scholarly journals POTENTIAL AND THERAPEUTIC BENEFITS OF TINOSPORA CORDIFOLIA

2021 ◽  
Vol 10 (3) ◽  
pp. 2965-2970
Author(s):  
Prashant L Pingale ◽  
Keyword(s):  
Tinospora Cordifolia ◽  
Immunomodulatory Activity ◽  
Antipyretic Activity ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Potential Benefits ◽  
Anti Oxidant ◽  
Large Application ◽  
Ayurvedic Treatment

Essential crude products with potential benefits are steadily achieving significance in clinical studies and research because of their quality of minimal adverse effects as associated with allopathic medications. Tinospora cordifolia usually recognized as Guduchi is known for its large application in the therapy and cure of various diseases in conventional ayurvedic treatment. Recently the classification of active constituents of Guduchi and their inherent function in disease limitation has led us to an active activity in the plant around the globe. This review comprises the genetic variety of the parts of Tinospora cordifolia and active ingredients isolated from Tinospora cordifolia and helps in treating diseases due to their potential benefits such as Anti-oxidant activity, Anti-diabetic activity, Immunomodulatory activity, Anti-cancer activity, Anti-toxic effect, Anti-hyperlipidemic Property, Analgesic, anti-inflammatory, antipyretic activity, and many others. This review aims to utilize the biochemical and significant routes induced by the aggregates separated from Tinospora cordifolia to allow different and efficient therapeutic formulations in disease elimination.

1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects

2019 ◽  
Vol 19 (15) ◽  
pp. 1219-1254 ◽  
Author(s):  
Abhinav Prasoon Mishra ◽  
Ankit Bajpai ◽  
Awani Kumar Rai
Keyword(s):  
Calcium Ion ◽  
Heterocyclic Compounds ◽  
Channel Blocker ◽  
Heterocyclic Ring ◽  
Therapeutic Effects ◽  
Voltage Gated ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Synthetic Medicinal

: Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its derivatives. An extensive review of Pubmed-Medline, Embase and Lancet’s published articles was done to find all relevant studies on the activity of 1,4-DHP and its derivatives. 1,4-DHP is a potent Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti- anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic, anti-dyslipidemic, and anti-ulcer agent. From the inferences of the study, it can be concluded that the basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives that possess different important therapeutic effects. There is a need of further research of this basic nucleus as it is a multifunctional moiety, on which addition of different groups can yield a better drug for its other activities such as anti-convulsant, anti-oxidant, anti-mutagenic, and anti-microbial. This review would be significant for further researches in the development of several kinds of drugs by representing successful matrix for the medicinal agents.

scholarly journals Pharmacognostical and Phytochemical Evaluation of Haridra (Curcuma Longa Linn.)

AYUSHDHARA ◽  
2021 ◽  
pp. 3309-3315
Author(s):  
Prachisha.P.C ◽  
Sumit Nathani
Keyword(s):  
Tamil Nadu ◽  
Andhra Pradesh ◽  
Curcuma Longa ◽  
Phytochemical Analysis ◽  
Present Sample ◽  
Anti Cancer ◽  
North Eastern ◽  
Anti Oxidant ◽  
Increasing Demand

Curcuma longa Linn. is a very commonly used herb in the day-to-day life for therapeutic and culinary purposes. Haridra commonly known as ‘Golden spice’ belongs to Zingiberaceae  family and is very well known for its pharmacological actions like hepatoprotective, anti-allergic, immune-stimulant, anti-cancer, anti-tumor, anti-hyperlipidemic, anti-oxidant, anti-microbial, anti-diabetic etc. According to the growing regions there are so many varieties of Haridra like Kerala, Tamil Nadu, Maharashtra, Andhra Pradesh, Orissa and North Eastern varieties. All medicinal plants contain phytochemicals or bioactive compounds which plays the key role in its therapeutic action. Most of the drugs show variations in these phytochemicals due to its growing regions which results in severe variations of its quality and efficacy. Also the globalisation and increasing demand for Ayurveda drugs resulted in unavailability of authentic and quality drugs in market which meets the quality standards. Objective: Kerala variety of Turmeric is very well known for its high Curcumin, which is up to 6.5%. Present study is to evaluate the quality of Kerala variety of Haridra sample. Material and methods: This study involves pharmacognostical and phytochemical analysis of Kerala variety of Haridra samples to ensure its purity, safety and quality. Observations and Results: All the findings of the phytochemical and pharmacognostical study were within the standards of quality as per API. Conclusion: The present sample of Haridra, the Kerala variety was found to be rich in Quality and was safe, pure and authentic.

scholarly journals Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Feiyi Lei ◽  
Caroline S. Weckerle ◽  
Michael Heinrich
Keyword(s):  
Myeloid Leukemia ◽  
Scientific Evidence ◽  
Bioactive Metabolites ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Ophiopogon Japonicus ◽  
Anti Oxidant ◽  
Methodological Problems ◽  
Available Information

