scholarly journals FORMULATION AND EVALUATION OF LIPOSOMAL GEL CONTAINING EXTRACT OF PIPRINE

2020 ◽  
pp. 126-129
Author(s):  
YOGESH S. THORAT ◽  
NAGESH S. KOTE ◽  
VIRENDRA V. PATIL ◽  
AVINASH H. HOSMANI
Keyword(s):  
Room Temperature ◽  
Research Work ◽  
Herbal Extract ◽  
Piper Nigrum ◽  
Lipid Film ◽  
Hydroalcoholic Extract ◽  
Skin Repair ◽  
Pharmacological Potential ◽  
Herbal Formulations ◽  
Gel Formulations

Objective: The objective of present research work is to develop Liposomes as a carrier system for 70% Hydroalcoholic extract, its incorporation in to gel formulations and to characterize the prepared and develop Liposomal gel formulation. There are many reports revealing the pharmacological potential of Piper Nigrum. Methods: Cholestrol in various weight ratios were dissolved in 10 ml of Methanol: Chloroform (1:1) ratio used as a solvent. The extract solution was taken in a 500 ml round bottom flask. The flask was rotated in rotary flash evaporator at 40 rpm for 20 min in the thermostatically controlled water bath at 40 °C under vacuum 240 mmHg. The solvent was slowly removed by this process, and a very thin film of dry lipids was formed on the flask. The dry lipid film was slowly hydrated with 10 ml of Saline Phosphate Buffer pH 7.4 containing Insulin Drug. The flask was once again rotated at the same speed as before and at room temperature for 2 hr. The liposomal was left to overnight at 4°C, full lipid hydration. Results: This study was done for herbal formulations used for topical delivery of therapeutic agents at the time of injury to accelerate skin repair in the shortest time possible, with minimal pain. Plant Piper Nigrum. Family Piperaceac is extensively used. Conclusion: The present study revealed liposomal gel as an efficient carrier for herbal extract. Keywords: Piperine, Gel, Herbal extract, Liposomes, Liposomal gel.

scholarly journals Formulation development and evaluation of antiacne activity of ethosomal gel prepared using Plumbago zeylanica root extract

2020 ◽  
Vol 11 (4) ◽  
pp. 5511-5516
Author(s):  
Sandhya P ◽  
Snehalata J
Keyword(s):  
Physicochemical Properties ◽  
Research Work ◽  
Entrapment Efficiency ◽  
Root Extract ◽  
Formulation Development ◽  
Plumbago Zeylanica ◽  
Hydroalcoholic Extract ◽  
Drug Content ◽  
And Diffusion ◽  
Gel Formulations

The objective of present research work is, to develop an ethosome, as a carrier system for Plumbago root extract, its incorporation into gel formulations and to characterize the developed gel formulations by estimation of plumbagin content and study of antiacne activity. Roots of Plumbago zeylanica L (Plumbaginaceae) contains Plumbagin and is used for skin infections and intestinal worms. Topical therapy for acne includes comedolytic agents, antibiotics and anti-inflammatory drugs. The excessive use of antibiotics has led to the increased resistance of acne-causing bacteria. In this research work, plumbago roots have been screened for their potential use for the treatment of acne and hydroalcoholic extract of the roots was found to be effective. Seven batches (EF1-EF7) of ethosomes were prepared using soya lecithin (1-3%) and ethanol (10-45%) and the hydroalcoholic extract. The range of entrapment efficiency varied from 17.12 to 80.82%. The ethosomes EF6 having highest entrapment efficiency was incorporated into gel formulation. Carbopol 934P (0.5 -2%) was used to prepare ethosomal gel and evaluated for physicochemical properties, drug content and diffusion characteristics. The pH of the gel was in the range of 6.87 to 7.03. Viscosity was between 5600 - 9800 centipoises. The % drug content was in the range of 95.91% to 100.7%. The ethosome, in their gel formulation, showed good physicochemical properties, drug content and diffusion pattern. The anti-acne activity of F3 showed good zones of inhibition comparable with standard Clindamycin. The present study suggested ethosomal gel as an efficient carrier for plumbago root extract for antiacne activity.

scholarly journals Thermal, Viscoelastic, Mechanical and Wear Behaviour of Nanoparticle Filled Polytetrafluoroethylene: A Comparison

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1940 ◽  
Author(s):  
Levente Ferenc Tóth ◽  
Patrick De Baets ◽  
Gábor Szebényi
Keyword(s):  
Room Temperature ◽  
Filler Content ◽  
Research Work ◽  
Tensile Modulus ◽  
Al2o3 Content ◽  
Wear Behaviour ◽  
X Ray ◽  
Mechanical Stirring ◽  
Wear Analysis ◽  
Sintering Method

