This chapter explains the origination, evolution, emerging results, and potential long-term impacts of one particularly daunting enterprise transformation effort within the US Department of Defense. It offers a unique case study for a multi-disciplinary endeavor referred to as the project to Transform US Army Supply Chains (TASC Project). The TASC project pursued comprehensive and creative applications using a variety of Operations Research methods, advanced analytics, and management innovation to improve tactical, operational, and strategic decision making for the military's global sustainment enterprise. This chapter may be of interest to those confronting supply chain and other complex enterprise transformation challenges: national security officials; aerospace, defense, and industrial professionals; university graduate students and professors of engineering systems, operations research, and management. The strategy described herein offers potential solutions broadly applicable to other public institutions and government bureaucracies as well.