Review: Emerging role of nanosuspensions for drug delivery and stability

: Poor aqueous solubility of some of the drug molecules are of a major concern, which can be emerged in the nano-suspension for better delivery. Coming up to the nanoparticles, it enhances the bioavailability along with the aqueous solubility of the drug which is accomplished by increasing the active surface area of the drug. The gained attention of the nanosuspension is due to its stabilization facility which is done by polymers such as polyethylene glycol (PEG) having a particular size range of 10-100 nm. Hence, to our notice, these nanoparticles have the capacity of binding in the targeted parts with a very low damage to the healthy tissues. These are seen to be prepared by various methods such as media milling, high pressure homogenization, and emulsification along with melt emulsification. Apart it can also be seen that surface modification and solidification have been used to add specific properties to the advanced therapies as post-processing techniques. These days, it is very evident that the drugs are water insoluble and thus have a poor bioavailability which have been developed from the drug delivery programmes and in order to combat this obstacle, nanotechnology have been found to be of specific interest. In order to elevate the bioavailability by increasing the dissolution rate, the methodology of reduction of the associated drug particles into its subsequent submicron range is incorporated. For oral and non-oral administration, these nanosuspensions formulations are used for delivering of the drugs.