In this research work, unfilled and mono-filled polytetrafluoroethylene (PTFE) materials were developed and characterised by physical, thermal, viscoelastic, mechanical, and wear analysis. The applied fillers were graphene, alumina (Al2O3), boehmite alumina (BA80), and hydrotalcite (MG70) in 0.25/1/4/8 and 16 wt % filler content. All samples were produced by room temperature pressing–free sintering method. All of the fillers were blended with PTFE by intensive dry mechanical stirring; the efficiency of the blending was analysed by Energy-dispersive X-ray spectroscopy (EDS) method. Compared to neat PTFE, graphene in 4/8/16 wt % improved the thermal conductivity by ~29%/~84%/~157%, respectively. All fillers increased the storage, shear and tensile modulus and decreased the ductility. PTFE with 4 wt % Al2O3 content reached the lowest wear rate; the reduction was more than two orders of magnitude compared to the neat PTFE.

Studies Concerning the Corrosion Behaviour of the Cast Stainless Steel Used for Chemical Industry

2013 ◽  
Vol 371 ◽  
pp. 338-342
Author(s):  
Gheorghe Simionescu ◽  
Mirela Gheorghian
Keyword(s):  
Chemical Industry ◽  
Room Temperature ◽  
Corrosion Behaviour ◽  
Research Work ◽  
Experimental Tests ◽  
Hot Environment ◽  
Chemical Agents ◽  
The Subject ◽  
Materials Used ◽  
Cast Stainless Steel

The current work deals with experimental tests concerning the behaviour of different materials used in chemical industry when are exposed to diverse corrosions environments. During the research work four different metals have been tested, namely T15NiCr180, T15MoNiCr180, W4027 and W4059. The presented work is trying to classify the tested materials function to different chemical environment, different concentration of the environment, different temperature of the environment, and different expose time. Some of the substances which were considered as corrosion environment are: HNO3, H3PO4, NaCl, NH4Cl, C2H5OH, Petrol, NH4NO3, KNO3, K2CO3, Na2CO3, KMnO4, KOH and Ca (OH)2. The concentration of the corrosion solutions varies between 1% and 96%. Tests have been done at room temperature and hot environment of 100°C. Time is playing an important role on evolution of the corrosion. For this reason the samples have been analyzed after 48, 336, 720 and 2160 hours of exposes to chemical agents. To understand the comportment of the subject metals when are used in industry, samples have been tested for longer period of time, respectively 1, 3, 6 and 12 months. After each selected period of time the metallic samples were analyzed and measured to quantify the effect of the environment on the corrosion speed.

scholarly journals Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Nadia Afsheen ◽  
Khalil-ur-Rehman ◽  
Nazish Jahan ◽  
Misbah Ijaz ◽  
Asad Manzoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Medicinal Plants ◽  
Plasmid Dna ◽  
Research Work ◽  
Antioxidant Potential ◽  
Piper Nigrum ◽  
Coronary Artery Ligation ◽  
Hemodynamic Parameters ◽  
Metabolomic Profiling

In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina, Terminalia arjuna, Coriandrum sativum, Elettaria cardamom, Piper nigrum, Allium sativum, and Crataegus oxyacantha was performed. The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay. The C. oxyacantha and T. arjuna showed maximum antioxidant potential, while the E. cardamom showed poor antioxidative strength even at its high concentration. Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against H2O2 damage as compared to the plasmid DNA merely treated with H2O2. The metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential. During in vivo analysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac and hemodynamic parameters. The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal. The histopathological examination also confirmed the cardioprotective potential of HC4. Thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs.

scholarly journals Synthesis of Cu and Ce co-doped ZnO nanoparticles: crystallographic, optical, molecular, morphological and magnetic studies

2017 ◽  
Vol 35 (2) ◽  
pp. 427-434 ◽  
Author(s):  
Mohit Rawat ◽  
Jasmeet Singh ◽  
Jagpreet Singh ◽  
Chamkaur Singh ◽  
Amritpal Singh ◽  
...  
Keyword(s):  
Room Temperature ◽  
Sol Gel ◽  
Research Work ◽  
Yellow Emission ◽  
Near Band Edge ◽  
Band Edge Emission ◽  
Ferromagnetic Behavior ◽  
Magnetic Studies ◽  
Transmission Electron Microscopy Analysis ◽  
Co Doped

