Role and rationale of Kaala in the field of Ayurvedic Pharmaceutics - A Conceptual Approach

Author(s):  
Vrinda Bhat ◽  
Surekha S. Medikeri ◽  
Shobha G. Hiremath

Samskara is defined as a process of bringing about a desired modification or establishing a change of property in a drug or group of drugs. In the process of Aushadhi Nirmana, varied number of procedures (Samskaras) are adopted to inculcate the desired dosage form and efficacy to the medicine. Among all Samskaras, Kaala plays a vital role in Ayurvedic pharmaceutics. Kaala is a constant factor which follows incoherently in every step of Aushadhi Nirmana. Active principles of plants vary in every season and at different quarters of the day. After the collection of drugs for a pharmaceutical preparation, Kaala plays its role during Paka of various formulations. The definition of pharmaceutics does not end with mere production of a dosage form but also includes its safety and efficacy. Kaala has the potential to influence both these factors. Thus, our Acharyas have provided meticulous information on Ayurvedic pharmaceutics giving prime importance to a minute, yet very significant aspect called “Kaala”.

Author(s):  
Steven J. R. Ellis

Tabernae were ubiquitous among all Roman cities, lining the busiest streets and dominating their most crowded intersections, and in numbers not known by any other form of building. That they played a vital role in the operation of the city—indeed in the very definition of urbanization—is a point too often under-appreciated in Roman studies, or at best assumed. The Roman Retail Revolution is a thorough investigation into the social and economic worlds of the Roman shop. With a focus on food and drink outlets, and with a critical analysis of both archaeological material and textual sources, Ellis challenges many of the conventional ideas about the place of retailing in the Roman city. A new framework is forwarded, for example, to understand the motivations behind urban investment in tabernae. Their historical development is also unraveled to identify three major waves—or, revolutions—in the shaping of retail landscapes. Two new bodies of evidence underpin the volume. The first is generated from the University of Cincinnati’s recent archaeological excavations into a Pompeian neighborhood of close to twenty shop-fronts. The second comes from a field survey of the retail landscapes of more than a hundred cities from across the Roman world. The richness of this information, combined with an interdisciplinary approach to the lives of the Roman sub-elite, results in a refreshingly original look at the history of retailing and urbanism in the Roman world.


2021 ◽  
pp. 112067212110221
Author(s):  
Daniele Giovanni Ghiglioni ◽  
Anna Maria Zicari ◽  
Giuseppe Fabio Parisi ◽  
Giuseppe Marchese ◽  
Cristiana Indolfi ◽  
...  

Vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are potentially severe and complex disease in its management among the various allergic eye diseases. In this regard, studies clarified the etiopathogenetic mechanisms. The workup should be multidisciplinary. The treatment includes topical and systemic medications with anti-inflammatory and immunosuppressant activity. However, a definition of nationally- and internationally-shared diagnostic protocols would also be needed and validated access to therapeutic options of proven safety and efficacy to avoid the use of galenic preparations, up to now still essential in the management of moderate-severe VKC. Finally, recognizing VKC and AKC, among rare diseases, at a national and international level would be an essential step to allow the management of VKC with adequate timings and settings within the National Health System.


2021 ◽  
Vol 7 (1) ◽  
pp. 439
Author(s):  
Lailatul Jannah ◽  
Mega Tri Herawati ◽  
Istiana Rachmawati

Bengkok land is village property in the form of village land. This bent land is widely known as village treasury land or village property. The definition of bent land itself is not explicitly regulated in statutory regulations. The definition of crooked land is implicitly regulated by statutory regulations. Based on the explanation of Article 72 of Law Number 6 of 2014 concerning Villages (hereinafter referred to as the Village Law), it is stated that bent land is the result of business. The provisions in Law Number 6 of 2014 concerning Villages indicate that Village Treasury Land or village assets which include bent land are certified in the name of the Village Government. In addition, the Regulation of the Minister of Home Affairs of the Republic of Indonesia Number 1 of 2016 concerning Village Asset Management, regulates the same thing as Law Number 6 of 2014 concerning Villages. This research approach uses a statutory approach (statute approach) and a conceptual approach (conceptual approach). Based on the research results, which crooked land that is starting to lose its existence is certified in the name of the Village Government


2021 ◽  
Vol 2 (2) ◽  
pp. 297-301
Author(s):  
Ida Ayu Mas lndriani ◽  
Ni Made Jaya Senastri ◽  
Ni Made Puspasutari Ujianti

