Quaternary geomorphological and climatic changes associated with the diversification of Iberian freshwater fishes: the case of the genus Cobitis (Cypriniformes, Cobitidae)

We studied the population genetic structure of Cobitis vettonica, an endangered freshwater fish species endemic to the Iberian Peninsula in order to propose a biogeographic model of the responses of species to the multiple changes that occurred in the Iberian hydrological system during the Quaternary period. We also deciphered the relationship of C. vettonica with its sister species C. paludica, particularly in sympatric areas and provide genetic information for conservation purposes. To achieve this end, we analysed both mitochondrial and nuclear data (the cytochrome b and the nuclear recombination activating 1 genes) and a battery of single nucleotide polymorphisms (SNPs) of 248 individuals of C. vettonica or C. paludica from 38 localities, including some sympatric ones, covering the entire distribution area of C. vettonica. We highlight the important role played by the hydrogeomorphological processes and climatic changes that occurred in the Iberian Peninsula during the Quaternary on both the population structure of C. vettonica and its relationship with its sister species C. paludica. Our results support the genetic introgression of populations at the eastern limit of the distribution of C. vettonica. Furthermore, we postulate genetic introgression in sympatric areas. Finally, we propose the establishment or expansion of four OCUs for C. vettonica, and highlight the threat faced by its populations due to the low level of genetic diversity detected for some of its populations and genetic introgression with C. paludica, which could eventually displace C. vettonica, resulting in a loss of diversity in this species.

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Aire et gestion des ressources en chêne du canton de Vaud: dossier d'un avenir immédiat | Resource management and distribution area of oak in canton Vaud: an issue for the immediate future

Schweizerische Zeitschrift fur Forstwesen ◽

10.3188/szf.2009.s0065 ◽

2009 ◽

Vol 160 (s1) ◽

pp. s65-s73

Author(s):

Denis Horisberger ◽

Micheline Meylan

Keyword(s):

Resource Management ◽

Tree Species ◽

Climatic Changes ◽

Distribution Area ◽

Oak Forests ◽

Genetic Inheritance ◽

Main Species ◽

Forestry Management ◽

New Situation

When climatic changes are taken into account in forestry management, the question arises of the choice of tree species in order to adapt the forests to increased temperatures and stress arising from lack of water. The oak could be the main species accommodating itself to the new situation up to an altitude of about 900 m. A maximal development of this genetic inheritance adapted to our soils and the reinstallation of a network of oak forests would in fact give a new boost to the exceptional biodiversity linked to this species. In canton Vaud, the application of a sylviculture favourable to the oak would concern a relatively small and reasonable area of approximately 8,000 hectares, which corresponds to less than 20% of the surface theoretically adapted to this species, with a rhythm of rejuvenation of about 40 hectares a year.

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Genetic Polymorphisms and the Risk of Diabetic Foot: A Systematic Review and Meta-Analyses

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734620977599 ◽

2020 ◽

pp. 153473462097759

Author(s):

Jun Zhao ◽

Le-Xuan Zhang ◽

Yu-Ting Wang ◽

Yang Li ◽

Hong-Lin Chen, MD

Keyword(s):

Genetic Polymorphisms ◽

Diabetic Foot ◽

Protective Factor ◽

Meta Analysis ◽

Nucleotide Polymorphisms ◽

Asian Populations ◽

Tnf Α ◽

Newcastle Ottawa Scale ◽

Meta Analyses ◽

Relationship Of

Background Diabetic foot (DF) is a dangerous complication of diabetes. The aim of the study was to synthesize all the published single nucleotide polymorphisms (SNPs) of DF to objectively evaluate the relationship of SNPs and DF risks. Methods The HuGE database and CNKI were searched for eligible publications on genetic polymorphisms and the risk of DF systematically. The quality of literatures was evaluated by the Newcastle-Ottawa scale. Pooled odds ratios with a 95% confidence interval for SNPs were evaluated through 3 genetic models. Results Citing 29 different polymorphisms from 24 articles and the study met our selection criteria. There were 24 polymorphisms summarized systematically, and 5 merged polymorphisms for a meta-analysis: 9 positively associated with DF: HIF-1α rs11549465, TNF-α rs1800629, TLR-9 rs5743836, FIB rs6056, HSP70-2437C/T, VDR rs2228570, LOX rs1800449, ITLN1 rs2274907, and OPG rs2073617, but OPG rs3134069 was not a risk factor in DF; 6 negatively associated with DF: VEGF rs833061 and rs2010963, MCP-1 rs1024611, SDF-1 rs1801157, SIRT1 rs12778366, and OPG rs2073617. In addition, 13 polymorphisms were not associated with DF: MMP-9 rs3918242, eNOS rs1799983, VEGF rs3025039, -7C/T, rs1570360, rs13207351, and rs699947, IL-6 rs1800795, HIF-1α rs11549467, TNF-α rs361525, TLR-2 rs3804100, SIRT1 rs3758391, and TIMP-1 rs2070584. Conclusions The study provided some evidence for SNPs to the development of diabetic foot. The meta-analysis showed that rs1024611 of MCP-1 may be regarded as a protective factor, especially in Asian populations. Other loci indicated inconsistent results.

