scholarly journals A Study on Metabolic Health Status as a Risk Factor for Female Bladder Cancer Incidence: Analysis From the National Health Checkups Database of Korea

2021 ◽  
Vol 19 (4) ◽  
pp. 223-231
Author(s):  
Da Eun Han ◽  
Sun Tae Ahn ◽  
Jong Wook Kim ◽  
Mi Mi Oh ◽  
Du Geon Moon ◽  
...  

Purpose: This study investigated metabolic health status as a risk factor for female bladder cancer using the National Health Checkups databases of Korea.Materials and Methods: We defined obesity if body mass index was ≥25 kg/m2 and normal weight as <25 kg/m2. Metabolic unhealthiness was defined when 3 or more criteria of metabolic syndrome were met. A total of 11,461,618 women who took National health Checkups between 2009 and 2012 were categorized as metabolic healthy normal weight (MHNW), metabolic unhealthy normal weight (MuHNW), metabolic health obese (MHO), and metabolic unhealthy obese (MuHO). Multivariable-adjusted Cox regression was done to analyze the hazard ratio of bladder cancer.Results: The mean age was 48±11.55 years and body mass index was 23.19±2.13 kg/m2. During 5.4±1.1 years of follow-up, 3,893 patients were newly diagnosed with bladder cancer. Compared to MHNW group, the hazard ratio of MuHNW group and MuHO group were 1.237 and 1.288, respectively, while 0.997 in the MHO group. As the number of metabolic unhealthy criteria increased, the cumulative incidence of bladder cancer increased.Conclusions: As a result of a large-scale study conducted on the female population in Korea, the risk of bladder cancer increased with metabolic unhealthiness. Even with normal weight, if metabolically unhealthy, the risk of bladder cancer increased. The greater the degree of metabolic unhealthiness, the higher the risk of bladder cancer. Education on metabolic healthiness concerning female bladder cancer is necessary.

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Feon W. Cheng ◽  
Xiang Gao ◽  
Diane C. Mitchell ◽  
Craig Wood ◽  
Christopher Still ◽  
...  

2021 ◽  
Author(s):  
Yu.V. Shvechikhina ◽  
K.S. Ishchenko ◽  
L.M. Kavelenova

The article is devoted to the study of body mass index (BMI) indicators of biology students at Samara University in 20008-2020. For girls, against the background of fluctuations over the years, from 2015-2016 to 2020. there is a consistent decrease in the proportion of people with underweight, an increase in the proportion of people with normal weight. For young men, changes in the BMI structure are of a more pronounced oscillatory character. The negative features of the 2019 and 2020 contingent are the emergence of overweight and obese people. Key words: students, physical health, body weight, Samara region, body mass index.


BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037095
Author(s):  
Yunhui Tang ◽  
Mingzhi Zhao ◽  
Luling Lin ◽  
Yifei Gao ◽  
George Qiaoqi Chen ◽  
...  

ObjectiveEndometriosis is considered as a serious gynaecological disease in women at a reproductive age. Lower body mass index (BMI) is thought to be a risk factor. However, recent studies indicated that women with normal BMI were also more likely to develop endometriosis, suggesting the association with BMI is controversial. We therefore investigated the association of BMI and surgically diagnosed endometriosis in a cohort of Chinese women.DesignRetrospective case–control study.SettingTertiary hospital.Patients709 women with endometriosis and 807 age matched controls between January 2018 and August 2019.InterventionAge at diagnosis, parity, gravida, BMI and self-reported dysmenorrhoea status were collected and the association of BMI and endometriosis was analysed.Measurement and main resultsOverall, the median BMI was not different between patients and controls (21.1 kg/m2 vs 20.9 kg/m2, p=0.223). According to the BMI categories for Asians/Chinese by WHO (underweight: <18.5 kg/m2, normal weight: 18.5–22.99 kg/m2, overweight: 23–27.49 kg/m2, obese: ≥27.50 kg/m2), overall, there was no difference in the association of BMI and endometriosis (p=0.112). 60% of patients were of normal weight. However, the OR of obese patients (BMI over 27.50 kg/m2) having endometriosis was1.979 (95% CI 1.15 to 3.52, p=0.0185), compared with women with normal weight. 50.3% patients reported dysmenorrhoea, and the OR of developing severe dysmenorrhoea in obese patients (BMI over 27.50 kg/m2) was 3.64 (95% CI 1.195 to 10.15, p=0.025), compared with patients with normal weight.ConclusionOur data demonstrate that overall there was no association between BMI and the incidence of endometriosis, but there was a significant increase in the incidence of endometriosis in obese women, compared with women with normal weight. Obesity was also a risk factor for severe dysmenorrhoea.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S815-S815
Author(s):  
Yingxiao Hua ◽  
Yingxiao Hua ◽  
Dexia Kong ◽  
XinQi Dong

