scholarly journals PENGENDALIAN DEMAM BERDARAH DENGUE DENGAN MENGGUNAKAN MODEL TERINTEGRASI PENGENDALIAN VEKTOR TOTAL BERBASIS MASYARAKAT DAN STICKY AUTOCIDAL MOSQUITO TRAP

2020 ◽  
Vol 12 (2) ◽  
pp. 133-146
Author(s):  
Malik Saepudin ◽  
Ani Hermilestari ◽  
Bambang Supraptono ◽  
Heru Subaris Kasjono
Keyword(s):  
Time Series ◽  
Aedes Aegypti ◽  
Interrupted Time Series ◽  
Integrated Model ◽  
Control Group ◽  
Treatment Control ◽  
Mosquito Trap ◽  
Intervention Area ◽  
Group Time ◽  
Treatment Control Group

Dengue Hemorrhagic Fever (DHF) is still a health problem in Indonesia, including in West Kalimantan Province. The Integrated Model of Community-Based Total Vector Control (PVTBM) and Sticky Autocidal Mosquito Trap (SAMT) is expected to reduce the density of larvae, so that the incidence of dengue can be reduced to the lowest point in the endemic area of Pontianak. This study analyzed the effects of the PVTBM-SAMT integrated model in controlling dengue vectors in endemic areas of Pontianak City. This type of research is Interrupted time series with a nonequivalent no-treatment control group time series. The sample of this study was 200 houses, consisting of 100 houses in the intervention area and 100 houses in the control area. The results showed a decrease in the mean larval density index in the intervention area, namely; HI was 25%, CI was 11.17%, BI was 38%. Statistical analysis showed that the PVTBM-SAMT integration model had a significant effect on the density of larvae: HI, CI, and BI with p values: 0.049, 0.047, and 0.042. It is recommended that the health office and primary health care be able to apply the PVTBM-SAMT method in controlling DHF vector activities and also in the implementation of surveillance and control of Aedes aegypti vector. Abstrak Demam Berdarah Dengue (DBD) masih menjadi masalah kesehatan di Indonesia, termasuk di Provinsi Kalimantan Barat. Aplikasi Model Terpadu Pengendalian Vektor Total Berbasis Masyarakat (PVTBM) dan Sticky Autocidal Mosquito Trap (SAMT) bertujuan menurunkan densitas Larva. Penelitian ini menganalisis efek model terintegrasi PVTBM-SAMT dalam pengendalian vektor DBD di wilayah endemis Kota Pontianak. Jenis penelitian ini adalah eksperimen murni dengan rancangan Interrupted time series with a nonequivalent no-treatment control group time series. Sampel penelitian ini sebanyak 200 rumah, terdiri dari 100 rumah di wilayah intervensi dan 100 rumah di wilayah pembanding. Hasil penelitian menunjukan terjadi penurunan rerata indeks kepadatan larva pada wilayah intervensi yaitu; HI sebesar 25%, CI sebesar 11,17%, BI sebesar 38% dan wilayah pembanding. Analisis statistik terdapat perbedaan densitas larva: HI, CI, dan BI sebelum dan sesudah perlakuan secara signifikan dengan nilai p: 0,049, 0,047, dan 0,042. Dinas kesehatan dan puskesmasisarankan dapat menerapkan metode PVTBM-SAMT dalam kegiatan pengendalian vektor DBD dan juga dalam pelaksanaan surveilans serta pengendalian vektor Aedes aegypti.

Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium

2014 ◽  
Vol 306 (2) ◽  
pp. H286-H290 ◽  
Author(s):  
Calvin K. Chan ◽  
Song Yan Liao ◽  
Yue Lin Zhang ◽  
Aimin Xu ◽  
Hung Fat Tse ◽  
...  
Keyword(s):  
Area Under The Curve ◽  
Treated Group ◽  
Control Group ◽  
Protective Effects ◽  
Treatment Control ◽  
Porcine Coronary Artery ◽  
Endogenous Histamine ◽  
Coronary Endothelium ◽  
Treatment Control Group

