scholarly journals Optimasi Formula Pasta Gigi Kombinasi Ekstrak Rimpang Temu Kunci dan Sereh dengan CMC-Na dan Carbomer sebagai Bahan Pengikat Menggunakan Metode Simplex Lattice Design

2021 ◽  
pp. 25-33
Author(s):  
Anita Kumala Hati ◽  
Niken Dyahariesti ◽  
Richa Yuswantina
Keyword(s):  
Design Method ◽  
Average Diameter ◽  
Positive Control ◽  
Premature Aging ◽  
P Value ◽  
Binding Agent ◽  
Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Post Hoc

Comercial toothpaste contain fluoride to prevent dental caries. The usage of fluoride in large quantities may cause irreversible enamel fluorosis, brittle bones, brittle teeth, premature aging, spontaneous abortion, and carcinogenic. Objective this experiment is knowing the extract concentration of finger roots and lemongrass which is equivalent to positive control and then performed optimization of toothpaste preparation formula with different concentrations of CMC-Na and carbomer with pH and viscosity parameters using the Simple Lattice Design method. The antibacterial test of lemongrass extract, finger roots and its combination with a concentration of 5% against Streptococcus mutans bacteria, showed the average diameter of the largest clear zone: finger roots extract was 11.167±0.288mm; combination of lemongrass extract:finger roots extract (1:2) was 10.83±0.288mm; combination of lemongrass extract: finger roots (2:1) was 10,067±1,006mm; lemongrass extract was 9.33±0.751mm; The combination of lemongrass extract:finger roots extract (1:1) was 9,133±0,321mm.. Post Hoc test results shows comparable to positive controls were 5% finger roots extracts, combination of lemongrass:finger roots 1:2 combination, and 2:1 combination. The optimum formula was obtained using the SLD method with a combination of 0.900% CMC-Na and 1,100% carbomer as a binding agent. The optimum pH formula of toothpaste was 7,613±0,076 and Viscosity 2,43,104cps±2571,640. The paired t-test pH obtained p-value 0.222 and the viscosity obtained p-value 0.934. The experimental results were not significantly different from the results predicted by the software simply latex design. The 5% finger roots extract can be developed into an herbal toothpaste with binding agent CMC-Na and a carbomer ratio of 0,9:1,1.

scholarly journals OPTIMASI HPMC DAN KARBOPOL DALAM FORMULASI SEDIAAN GEL ANTISEPTIK EKSTRAK ETANOL DAUN BELUNTAS DAN AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus

2020 ◽  
Vol 3 (2) ◽  
pp. 327-336
Author(s):  
Muhammad Dienulloh Qasyfur Rohman ◽  
◽  
Iwan Setiawan ◽  
Ardy Prian Nirwana
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Design Method ◽  
Ethanol Extract ◽  
Average Diameter ◽  
Inhibition Zone ◽  
Lattice Design ◽  
Simplex Lattice ◽  
Gel Preparation ◽  
Optimum Formula

Beluntas leaf (Pluchea indica, L.) is one of the plants that has potential as an antibacterial, Where the leaves of Beluntas have several compounds, one of these is a flavonoid which has antibacterial activity. The aim of this research is to determine the optimum composition of HPMC and carbopol which will be formulated in the preparation of antiseptic gel ethanol extract of beluntas leaf using the SLD method. The extraction method used in this study is Maseration with ethanol as a solvent. Antiseptic gel manufacturing is done by optimizing the base of HPMC and Carbopol, Then testing the quality of the gel preparation and the results obtained that meet the requirements of the homogeneity, pH, dispersion, viscosity, consistency and stability test of the gel preparation. The optimum formula of antiseptic gel based on the simplex lattice design method is on a combination of a 4.5% HPMC base and a 0.5% carbopol. Antibacterial activity test found inhibition zone, this shows that the antiseptic gel preparation of the ethanol extract of beluntas leaves has the ability to inhibit against Staphylococcus aureus bacteria with an average diameter of the zone of inhibition by 17,66 mm.