The closely related genera Liriope and Ophiopogon (Asparagaceae), collectively known in English as liriopogons, have similar therapeutic uses in treating cough, rheumatoid arthritis, and cleaning heat. The main aim of this review is to understand the current phytochemical and pharmacological knowledge including an assessment of the quality of the scientific evidence. A literature search was conducted in line with PRISMA guidelines, by retrieving available information up to 2020 from five online resources. The bioactive metabolites of liriopogons include steroidal saponins, flavonoids, polysaccharides, organic acids, phenols. Cardiovascular protective, anti-inflammatory, anti-diabetic, anti-oxidant, anti-cancer, neuroprotective, anti-viral, anti-acute myeloid leukemia and hepatoprotective effects have been at the center of attention. From a toxicological perspective Ophiopogon japonicus seems to be safe. Some problems with the quality of the pharmacological evidence stand out including the application of excessive dose level and methodological problems in the design. Additionally, a reasonable link between local/traditional uses and pharmacological assessment is often vague or not reflected in the text. Future researches on liriopogons are required to use rigorous scientific approaches in research on evidence-based natural products for the future benefits of patients.

Phytic acid and phosphorus in crop seeds and fruits: a global estimate

2000 ◽  
Vol 10 (1) ◽  
pp. 11-33 ◽  
Author(s):  
John N.A. Lott1 ◽  
Irene Ockenden ◽  
Victor Raboy ◽  
Graeme D. Batten
Keyword(s):  
Phytic Acid ◽  
Fruit Production ◽  
Mineral Fertilizers ◽  
Global Estimate ◽  
Anti Cancer ◽  
Potential Benefits ◽  
Anti Oxidant ◽  
Total Crop ◽  
Cancer Agent ◽  
Seeds And Fruits

AbstractA very important mineral storage compound in seeds is phytate, a mixed cation salt of phytic acid (myo-inositol hexakis phosphoric acid). This compound is important for several reasons: (1) It is vital for seed/grain development and successful seedling growth. (2) It is often considered to be an antinutritional substance in human diets, but it may have a positivenutritional role as an anti-oxidant and an anti-cancer agent. (3) It represents a very significant amount of phosphorus being extracted from soilsand subsequently removed with the crop. (4) It plays a role in eutrophication of waterways. A key part of this review is an estimate of the annualtonnage of phosphorus and phytic acid sequestered in up to 4.1 billion metric tonnes of crop seeds and fruits globally each year. We estimate thatnearly 35 million metric tonnes of phytic acid, containing 9.9 million metric tonnes of P, is combined with about 12.5 and 3.9 million metric tonnes of K and Mg respectively, to form each year over 51 million metric tonnes of phytate. The amount of P inthis phytate is equal to nearly 65÷ of the elemental P sold world wide for use in mineral fertilizers. Dry cereal grains account for 69÷ of the total crop seed/fruit production but account for 77÷ of the total phytic acid stored each year. Low phytate mutants, that are now available for some key staple food crops such as maize and barley, offer potential benefits in such areas as the sustainability of lands used to grow crops, the mineral nutrition of humans and animals, and reduction in pollution of waterways.

Pharmacological Potential of Natural Herbs against Covid-19: A Review

2021 ◽  
pp. 269-274
Author(s):  
Priyanka K. Shinde ◽  
Dattaprasad N. Vikhe ◽  
Ravindra S. Jadhav ◽  
Ganesh S. Shinde
Keyword(s):  
Withania Somnifera ◽  
Research Unit ◽  
Tinospora Cordifolia ◽  
Immunomodulatory Activity ◽  
Primary Case ◽  
The World ◽  
Prevention And Treatment ◽  
Anti Oxidant ◽  
Pharmacological Potential ◽  
Steroidal Lactone

The unknown coronavirus has been unfold all over within the world. The primary case was declared in Dec 2019, and this coronavirus malady has become a virulent disease. Infection of this virus is directly attacked on the system of the flesh or animals. Nowdays there’s a deficiency of correct management or vaccinum out there to stop this malady that principally attacks the system of body. Hindrance is healthier than cure. This term is extremely renowned to any or all people. Thus currently this time has come back to used for our savings of lives. Ayurveda is the ancient system of drugs which is originated in India. During this covid -19 amount boosting of our system is that the excellent thanks to fight against this corona virus. Many seasoning plants unit accessible in our shut that unit used for immunity boosting throughout Covid 19. Some seasoning plants like Tinospora cordifolia, Withania somnifera, Nyctanthes arbortristis that unit commonly used for immunity boosting. This herb contains compounds like glycosides, steroids, diterpenoid lactones, alkaloids, steroidal lactone,etc. vary of research unit accessible on Tinospora cordifolia, Ashwagandha, and Nyctanthes arbortristis to prove its immunomodulatory activity, anti-oxidant activity, anti- inflammatory activity, anti-pyretic activity. Throughout this general review we’ve a bent to targated on the role, drugs activities of Tinospora cordifolia, Withania somnifera, Nyctanthes arbortristis to prevention and treatment of COVID 19 or CORANA VIRUS infection.