In the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction. Pigs were treated chronically with pyrilamine (H1 receptor inhibitor, 2 mg·kg−1·day−1) with part of their coronary endothelium and allowed to regenerate for 28 days after balloon denudation. The results showed a reduction in relaxation to bradykinin (Gq protein dependent) only in the pyrilamine-treated group (area under the curve, 269.7 ± 13.4 vs. 142.0 ± 31.0, native endothelium vs. regenerated endothelium) but not in the control group (253.0 ± 22.1 vs. 231.9 ± 29.5, native endothelium vs. regenerated endothelium). The differences in the relaxation to serotonin (Gi protein dependent) between native and regenerated endothelium were not affected by the pyrilamine treatment (control group, 106.3 ± 17.0 vs. 55.61 ± 12.7; and pyrilamine group, 106.0 ± 8.20 vs. 49.30 ± 6.31, native endothelium vs. regenerated endothelium). These findings indicate that during regeneration of the endothelium, the activation of H1 receptors by endogenous histamine may be required to maintain the endothelium-dependent Gq protein-mediated relaxation to bradykinin, suggesting a beneficial role of the monoamine in the process of endothelial regeneration.

A Treatment/Control Group Study of Growth Hormone Treatment

2000 ◽  
Vol 10 (Supplement 1) ◽  
pp. 31S-37S ◽  
Author(s):  
Barbara Y. Whitman ◽  
Susan Myers ◽  
Aaron Carrel ◽  
David Allen
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Control Group ◽  
Treatment Control ◽  
Treatment Control Group

Can placebos prevent intrusive memories?

2022 ◽  
Author(s):  
Tobias Kube ◽  
Irving Kirsch ◽  
Julia Glombiewski ◽  
Philipp Herzog
Keyword(s):  
Psychological Trauma ◽  
Traumatic Experiences ◽  
Control Group ◽  
Treatment Control ◽  
Open Label ◽  
Intrusive Memories ◽  
Experimental Psychopathology ◽  
Negative Appraisal ◽  
Treatment Control Group ◽  
Healthy Participants

After traumatic experiences, intrusive memories can flash back and evoke significant distress. Here, we investigated whether the occurrence of intrusions can be prevented by placebo. After the exposure to an experimental psychopathology model of psychological trauma, healthy participants (N=112) were randomised to deceptive placebo (DP), open-label placebo (OLP), or a no-treatment control group. The results show that one week later, the groups did not differ in the frequency of intrusive memories. However, participants receiving OLP reported the lowest intensity of intrusions. Participants receiving DP reported the lowest burden of intrusions. Across groups, the expectation that intrusions will be intense and hardly controllable was associated with a higher frequency of intrusions, higher distress, higher burden, and more negative appraisal. The results suggest that expectations play a crucial role in the emergence of intrusive memories and that at least some of the disabling aspects of intrusive memories can be reduced by placebo.

scholarly journals Identifying Key MicroRNAs Targeted by Narenmandula in a Rodent Nephropathy Model

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiulan Wang ◽  
Chun Chang ◽  
Wenjie Jin ◽  
Arun Arun ◽  
Sudunabuqi Sudunabuqi ◽  
...  
Keyword(s):  
Renal Function ◽  
Differential Expression ◽  
Target Genes ◽  
Enrichment Analysis ◽  
Control Group ◽  
Doxorubicin Hydrochloride ◽  
Treatment Control ◽  
Number Of Genes ◽  
Version 2.0 ◽  
Treatment Control Group

Background. Untreated nephropathy can progress to renal failure. The traditional Mongolian remedy Narenmandula regulates the kidney “yang.” This study aimed to identify key microRNAs (miRNAs) targeted by Narenmandula in a rat model of nephropathy. Methods. Fifteen rats exhibiting normal renal function were randomized to three study arms. Nephropathy was induced in n = 10 rats using doxorubicin hydrochloride, followed by either Narenmandula treatment (treatment group) or no treatment (control group). In n = 5 rats, no doxorubicin was given and renal function remained unchanged (healthy group). Microarray analysis identified miRNAs which were differentially expressed (DE-miRNAs) between groups. Target genes of DE-miRNAs were predicted using miRWalk version 2.0, followed by enrichment analysis using DAVID, and construction of the miRNA coregulatory network using Cytoscape. Results. Nephropathy was successfully induced, with doxorubicin resulting in differential expression of 3645 miRNAs (1324 upregulated and 2321 downregulated). Narenmandula treatment induced differential expression of a total of 159 miRNAs (102 upregulated and 57 downregulated). Upregulated DE-miRNAs (e.g., miR-497-5p, miR-195-5p, miR-181a-5p, miR-181c-5p, and miR-30e-5p) and downregulated DE-miRNAs (e.g., miR-330-3p and miR-214-3p) regulated a high number of target genes. Moreover, the miRNA pairs (e.g., miR-195-5p—miR-497-5p, miR-181a-5p—miR-181c-5p, and miR-30e-5p—miR-30a-5p) coregulated a high number of genes. Enrichment analysis indicated functional synergy between miR-30e-5p—miR-30a-3p, miR-34a-5p—miR-30e-5p, miR-30e-5p—miR-195-3p, and miR-30a-3p—miR-195-3p pairs. Conclusion. Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR-497-5p, miR-195-5p, miR-181a-5p, miR-181c-5p, miR-30e-5p, miR-330-3p, miR-214-3p, miR-34a-5p, miR-30a-3p, and miR-30a-5p.

