scholarly journals EFFECT OF TRIDAXPROCUMBENS EXTRACTS ON BLOOD CLOTTING

2019 ◽  
pp. 8-13
Author(s):  
Atchade S. Pascal ◽  
Hoteyi Ismael ◽  
Seibou Toleba Soumanou ◽  
Bello Kaokab ◽  
Sezan Alphonse
Keyword(s):  
Platelet Count ◽  
Blood Clotting ◽  
Bleeding Time ◽  
Blood Parameters ◽  
The Body ◽  
Free Access ◽  
Phytochemical Screening ◽  
Coagulation Time ◽  
Access To Water ◽  
The Mean

Objective: The present work has focused on evaluating the effect of tridaxprocumbens on blood clotting.Methods: in the course of our study we have therefore carried out a Hydro ethanol extraction (50/50), Liquid-Solid extraction, and phytochemical screening. Thereafter our study was carried out on nine (09) male and female Wistar type rats aged from 10 to 12 w and weighing between 100 and 200 g. These animals were raised at the laboratory of Biomembranes Laboratory and Cell Signaling from FAST to UAC under standard environmental conditions. Animals have free access to water and food. 09 rats are experienced, divided in three batches of 3 rats each, submitted respectively to the following treatment: fed with distilled water, fed with 100 mg/kg P. C tridax extract procumbens, fed at 300 mg/kg P. C tridax extract procumbens. Evolution of the weight of rats during treatment was measured. After 7 d of treatment, the blood of the rats is taken for an experience of bleeding time, experience of coagulation time, and dosage of some blood parameters (platelet, partial thromboplastin, prothrombin).Results: Phytochemical screening carried out on the leaf and stem powder of Tridaxprocumbens revealed the presence of phenolic compounds, flavonoids, reducing sugar, mucilage, terpene and sterol, but at varying proportions. After 7 d of treatment, evaluation of the effect of the extractions on the body weight of the rats gave interesting conclusions. The weight of the control rats did indeed increase while that of the rats treated with the dose of (100 and 300 mg/kg) dropped. In addition, the effect of the hydroethanolic extract of the leaves and stems of Tridaxprocumbens on the coagulation of blood has been studied in order to verify the alleged property that the said extract can be used to manage bleeding. This was done by examining the effect of the extract on bleeding time, coagulation time, platelet count, activated partial thromboplastin time and prothrombin rate. These were carried out using the Duke method and the Lee and White method. In the bleeding time experiment, the mean time without adding the extract was 2.58±0.31 min, while the mean bleeding time after treatment with the extract was 1.61±0.70 min at a dose of 100 mg/kg PC and 1.77±0.69 min at a dose of 300 mg/kg PC, achieving 57% of the decrease in normal bleeding time. Thus the extract significantly lowers the bleeding time.When the extract was used for the coagulation time, it was found that the extract promotes blood clotting. In addition, this study reveals that Tridaxprocumbens significantly influences TCA, TP and platelet count at varying doses.Conclusion: The plant material studied in this study is, therefore, a credible alternative for an effective fight against bleeding and also promotes the coagulation of blood.

Body Temperature of the Camel and Its Relation to Water Economy

1956 ◽  
Vol 188 (1) ◽  
pp. 103-112 ◽  
Author(s):  
Knut Schmidt-Nielsen ◽  
Bodil Schmidt-Nielsen ◽  
S. A. Jarnum ◽  
T. R. Houpt
Keyword(s):  
Body Temperature ◽  
Water Conservation ◽  
Skin Surface ◽  
Diurnal Variations ◽  
The Body ◽  
Free Access ◽  
Heat Gain ◽  
Hot Environment ◽  
Access To Water ◽  
The Given

The rectal temperature of normal healthy camels at rest may vary from about 34°C to more than 40°C. Diurnal variations in the winter are usually in the order of 2°C. In summer the diurnal variations in the camel deprived of drinking water may exceed 6°C, but in animals with free access to water the variations are similar to those found in the winter. The variations in temperature are of great significance in water conservation in two ways. a) The increase in body temperature means that heat is stored in the body instead of being dissipated by evaporation of water. At night the excess heat can be given off without expenditure of water. b) The high body temperature means that heat gain from the hot environment is reduced because the temperature gradient is reduced. The effect of the increased body temperature on heat gain from the environment has been calculated from data on water expenditure. These calculations show that under the given conditions the variations in body temperature effect a considerable economy of water expenditure. The evaporative heat regulation in the camel seems to rest exclusively on evaporation from the skin surface (sweating), and there is no apparent increase in respiratory rate or panting connected with heat regulation. The evaporation from isolated skin areas increases linearly with increased heat load. The critical temperature at which the increase sets in is around 35°C. The fur of the camel is an efficient barrier against heat gain from the environment. Water expenditure is increased in camels that have been shorn.