scholarly journals Can Hemp Help? Low-THC Cannabis and Non-THC Cannabinoids for the Treatment of Cancer

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1033 ◽  
Author(s):  
Farjana Afrin ◽  
Mengna Chi ◽  
Andrew L. Eamens ◽  
Ryan J. Duchatel ◽  
Alicia M. Douglas ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Cannabinoid Receptors ◽  
Redox Homeostasis ◽  
G Protein Coupled Receptors ◽  
Therapeutic Benefits ◽  
Potential Efficacy ◽  
Anti Cancer ◽  
Potential Benefits ◽  
G Protein Coupled ◽  
Cancerous Cells

Cannabis has been used to relieve the symptoms of disease for thousands of years. However, social and political biases have limited effective interrogation of the potential benefits of cannabis and polarised public opinion. Further, the medicinal and clinical utility of cannabis is limited by the psychotropic side effects of ∆9-tetrahydrocannabinol (∆9-THC). Evidence is emerging for the therapeutic benefits of cannabis in the treatment of neurological and neurodegenerative diseases, with potential efficacy as an analgesic and antiemetic for the management of cancer-related pain and treatment-related nausea and vomiting, respectively. An increasing number of preclinical studies have established that ∆9-THC can inhibit the growth and proliferation of cancerous cells through the modulation of cannabinoid receptors (CB1R and CB2R), but clinical confirmation remains lacking. In parallel, the anti-cancer properties of non-THC cannabinoids, such as cannabidiol (CBD), are linked to the modulation of non-CB1R/CB2R G-protein-coupled receptors, neurotransmitter receptors, and ligand-regulated transcription factors, which together modulate oncogenic signalling and redox homeostasis. Additional evidence has also demonstrated the anti-inflammatory properties of cannabinoids, and this may prove relevant in the context of peritumoural oedema and the tumour immune microenvironment. This review aims to document the emerging mechanisms of anti-cancer actions of non-THC cannabinoids.

scholarly journals A review on Tinospora cordifolia: as an Immunomodulating agent

2021 ◽  
pp. 6-14
Author(s):  
Pritika Devi
Keyword(s):  
Clinical Studies ◽  
Indian Subcontinent ◽  
Tinospora Cordifolia ◽  
Skin Disorders ◽  
Anti Cancer ◽  
The Family ◽  
Different Types ◽  
Anti Oxidant ◽  
Immunomodulating Property ◽  
Cancer Agent

Guduchi is a plant also known as Tinospora cordifolia, having heart shaped leave, an herb of the family Menispermaceae native of hot areas of the Indian subcontinent. In our classical Ayurvedic texts, it is indicated to be beneficial in treating various types of diseases like skin disorders, different types of fever, jaundice & gout. Guduchi also claimed to have various properties as an anti-oxidant, antihyperglycemic, antihyperlipidemic, hepatoprotective, cardiovascular protective, neuroprotective, osteoprotective, radioprotective, anti-anxiety, adaptogenic agent, analgesic, anti-inflammatory, antipyretic, athrombolytic agent, anti-diarrheal, anti-ulcer, antimicrobial and anti-cancer agent. Several experimental and clinical studies based on available reports, present paper is an attempt to assemble the information on immunomodulating property of Tinospora cordifolia

Evaluation of antipyretic activity of Capsicum annuum by Brewer’s yeast method

2020 ◽  
Vol 9 (1) ◽  
pp. 11-13
Author(s):  
Dinesh Babu J
Keyword(s):  
Weight Loss ◽  
Capsicum Annuum ◽  
Chemical Constituents ◽  
Gastrointestinal Function ◽  
Standard Drug ◽  
Antipyretic Activity ◽  
Similar Chemical ◽  
Anti Cancer ◽  
Science Investigations ◽  
Crucial Ingredient

Plants are being used in medicine and treatment of diseases from years in the evolution. During the development of science, investigations to establish eh scientific proof and validation for the activities and mechanism of herbs to treat diseases. Capsicum annuum has anti-cancer properties, analgesic properties, anti lithogenic and thermogenic properties. It is used to alter the gastrointestinal function and boost metabolism. Many formulations are enriched with capsaicin which is a crucial ingredient in Capsicum to exhibit its weight loss properties. Based on the anti-inflammatory and analgesic properties of the plant and taking into consideration, the current research will focus on the investigation and comparison of the antipyretic activity of Capsicum in fruits and leaves. Results show that the leaves have similar chemical constituents that had antipyretic potential compared to the fruits. Overall, the Capsicum showed a comparatively same activity with the standard drug, paracetamol.

Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1208-1212
Author(s):  
Amol Madhav Deshpande ◽  
Mayuri Amol Deshpande
Keyword(s):  
Recurrent Infection ◽  
Symptomatic Patient ◽  
H1n1 Influenza ◽  
Drug Of Choice ◽  
Asymptomatic Patients ◽  
Diseased Person ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Respiratory Droplets

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

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