scholarly journals A review on Tinospora cordifolia: as an Immunomodulating agent

2021 ◽  
pp. 6-14
Author(s):  
Pritika Devi
Keyword(s):  
Clinical Studies ◽  
Indian Subcontinent ◽  
Tinospora Cordifolia ◽  
Skin Disorders ◽  
Anti Cancer ◽  
The Family ◽  
Different Types ◽  
Anti Oxidant ◽  
Immunomodulating Property ◽  
Cancer Agent

Guduchi is a plant also known as Tinospora cordifolia, having heart shaped leave, an herb of the family Menispermaceae native of hot areas of the Indian subcontinent. In our classical Ayurvedic texts, it is indicated to be beneficial in treating various types of diseases like skin disorders, different types of fever, jaundice & gout. Guduchi also claimed to have various properties as an anti-oxidant, antihyperglycemic, antihyperlipidemic, hepatoprotective, cardiovascular protective, neuroprotective, osteoprotective, radioprotective, anti-anxiety, adaptogenic agent, analgesic, anti-inflammatory, antipyretic, athrombolytic agent, anti-diarrheal, anti-ulcer, antimicrobial and anti-cancer agent. Several experimental and clinical studies based on available reports, present paper is an attempt to assemble the information on immunomodulating property of Tinospora cordifolia

A Review on the Anti-Viral Activity of Houttuynia cordata: A Possible Herb for the Management and Treatment of COVID-19

2021 ◽  
Vol 4 (2) ◽  
pp. 3-10
Author(s):  
Emdormi Rymbai ◽  
Keyword(s):  
Vital Role ◽  
Viral Agent ◽  
Houttuynia Cordata ◽  
Traditional Medicines ◽  
Virulent Newcastle Disease Virus ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
Anti Oxidant

Plants are an important source of natural products and they play a vital role in the field of medicinal chemistry and pharmaceutical science. Traditional medicines have been practiced and used for thousands of years, mostly in Asian countries, where plants are the main sources of medicine. Houttuynia cordata, a herb that belongs to the family Saururaceae, has a wide range of pharmacological activities and is used traditionally in conditions like anisolobis sores, heatstroke, lung carbuncles, malaria, scrotal abscess, tonsillitis, salammoniac poison and has also been widely accepted to possess anti-cancer, anti-oxidant, anti-hypertension, anti-inflammatory, anti-mutagenic, antibacterial, anti-viral and anti-purulent activity. Moreover, it is one of the herbs that was recognized during pandemic outbreaks, such as Severe Acute Respiratory Syndrome Coronavirus (SARS CoV) in China, virulent Newcastle Disease Virus (VNDV) in Java (Indonesia) and Newcastle (England). In this review, we briefly discuss the role of H. cordata as an anti-viral agent and the possibility of developing a dosage form against Coronavirus disease-19 (COVID-19).

The influence of lactoferrin on the epigenetic characteristics of mammalian cells of different types

2021 ◽  
Vol 21 (1) ◽  
pp. 85-95
Author(s):  
Kinda Ali Sharrouf ◽  
Irina O. Suchkova
Keyword(s):  
Mammalian Cells ◽  
Milk Protein ◽  
Epigenetic Mechanisms ◽  
Huge Amount ◽  
Factors Affecting ◽  
Chromatin Compaction ◽  
Anti Cancer ◽  
Different Types ◽  
Exogenous Factors ◽  
Cancer Agent

Despite the huge amount of accumulated data, the study of the main mechanisms of interaction between proteins and epigenetic mechanisms in health and various pathologies remains one of the most important problems of molecular biology. The search for various endogenous and exogenous factors affecting the epigenome of eukaryotes continues to be relevant. Lactoferrin is the second most abundant milk protein and has proven to be a very promising anti-inflammatory, antifungal, antibacterial, and anti-cancer agent. This protein can act as a transcription factor regulating the expression of some genes. However, little attention has been paid to the use of lactoferrin as an epigenetic modulating factor. This review demonstrates that lactoferrin can directly and/or indirectly influence epigenetic mechanisms (DNA methylation, histone modification, chromatin compaction, and microRNA pathways) in different types of cells, in particular cancer cells.

