scholarly journals Additional insight into creative contribution of Le Corbusier

2019 ◽  
Vol 17 (3) ◽  
pp. 283-297
Author(s):  
Jasenka Cakaric ◽  
Aida Idrizbegovic-Zgonic
Keyword(s):  
Urban Design ◽  
20Th Century ◽  
Urban Landscape ◽  
Le Corbusier ◽  
Additional Insight ◽  
Urban And Regional Planning ◽  
New Era ◽  
Creative Contribution ◽  
Modern Era ◽  
Insight Into

Social turbulences and discontinuities of the 20th century, have as always reflected upon scientific and creative achievements, most visible in changes in architectural thought and relation to space. First half of the 20th century was shaped by the modernist movement, represented through technical and technological achievements of building into economy, social context and culture giving an overall sense of units and spirt of urbanism and architecture of the modern era. In architecture there is a special place for the architect of the new era Le Corbusier whose narrative shaped and dominated the urban and architectural medium. Through research one can draw an analogy conceived by Le Corbusier between a typical serial housing unit and his functionalist urban and regional planning. He was at the same time praised and despised, but has definitely shaped the urban landscape as we know it today. Through research into his essence and paradigms and contribution, this paper aims to reflect his urban design process that originated in multiplication and standardization of single units (family or collective) combined with his visions for an expanding cityscape.

scholarly journals Blake Studies in the 21st Century

2021 ◽  
Vol 6 (2) ◽  
pp. 456-477
Author(s):  
Vera V. Serdechnaia
Keyword(s):  
Gender Studies ◽  
20Th Century ◽  
21St Century ◽  
Comparative Studies ◽  
Textual Criticism ◽  
Postcolonial Studies ◽  
Cultural Influence ◽  
New Era ◽  
Linguistic Research ◽  
Modern Era

The author summarizes Blake studies of the 21st century. The beginning of the modern era of Blake studies can be considered with the paradigm of deconstruction. At the end of the 20th century, synthetic analysis took a special place in Blake studies, when Blake’s illuminated books were studied as an inseparable unity of verbal and visual. Blake’s legacy has undergone a significant evolution related to deconstruction and postmodern approaches, and linguistic research. The development of traditional areas of research, such as psychoanalysis, textual criticism of manuscripts, religious and mystical allusions, and comparative studies is also traced. Postmodernism, which owes much to the Romanticism (i.e. the concept of irony, fragmentation, the category of the exalted, the original lonely hero), brought new features to Blake studies and greatly contributed to its approval among canonical authors of the Romanticism. In modern Blake studies, such areas as gender studies, postcolonial studies, studies in digital reality environments are most actively developing. Starting from the 2000s, the main direction in Blake studies has become reception, that is, the cultural influence of Blake’s writings on later culture, including the culture of other countries: poetry, literature, music and cinema. Each new era reveals fundamentally similar features and adds meanings to Blake: this process is going from symbolism and psychoanalysis to the present day.

scholarly journals Blake Studies in the 21st Century

2021 ◽  
Vol 6 (2) ◽  
pp. 456-477
Author(s):  
Vera V. Serdechnaia
Keyword(s):  
Gender Studies ◽  
20Th Century ◽  
21St Century ◽  
Comparative Studies ◽  
Textual Criticism ◽  
Postcolonial Studies ◽  
Cultural Influence ◽  
New Era ◽  
Linguistic Research ◽  
Modern Era

The author summarizes Blake studies of the 21st century. The beginning of the modern era of Blake studies can be considered with the paradigm of deconstruction. At the end of the 20th century, synthetic analysis took a special place in Blake studies, when Blake’s illuminated books were studied as an inseparable unity of verbal and visual. Blake’s legacy has undergone a significant evolution related to deconstruction and postmodern approaches, and linguistic research. The development of traditional areas of research, such as psychoanalysis, textual criticism of manuscripts, religious and mystical allusions, and comparative studies is also traced. Postmodernism, which owes much to the Romanticism (i.e. the concept of irony, fragmentation, the category of the exalted, the original lonely hero), brought new features to Blake studies and greatly contributed to its approval among canonical authors of the Romanticism. In modern Blake studies, such areas as gender studies, postcolonial studies, studies in digital reality environments are most actively developing. Starting from the 2000s, the main direction in Blake studies has become reception, that is, the cultural influence of Blake’s writings on later culture, including the culture of other countries: poetry, literature, music and cinema. Each new era reveals fundamentally similar features and adds meanings to Blake: this process is going from symbolism and psychoanalysis to the present day.

Classification of Infant Vocalizations by Untrained Listeners

2019 ◽  
Vol 62 (9) ◽  
pp. 3265-3275
Author(s):  
Heather L. Ramsdell-Hudock ◽  
Anne S. Warlaumont ◽  
Lindsey E. Foss ◽  
Candice Perry
Keyword(s):  
Formal Education ◽  
Additional Insight ◽  
Listener Responses ◽  
Infant Vocalization ◽  
Early Infant ◽  
Infant Vocalizations ◽  
Audio Recordings ◽  
Speech And Language Development ◽  
Insight Into

Purpose To better enable communication among researchers, clinicians, and caregivers, we aimed to assess how untrained listeners classify early infant vocalization types in comparison to terms currently used by researchers and clinicians. Method Listeners were caregivers with no prior formal education in speech and language development. A 1st group of listeners reported on clinician/researcher-classified vowel, squeal, growl, raspberry, whisper, laugh, and cry vocalizations obtained from archived video/audio recordings of 10 infants from 4 through 12 months of age. A list of commonly used terms was generated based on listener responses and the standard research terminology. A 2nd group of listeners was presented with the same vocalizations and asked to select terms from the list that they thought best described the sounds. Results Classifications of the vocalizations by listeners largely overlapped with published categorical descriptors and yielded additional insight into alternate terms commonly used. The biggest discrepancies were found for the vowel category. Conclusion Prior research has shown that caregivers are accurate in identifying canonical babbling, a major prelinguistic vocalization milestone occurring at about 6–7 months of age. This indicates that caregivers are also well attuned to even earlier emerging vocalization types. This supports the value of continuing basic and clinical research on the vocal types infants produce in the 1st months of life and on their potential diagnostic utility, and may also help improve communication between speech-language pathologists and families.

Optimum Infinite is a new era of oxygen permeability material for contact lenses

The Eye ◽  
2020 ◽  
Vol 22 (129) ◽  
pp. 44-46
Author(s):  
Mark Eddleston
Keyword(s):  
Contact Lens ◽  
Oxygen Permeability ