GENERAL OVERVIEW OF PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL OF RHEUM PALMATUM (CHINESE RHUBARB)

2020 ◽  
pp. 5-9
Author(s):  
AAMIR KHAN KHATTAK ◽  
SYEDA MONA HASSAN ◽  
SHAHZAD SHARIF MUGHAL
Keyword(s):  
Mineral Elements ◽  
Holistic Health ◽  
Chronic Illnesses ◽  
Traditional System ◽  
Rheum Palmatum ◽  
Therapeutic Uses ◽  
Anthraquinone Derivatives ◽  
Antiviral Activities ◽  
Aloe Emodin ◽  
Pharmacological Potential

Recent probe of medicinal plants incorporated in traditional systems for curing infection and sustaining holistic health, has exposed good sum of therapeutic efficiency against deleterious infections and chronic illnesses. Rheum palmatum (Chinese Rhubarb, family Polygonaceae) is a significant medicinal herb, which finds an extensive use in Unani (Traditional) system of medicine. It has been traditionally employed as antiseptic, liver stimulant, diuretic, diabetes, stomachic, purgative/cathartic, anticholesterolemic, antitumor, Alzheimer’s, Parkinson’s, tonic, antidiabetic, and wound healer. The most vital components from Rheum palmatum are the phenolics, flavonoids, terpenoids, saponins, and anthraquinone derivatives such as aloe-emodin, chrysophanol, physcion, rhein, emodin and its glucorhein, and glycoside. Rhubarb also contains tannins which include hydrolysable-tannins, containing glycosidic or ester bonds composed of glucose, gallic acid, and other monosaccharide’s and condensed tannins, resulting principally from the flavone derivatives leukocyanidin and catechin. In recent years, new components such asrevandchinone-1, revandchinone-2, revandchinone-3, revandchinone-4, sulfemodin8-O-b-Dglucoside, and 6-methyl-rhein and aloe-emodin have been reported from the same class. It also encompasses some macro and micro mineral elements such as Ca, K, Mn, Fe, Co, Zn, Na, Cu, and Li. Anthraquinone derivatives demonstrate evidence of anti-microbial, antifungal, anti-proliferative, anti-Parkinson’s, immune enhancing, anticancer, antiulcer, antioxidant, and antiviral activities. This review article covers published study on therapeutic uses of different constituents from rhubarb.

scholarly journals Phytochemistry, Ethnopharmacological Uses, Biological Activities, and Therapeutic Applications of Cassia obtusifolia L.: A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6252
Author(s):  
Md Yousof Ali ◽  
Seongkyu Park ◽  
Munseog Chang
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Pharmacological Properties ◽  
Cassia Obtusifolia ◽  
Antiplatelet Aggregation ◽  
Natural Remedy ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anthraquinone Derivatives ◽  
Aloe Emodin

Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, and natural remedy for treating headache, dizziness, constipation, tophobia, and lacrimation and for improving eyesight. It is commonly used in tea in Korea. Various anthraquinone derivatives make up its main chemical constituents: emodin, chrysophanol, physcion, obtusifolin, obtusin, au rantio-obtusin, chryso-obtusin, alaternin, questin, aloe-emodin, gluco-aurantio-obtusin, gluco-obtusifolin, naphthopyrone glycosides, toralactone-9-β-gentiobioside, toralactone gentiobioside, and cassiaside. C. obtusifolia L. possesses a wide range of pharmacological properties (e.g., antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, and neuroprotective properties) and may be used to treat Alzheimer’s disease, Parkinson’s disease, and cancer. In addition, C. obtusifolia L. contributes to histamine release and antiplatelet aggregation. This review summarizes the botanical, phytochemical, and pharmacological features of C. obtusifolia and its therapeutic uses.

scholarly journals A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3138
Author(s):  
Komal Rizwan ◽  
Shakeel Ahmad Khan ◽  
Ikram Ahmad ◽  
Nasir Rasool ◽  
Muhammad Ibrahim ◽  
...  
Keyword(s):  
Neurological Diseases ◽  
Economic Value ◽  
Nutritional Composition ◽  
Pharmacological Properties ◽  
Human Beings ◽  
Therapeutic Uses ◽  
Cosmetic Industry ◽  
Pharmacological Potential ◽  
Pharmaceutical Agents ◽  
Promising Source