The Use of Varying High-Confusion versus Low-Confusion Sequences to Teach Letter Discrimination

1976 ◽  
Vol 8 (2) ◽  
pp. 161-171
Author(s):  
Rosemery O. Nelson ◽  
Kenneth S. Wein
Keyword(s):  
Preschool Children ◽  
Discrimination Training ◽  
Matching To Sample ◽  
Control Group ◽  
Treatment Control ◽  
Distinctive Features ◽  
Training Groups ◽  
Different Types ◽  
Treatment Control Group

Within Gibson's framework of teaching children to discriminate the distinctive features of letters, 28 preschool children were trained in letter discrimination using three different types of matching-to-sample alternatives: (1) high-confusion alternatives; (2) low-confusion alternatives; or (3) a sequence of low-, middle-, and high-confusion alternatives. On posttest 1, given after a criterion of two consecutive errorless training days, only the high-confusion and sequence groups significantly improved over their pretest scores as compared with the no-treatment control group. On posttest 2, however, given after a standard number of 20 training days, the performance of all three training groups, including low-confusion, was superior to the control group; no differences were found among the three training groups. The implications of these and other findings for letter discrimination training were discussed.

Increasing Verbalization of Chronic Mental Patients with Operant Techniques: Partial Replication

1973 ◽  
Vol 37 (1) ◽  
pp. 205-206
Author(s):  
Robert E. Pawlicki ◽  
Gary H. Miller ◽  
Graham A. Haley
Keyword(s):  
Behavior Modification ◽  
Attention Control ◽  
Control Group ◽  
Partial Replication ◽  
Treatment Control ◽  
Research Attention ◽  
Mental Patients ◽  
Simple Motor ◽  
Treatment Control Group ◽  
Modification Treatment

The present study replicated previous results showing the effectiveness of behavior-modification techniques in reinstating verbalization in mute psychotics. Those patients experiencing behavior-modification treatment increased their verbalization level significantly more than patients in either an attention-control or a no-treatment control group. Commencing behavior-modification at a simple motor level offers important practical advantages and deserves research attention.

Prevention of Depressive Symptoms in Schoolchildren: Two-Year Follow-Up

1995 ◽  
Vol 6 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Jane E. Gillham ◽  
Karen J. Reivich ◽  
Lisa H. Jaycox ◽  
Martin E.P. Seligman
Keyword(s):  
Depressive Symptoms ◽  
Problem Solving ◽  
Social Problem ◽  
Sixth Grade ◽  
Social Problem Solving ◽  
Control Group ◽  
Children At Risk ◽  
Treatment Control ◽  
Treatment Control Group

After teaching cognitive and social-problem-solving techniques designed to prevent depressive symptoms, we followed 69 fifth- and sixth-grade children at risk for depression for 2 years We compared these children with 49 children in a matched no-treatment control group The prevention group reported fewer depressive symptoms through the 2-year followup, and moderate to severe symptoms were reduced by half Surprisingly, the effects of the prevention program grew larger after the program was over We suggest that psychological immunization against depression can occur by teaching cognitive and social skills to children as they enter puberty

scholarly journals Penurunanan Tekanan Darah pada Lansia Hipertensi dengan Senam Ergonomik

2020 ◽  
Vol 5 (1) ◽  
pp. 71
Author(s):  
Sri Muharni ◽  
Utari Christya Wardhani
Keyword(s):  
Blood Pressure ◽  
Time Series ◽  
Pharmacological Therapy ◽  
T Test ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Purposive Sampling ◽  
Group Time ◽  
Paired T Test