Abstract In the present research work, crystallographic, optical, molecular, morphological and magnetic properties of Zn1-xCuxO (ZnCu) and Zn1-x-yCeyCuxO (ZnCeCu) nanoparticles have been investigated. Polyvinyl alcohol (PVA) coated ZnCu and ZnCeCu nanoparticles have been synthesized by chemical sol-gel method and thoroughly studied using various characterization techniques. X-ray diffraction pattern indicates the wurtzite structure of the synthesized ZnCu and ZnCeCu particles. Transmission electron microscopy analysis shows that the synthesized ZnCu and ZnCeCu particles are of spherical shape, having average sizes of 27 nm and 23 nm, respectively. The incorporation of Cu and Ce in the ZnO lattice has been confirmed through Fourier transform infrared spectroscopy. Room temperature photoluminescence spectra of the ZnO doped with Cu and co-doped Ce display two emission bands, predominant ultra-violet near-band edge emission at 409.9 nm (3 eV) and a weak green-yellow emission at 432.65 nm (2.27 eV). Room temperature magnetic study confirms the diamagnetic behavior of ZnCu and ferromagnetic behavior of ZnCeCu.

scholarly journals Ultraviolet Protection Activity of Selected Herbal and Biopolymer for Textile Application

2021 ◽  
Vol 7 (03) ◽  
pp. 80-83
Author(s):  
Dr. Banupriya J and Dr. V Maheshwari
Keyword(s):  
Ultraviolet Radiation ◽  
Research Work ◽  
Herbal Extract ◽  
Ultraviolet Rays ◽  
Ft Ir ◽  
Encapsulation Method ◽  
Ultraviolet Protection ◽  
Chitosan Biopolymer ◽  
Protection Activity ◽  
Finished Sample

The textile protection of human skin against ultraviolet radiation is very important problem and over recent years researches have shown increasing interests in this area. This research work deals with the causing harm effects of ultraviolet rays and protection against them through the woven materials by using Opuntia littoralis herbal extract and Chitosan biopolymer extract with nano encapsulation method. Finishing of fabric with an eco friendly manner is getting very advanced nowadays. So, this research work is fully based on ecofriendly and skin friendly. The samples were imparted with herb and biopolymer nanocapsules which showed best results for ultraviolet protection even after 30 washes.The finished sample was analyzed for its morphology using FESEM and FT-IR.

scholarly journals The Impact of Package Type and Temperature on the Changes in Quality and Fatty Acids Profile of Table Eggs during Their Storage

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2047
Author(s):  
Kamil Drabik ◽  
Tomasz Próchniak ◽  
Damian Spustek ◽  
Karolina Wengerska ◽  
Justyna Batkowska
Keyword(s):  
Fatty Acids ◽  
Room Temperature ◽  
Research Work ◽  
Storage Period ◽  
Specific Weight ◽  
Water Conductivity ◽  
Shell Weight ◽  
Fatty Acids Profile ◽  
Lower Permeability ◽  
The Impact

The aim of the study was to evaluate the possibility of reducing changes in the quality of consumer hen eggs by storing them in various package type and under various temperature conditions (room and refrigeration). The material consisted of 960 chicken eggs packed in cardboard or plastic boxes, 10 pcs in each. Half of the packages were stored at room temperature (21 °C), the rest in the refrigerator (5 °C). The eggs were stored for 28 days qualitatively evaluated at 14-day intervals. The characteristics of whole egg (weight, specific weight, proportion of morphological elements, air cell depth) as well as of shell (weight, color, crushing strength, thickness, density, water conductivity), albumen (height, Haugh units, weight, pH) and yolk (weight, color, pH) were analyzed. The fatty acids profile of yolks was also evaluated as a freshness indicator. Packaging types available on the market, apart from its marketing and eggs protection function, can also influence the quality and stability of the product during storage. The use of plastic boxes can help to maintain higher eggs quality during the storage period, even after a significant extension of the storage time. Eggs stored in plastic boxes at room temperature had very similar results to those stored under refrigeration using conventional cardboard boxes. This effect is probably related to the lower permeability of plastic boxes in comparison to cardboard ones, but detailed research work in this direction is necessary to verify this relation.