Viola betonicifolia (Violaceae) is commonly recognized as “Banafsha” and widely distributed throughout the globe. This plant is of great interest because of its traditional, pharmacological uses. This review mainly emphases on morphology, nutritional composition, and several therapeutic uses, along with pharmacological properties of different parts of this multipurpose plant. Different vegetative parts of this plant (roots, leaves, petioles, and flowers) contained a good profile of essential micro- and macronutrients and are rich source of fat, protein, carbohydrates, and vitamin C. The plant is well known for its pharmacological properties, e.g., antioxidant, antihelminthic, antidepressant, anti-inflammatory, analgesic, and has been reported in the treatment of various neurological diseases. This plant is of high economic value. The plant has potential role in cosmetic industry. This review suggests that V. betonicifolia is a promising source of pharmaceutical agents. This plant is also of significance as ornamental plant, however further studies needed to explore its phytoconstituents and their pharmacological potential. Furthermore, clinical studies are needed to use this plant for benefits of human beings.

scholarly journals Antiviral properties of chalcones and their synthetic derivatives: a mini review

Pharmacia ◽  
2020 ◽  
Vol 67 (4) ◽  
pp. 325-337
Author(s):  
Radoslav Marinov ◽  
Nadezhda Markova ◽  
Stefka Krumova ◽  
Kamelia Yotovska ◽  
Maya M. Zaharieva ◽  
...  
Keyword(s):  
Antiviral Effect ◽  
Mechanisms Of Action ◽  
General Information ◽  
Structural Requirements ◽  
Aromatic Ketones ◽  
Antiviral Activities ◽  
Induction Of Apoptosis ◽  
Pharmacological Potential ◽  
Synthetic Derivatives

Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions. Recent scientific advances show that chalcones exhibit different bio-medical activities, including antiviral, which is related to the variety substitutions. This review provides general information on the origin, sources, virucidal and direct antiviral properties of chalcones in vitro, as well as a brief overview of the possible application and molecular modes of action of these compounds. The antiviral effect of chalcones probably results from the disruption of the different stage of viral replication cycle, inhibition of viral or cell enzymes, induction of apoptosis and others. Structural requirements for antiviral activities vary according to the mechanisms of action. Based on the published information, it could be considered that synthetic chalcones are very perspective antiviral candidates and deserve further studies for elucidating of their pharmacological potential.

scholarly journals COVID-19 prevention and management: Potential applications of humic substances

2021 ◽  
Vol 2 (2) ◽  
pp. 61
Author(s):  
Diksha Koul ◽  
Jasmine K. Khosla ◽  
Ravi S. Manhas ◽  
Devtulya Chander ◽  
Asha Chaubey
Keyword(s):  
Humic Substances ◽  
Specific Treatment ◽  
Vital Role ◽  
Traditional System ◽  
Potential Applications ◽  
Current Scenario ◽  
Antiviral Activities ◽  
And Control ◽  
Survival Of The Fittest ◽  
Better Than

Background: COVID-19 pandemic has forced the human population to rethink over the lifestyle and food habits being followed by them. During the current scenario, when cases of more virulent new strain are emerging and specific treatment are still underway, we must look back to the Darvin’s theory of “Survival of the fittest” and in order to sustain the pandemic, we must follow the rule “Prevention is better than cure”. Traditional Medicinal System can bring possible solution including prevention and control of COVID-19. Humic substances have been used for antiviral activities, signifying that it has potential applications in the management and prevention of infectious diseases. Summary: Present article is focused on the assessment of the naturally occurring humic substances, which are major constituents of Shilajit, being used in traditional system of medicine and can be used against for the prevention of COVID-19. Key message: Humic substances not only improve the immune system, but also have anti-inflammatory, antioxidant and antiviral activities against human RNA viruses. Therefore, while the entire world is preparing to deal with alarming threat of community spread of COVID-19, Humic substances may play a vital role in improving the innate immunity for prevention and management of SARS-CoV-2 infection

scholarly journals Dalchini (cinnamomum zeylanicum): a versatile spice with significant therapeutic potential