Effect Of Prednisone On Platelet Function In Patients With Bleeding Disorders

1981 ◽  
Author(s):  
R McKenna ◽  
F Bachmann ◽  
O Pichairut ◽  
B Whittaker
Keyword(s):  
Platelet Count ◽  
Platelet Function ◽  
Bleeding Time ◽  
Platelet Factor ◽  
Von Willebrand's Disease ◽  
Von Willebrand’S Disease ◽  
Before And After ◽  
History Of ◽  
The Mean ◽  
One Year

There is considerable controversy regarding the effect of Prednisone on the hemostatic mechanism of normal people versus patients with bleeding diatheses. We administered Prednisone 15 mg TID to patients with a positive history of a bleeding disorder, and evaluated the bleeding time and other in-vitrc tests of platelet function prior to and between the 5th and 7th day after Prednisone.Eleven patients were admitted into this study over a one year period. All patients had a history of excessive bruising, epistaxis, bleeding after dental extractions, and gastrointestinal or other bleeding in various combinations. Two out of the eleven had template bleeding times of greater than 15 minutes both before and after the Prednisone. These two patients were subsequently proven to have von Willebrand’s disease by the washed platelet ristocetin assay. In the remaining 9 patients, the pre-Prednisone bleeding time was 9.3 ±3.7 minutes (x ± 1 S.D.) whereas the post-Prednisone bleeding time was 5.8 ±3.6 minutes (x ±1 S.D.). These results were significant(td=3.83;df:7;p=0.007).Platelet aggregation in response to exogenous ADP (1 μM, 3 μM) Sigma bovine tendon collagen (1.8 mg/ml F) and epinephrine (5.5 × 104M), platelet retention in a glass bead column or platelet factor 3 availability did not improve or worsen after Prednisone therapy. The mean platelet count of 328,000±94,000 (x ±1 S.D.) was significantly (p=0.05) higher than the mean pre-Prednisone platelet count of 268,000±77,000 (x ±1 S.D.).In conclusion, we have shown that large doses of Prednisone appear to shorten the bleeding time in patients with significant defects in the primary hemostatic mechanism. However the bleeding time improvement is not evident in patients with von Willebrand’s disease.

Effects of biological variations on platelet count in healthy subjects in China

2004 ◽  
Vol 91 (02) ◽  
pp. 367-372 ◽  
Author(s):  
Jing Yang ◽  
Xiaojun Lu ◽  
Tokuhiro Okada ◽  
Tamiaki Kondo ◽  
Changgeng Ruan ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Healthy Subjects ◽  
Bleeding Time ◽  
Platelet Volume ◽  
Platelet Counts ◽  
Normal Platelet Count ◽  
Normal Platelet ◽  
Low Platelet Count ◽  
The Mean

SummaryThe effects of biological variations on platelet counts were investigated in 694 healthy subjects aged 18 to 60 years living in three cities including Chengdu (Sichuan Province), Suzhou (Jiangsu Province) and Harbin (Heilongjang Province) in China. Platelet counts in healthy subjects were significantly lower in Chengdu (52∼202 X 109/L) and Suzhou (60∼259 X 109/L) than in Harbin (154∼348 X 109/L)(p <0.0001), but the mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, the MPV values were significantly higher in Chengdu (11.8∼15.6 fl) and Suzhou (10.9∼15.8 fl) than in Harbin (9.5∼12.9 fl) (p < 0.0001). Platelet counts were significantly higher in summer (73∼289 X 109/L) than in winter (52∼202 X 109/L) (p <0.0001), but the MPV values were lower in summer (11.2∼14.7 fl) than in winter (11.8∼15.6 fl) (p <0.05) in Chengdu. Platelet associated immunoglobulin (PA-IgG) in Chengdu was revealed to be significantly higher in the low platelet count group (<150 X 109/L, 13.5 ± 7.1 ng/107 PLT) than in the normal platelet count group (≥150 X 109/L, 8.3 ± 2.7 ng/107 PLT)(p <0.0001). Similar results were observed in Suzhou for the reticulated platelet ratio, which was significantly higher in the low platelet count group (19.5 ± 7.1%) than in the normal platelet count group (11.6 ± 2.7%)(p <0.01). The bleeding time in Chengdu showed a significantly longer time in the low platelet count group (8.6 ± 2.3 min) than in the normal platelet count group (6.0 ± 1.2 min)(p <0.01). With regard to the effects of lipids on platelet counts, the HDL values were significantly higher in the normal platelet count group (1.60 ± 0.76 mmol/L) than the low platelet count group (1.23 ± 0.31 mmol/L) (p <0.01); but no significant differences in cholesterol and triglycerides values between the normal and low platelet count groups (p >0.05) were recorded. These findings suggest that the platelet counts could be greatly influenced in healthy subjects by biological variations such as geographical, seasonal, and lipid variations.