scholarly journals Optimasi Formula Tablet Piroksikam Menggunakan Eksipien Laktosa, Avicel pH-101, dan Amprotab dengan Metode Simplex Lattice Design

2020 ◽  
Vol 17 (1) ◽  
pp. 31-44
Author(s):  
Ikhwan Yuda Kusuma ◽  
Rani Prabandari
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Dominant Factor ◽  
Content Uniformity ◽  
Compression Tests ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Contour Plots ◽  
Simplex Lattice ◽  
Optimum Formula

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it’s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet’s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154–100%), avicel PH-101 (0–12,437%), and amprotab (0–5,425%).

scholarly journals Metoclopramide-OROS Dispersible Tablets Optimized Formula Bioavailability Study

2020 ◽  
Vol 8 (A) ◽  
pp. 338-341
Author(s):  
Samran Samran ◽  
Hari Ronaldo Tanjung
Keyword(s):  
High Performance ◽  
Corn Starch ◽  
Reference Product ◽  
Design Method ◽  
In Vivo Test ◽  
Lattice Design ◽  
Dispersible Tablet ◽  
Simplex Lattice ◽  
Optimum Formula

BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product. AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan® as the reference product. METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)-metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measured by high-performance liquid chromatography instrument. RESULTS: The study revealed that the tmax, Cmax, and area under curve (AUC) of ODT-metoclopramide FCL-6 were 60 min, 1.95 ± 0.13 μg/mL, and 1118.20 ± 150 μg/mL. min consecutively. The Cmax and the concentration of the drug absorbed in the blood (AUC) of ODT-metoclopramide were larger than Primperan® tablets. Statistical data of the optimized ODT-metoclopramide compared with Primperan® showed that the Cmax and AUC significance values were <0.05 (p < 0.05). CONCLUSION: The optimized formula of ODT-metoclopramide revealed a better characteristic of Cmax and AUC concentration compared with Primperan®. The optimized ODT-metoclopramide with tapai extract was found to be promising to improved bioavailability of metoclopramide.

scholarly journals OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.)

2019 ◽  
Vol 1 (3) ◽  
pp. 225-237
Author(s):  
Dwi Saryanti ◽  
Iwan Setiawan ◽  
Romadona Ayu Safitri
Keyword(s):  
Stearic Acid ◽  
Maximum Concentration ◽  
Design Method ◽  
Minimum Concentration ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Significant Difference ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Optimal Formula

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.

scholarly journals Optimasi Propilen Glikol dan Etanol sebagai Peningkat Penetrasi Ibuprofen dalam Sediaan Gel dengan Metode Simplex Lattice Design (Propylene Glycol and Ethanol Optimization as Ibuprofen Penetration Enhancer in Gel Dosage using Simplex Lattice Design Metho

2018 ◽  
Vol 6 (1) ◽  
pp. 11
Author(s):  
Baiq Wahyudyati Karnia Qisti ◽  
Dwi Nurahmanto ◽  
Viddy Agustian Rosyidi
Keyword(s):  
Propylene Glycol ◽  
Penetration Rate ◽  
Design Method ◽  
Penetration Enhancers ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Rate Optimization ◽  
Optimum Formula ◽  
Optimum Solution

Ibuprofen is a non-steroid anti inflammatory drug (NSAID) used for rheumatoid arthritis treatment. In this study, formulation, evaluation, and optimization of ibuprofen gel formula were conducted in order to determine the best ibuprofen penetration rate through the rats skin using propylene glycol and ethanol as penetration enhancers and to find out the optimum formula to get the best penetration rate with simplex lattice design method. Evaluations included organoleptic, pH, viscosity, gel dispersive, assay of gel formulations, and ibuprofen penetration rate assay. Penetration rate was determined by paddle type dissolution and the samples were analyzed by spectrophotometry UV-Vis. The results of ibuprofen penetration rate assay were analyzed and optimized using design expert trial version 10. The results of ibuprofen penetration rate were F1 1.524 ± 0.121 µg/cm2.minute; F2 1.945 ± 0.0104 µg/cm2.minute; and F3 1.173 ± 0.216 µg/cm2.minute. Penetration rate optimization resulted in one optimum solution formula which was 18.000% propylene glycol and 12.000% ethanol with a maximum flux of 1.957 ug/cm2.minute and desirability 1. It can be concluded that the best ibuprofen penetration rate was F2 with flux 1.945 ± 0.0104 µg/cm2.minute with 15% propylene glycol and 15% ethanol.   Keywords: gel, ibuprofen, propylene glycol, ethanol, simplex lattice design  