2021 ◽  
pp. 126-136
Author(s):  
Shifali Thakur ◽  
Bhawna Walia ◽  
Gitika Chaudhary
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Active Principle ◽  
Cinnamomum Zeylanicum ◽  
Traditional System ◽  
Therapeutic Uses ◽  
Chewing Gums ◽  
Ancient Times ◽  
Modern Era ◽  
Anti Hiv

Cinnamomum zeylanicum is a widely utilized condiment for its therapeutic uses since ancient times. It is indigenous to Sri Lanka and Southern India. Cinnamon is one of the ancient spice which belongs to the Lauraceae family. In the modern era, it is widely used in industrial products like candies, chewing gums, mouthwash, and toothpaste. It is a well-considered plant remedy used in the treatment of many diseases in a traditional system like Ayurveda and the Folk system of medicine. It is used in many polyherbal formulations for curing various ailments. The plant is enriched with many vital oils and other derivatives such as cinnamaldehyde, cinnamic acid, and cinnamate. Eugenol is the active principle constituent associated with many biological activities. The main therapeutic actions of the plant are antimicrobial, wound healing, antidiabetic, anti-HIV, anti-anxiety, and anti-Parkinson’s. The present review has summarized the therapeutic and pharmacological value of Cinnamomum zeylanicum along with its utilization in the Folklore medicinal system.   

Therapeutic uses of Vilwa (Aegle marmelos) in Ayurveda with Pharmacological Evidence

2021 ◽  
pp. 51-54
Author(s):  
Purnendu Panda ◽  
Banamali Das ◽  
G.C. Bhuyan ◽  
M.M. Rao
Keyword(s):  
Indian Subcontinent ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Therapeutic Effects ◽  
Gi Tract ◽  
Aegle Marmelos ◽  
Traditional System ◽  
Therapeutic Uses ◽  
Irritable Bowel

Aegle marmelos, a plant indigenous to India has been used by the inhabitants of the Indian subcontinent for over 5000 years. The leaves, bark, roots, fruits and seeds are used extensively in the Indian traditional system of medicine the Ayurveda and in various folk medicine to treat myriad ailments. It possesses broad range of therapeutic effects that includes free radical scavenging, antioxidant, inhibition of lipid peroxidation, antibacterial, antiviral, anti-diarrheal, gastroprotective, antiulcerative colitis, hepatoprotective, anti-diabetic, cardioprotective and radioprotective effects.In Ayurveda it has been used for the treatment of Atisara (loose stool), Pravahika (dysentery), Shoth (generalised or localised swelling), Gulma (localised gas in abdominal region), Arsha ( haemorrhoids), Grahani (irritable bowel syndrome), Pandu (anaemia), Shvasa (respiratory disorders), Hikka (hiccough), Kasa (cough), Parshwashula (pain in chest bilaterally), Hritshula (cardiac problems), Udararoga (disorders of GI tract), Halimaka (a type of jaundice), Vataroga (nervine disorder).

scholarly journals Bioactive anthraquinones found in plant foods interact with human serum albumin and inhibit the formation of advanced glycation endproducts

2018 ◽  
Vol 4 ◽  
Author(s):  
Weixi Liu ◽  
Ang Cai ◽  
Rachel Carley ◽  
Robert Rocchio ◽  
Zoe M. Petrovas ◽  
...  
Keyword(s):  
Protein Structure ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Advanced Glycation Endproducts ◽  
Critical Role ◽  
Titration Calorimetry ◽  
Vis Spectroscopy ◽  
Anthraquinone Derivatives ◽  
Aloe Emodin

The glycation of human serum albumin (HSA) plays a critical role in the development of many disorders. Herein, the anti-glycation effects of several natural dietary anthraquinone derivatives including aloin, aloe-emodin, chrysophanol, emodin, physcion, and rhein were evaluated. The anthraquinones at 100 μM reduced fructose-, methylglyoxal-, and glyoxal-induced HSA glycation by 21% (aloe-emodin) to 92% (aloin), 17% (physcion) to 94% (emodin), and 16% (anthraquinone) to 67% (emodin), respectively. These anthraquinone derivatives also protected HSA by maintaining its free amino acid residues and secondary protein structure as characterized by circular dichroism. The mechanisms of their anti-glycation effects were investigated using rhein as a representative anthraquinone. The interactions between rhein and HSA were evaluated by biophysical characterizations, namely, isothermal titration calorimetry and UV-vis spectroscopy as well as computational modeling. Our findings suggest that the anti-glycation effects of these anthraquinones may be attributed to their binding capacity and stabilization of the HSA protein structure.