scholarly journals THE EFFECT OF BLACK CUMIN SEED OIL CONSUMPTION ON CLOTTING TIME, BLEEDING TIME, AND PLATELET COUNTS IN HEALTHY-SMOKER VOLUNTEERS

2021 ◽  
pp. 88-92
Author(s):  
AKROM AKROM ◽  
NELLY RATNASARI ◽  
DJATUN NIQOTAINI
Keyword(s):  
Platelet Count ◽  
Seed Oil ◽  
Bleeding Time ◽  
Clotting Time ◽  
Healthy Smoker ◽  
Black Cumin ◽  
Platelet Counts ◽  
The Mean ◽  
Black Cumin Seed ◽  
Cumin Seed

Objective: The objective of the study was to determine the effect of consumption of black cumin seed oil (BCSO) on platelet count, clotting time (CT), and bleeding time (BT) in healthy-smoker volunteers (HSV). Methods: Participants were 39 healthy male smokers aged 18-66 y. Participants were divided into four groups randomly. The treatment group received BCSO for thirties days in 3x1, 3x2, and 3x3 capsules/day doses. The placebo group received a placebo preparation. We measured CT, BT, and platelet count on day 31. An analysis of the mean difference between CT, BT, and platelet counts was performed using one-way ANOVA. Result: The results showed that the CT, BT, and platelet counts in all groups were within normal. Consumption of BCSO for 30 d did not affect CT, BT, and platelet counts of HSV. The results of the analysis of the mean difference test between groups of CT, BT, and platelet counts indicated that there was no difference with p>0.05. Conclusion: We concluded that the 30-day BCSO consumption did not affect the CT, BT, and platelet count values in HSV.

scholarly journals PLATELET COUNTS AND PLATELET FUNCTION

Blood ◽  
1946 ◽  
Vol 1 (6) ◽  
pp. 472-496 ◽  
Author(s):  
PAUL M. AGGELER ◽  
JOAN HOWARD ◽  
S. P. LUCIA ◽  
EDITH MILLS
Keyword(s):  
Platelet Count ◽  
Platelet Function ◽  
Significant Relationship ◽  
Bleeding Time ◽  
Clot Retraction ◽  
Normal Range ◽  
Coagulation Time ◽  
Thrombocytopenic Purpura ◽  
Platelet Counts ◽  
Abnormal Bleeding

Abstract Determinations of the platelet count, clot retraction, bleeding time, capillary fragility, and coagulation time were made in 64 normal subjects and in 404 patients suffering from various diseases. The normal values for the platelet count done by an experienced technician using the Rees and Ecker method were: mean, 409,000 per cu. mm.; standard deviation, 68,000 per cu. mm.; normal range (M ± 2.σ), 273,000 per cu. mm. to 545,000 per cu. mm. There was a statistically significant relationship between the platelet count and the results of tests of clot retraction, bleeding time, and capillary fragility, but there was no significant relationship between the platelet count and the coagulation time. Factors other than platelet count or platelet function which may influence the results of these tests are discussed. The critical level of the platelet count, below which abnormal bleeding is likely to occur, was found to be approximately 190,000 per cu. mm. in primary thrombocytopenic purpura and 230,000 per cu. mm. in secondary thrombocytopenic purpura. However, platelet counts as low as 100,000 per cu. mm. were found in one patient without abnormal bleeding, and counts as high as 280,000 per cu. mm. were found in another patient with classical primary thrombocytopenic purpura. In all patients in the active phase of bleeding in primary thrombocytopenic purpura and in most with secondary thrombocytopenic purpura, the bleeding time was markedly prolonged and clot retraction was definitely diminished. In approximately one half of the patients suffering from thrombocytopenia without bleeding or from thrombocytopenia complicating other hemorrhagic states, the results of these tests were abnormal. Capillary fragility was increased in approximately three fourths of the patients with primary thrombocytopenic purpura, one half with secondary thrombocytopenic purpura, and less than one half with thrombocytopenia without bleeding or with thrombocytopenia complicating other hemorrhagic states. In the stage of recovery from thrombocytopenic purpura, dissociation of the results of the various tests was sometimes found. In some patients the platelet counts returned to normal hut abnormalities persisted in the tests of the bleeding time, clot retraction, or capillary fragility. In other patients the results of one or all of these tests returned to normal before the platelet count had reached the normal range. These results have been interpreted as evidence of variability in the functional capacity of the platelets.