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IL-1R2 Polymorphisms and its Interaction Associates With Osteoporosis Susceptibility in Chinese Han Population

10.21203/rs.3.rs-25428/v1 ◽

2020 ◽

Author(s):

Kai Rong ◽

Zhiquan Liang ◽

Wenyuan Xiang ◽

Zhan Wang ◽

Fengli Wen ◽

...

Keyword(s):

Negative Regulator ◽

Chinese Han Population ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Single Nucleotide ◽

Han Population ◽

Testing Accuracy ◽

Relationship Of ◽

The Relationship ◽

Osteoporosis Risk

Abstract Background: IL-1R2, serves as a negative regulator of IL-1 signaling, is involved in the pathogenesis of osteoporosis. This study aimed to determine the correlation between IL-1R2 polymorphism and osteoporosis susceptibility among the Chinese Han population.Methods: We recruited 594 osteoporosis patients and 599 healthy controls. Six single nucleotide polymorphisms (SNPs) in IL-1R2 were selected for genotyping using Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) was calculated through logistic regression analysis with adjustment for age and sex. Linkage disequilibrium analysis was plotted by Haploview v4.2. Multifactor dimension reduction (MDR) was performed to estimate the SNP-SNP interaction of IL-1R2 variants.Results: Our result revealed that rs11674595 (OR = 1.86, p = 0.020), rs2072472 (OR = 1.26, p = 0.019) and rs4851527 (OR = 0.78, p = 0.007) were related to the risk of osteoporosis. Moreover, the contribution of IL-1R2 polymorphisms to osteoporosis risk presented age, sex and BMI difference. We found the relationship of Trs11674595Ars4851527 (OR = 0.80, p = 0.015), Crs11674595Grs4851527 (OR = 1.22, p = 0.043) and Ars3218977Grs2072472 (OR = 1.25, p = 0.022) haplotypes to osteoporosis occurrence, and a potential accumulated effect of IL-1R2 SNPs (testing accuracy = 0.5783 and CVC = 10/10) on osteoporosis susceptibility.Conclusion: IL-1R2 polymorphisms (rs11674595, rs4851527, rs2072472 and rs3218977) might contribute to osteoporosis risk among the Chinese Han population. Our finding may increase our understanding of the effects of IL-1R2 polymorphisms on the predisposition of osteoporosis.

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Genome-wide markers reveal differentiation between and within the cryptic sister species, sunset and vermilion rockfish

Conservation Genetics ◽

10.1007/s10592-021-01397-4 ◽

2021 ◽

Author(s):

Gary C. Longo ◽

John Harms ◽

John R. Hyde ◽

Matthew T. Craig ◽

Ana Ramón-Laca ◽

...

Keyword(s):