Intellectual property rights including industrial designs. The idea of ​​industrial design safety is based on the belief that human imagination, taste and initiative are closely linked to industrial design. The state grants protection against new industrial designs. The definition of the rule of law used in the legal protection of industrial designs is based on Law No. 31 of 2000. One of the components in this case is the protection of human rights which is the guideline for the legal protection of industrial designs. There are two forms of industrial design legal protection, which include preventive legal protection and repressive legal protection. This study aims to examine the form of legal protection for industrial designs based on Law No. 31 of 2000 and analyze the legal implications if the design rights holder does not register their industrial designs. This research was designed using normative research with a conceptual approach. The data used are primary and secondary data obtained through documentation and recording. The results of the study indicate that preventive legal protection is contained in the Act which is used to prevent violations and a description of the implementation of obligations while repressive legal protection is security in the form of sanctions for violations that have been committed. In view of this and considering the existence of protection in the form of the industrial design law, the designer can prevent the occurrence of plagiarism of his industrial design by registering his industrial design.


2021 ◽  
Author(s):  
Xavier Rubio-Campillo ◽  
Eduard Ble ◽  
Àngels Pujol ◽  
Roger Sala ◽  
Robert Tamba

Landscape plays a vital role in the development of military campaigns through the definition of geostrategic landmarks that structure the control of the territory, the imposition of constraints to the movement of armies, and the identification of positions that facilitate defensive tactics against aggressors. These factors are linked to the study of past spatial mobility which is typically performed using Least-Cost Path analysis (LCP). LCP identifies the optimal route that connects any two given points based on minimizing the accumulated cost based on a friction surface map, thus allowing archaeologists to identify the most efficient pathways across a territory. The main challenge of LCP analysis for archaeological regions is that optimal pathways are not well suited to define general mobility patterns within highly uncertain scenarios. Connectivity modelling based on Circuit Theory (CT) is an alternative approach to the study of mobility. CT does not generate a single path like LCP does; it captures the connectivity of an entire region identifying not only optimal paths, but also bottlenecks, dead-ends and any other spatial feature that may impact movement.We present here a framework to study landscapes of conflict using connectivity modelling; the framework combines CT, visibility analysis and statistical hypothesis testing to understand the reasons behind the assault and destruction of Puig Ciutat (NE Iberian Peninsula) during Julius Caesar's civil war. Results suggest that the site exerted decisive control over a highly connected area linking two possible logistical bases (Emporion and Massalia) to the armies fighting at Ilerda (49 BC).


Author(s):  
Alan W. Brown ◽  
David J. Carney ◽  
Edwin J. Morris ◽  
Dennis B. Smith ◽  
Paul F. Zarrella

A central theme of this book is the three-level approach to CASE environment design and construction that distinguishes conceptual issues (the services) from implementation issues (the mechanisms) and stresses the need for a design context (the process) that the CASE environment must support. Previous chapters have discussed this theme, as well as provided insight into a conceptual model that identifies and classifies the services that might be found in a CASE environment. However, regardless of the service model or conceptual approach selected, environment builders must eventually face the bottom-line decision of how to actually carry out tool integration. The choices they face in terms of potential mechanisms are numerous and include a full range of selections that provide varying degrees of effort and integrated capability. In this chapter, we first consider the properties of integration by continuing the discussion of integration as a relationship (see Section 2.2). In this discussion (Section 5.2), we highlight properties that are addressed by various integration mechanisms. Later sections of this chapter focus on the specific relationship between two particular classes of integrating mechanisms: those based on the sharing or transfer of data between tools (data integration), and those based on synchronization and communication between tools (control integration). In Section 2.2 we introduced the concept put forward by Thomas and Nejmeh that integration can be considered by defining the properties required of the relationships between different environment components. Their definition of integration is exclusively a conceptual view, and is independent of the particular technology being used to implement that integration.


2019 ◽  
Vol 99 (8) ◽  
pp. 1056-1068 ◽  
Author(s):  
Christina Ziebart ◽  
Joy C MacDermid

AbstractBackgroundMany practitioners experience complex, uncertain, and unique clinical practice situations that can be navigated with reflection. Little is known about the theoretical and pragmatic perspectives of reflection in physical therapy.PurposeThe purpose of this paper was to examine the literature on reflection in physical therapy and identify gaps in the literature.Data SourceThe Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, EMBASE, Scopus, and PsycINFO were used to identify articles.Study SelectionStudies were selected to describe: (1) theoretical concepts related to reflection, (2) examples of reflection, and (3) the use of reflection in clinical or educational contexts.Data ExtractionAuthors, year of publication, country of origin, publication type or source, methodology, conceptual approach (including terminology used, definition of terminology used), and practical approach (including theoretical underpinning, context of reflection/reflective practice, and target group) guided the data extraction.Data SynthesisA total of 46 articles were reviewed spanning from 1992 to 2017, which included research studies, field articles, editorials, and a review article. Theoretical underpinnings of reflection were based on the thoughts of Donald Schön. Written approaches to reflection were most common, and reflection was used to inform education, clinical practice, and professional growth.LimitationsAs with any review paper, there is a certain level of interpretation required when collating and interpreting data.ConclusionsReflection in physical therapy could be advanced by a thorough conceptualization of reflective practice, a broader and deeper pool of research to inform optimal implementation of reflection across the career span from learners to experts, and a clear definition and linkage of reflection to epistemologies of physical therapy practice.