Phytic acid and phosphorus in crop seeds and fruits: a global estimate

2000 ◽  
Vol 10 (1) ◽  
pp. 11-33 ◽  
Author(s):  
John N.A. Lott1 ◽  
Irene Ockenden ◽  
Victor Raboy ◽  
Graeme D. Batten
Keyword(s):  
Phytic Acid ◽  
Fruit Production ◽  
Mineral Fertilizers ◽  
Global Estimate ◽  
Anti Cancer ◽  
Potential Benefits ◽  
Anti Oxidant ◽  
Total Crop ◽  
Cancer Agent ◽  
Seeds And Fruits

AbstractA very important mineral storage compound in seeds is phytate, a mixed cation salt of phytic acid (myo-inositol hexakis phosphoric acid). This compound is important for several reasons: (1) It is vital for seed/grain development and successful seedling growth. (2) It is often considered to be an antinutritional substance in human diets, but it may have a positivenutritional role as an anti-oxidant and an anti-cancer agent. (3) It represents a very significant amount of phosphorus being extracted from soilsand subsequently removed with the crop. (4) It plays a role in eutrophication of waterways. A key part of this review is an estimate of the annualtonnage of phosphorus and phytic acid sequestered in up to 4.1 billion metric tonnes of crop seeds and fruits globally each year. We estimate thatnearly 35 million metric tonnes of phytic acid, containing 9.9 million metric tonnes of P, is combined with about 12.5 and 3.9 million metric tonnes of K and Mg respectively, to form each year over 51 million metric tonnes of phytate. The amount of P inthis phytate is equal to nearly 65÷ of the elemental P sold world wide for use in mineral fertilizers. Dry cereal grains account for 69÷ of the total crop seed/fruit production but account for 77÷ of the total phytic acid stored each year. Low phytate mutants, that are now available for some key staple food crops such as maize and barley, offer potential benefits in such areas as the sustainability of lands used to grow crops, the mineral nutrition of humans and animals, and reduction in pollution of waterways.

scholarly journals Purification, Structural Characteristics, and Biological Activities of Exopolysaccharide Isolated From Leuconostoc mesenteroides SN-8

2021 ◽  
Vol 12 ◽  
Author(s):  
Junrui Wu ◽  
Danli Yan ◽  
Yumeng Liu ◽  
Xue Luo ◽  
Yang Li ◽  
...  
Keyword(s):  
Leuconostoc Mesenteroides ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Molecular Weights ◽  
Cycle Arrest ◽  
Glycosidic Bonds ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Inhibitory Potential ◽  
Cancer Agent

In this study, a novel exopolysaccharide (EPS) was extracted from Leuconostoc mesenteroides Shen Nong’s (SN)-8 which can be obtained from Dajiang. After the purification step, EPS-8-2 was obtained with molecular weights of 1.46 × 105 Da. The structural characterization of EPS indicated that the EPS belonged to the class polysaccharide, mainly composed of glucan and also contained certain mannose residues that were found to be connected by α-1,6 glycosidic bonds. Moreover, the results demonstrated that EPS displayed a significant capacity to scavenge free radical to some extent, and this anti-oxidant potential was found to be concentration dependent. The results further revealed that EPS displayed a significant inhibitory potential on the growth of HepG2 cells by promoting apoptosis and induced cell cycle arrest in G1 and G2 phases. Overall, these results suggested that EPS can be explored as a possible anti-cancer agent.

scholarly journals Anticancer effects of Melissa officinalis: A traditional medicine

2021 ◽  
Author(s):  
Parviz Faraji ◽  
Mostafa Araj-Khodaei ◽  
Maryam Ghaffari ◽  
Jafar Ezzati Nazhad Dolatabadi
Keyword(s):  
Cancer Cells ◽  
Potential Effect ◽  
Biological Processes ◽  
Melissa Officinalis ◽  
Anticancer Effects ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
Medical Plant ◽  
Cancer Agent