Management Strategies ◽

Cost Effective ◽

Sister Species ◽

Nucleotide Polymorphisms ◽

Relative Contribution ◽

Genetic Groups ◽

Cost Effective Method ◽

Species Population ◽

Single Complex ◽

Species Specific

AbstractThe vermilion rockfish complex, which consists of the cryptic sister species vermilion and sunset rockfish, is one of the most valuable recreational fisheries on the U.S. West Coast. These species are currently managed as a single complex, and because of uncertainty surrounding the relative contribution of each species within existing data sources, the stock status of each species is not fully known. A reliable and cost-effective method is needed to disentangle these species that will allow for the development of abundance indices, life history profiles, and catch histories that may potentially support species-specific stock assessments. Using restriction-site associated DNA sequence (RADseq) markers we generated 10,003 polymorphic loci to characterize the vermilion rockfish complex. PCA and Bayesian clustering approaches based on these loci clearly distinguished between sunset and vermilion rockfishes and identified hybrid individuals. These loci included 203 highly differentiated (FST ≥ 0.99) single nucleotide polymorphisms, which we consider candidates in the planned development of a diagnostic assay capable of distinguishing between these cryptic species. In addition to clearly delineating to species, subsets of the interspecific markers allowed for insight into intraspecific differentiation in both species. Population genetic analyses for sunset rockfish identified two weakly divergent genetic groups with similar levels of genetic diversity. Vermilion rockfish, however, were characterized by three distinct genetic groups with much stronger signals of differentiation and significantly different genetic diversities. Collectively, these data will contribute to well-informed, species-specific management strategies to protect this valuable species complex.

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Palaeosols as indicators of the climatic changes during Quaternary period in S. Anatolia

Journal of Arid Environments ◽

10.1006/jare.1996.0003 ◽

1996 ◽

Vol 32 (1) ◽

pp. 23-35 ◽

Cited By ~ 21

Author(s):

İbrahim Atalay

Keyword(s):

Climatic Changes ◽

Quaternary Period

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Redescription and mitochondrial identification of Chiromantes boulengeri (Calman, 1920) (Decapoda: Brachyura: Sesarmidae) based on fresh material from the Persian Gulf, Iran

Zootaxa ◽

10.11646/zootaxa.2128.1.3 ◽

2009 ◽

Vol 2128 (1) ◽

pp. 61-68 ◽

Cited By ~ 7

Author(s):

REZA NADERLOO ◽

CHRISTOPH D. SCHUBART

Keyword(s):

Mitochondrial Dna ◽

Persian Gulf ◽

Type Species ◽

East Asian ◽

Sister Species ◽

Species Relationship ◽

Asian Species ◽

Fresh Material ◽

The Persian Gulf ◽

Relationship Of

Chiromantes boulengeri (Calman, 1920) is redescribed based on fresh material from Iran. The species is morphologically more similar to C. dehaani (H. Milne Edwards, 1853) than both of these species are to the type species of the genus, C. haematocheir (De Haan, 1833). Results from mitochondrial DNA, however, propose a closer sister species relationship of the two East Asian species, C. haematocheir (De Haan, 1833) and C. dehaani.

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The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury

Biological Research For Nursing ◽

10.1177/1099800418785982 ◽

2018 ◽

Vol 20 (5) ◽

pp. 566-576 ◽

Cited By ~ 3

Author(s):

Karin Reuter-Rice ◽

Michael Regier ◽

Ellen Bennett ◽

Daniel Laskowitz

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Cerebral Vasospasm ◽

Functional Outcomes ◽

Injury Severity ◽

Apoe Genotype ◽

Apoe Gene ◽

Nucleotide Polymorphisms ◽

Relationship Of ◽

The Relationship

Background: Pediatric traumatic brain injury (TBI) is a leading cause of death and disability. Polymorphisms in the apolipoprotein E ( APOE) gene have been linked to cerebral vasospasm (CV) and poor outcomes in adults with TBI, yet these associations remain poorly defined in children. Objective: We examined the effect of the relationship between APOE polymorphisms and CV on functional outcomes in children with a TBI. Method: This prospective, descriptive study examined 60 children (aged 10 days to 15 years) with a TBI. Data included demographic information, genetic sampling for the APOE gene and single-nucleotide polymorphisms (SNPs; rs405509, rs429358, rs7412), and daily transcranial Doppler ultrasounds to evaluate for CV. We examined Glasgow Outcome Scale–Extended Pediatrics (GOS-E Peds) scores at the time of discharge and 4–6 weeks after discharge. Results: More than half (56.7%) of the 60 children ( Mage = 5.9 years) were male. Twenty-six participants (43.3%) experienced an occurrence of CV. There were significant differences in injury mechanism (unadjusted p = .048) and age (unadjusted p = .02) between those with and without CV. Also, the noncoding promoter SNP rs405509 T/T, when considered with injury severity, appeared to modify the relationship of APOE genotype to CV. The relationship between APOE and CV had no significant effect on GOS-E Peds scores. Conclusion: Injury severity and the APOE noncoding promoter SNP rs405509 may modify the relationship between APOE and CV in children with TBI. More studies are needed to understand the role of APOE polymorphisms in outcomes in children with TBI.

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