scholarly journals Evaluation of Primary Screening Test for Platelet Homeostasis in Patients with Chronic Kidney Disease

2013 ◽  
Vol 21 (2) ◽  
pp. 55-57
Author(s):  
Md Nazrul Islam ◽  
Shah Md Sarwer Jahan ◽  
Shah Md Badrudduza ◽  
Md Zakir Hossain
Keyword(s):  
Chronic Kidney Disease ◽  
Platelet Count ◽  
Kidney Disease ◽  
Screening Test ◽  
Bleeding Time ◽  
Bleeding Diathesis ◽  
Platelet Function Test ◽  
Function Test ◽  
The Mean

This observational study was done on 50 cases of predialytic chronic kidney disease (CKD) patients. The aim of the study was to determination of total platelet count and bleeding time, comparison of the platelet count and bleeding time with the severity of chronic kidney disease. The mean age of the patients was 41.22±2.0 years, mean haemoglobin 4.96 ±0.32gm/dl, serum creatinine430.74± 11.92 ?mol/L, platelet count 246.50 ± 13.63x109/L and bleeding time were 4.13± 0.28 min respectively. Thrombocytopenia (<150x109/L) were found in 19(38%) cases. Bleeding time was prolonged (>9min) 6(12%) cases , among them only 4(8% ) cases were thrombocytopenic. There was no significant relationship between platelet count and serum creatinine. No correlation was found between platelet count and bleeding time. No significant correlation was also found in Bleeding time and creatinine. Therefore, it can be concluded that platelet count is highly variable in chronic kidney disease and it is not a reliable screening test for bleeding diathesis in chronic kidney disease patients. Bleeding time is the best platelet function test that correlates clinical bleeding.DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13610 Bangladesh J Medicine 2010; 21: 55-57

A CASE-CONTROL STUDY ABOUT HEMATOLOGICAL PROFILE AND MORBIDITY OF NEWBORNS AT BIRTH, BORN TO MOTHERS WITH HYPERTENSION IN PREGNANCY.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Sameer Jagrwal ◽  
Gourav Kumar Goyal ◽  
SK Tak
Keyword(s):  
Platelet Count ◽  
Bleeding Time ◽  
Gestational Hypertension ◽  
Hematological Parameters ◽  
Mean Value ◽  
Control Group ◽  
Study Group ◽  
Clotting Time ◽  
Hypertensive Disorders ◽  
The Mean

Background: Hypertensive disorders of pregnancy complicate about 8% of all gestations. Hypertensive disorders are responsible for significant maternal and perinatal morbidity and mortality. AIMS: To determine the hematological parameters and morbidity in neonates born to mothers with gestational hypertension, pre-eclampsia or eclampsia syndrome and in neonates born to normotensive mothers without any maternal complications or medical illness with special reference to platelet count and neutrophil count. Methods and Material: The study was a prospective study conducted on neonates born to pregnant women complicated with gestational hypertension, pre-eclampsia or eclampsia syndrome and neonates born to normotensive mothers recruited at Neonatal Intensive Care Unit and Post natal wards who were delivered at Ananta Hospital and AIMS & RC, Rajsamand (Raj.) from October 2018 to September 2019 and the hematological parameters of these babies were studied. Results: In our study we observed that the mean value of platelet count were significantly lower in study group compared to control group which was highly Statistical significant (p<0.001). The mean value of PT, aPTT, Bleeding Time and Clotting time were significantly higher in study group, as compared to control group. The statistical analytic differences were highly significant in all parameters i.e. PT, aPTT, Bleeding Time and Clotting time (P<0.001). Conclusion: To conclude early hematological screening of babies are recommended to facilitate early detection and management of serious neonatal complications describes above, to decrease morbidity and improved growth, development and survival. Keywords:  Pre-eclampsia, Eclampsia, Gestational Hypertension, Newborns.

