Pharmaceutico - Analytical Study of Triphala Guggulu

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Gandhi T. N. ◽  
Gupta S. N. ◽  
Patel M. V. ◽  
Kalsariya B. D.
Keyword(s):  
Large Scale ◽  
Analytical Study ◽  
Water Soluble ◽  
Scale Production ◽  
Large Scale Production ◽  
Acid Protein ◽  
Quality Control Parameters ◽  
Large Production ◽  
Small Production ◽  
Amino Acid Protein

There are many formulations mentioned in Ayurvedic classics to treat various disease used as internally as well as external applications, Guggulu Kalpana is one of them. It is a very popular, safe and effective formulation for mitigation of Tridosha mainly Vatadosha. Two methods for preparation of Guggulu Kalpana areused; 1. Kuttana (pounding) and 2. Analapaka (heating). Mostly small production of Guggulu Kalpana is made by Kuttana and large production is made by Analapaka. Amidst of all Guggulu Kalpana, Triphala Guggulu is one of the most momentous and widely used in Vrana Shodhana and Vrana Ropana Karma in practice. Triphala Guggulu is indicated in Bhagandara, Gulma, Shotha, Arsha, Vatarakta, Kushtha, Pakva-vidradhi, Gandamala, Asthibhagna which is described in Sharangdhara Samhita, Yogaratnakara and Bhavaprakasha. Three batches of Triphala Guggulu were prepared with reference of Sharangdhara Samhita and follow the in house quality control parameters to standardized the medicine in large scale production by heating method. The size of Triphala Guggulu was form 10.27mm to 10.28mm in diameter, pH 5.9 to 6.2, loss on drying 0.8% to 1.6%, ash value 6.0%w/w to 7.5%w/w, acid-insoluble ash value 0.8%w/w to 1.2%w/w, alcohol-soluble extractive value 16.4%v/w to 30.2%v/w and water-soluble extractive value 32.0% to 38.0%. Phytochemical screening of Triphala Guggulu shows that Glycoside, Amino acid, Protein, Carbohydrate, Flavanoid, Tannin, Steroid, Saponin and Alkaloid were present in all batches. On the basis of this study it is clear that, if we follow the same procedure with authentic drugs then large scale production also have quality assurance.

Pharmaceutical Standardization of Saptamrita Lauha

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Dr. Pranav K. Shah ◽  
L B. Singh ◽  
P U Vaishnav ◽  
Bharat Kalsariya
Keyword(s):  
Large Scale ◽  
Oral Route ◽  
Water Soluble ◽  
Scale Production ◽  
External Application ◽  
Chemical Screening ◽  
Large Scale Production ◽  
Acid Protein ◽  
Almost All ◽  
Amino Acid Protein

Shalakya Tantra is a one of the branch of Ashtanga Ayurveda and Netra Chikitsa is a part of Shalakya Tantra. There are so many formulations are mentioned in the treatment of Netra Roga by oral route as well as external application, Saptamrita Lauha is one of them. It is a very popular, very safe and effective formulation for eye diseases. In Ayurveda classics there are so many references are available for Saptamrita Lauha. These formulation are mainly described in Netra Roga and Shoola Roga in almost all the books. In majority references Saptamrita Lauha powder is taken with Anupana or Sahapana of honey and ghee. Sundar Ayurveda Teaching Pharmacy is also manufacturing many batches of Saptamrita Lauha with the reference from Bheshaja Samhita, chapter 4/54, Loha andMandura Kalpana and follow the in house quality control parameters to standardized the medicine in large scale production. The particle size of Saptamrita Lauha is 3.2 μm to 3.8 μm, pH from 6.0 to 6.9,loss on drying from 1.2 % to 1.8%, ash value 16.2 %w/w to 24.5 %w/w, acid insoluble ash value from 2.6 %w/w to3.6 %w/w, alcohol soluble extractive value from 42.9% v/w to 47.7 %v/w, water soluble extractive value from 21.1 % to 26.8%. Phyto-chemical screening of Saptamrita Lauha shows Glycoside, Amino acid, Protein, Carbohydrate, Flavanoid, Tannin, Steroid, Saponin and Alkaloid were present in all batches. On the basis of this study it’s clear that, if we follow the same procedure with authentic drugs then large scale production also having Quality assurance.

I. S. A. Baud. Forms of Production and Women's Labour: Gender Aspects of Industrialisation in India and Mexico. New Delhi: Sage Publications. 1992. 321 pp.Hardbound. Price: Indian Rs 295.00.