scholarly journals Optimasi Asam Glikolat dan Asam Sitrat dalam Krim Tabir Surya Kombinasi Titanium Dioksida, Avobenzone dan Octyl Methoxycinnamate

2020 ◽  
Vol 8 (3) ◽  
pp. 139
Author(s):  
Desy Diana Sari ◽  
Lidya Ameliana ◽  
Dwi Nurahmanto
Keyword(s):  
Titanium Dioxide ◽  
Citric Acid ◽  
Adverse Effects ◽  
Uv Radiation ◽  
Glycolic Acid ◽  
Design Method ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Ultraviolet (UV) radiation is the main cause of sunburn and skin cancer. The adverse effects of UV radiation are solved by sunscreen as protection for longer outdoors. In this study, optimization of glycolic acid and citric acid in sunscreen cream combination of titanium dioxide, avobenzone, and octyl methoxycinnamate were investigated using simplex lattice design method. The sunscreen cream evaluation includes physicochemical testing (organoleptic, homogeneity, emulsion type, spreadability, viscosity, and pH) and sunscreen effectiveness (SPF, % erythema transmission, and % pigmentation transmission). The value of physicochemical testing are 5,96 cm - 6,3 cm of  spreadability testing; 83,33 dPa.s – 108,33 dPa.s of viscosity testing; 4,06 – 4,67 of pH testing. The value of sunscreen effectiveness are 9,79 – 13,35 of SPF testing; 4,55x10-06 - 0,15x10-06% of % erythema transmission; 5,77 – 7,16 % of % pigmentation transmission. The optimum formula was obtained by combining glycolic acid 2% and citric acid 0% with a desirability value of 0,649.

scholarly journals OPTIMASI GEL HAND SANITIZER OLEUM CITRI DENGAN KOMBINASI CARBOPOL, LIDAH BUAYA DAN TEA MENGGUNAKAN SIMPLEX LATTICE DESIGN

2021 ◽  
Vol 6 (1) ◽  
pp. 21-28
Author(s):  
Joko Santoso ◽  
◽  
Heru Nurcahyo
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Aloe Vera ◽  
Homogeneity Test ◽  
Stabilizing Agents ◽  
Hand Sanitizer ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Handsanitizer gel is composed of various additives such as geling agents, humectants and neutralizing / stabilizing agents. This material is certainly a basic ingredient that will affect the shape and quality of the preparation. Carbopol is very good when used, so that low levels can provide a significant viscosity response. Eleven hand sanitizer gel formulas with variations of carbomer, aloe vera and TEA were tested for their physical properties including organoleptic, homogeneity test, pH test, spreadability and adhesion test . The optimum formula is obtained by using the Simplex Lattice Design method, then the results are analyzed using an expert design software. The optimum formula for oleum citri hand sanitizer gel contains 0.944 with carbomer 0 (0.5%), aloe vera 0.471 (5.239%) and TEA 0.529 (0.576%). The t test results obtained showed insignificant differences between the response of the physical properties of the experiment results and the prediction software.

scholarly journals Optimasi Konsentrasi Amylum Sagu (Metroxylon rumphii) sebagai Co-Processed pada Pembuatan Tablet Teofilin

2019 ◽  
Vol 14 (2) ◽  
pp. 72-80
Author(s):  
Nor Laili ◽  
Annisa' Meyndra Komala ◽  
Hidayaturrizqika Maulida ◽  
Suprapto Suprapto
Keyword(s):  
Design Method ◽  
Low Cost ◽  
Production Costs ◽  
Flow Properties ◽  
Design Expert ◽  
Software Analysis ◽  
Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Optimum Flow