2010 ◽  
Vol 7 (4) ◽  
pp. 1326-1333 ◽  
Author(s):  
Freddy H. Havaldar ◽  
Dharmendra L. Vairal

A simple, specific, accurate and economical gradient reversed phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for the determination of glimipiride, rosiglitazone and pioglitazone hydrochloride. Separation was achieved with a nucleodur C–18 column having 250×4.6 mm i.d. with 5 µm particle size and water HPLC grade adjusted to pH 3.0 using diluted orthophosphoric acid and acetonitrile (80:20 v∕v) with gradient program as eluent at a constant flow rate of 0.8 ml per min. UV detection was performed at 215 nm. The retention time of glimipiride, rosiglitazone and pioglitazone hydrochloride were about 17.9 min, 6.31 min and 8.24 min respectively. This method is simple, rapid and selective and can be used for routine analysis of antidiabetic drugs in pharmaceutical preparation. The proposed method was validated and successfully used for estimation of glimipiride, rosiglitazone and pioglitazone hydrochloride in the pharmaceutical dosage form.


2018 ◽  
Vol 1 (2(14)) ◽  
pp. 105-116
Author(s):  
Inna Illivna Strelchenko ◽  
Vitalina Vitaliivna Komirna ◽  
Inna Oleksandrivna Arakelova

Urgency of the research. In the light of changes in the global security system, the problem of an adequate assessment of economic security in a regional context is acute. Existing methods provide for the calculation of a complex indicator or system of indicators for assessing economic security. Instead, the realities of today require a revision of the conceptual approach to the definition of "economic security", which will take into account the impact of the processes of interpenetration and the integration of economic systems of individual regions. Target setting. The problem of finding and testing new methods to assess the economic security of regions arises. Actual scientific researches and issues analysis. A considerable amount of research is devoted to the quantitative and qualitative assessment of the country's economic security. The classic approach to assessing economic security involves calculating the integral index and does not take into account the integration of individual regions and the country as a whole into world markets. Uninvestigated parts of general matters defining. The need to change the angle of view on the monitoring of regional economic security arose in connection with: an increase in the scale and acceleration of the processes of globalization; difficult geopolitical situation in the country. The research objective. The purpose of this study is to assess the feasibility of combining theoretical approach and indicative of the theory of open systems to assess the level of economic security of the region. The statement of basic materials. In this work an algorithm for using the apparatus of the theory of neural networks for the estimation of the economic system of the regions is developed. The obtained economic-mathematical model allows to perform clusterization of territorial units according to selected indicators of economic security. Testing of the developed algorithm is conducted on the basis of data on the state of economic development of the regions of Ukraine. Conclusions. The result of the simulation is a cluster structure that divided the totality of regions of Ukraine into four clusters according to selected classification characteristics. The results obtained have a clear economic interpretation.


Yuridika ◽  
2019 ◽  
Vol 34 (2) ◽  
pp. 215
Author(s):  
Adrian Adhitana Tedja ◽  
Erni Agustin

The increase of economic growth in Indonesia can not ignore the increasing growth of business in property by the Indonesia people. Investors does not only focus on doing business on land and landed house, but also the emergence of apartment and condominium answers the necessity towards the scarcity of land. Various form of property investment is offered, one of which is investment in the form of condotel. Condotel or condominium hotel is a new form of business in Indonesia without any specific regulation which regulates it. First, the definition of condotel is a form of high-rise building which can be owned separately and consist of joint land, joint property, and joint parts which is functioned as a hotel. These function as a hotel that needs condotel management contract to alter a regular apartment into a condotel. Condotel management contract is an innominate contract therefore it needed a further study to analyze its clauses, such as management obligation, profit sharing, duration, and discharge of contract. The characteristics of condotel management contract includes irrevocable power of attorney and obligation of building care and maintenance as well as legal relationship between the owner of condotel unit and the third parties. Understanding the characteristics of condotel management contract will determine the person liable for damages caused. This research uses normative method of research and uses statute as well as conceptual approach.


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