Abstract Body composition has been proposed as an important modifiable risk factor of cognitive decline in multiple epidemiological studies. However, the relationship between body mass index (BMI) and cognitive function remains controversial and conflicting in diverse populations. This study aims to investigate the association between BMI and cognitive decline in U.S. Chinese older adults. Classifications of BMI are based on Asian criteria recommended by WHO (underweight: BMI&lt;18.5, normal weight: 18.5≤BMI&lt;23, overweight: 23≤bmi&lt;27.5, obesity: bmi≥27.5). Logistic regression models were conducted. Compared with normal-weight participants, underweight participants were more likely to experience decline in episodic memory (OR=1.68, p=0.002) and work memory (OR=1.38, p=0.05). Being overweight and obesity were not associated with cognitive function decline. The findings indicate that underweight could potentially be a risk factor of cognitive function decline among U.S. Chinese older adults. Perspective studies may further investigate the association between weight loss and cognitive decline for the development of prevention strategies.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A4-A5
Author(s):  
Débora Barroggi Constantino ◽  
Nicoli Xavier ◽  
Till Roenneberg ◽  
Maria Hidalgo ◽  
Luísa Pilz

Abstract Introduction: Light/dark cycles are the main synchronizing signal (zeitgeber) that entrain human’s internal clock to the 24h-days. Some aspects of urban environments, including irregular light exposure and weak zeitgebers, influence the circadian organization and thereby may have an impact on metabolism. Comparing communities at different levels of urbanization and with different histories of access to electricity might provide evidence to support associations previously found between disrupted patterns of light exposure and increased populational rates of overweight and obesity. The present study aimed to investigate whether living at a higher level of urbanization would be associated with higher body mass index (BMI). It was hypothesized that BMI is higher in urbanized communities, since their inhabitants have weaker zeitgebers, often associated with disrupted circadian rhythms. Methods: We conducted a cross-sectional study in Quilombolas communities, located in the south of Brazil. Subjects were categorized into 5 groups based on their communities’ stage of urbanization and history of access to electricity: from rural with no access to electricity to highly urbanized communities that have access to the grid. We used data from 134 participants aged 16 - 92 years old (63% women), who had 7 days of light exposure recordings collected using wrist-worn actimeters. We also collected anthropometric data to calculate BMI, which was then categorized as follows: ≥18.5 kg/m² to &lt;25 kg/m² = normal weight; ≥25 kg/m² to &lt; 30 kg-m² = overweight; ≥ 30 kg/m² = obesity. We used Shapiro-Wilk to test for normality, Kruskal-Wallis followed by Dunn to compare BMI between groups and Spearman to assess whether there was an association between patterns of light exposure and BMI. Results: Kruskal-Wallis/Dunn test showed a significant difference in BMI between the urban group and the rural ones (KW: X² = 11.987, p &lt; 0.001). Lower average light exposure between 7 am and 5 pm was significantly correlated with higher BMI (Spearman, r = - 0.296, p &lt; 0.001). Also, higher average light exposure at night (from 1 am to 6 am) was significantly correlated with higher BMI (Spearman, r = 0.256, p = 0.002). Conclusions: Our results support the hypothesis that low amplitudes of light exposure may be a risk factor contributing to the high prevalence of obesity worldwide. Studies have previously shown associations between BMI and social jetlag, suggesting the correlations found in our study may be related to higher levels of circadian misalignment, more often present where zeitgeber strength is lower, as in urban environments. Future research is needed to address causal relationships between light exposure and excessive body mass in humans. Provided light exposure is a risk factor for obesity, these results point to potential new targets for intervention and prevention strategies.