<div class="Section1"><p><em><em>Hypertension is one of the most common cardiovascular problem in elderly.  Prolonged high blood pressure canlead to destructionof the blood vessels throughout the body. However it can be controlled with pharmacology and non-pharmacology technique, one of the non-pharmacological therapy is ergonomic exercise. Ergonomic exercise is the gymnastic motion which is combined with breathing techniques. This study aimed was to know about the effect of ergonomic exercise to decreasing blood pressure in elderly with hypertensions in Community Health Center Sei Pancur region. The design was One Group Time Series, intervention given to one group only, without control group. Ergonomic exercise efectivity rated by comparing blood pressure pre and post exercise, during first, second, and third week. Sampling technique was used purposive sampling with 50 respondents. The respondents were given interventions four times. The data analysis used Paired T-Test and Annova Test. The results were shown that the blood pressure significantly decreased during fourth week, with p value: 0.00 for both systolic and diastolic blood pressure. As conclusions, ergonomic exercise had effect to decreasing blood pressure in elderly with hypertensions</em></em></p><p><em><br /></em></p><p><em>Hipertensi adalah salah satu masalah kardiovaskular yang sering terjadi pada lansia. Tekanan darah yang tinggi akan mengakibatkan kerusakan pembuluh darah di seluruh tubuh, kerusakan  tersebut dapat kita  kendalikan dengan terapi farmakologi maupun non farmakologi, salah satunya adalah senam ergonomik. Senam ergonomik adalah  suatu gerakan senam yang dikombinasikan dengan teknik pernapasan. Penelitian ini bertujuan untuk mengetahui pengaruh senam ergonomik terhadap penurunan tekanan darah  pada lansia  hipertensi di wilayah kerja Puskemas Sei Pancur. Desain dalam penelitian ini adalah One Group Time Series Design dengan mengintervensi satu kelompok saja tanpa kelompok pembanding. Efektifitas perlakukan senam ergonomik dinilai dengan cara membandingkan tekanan darah sebelum diberikan senam ergonomik dengan hasil tekanan darah setelah senam ergonomik minggu pertama,kedua dan ketiga. Dimana Teknik sampling yang digunakan adalah Purposive Sampling dengan jumlah sampel 50 responden. Pemberian sebanyak 4  kali intervensi. Analisa data menggunakan uji Paired T-Test dan Annova Test. Hasil penelitian menunjukkan bahwa tekanan darah mulai turun signifikan pada minggu ke-4, dengan nilai p = 0,00 untuk tekanan darah sistole dan 0,00 untuk tekanan darah diastol. Kesimpulan dalam penelitian ini adalah senam ergonomik berpengaruh terhadap penurunan tekanan darah pada lansia dengan hipertensi</em></p></div>

scholarly journals Treatment with Molgramostim (Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor, Rhugm-Csf, Mielogen) and Lenograstim (Granulocyte-Colony Stimulating Factor) Improves Experimental Colitis in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Apostolos E. Papalois ◽  
Calypso Barbatis ◽  
Dimosthenis Chrysikos ◽  
Maria Korontzi ◽  
Michail Sideris ◽  
...  
Keyword(s):  
Experimental Colitis ◽  
Control Group ◽  
Colony Stimulating Factor ◽  
Treatment Control ◽  
Group 4 ◽  
Histological Score ◽  
Group 3 ◽  
Group 5 ◽  
Treatment Control Group ◽  
Stimulating Factor

Background/Aim. Treatment with growth factors could be beneficial in both inflammatory bowel disease and experimental colitis. The aim of this study was to investigate the effect of Colony Stimulating Factor (CSF), and Recombinant Human (rHu) Granulocyte Stimulating Factor (GSF) in experimental colitis in rats. Methods. Experimental colitis was induced in 62 male Wistar rats, divided into 9 groups, using 2,4,6-trinitrobenzensulfonic acid (TNBS). Group 1: Ten rats with colitis without treatment (control group). Euthanasia after 15 days. Group 2: Ten animals with colitis without treatment (control group). Euthanasia after 30 days. Group 3: Six animals with colitis. Immediate treatment with CSF. Euthanasia after 19 days. Group 4: Six animals with colitis. Treatment started 7 days after the induction of colitis. Animals were kept for 19 days. Group 5: Six animals with colitis. Treatment started 2 weeks after the induction of colitis. Group 6: Six animals with colitis, the same as in group 3. Treatment with GSF. Group 7: Six animals with colitis, the same as in group 4. Treatment with GSF. Group 8. Six animals with colitis, the same as in group 5. Treatment with GSF. Group 9: Six animals with colitis. Immediate treatment with prednisolone. Euthanasia after 15 days. Results. CSF and GSF administration significantly improved the histological score (P<0.05) and reduced malondialdehyde contents (P<0.05), compared to control groups in all animals. CSF was superior to GSF and to prednisolone. Conclusion. Administration of both CSF and GSF could significantly improve the histological score and oxidative stress in experimental colitis in rats.

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