1993 ◽  
Vol 32 (1) ◽  
pp. 129-131
Author(s):  
Naureen Talha
Keyword(s):  
Large Scale ◽  
Indian Society ◽  
New Delhi ◽  
Scale Production ◽  
Female Labour ◽  
Self Employment ◽  
Commodity Production ◽  
Large Scale Production ◽  
Mexican Society ◽  
Small Production

The literature on female labour in Third World countries has become quite extensive. India, being comparatively more advanced industrially, and in view of its size and population, presents a pictures of multiplicity of problems which face the female labour market. However, the author has also included Mexico in this analytical study. It is interesting to see the characteristics of developing industrialisation in two different societies: the Indian society, which is conservative, and the Mexican society, which is progressive. In the first chapter of the book, the author explains that he is not concerned with the process of industrialisation and female labour employed at different levels of work, but that he is interested in forms of production and women's employment in large-scale production, petty commodity production, marginal small production, and self-employment in the informal sector. It is only by analysis of these forms that the picture of females having a lower status is understood in its social and political setting.

scholarly journals Rapid synthesis and characterization of silver-loaded graphene oxide nanomaterials and their antibacterial applications

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Jiang Zhu ◽  
Haitao Ni ◽  
Chunyan Hu ◽  
Yuxiang Zhu ◽  
Jinxia Cai ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Graphene Oxide ◽  
Large Scale ◽  
Structural Characteristics ◽  
Water Soluble ◽  
Scale Production ◽  
Energy Dispersion Spectroscopy ◽  
Gram Positive Bacteria ◽  
Transmission Electron ◽  
Large Scale Production

With the promising potential application of Ag/graphene-based nanomaterials in medicine and engineering materials, the large-scale production has attracted great interest of researchers on the basis of green synthesis. In this study, water-soluble silver/graphene oxide (Ag/GO) nanomaterials were synthesized under ultrasound-assisted conditions. The structural characteristics of Ag/GO were confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy and energy dispersion spectroscopy, respectively. The results showed the silver particles (AgNPs) obtained by reduction were attached to the surface of GO, and there was a strong interaction between AgNPs and GO. The antibacterial activity was primarily evaluated by the plate method and hole punching method. Antibacterial tests indicated that Ag/GO could inhibit the growth of Gram-negative and Gram-positive bacteria, special for the Staphylococcus aureus .

scholarly journals Application of Microfluidics in the Production and Analysis of Food Foams

Foods ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 476 ◽  
Author(s):  
Boxin Deng ◽  
Jolet de Ruiter ◽  
Karin Schroën
Keyword(s):  
Large Scale ◽  
Droplet Microfluidics ◽  
Water Soluble ◽  
Scale Production ◽  
Foam Formation ◽  
Long Term Stability ◽  
Current State ◽  
Large Scale Production ◽  
Recent Developments ◽  
Millisecond Time Scale

Emulsifiers play a key role in the stabilization of foam bubbles. In food foams, biopolymers such as proteins are contributing to long-term stability through several effects such as increasing bulk viscosity and the formation of viscoelastic interfaces. Recent studies have identified promising new stabilizers for (food) foams and emulsions, for instance biological particles derived from water-soluble or water-insoluble proteins, (modified) starch as well as chitin. Microfluidic platforms could provide a valuable tool to study foam formation on the single-bubble level, yielding mechanistic insights into the formation and stabilization (as well as destabilization) of foams stabilized by these new stabilizers. Yet, the recent developments in microfluidic technology have mainly focused on emulsions rather than foams. Microfluidic devices have been up-scaled (to some extent) for large-scale emulsion production, and also designed as investigative tools to monitor interfaces at the (sub)millisecond time scale. In this review, we summarize the current state of the art in droplet microfluidics (and, where available, bubble microfluidics), and provide a perspective on the applications for (food) foams. Microfluidic investigations into foam formation and stability are expected to aid in optimization of stabilizer selection and production conditions for food foams, as well as provide a platform for (large-scale) production of monodisperse foams.

Gold cellular networks inside water-soluble sodium alginate sol

2012 ◽  
Vol 90 (6) ◽  
pp. 551-556
Author(s):  
Jishi Wei ◽  
Jianmao Yang ◽  
Shuyan Gao
Keyword(s):  
Sodium Alginate ◽  
Cellular Networks ◽  
Present Method ◽  
Large Scale ◽  
Water Soluble ◽  
Metal Nanostructures ◽  
Scale Production ◽  
Large Scale Production ◽  
Nanoscale Electronics ◽  
Robust Evidence

The present work demonstrates the fabrication of unique gold cellular networks inside water-soluble sodium alginate sol. In conjunction with control experiments, UV–vis spectra and TEM images structurally give a piece of robust evidence that Au(III) and sodium alginate combined with preparation parameters synergically favor the formation of gold cellular networks. From the viewpoint of green chemistry, the cheap and safe reactant sodium alginate and the friendly aqueous medium make the present method possible for applications in large-scale production of metallic cellular networks. Thus, coupled with facile and green creation, the gold cellular networks open new opportunities for noble metal nanostructures, with different morphologies, as biological labels, energy transfer pairs, and other nanoscale electronics.