Tablet preparations are widely used many people for treatment, so the level of production of tablet preparations is quite large and always develops in its formulation. Excipients are generally used in the form of 95% imported materials which are relatively expensive so that production costs will affect the price of tablet preparations which will be more expensive. Based on these considerations, this study uses Indonesian natural excipient with a relatively low cost in the form of sago amylum. This study combines sago amylum and Avicel pH 101 with 5 concentration variations, 90%: 10% (formula 1), 80%: 20% (formula 2), 70%: 30% (formula 3), 60%: 40% (formula 4), and 50%: 50% (formula 5) which produces a co-processed excipient. This co-processed was applied in the manufacture of the Theophylline tablet as a filler, binder and shredder with the direct compression method and tested based on parameters in the Indonesian Pharmacopoeia V. Data analysis using Design Expert® version 11 software to obtain the optimum formula. The co-processed characterization produced has optimum flow properties which are 11.11 g / sec, compressibility = 3.0%, and the stationary angle = 32.0 ° and evaluation of tablet quality uniformity CV = 10.3, hardness x̅ = 6 , 2 kg, fragility = 1.8%, and 46.2 seconds destroyed time. Based on the analysis by Simplex Lattice Design method, it is proved that the more amylum sago concentration increases friability and decreases hardness, while more of Avicel pH 101 decreases friability  and increases hardness. It is concluded with the Design Expert software analysis, the optimum co-processed formula was obtained in the form of a combination of 50% sago amylum; 18,18% pasta amylum sago and 31.82% Avicel pH 101.

scholarly journals Formula Optimization of Fast Disintegrating Tablet (FDT) of Centella asiatica (L.) Urb. Ethanolic Extract

2018 ◽  
Vol 16 (1) ◽  
pp. 94
Author(s):  
Agatha Budi Susiana Lestari ◽  
Achmad Fudholi ◽  
Akhmad Kharis Nugroho ◽  
Erna Prawita Setyowati
Keyword(s):  
Dosage Form ◽  
Design Method ◽  
Ethanolic Extract ◽  
Centella Asiatica ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Fast Disintegrating Tablet ◽  
Simplex Lattice ◽  
Optimum Formula

It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethanol-water in ratio 75%:25% as a solvent. Direct compress method was used to produce the FDT. The results show that the optimum composition between excipients FDT formula could be reached, which fullfiled the physical properties parameter which are the hardness, friability and disintegration time of FDT.

scholarly journals Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

2021 ◽  
Vol 21 (2) ◽  
pp. 501
Author(s):  
Wahida Hajrin ◽  
Windah Anugrah Subaidah ◽  
Yohanes Juliantoni ◽  
Dyke Gita Wirasisya
Keyword(s):  
Optimization Design ◽  
Design Method ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Optimization Parameters ◽  
Angelica Keiskei ◽  
Potential Activity ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
The Right

Ashitaba is known to have antioxidant activity and gram-positive antibacterial activity that causes body odor. This is the potential activity for an active substance to be developed as deodorant. The appropriate formula is needed, so it is necessary to optimize the formula using the right method. This study aimed was to determine the application of the simplex lattice design method on the optimization of a deodorant roll-on formula of ashitaba extract. Ashitaba was extracted by the maceration method. The formula optimization design was determined using the simplex lattice design method by Design Expert®7.5.1. The components for optimization were the concentration of carbopol and concentration of TEA, and the optimization parameters were the spreadability test, sticky power, and pH test. The optimum formula of deodorant consists of 0.45% carbopol and 2.05% TEA. The responses of optimum formula obtained spreadability test 6.32 ± 0.33 cm, sticky power 44.67 ± 3.94 seconds, and pH 7.73 ± 0.17. These results meet the criteria for good preparation but need further testing related to the effectiveness of the preparation and the level of acceptance of the preparation by the user.

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