2007 ◽  
Vol 52 (02) ◽  
pp. 191-200
Author(s):  
SHAKIL QUAYES ◽  
A. M. M. JAMAL
Keyword(s):  
Interest Rates ◽  
Corporate Bonds ◽  
Federal Budget ◽  
Private Investment ◽  
Budget Deficits ◽  
Real Rate ◽  
The Us ◽  
Potential Impact ◽  
Post War

Many economists believe that federal government's budget deficits result in higher interest rates. This increase in interest rates can stifle private investment and impede the real rate of economic growth for the economy. This paper examines the potential impact of federal budget deficits on long-term interest rates for corporate bonds. The study is based on post-war annual US data, and employs a standard demand-supply model. The empirical results in our study provide evidence that the increasing budget deficits lead to higher interest rate for corporate bonds. In this regard, our study supports arguments for the crowding out theory.

scholarly journals Stories of the Experience of Searching for Long-Term Care and Eldercare: Case Study and Narrative Perspectives

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 76-76
Author(s):  
Connie Corley ◽  
Ryan McCarty
Keyword(s):  
Home Health Care ◽  
Adult Children ◽  
Long Term Care ◽  
Policy Research ◽  
Decision Makers ◽  
Term Care ◽  
Research Education ◽  
The Us

Abstract With over 40 million individuals aged 65 years and older in the US, and by 2050 rising to an estimated 89 million, age matters, driving an increased need for long-term care/eldercare. Coupled with the higher costs of care, the search for long-term care/eldercare services can be a difficult prospect for adult children decision-makers. We present the experiences of adult children decision-makers in the US, using two methodological approaches: narrative and case study using autoethnography. In a narrative inquiry of 9 caregivers responsible for making long-term care/eldercare decisions for their parent(s) the zoom model was applied to conduct the analysis. Findings suggest that decision-makers have a strong sense of duty towards helping their loved ones find long-term care solutions. Decision-makers searched for many types of care solutions ranging from home health care to nursing homes. The experiential response most consistently stated by the participants was stress. These results are augmented by an autoethnographic case study in “six acts” illustrating how sense of agency in the caregiving journey can be enhanced. Participants with industry experience had a minimal advantage over those with no experience when it came to navigating the search for long-term/eldercare. We highlight why stories of family search for long-term care/eldercare matter, and how they can be leveraged for fundraising, advocacy, and healing. Implications for policy, research, education and practice are highlighted.

scholarly journals Writing Famine, Writing Empire: Food Crisis and Anticolonial Aesthetics in Liam O'Flaherty's Famine and Bhabani Bhattacharya's So Many Hungers!

2019 ◽  
Vol 49 (1) ◽  
pp. 54-73 ◽  
Author(s):  
Sourit Bhattacharya
Keyword(s):  
British Empire ◽  
Food Availability ◽  
European Countries ◽  
Food Crisis ◽  
Irish Famine ◽  
The World ◽  
Nineteenth And Twentieth Centuries ◽  
Agrarian Crisis

In the nineteenth and twentieth centuries, the colonies controlled by the British, the Dutch, and other European countries witnessed a number of devastating famines. These famines did not solely arise for the ‘natural’ reasons of the shortage of rainfall or food availability problems, but were aggravated by the systemic imperialist exploitation of the world by these major European powers. Taking as its case study the two great famines in Ireland and India – the 1845–52 Irish Famine and the 1943–44 Bengal Famine – the essay offers a reading of Liam O'Flaherty's Famine (1937) and Bhabani Bhattacharya's So Many Hungers! (1947). It shows that these works – apart from registering the devastating impact of the famines on the colonial population – have pointed through their powerful uses of content, form, and style to the world-historical reasons of long-term agrarian crisis, political instability, tyranny of the landlord classes, inefficiency of the British Empire, and others as responsible for the famines.

The Foreign Policies of Small States: Challenging Neorealism in Its Own Backyard

1995 ◽  
Vol 25 (2) ◽  
pp. 171-217 ◽  
Author(s):  
Miriam Fendius Elman
Keyword(s):  
Security Policy ◽  
Small States ◽  
Institutional Formation ◽  
Us Military ◽  
Institutional Structures ◽  
The Us ◽  
Foreign Policies ◽  
Distribution Of Power

The received wisdom in international relations suggests that we can best account for the foreign policies of small states by examining structural/systemic rather than domestic level factors. This article challenges this scholarly consensus. The distribution of power and the balance of threat do influence domestic institutional formation and change in emerging states. However, the subsequent military strategies of these weak states are likely to reflect such domestic institutional choices in a number of important and predictable ways. The article tests this argument against pre-1900 US domestic regime change and foreign security policy. The historical evidence suggests that while international preconditions were critically linked to constitutional reform, the institutional structures and rules of democratic presidentialism affected both the timing and substance of US military strategies in later periods. The US case study provides a springboard for speculating on the international context of democratization in Eastern Europe and the long-term foreign-policy consequences of this domestic regime choice.

Defense Supply Chain Operations

2019 ◽  
pp. 277-300
Author(s):  
Greg H. Parlier
Keyword(s):  
Supply Chain ◽  
Operations Research ◽  
Strategic Decision ◽  
Management Innovation ◽  
Engineering Systems ◽  
Us Army ◽  
The Us ◽  
Enterprise Transformation

This chapter explains the origination, evolution, emerging results, and potential long-term impacts of one particularly daunting enterprise transformation effort within the US Department of Defense. It offers a unique case study for a multi-disciplinary endeavor referred to as the project to Transform US Army Supply Chains (TASC Project). The TASC project pursued comprehensive and creative applications using a variety of Operations Research methods, advanced analytics, and management innovation to improve tactical, operational, and strategic decision making for the military's global sustainment enterprise. This chapter may be of interest to those confronting supply chain and other complex enterprise transformation challenges: national security officials; aerospace, defense, and industrial professionals; university graduate students and professors of engineering systems, operations research, and management. The strategy described herein offers potential solutions broadly applicable to other public institutions and government bureaucracies as well.

INCENTIVE TOURISM AS A WAY OF PERSONNEL MOTIVATION

2016 ◽  
Vol 10 (5) ◽  
pp. 40-48
Author(s):  
Ирина Агальцова ◽  
Irina Agaltsova
Keyword(s):  
Positive Impact ◽  
European Countries ◽  
Indoor Climate ◽  
Quality Of Work ◽  
Incentive Programs ◽  
The Us ◽  
Basic Features ◽  
Positive Results

The article investigates the incentive tourism as one of the effective ways of non-monetary encouragement of staff. The author defines the incentive tourism as one of the components of business tourism and the considers the basic features of the organization of incentive tour. The article presents the statements of well-known motivation theories and based on them analyzes incentive tourism as a way of motivation. The author proves that incentive programs can meet the specific needs of an employee, encouraging to a more qualitative and productive work. The article also notes the high valence of incentive tourism, and explains why this type of tourism is not well developed in Russia in comparison with the US and European countries. The author concludes that the using by companies incentive tourism programs not only can positively affect the indoor climate in the team, but also have a positive impact on strengthening the company´s commitment, improving the quality of work, professional-level rise, and this, in turn, necessarily affect on the favorable development and prosperity of the organization. Thus, the use by organizations of incentive programs is regarded as an effective investment, bringing positive results over the long term.

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