Aconitum heterophyllum Wall. ex Royle; an endemic, highly medicinal and critically endangered plant species of Northwestern Himalaya in peril

2021 ◽  
Vol 07 ◽  
Author(s):  
Zishan Ahmad Wani ◽  
Shreekar Pant
Keyword(s):  
Biologically Active ◽  
Critically Endangered ◽  
Conservation Strategies ◽  
Endangered Plant ◽  
Important Ingredient ◽  
Therapeutic Uses ◽  
In The Wild ◽  
Pharmacological Potential ◽  
Endemic Medicinal Plant ◽  
Aconitum Heterophyllum

: Aconitum heterophyllum is a precious endemic medicinal plant of Northwestern Himalaya. It possesses a number of curative effects and is accounted for having diuretic, hepatoprotective, antipyretic, analgesic, antioxidant, alexipharmic, anodyne, anti-atrabilious, expectorant, immunostimulant, febrifuge, anthelminthic, anti- cancerous, anti-diarrhoeal, anti-emetic, anti-inflammatory, anti-flatulent, anti-periodic, anti-phlegmatic, anti-diabetic, antifungal, antimicrobial, antiviral and carminative properties. Further, it is an important ingredient of many Ayurvedic formulations. Its pharmacological potential may be attributed to of the presence of many biologically active phytochemicals like aconitine, mesaconitine, acetylaconitine, heterophylline A, and heterophylline B. Owing to its high therapeutic uses and market value, the plant is being exploited for its tubers from the wild. Further, there are some reproductive constraints due to which the population of the plant in the wild is waning at a rapid rate. Due to these factors, Aconitum heterophyllum has been categorized as critically endangered; demanding focused conservation strategies and cultivation efforts.

scholarly journals MEDICINAL PROPERTIES OF DIFFERENT PARTS OF ACACIA NILOTICA LINN (BABUL), ITS PHYTOCONSTITUENTS AND DIVERSE PHARMACOLOGICAL ACTIVITIES

2020 ◽  
pp. 8-14
Author(s):  
RUSHDA SAEEDI ◽  
ARSHIYA SULTANA ◽  
KHALEEQUR RAHMAN
Keyword(s):  
Acacia Nilotica ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Unani Medicine ◽  
Therapeutic Uses ◽  
Medicinal Properties ◽  
Antihypertensive Properties ◽  
Different Parts

Acacia nilotica Linn commonly known as Babul is a multipurpose tree. As the world is turning back towards the herbal drug, it is the need of the hour to re-evaluate the knowledge of traditional medicine through vast review. In the Unani traditional system of medicine, all parts of the plant have been used as a remedy for various diseases and are imputed for their medicinal properties. Hence, this review presents an overview of the medicinal properties of different parts of A. nilotica L. used in Unani medicine, its phytochemical constituents, and diverse pharmacological activities. The information related to this drug was retrieved using the classical Unani sources viz., Al-Qanun fi’l Tibb (Canon of Medicine), Iksir-i-A‘zam, Al Hawi fi’l Tibb (Continens Liber), Tarjuma Kamil al-Sana‘a al-Tibbiyya, Dhakhira Khawarizm Shahi, Biyaz-i-Kabir and Tibb-i-Akbar for medicinal properties used in Unani Medicine. Further for other traditional uses, phytoconstituents and pharmacological activities, different search engines like PubMed, Medline, Google Scholar, Ovid, Science Direct and Scopus were also browsed. A. nilotica possesses various medicinal properties as per classical Unani texts such as astringent, tonic, wound healing, aphrodisiac, expectorant, resolvent, and antispasmodic. In vivo, in vitro, and clinical studies from the published articles validate the fact that A. nilotica is a potential source of various bioactive compounds having various pharmacological properties and therapeutic uses. The various pharmacological activities are anti-inflammatory, analgesic, antibacterial, anticancerous, antidiabetic and antihypertensive properties. This review concludes that the Unani medicinal effects of A. nilotica are proven by scientific studies.

Sign in / Sign up

Export Citation Format

Share Document