2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 14-14
Author(s):  
Yoon Jin Choi ◽  
Dong Ho Lee

14 Background: Obesity is a well-known risk factor for the development of esophageal cancer (EC). However, the impact of underweight on esophageal squamous cell carcinoma (ESCC) has not been fully recognized to date. Therefore, we herein sought to determine the risk of EC in subjects with underweight. Methods: We analyzed the clinical data from a total of 264,084 individuals with the age of 40 years or older, who received healthcare checkups arranged by the national insurance program, between 2003 and 2008. Newly diagnosed EC was identified using the claims data during a median follow-up duration of 7.9 years. Results: The mean body mass index (BMI) of patients was 23.80 ± 3.05kg/m2, and 6,784 individuals (2.6%) were classified as being underweight (BMI < 18.5 kg/m2). During the study period, 278 individuals (0.1%) developed EC. It was determined that underweight and obesity—compared with normal weight—were significantly associated with 73% increased risk and 30% decreased risk of EC, respectively. Excess risk of EC in the underweight group was independent of age, gender, smoking, and alcohol consumption. Heavy alcohol use had a synergistically increasing effect for developing EC among those in the underweight group. Conclusions: The mean body mass index (BMI) of patients was 23.80 ± 3.05kg/m2, and 6,784 individuals (2.6%) were classified as being underweight (BMI < 18.5 kg/m2). During the study period, 278 individuals (0.1%) developed EC. It was determined that underweight and obesity—compared with normal weight—were significantly associated with 73% increased risk and 30% decreased risk of EC, respectively. Excess risk of EC in the underweight group was independent of age, gender, smoking, and alcohol consumption. Heavy alcohol use had a synergistically increasing effect for developing EC among those in the underweight group.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 919-920
Author(s):  
Reshma Jadhav ◽  
Kyriakos S Markides ◽  
Soham Al Snih

Abstract The objective of this study was to examine the effect of body mass index (BMI) on 12-year mortality among older Mexican Americans aged 75 years and older. Data are from wave 5 (N=1,367) of the Hispanic Established Population for the Epidemiologic Study of the Elderly (2004/2005-2016). Measures included socio-demographics, self-reported medical conditions, body mass index (BMI), disability, Mini-Mental-State-Examination (MMSE), short physical performance battery (SPPB), high depressive symptoms, and falls. BMI was classified as underweight (&lt; 18.5), normal weight (18.5 to &lt; 25), overweight (25 to &lt; 30), obesity type I (30 to &lt;35), and morbid obesity (≥ 35).Cox proportional hazards regression analysis was performed to estimate the hazard ratio of 12-year mortality as a function of BMI categories at baseline. The average of the sample was 81.2 years, 17.2% were underweight, 22.7% were normal weight, 27.4% were overweight, 31.9% were obesity type I, and 38.6% were morbid obesity. Mexican Americans aged ≥75 years with overweight or obesity Type I had a reduced hazard ratio (HR) of death (HR=0.80, 95% CI=0.68-0.93 and HR=0.73, 95% CI=0.60-0.88, respectively) over 12-years of follow-up. The HR of death for underweight and morbid obesity participants was 1.78 (95% CI=1.13-2.80) and 1.03 (95% CI=0.79-1.36), respectively. Female participants and those with high scores in the MMSE and SPPB had decreased risk of death. This study confirmed the protective effect of overweight and obesity on mortality seen in this population at a younger age, which might have implications when treating older adults with overweight and obesity.


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