scholarly journals Quality standards of Palasha Kshara Gritha with reference to different vessels

2020 ◽  
Vol 5 (06) ◽  
pp. 102-108
Author(s):  
H Pampanna Gouda ◽  
Seema MB ◽  
Ravindra Angadi
Keyword(s):  
Particle Size ◽  
Present Article ◽  
Final Stage ◽  
Large Scale ◽  
Analytical Study ◽  
Pharmaceutical Preparations ◽  
Quality Standards ◽  
Scale Production ◽  
Large Scale Production ◽  
Analytical Parameter

This article attempts to clear the dogma that exists in the preparation of Kshara Ghrita with reference to its critical final stage of Siddhi Laxanas. Palasha Kshara Ghrita (PKG) prepared from the Kshara of Palasha (Grewia asiatica) mentioned in Rasa Tarangini, which is indicated in the treatment of Granthi (tumor) is taken for the study. The present article is an extract of all the observations made during the pharmaceutical study of PKG. All these observations will be of great help when we go for large scale production. The study has tried to establish the ratios of Dravadravyas with Kshara, besides addressing the type of vessels appropriate in such preparations. After preparation of sample in different vessels, these were subjected to analytical study using relevant analytical parameters to find out any difference. During pharmaceutical process Copper vessel was found appropriate on the lines of pharmaceutical preparations. The analytical report of samples reveals no much difference in the parameter findings except pH of PKG 7.00, 9.91 and 9.46 in the vessels such as copper, iron and mud pot respectively. The particle size of Kshara was in between 429.7 to 667 nm under 15.00KV magnification 7.5 KX and EDAX report of Phalasha Kshara under 400 μm potassium Wt% 40.05 and Oxygen is Wt% 39.12. Under 50 μm potassium Wt% 48.91 and Oxygen Wt% 33.40. Under 70 μm potassium Wt% 27.90 and Oxygen Wt% 37.78. As per this study copper vesse l is found better for PKG than Iron and Mud pot for assessment of end process and also on analytical parameter.

An Efficient and Improved Process for the Synthesis of Itopride Hydrochloride and Trimethobenzamide Hydrochloride

2018 ◽  
Vol 15 (4) ◽  
pp. 572-575 ◽  
Author(s):  
Ponnusamy Kannan ◽  
Samuel I.D. Presley ◽  
Pallikondaperumal Shanmugasundaram ◽  
Nagapillai Prakash ◽  
Deivanayagam Easwaramoorthy
Keyword(s):  
Large Scale ◽  
Hydroxylamine Hydrochloride ◽  
Scale Production ◽  
One Pot ◽  
Hydrochloride Salt ◽  
Environmental Friendly ◽  
Large Scale Production ◽  
Non Ulcer Dyspepsia ◽  
Itopride Hydrochloride ◽  
Yield And Purity

Aim and Objective: Itopride is a prokinetic agent used for treating conditions like non-ulcer dyspepsia. Itopride is administered as its hydrochloride salt. Trimethobenzamide is used for treating nausea and vomiting and administered as its hydrochloride salt. The aim is to develop a novel and environmental friendly method for large-scale production of itopride and trimethobenzamide. Materials and Methods: Itopride and trimethobenzamide can be prepared from a common intermediate 4- (dimethylaminoethoxy) benzyl amine. The intermediate is prepared from one pot synthesis using Phyrdroxybenzaldehye and zinc dust and further reaction of the intermediate with substituted methoxy benzoic acid along with boric acid and PEG gives itopride and trimethobenzamide. Results: The intermediate 4-(dimethylaminoethoxy) benzylamine is prepared by treating p-hydroxybenzaldehyde and 2-dimethylaminoethyl chloride. The aldehyde formed is treated with hydroxylamine hydrochloride. The intermediate is confirmed by NMR and the purity is analysed by HPLC. Conclusion: Both itopride and trimethobenzamide were successfully synthesized by this method. The developed method is environmental friendly, economical for large-scale production with good yield and purity.

scholarly journals Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 241
Author(s):  
Shaden A. M. Khalifa ◽  
Eslam S. Shedid ◽  
Essa M. Saied ◽  
Amir Reza Jassbi ◽  
Fatemeh H. Jamebozorgi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biological Activities ◽  
Scale Production ◽  
Pharmacological Activities ◽  
Large Scale Production ◽  
Marine Products ◽  
Hiv 1 ◽  
Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

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