Melissa officinalis (M. officinalis) is an herbal-based plant from the family of Lamiaceae and native to Europe and the Mediterranean region, widely used to cure various cancers. Phytochemical investigations proved different compounds such as polyphenolic compounds, flavonoids, and essential oil in the stem and leaves of M. officinalis as main ingredients contributing to different antitumor activity, including antiproliferation and antioxidant antiangiogenetic, antimigratory, antiapoptotic, and change in cell cycle profile of cancer cells. Herbal formulations with colorful ingredients use several types of these mentioned biological processes to display synergistic cancer treatment activities. M. officinalis extracts a wide range from water to ethanol using varied mechanisms to reduce the viability of cancer cells. Hence, scientists are currently interested in evaluating these extracts based on the medical plant to minimize the adverse effects of conventional anti-cancer drugs and discover these mechanisms to pave the way for future studies. This review aimed to discuss the recent studies that M. officinalis have used as an anti-cancer agent to investigate its potential effect on several types of cancer. Therefore, after a short introduction of M. officinalis, we will explain the several biological processes by which M. officinalis exert an anti-cancer effect.

scholarly journals POTENTIAL AND THERAPEUTIC BENEFITS OF TINOSPORA CORDIFOLIA

2021 ◽  
Vol 10 (3) ◽  
pp. 2965-2970
Author(s):  
Prashant L Pingale ◽  
Keyword(s):  
Tinospora Cordifolia ◽  
Immunomodulatory Activity ◽  
Antipyretic Activity ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Potential Benefits ◽  
Anti Oxidant ◽  
Large Application ◽  
Ayurvedic Treatment

Essential crude products with potential benefits are steadily achieving significance in clinical studies and research because of their quality of minimal adverse effects as associated with allopathic medications. Tinospora cordifolia usually recognized as Guduchi is known for its large application in the therapy and cure of various diseases in conventional ayurvedic treatment. Recently the classification of active constituents of Guduchi and their inherent function in disease limitation has led us to an active activity in the plant around the globe. This review comprises the genetic variety of the parts of Tinospora cordifolia and active ingredients isolated from Tinospora cordifolia and helps in treating diseases due to their potential benefits such as Anti-oxidant activity, Anti-diabetic activity, Immunomodulatory activity, Anti-cancer activity, Anti-toxic effect, Anti-hyperlipidemic Property, Analgesic, anti-inflammatory, antipyretic activity, and many others. This review aims to utilize the biochemical and significant routes induced by the aggregates separated from Tinospora cordifolia to allow different and efficient therapeutic formulations in disease elimination.

A Review on Ethnobotanical, Phytochemical and Pharmacological studies of Nalpamaram

2021 ◽  
pp. 136-142
Author(s):  
Sreelakshmi. K. P ◽  
Ragunathan Muthuswamy
Keyword(s):  
The Body ◽  
Species Trees ◽  
Ficus Religiosa ◽  
Traditional System ◽  
Plant Parts ◽  
Ficus Benghalensis ◽  
Anti Cancer ◽  
The Family ◽  
Pharmacological Studies ◽  
Anti Oxidant

Ayurveda is an Indian traditional system of medicine used for various disease conditions. Plants are an important source of treatments and are extensively used for the preparation of different formulations. Herbal drugs are separately or in combination used for the treatment of various ailments in the traditional system of medicines. Nalpamaram is an important group of four trees used in Ayurveda which comprises trees like Ficus racemosa, Ficus microcarpa, Ficus benghalensis, and Ficus religiosa belongs to the family Moraceae. Trees have enormous medicinal values and they are lactiferous in nature. These trees are separately or in combination used for the treatment of various ailments in the traditional system of medicines. Different plant parts like bark, leaves, and fruits of ficus species are used as astringent, hemostatic, antiseptic, anti-inflammatory, anti-oxidant, and anti-cancer, and it useful in pitta and Kapha. They are also effective in the treatment of diarrhoea, dysentery, ulcers, vaginal disorders, leucorrhoea, menorrhea, and deficient lactation conditions. The barks of these trees are an important ingredient of many Ayurvedic formulations like Nalpamaradi Choorna, Nalpamaradi Tailam, Saribadyasavam, and Chandanasavam. The bark of tree is boiled with water; its decoction is used to cleanse the body of pregnant women towards reduce inflammation. This review article compiled the ethnobotanical and phytopharmacological properties of four ficus species trees of Nalpamaram.