Improving the Performance of Hydrogen Sensors with Novel TiO2 Nanotube Arrays Hybrid Structure

2019 ◽  
Vol 803 ◽  
pp. 120-123
Author(s):  
Xiong Bang Wei ◽  
Guo Dong Lv ◽  
Xiao Hui Yang ◽  
Tao Wu ◽  
Dong Shi ◽  
...  
Keyword(s):  
Room Temperature ◽  
Research Work ◽  
High Sensitivity ◽  
Hydrogen Sensor ◽  
Hybrid Structure ◽  
Nanotube Arrays ◽  
Hybrid Nanostructure ◽  
Hydrogen Sensors ◽  
Novel Structure ◽  
Titanium Wire

In this paper, a kind of novel TiO2 nanotube arrays (TNTs) hybrid structure was presented to improve the performance of hydrogen sensors. In this novel structure, palladium functionalized TNTs hybrid nanostructure supported on titanium wire. TNTs arrays was prepared by anodizing Ti wire using a standard electrochemical procedure. Pd nanomaterials were deposited on TNTs. Optimized experiments showed the hydrogen sensor supported on titanium wire showed a good response time of 8 s and high sensitivity of 94.8% at 1.9 vol% H2 at room temperature (25 °C). The research work revealed potential good hydrogen sensitivity of this kind of hybrid nanostructure.

The Effects of Electromigration to the Solder Joint Formation: A Comparison Between 99.3Sn-0.7Cu and 96.5Sn-3.0Ag-0.5Cu Lead Free Solder

2012 ◽  
Vol 622-623 ◽  
pp. 195-199 ◽  
Author(s):  
M.A.A. Mohd Salleh ◽  
A.R. Nik Nurhidayatul Suhada ◽  
Flora Somidin ◽  
Rafezi Ahmad Khairel ◽  
C.S. Lee ◽  
...  
Keyword(s):  
Solder Joint ◽  
Room Temperature ◽  
Solder Joints ◽  
Research Work ◽  
Cathode Region ◽  
Lead Free ◽  
Lead Free Solder ◽  
Joint Formation ◽  
Current Stress ◽  
Free Solder

Electromigration effects on the solder joint formation of 99.3Sn-0.7Cu and 96.5Sn-3.0Ag-0.5Cu lead-free solder with Cu electroplated Ni layer wire were investigated. The electromigration effects on the solder joints were studied after current density stressing at 1 x 103 A/cm2 in room temperature for 0 h, 120 h, and 240 h. The research work found that intermetallic compound (IMC) formation on the joint is increases for both solders with longer period of current stress applied. Higher IMC thickness growth in 99.3Sn-0.7Cu solder joint compared to 99.3Sn-0.7Cu is detected and both anode regions of the solder joints show higher IMC thickness growth compared to cathode region. Experimental results show 99.3Sn-0.7Cu solder joint is more prone to failure under current stress compared to 96.5Sn-3.0Ag-0.5Cu solder joint with thicker IMC which translates to higher brittleness.

Protective effects of fruit extracts of Hippophae rhamnoides L. against arsenic toxicity in Swiss albino mice

2006 ◽  
Vol 25 (6) ◽  
pp. 285-295 ◽  
Author(s):  
R Gupta ◽  
S JS Flora
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Room Temperature ◽  
Arsenic Concentration ◽  
Hippophae Rhamnoides ◽  
Herbal Extract ◽  
Fruit Extract ◽  
Fruit Extracts ◽  
Hippophaë Rhamnoides ◽  
Hippophae Rhamnoïdes L

Seabuckthorn (Hippophae rhamnoides L.) berry has a long history of applications as a food and medicinal ingredient in eastern countries. The present study was carried out to investigate the effect of different fruit extracts of H. rhamnoides on altered biochemical parameters indicative of haematological alterations, tissue oxidative stress, and arsenic concentration in arsenicexposed mice (2.5 mg/kg body weight, intraperitoneally). Two aqueous extracts (at room temperature and under reflux condition) and an ethanolic extract of H. rhamnoides at a dose of 500 mg/kg body weight were coadministered daily during arsenic exposure in mice for 3 weeks. Exposure to arsenic led to a significant inhibition of blood @aminolevulinic acid dehydratase (ALAD) activity, suggesting disturbed haem synthesis pathway. Arsenic also caused significant depletion of reduced hepatic glutathione (GSH) level, glutathione S-transferase (GST) and glutathione peroxidase and catalase activities, while it increased the level of thiobarbituric acid reactive substance (TBARS), suggesting liver oxidative stress. Most of the altered biochemical variables responded favorably to the co-supplementation of H. rhamnoides, particularly the aqueous fruit extract, extracted at room temperature (HF-WRT). However, arsenic concentration in blood and tissues remained unchanged, suggesting the lack of chelating property of fruit extract of H. rhamnoides. The present study, thus, led us to conclude that the fruit extract of H. rhamnoides has a significant protective role against arsenic-induced oxidative injury. However, it lacks the ability to remove arsenic from the binding sites, suggesting that the herbal extract could be co-administered with a chelating agent of known efficacy during treatment of arsenic to achieve the optimum effect of chelation treatment.

Sign in / Sign up

Export Citation Format

Share Document