Effect of weaning strategy on performance, behaviour and blood parameters of yak calves (Poephagus grunniens)

2018 ◽  
Vol 40 (3) ◽  
pp. 263 ◽  
Author(s):  
Peipei Liu ◽  
Shujie Liu ◽  
Allan Degen ◽  
Qiang Qiu ◽  
Quanmin Dong ◽  
...  
Keyword(s):  
Tibetan Plateau ◽  
Body Condition ◽  
Reproductive Performance ◽  
Blood Parameters ◽  
The Body ◽  
The Other ◽  
Free Access ◽  
Early Weaning ◽  
Calf Performance ◽  
Ad Libitum

Early weaning can improve the body condition and reproductive performance of cows, but can be very stressful to both the calf and cow. The objectives of this study were to examine and compare the performance, behaviour and blood parameters of yak calves that were weaned using different methods. Twenty-six calves (94.3 ± 2.4 days old) were assigned to four weaning treatments: (1) weaned naturally following ad libitum sucking (NW, n = 13); (2) weaned abruptly and separated permanently from their mothers (AW, n = 5); (3) separated temporarily from their mothers for 15 days and then reunited (TW, n = 5); and (4) fitted with nose plates to prevent sucking for 15 days but allowed free access to their mothers (NP, n = 3). Girth size, as a measure of calf performance, was largest in NW and AW calves, intermediate in NP calves and smallest in TW calves. This indicated that the AW calves were able to consume adequate energy to compensate for the absence of milk. The weaned calves (TW and NP) spent more time grazing and, in general, played less than NW calves. In addition, TW calves stood more but walked less, whereas NP calves lay more but grazed and stood less than NW calves. Blood insulin was lower on Day 19 in the TW calves than in the other three treatments. We concluded that abrupt and permanent weaning was an appropriate strategy for yak calves on the Qinghai-Tibetan plateau.

scholarly journals Metabolic Syndrome: What is the difference between the two definitions IDF and NCEP ATP III in Morocco? Case of the population of Marrakech

2021 ◽  
Vol 319 ◽  
pp. 01072
Author(s):  
Zineb Hannoun ◽  
Meryem Makdad ◽  
Khouloud Harraqui ◽  
Imane Boussenna ◽  
Ikram Kenfaoui ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Healthy Lifestyle ◽  
Blood Parameters ◽  
The Body ◽  
Prevention Strategies ◽  
The Metabolic Syndrome ◽  
The Mean ◽  
Spss Software ◽  
The Difference

The purpose of this study was to determine the frequency of metabolic syndrome according to the two definitions: NCEP-ATP III and IDF 2005 and to analyze their differences in a population in Marrakech, Morocco. The study was carried out at Ibn Zohr hospital in Marrakech. The body mass index (BMI) was calculated to assess the degree of obesity of each subject. The blood parameters were measured by an appropriate biochemistry automaton. The diagnosis of metabolic syndrome was made according to the definitions of NCEP-ATP III and IDF 2005. All statistical analyzes were performed using SPSS software. A total of 300 subjects participated in the study, including 57.3% of women and 42.7% of men, with a sex ratio of 0.74. The mean age of our population was 51.6 ± 13.42 years. According to NCEP-ATP III, 79 of the participants (26.3%) had the metabolic syndrome, with a predominance of women: 60 women (20.0%) and 19 men (6.3%); according to the IDF, 139 or (46.3%) of the participants had MS, in which 31.0% were women and 15.3% were men. Waist circumference and hyperglycemia were the two predominant criteria according to both definitions. The study showed that all criteria were statistically associated with the presence of MS. The metabolic syndrome is common in our population regardless of the definition criteria used. The implementation of prevention strategies and the encouragement of a healthy lifestyle will minimize serious health problems in Marrakech city.

REPLETION OF VASOPRESSIN AND OXYTOCIN IN THE POSTERIOR LOBE OF THE PITUITARY GLAND OF THE RAT

1968 ◽  
Vol 40 (3) ◽  
pp. 337-342 ◽  
Author(s):  
T. K. YOUNG ◽  
H. B. VAN DYKE
Keyword(s):  
Drinking Water ◽  
Pituitary Gland ◽  
Free Access ◽  
Posterior Lobe ◽  
Neurohypophysial Hormones ◽  
Depletion Rate ◽  
Access To Water ◽  
The Mean

SUMMARY Rats deprived of drinking water for 7 days showed a striking depletion of neurohypophysial hormones from the posterior lobe of the pituitary gland. The average daily depletion rate was estimated to be 93 m-u. for vasopressin and 97 m-u. for oxytocin. When rats were allowed free access to water, dehydration was rapidly corrected as shown by normal haematocrit values and plasma osmolarities. Repletion of neurohypophysial hormones, rapid in the first 24 hr., continued gradually thereafter. The mean calculated repletion rate was 41 m-u./day for vasopressin and 42 m-u./day for oxytocin. Repletion was completed about 14 days after rehydration.

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