scholarly journals Pistacia integerrima (Shringi)- A Plant with Significant Pharmacological Activities

2021 ◽  
Vol 10 (5) ◽  
pp. 323-330
Author(s):  
Manish Grover ◽  
Keyword(s):  
Skin Diseases ◽  
Pharmacological Activities ◽  
North West ◽  
Alpha Pinene ◽  
Anti Cancer ◽  
The Family ◽  
The World ◽  
Anti Oxidant ◽  
Phytochemical Constituents ◽  
Important Medicinal Plant

Pistacia integerrima is an important medicinal plant belongs to the family Anacardiacea. It is commonly called as Crab’s claw in English and Shani/Shringi in Hindi. It is a single-stemmed, dioecious tree widely distributed in countries like Nepal, China, Afghanistan, Pakistan, Armenia, North-west and West Himalayas. The plant has significant applications in the traditional systems of medications such as Ayurveda, Unani and Siddha. In addition, the plant is also used in many folkloric cultures around the world to treat a vast array of human ailments such as diarrhoea, dysentery, fever, vomiting, skin diseases, respiratory ailments and psoriasis appetizer, hepatitis and liver related disorders. The characteristic feature of the plant is its essential oil content comprised of many important phytochemical constituents such as alpha-pinene, camphene, di-limonene, 1:8-cineol, caprylic acid, alpha-terpineol and aromadendrene. However, the plant contains many other important secondary metabolites such as steroids, flavonoids, tannins, saponins and phenols which are associated with important pharmacological activities such as anti-bacterial, anti-oxidant, anti-inflammatory, cardio-protective, anti-cancer, antidiarrhoeal, anticonvulsant and muscle relaxant. The aim of the present study is to summarize the recent pharmacological activities of Pistacia integerrima along with its utilization in traditional medication systems

scholarly journals Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 846 ◽  
Author(s):  
Samson Samuel ◽  
Elizabeth Varghese ◽  
Peter Kubatka ◽  
Chris Triggle ◽  
Dietrich Büsselberg
Keyword(s):  
Breast Cancer ◽  
Clinical Studies ◽  
Current Knowledge ◽  
Chemotherapeutic Agents ◽  
Cancer Drug ◽  
Rapid Progression ◽  
Future Prospects ◽  
Anti Cancer ◽  
Cancer Agent ◽  
Tumor Agent

Interest has grown in studying the possible use of well-known anti-diabetic drugs as anti-cancer agents individually or in combination with, frequently used, chemotherapeutic agents and/or radiation, owing to the fact that diabetes heightens the risk, incidence, and rapid progression of cancers, including breast cancer, in an individual. In this regard, metformin (1, 1-dimethylbiguanide), well known as ‘Glucophage’ among diabetics, was reported to be cancer preventive while also being a potent anti-proliferative and anti-cancer agent. While meta-analysis studies reported a lower risk and incidence of breast cancer among diabetic individuals on a metformin treatment regimen, several in vitro, pre-clinical, and clinical studies reported the efficacy of using metformin individually as an anti-cancer/anti-tumor agent or in combination with chemotherapeutic drugs or radiation in the treatment of different forms of breast cancer. However, unanswered questions remain with regards to areas such as cancer treatment specific therapeutic dosing of metformin, specificity to cancer cells at high concentrations, resistance to metformin therapy, efficacy of combinatory therapeutic approaches, post-therapeutic relapse of the disease, and efficacy in cancer prevention in non-diabetic individuals. In the current article, we discuss the biology of metformin and its molecular mechanism of action, the existing cellular, pre-clinical, and clinical studies that have tested the anti-tumor potential of metformin as a potential anti-cancer/anti-tumor agent in breast cancer therapy, and outline the future prospects and directions for a better understanding and re-purposing of metformin as an anti-cancer drug in the treatment of breast cancer.

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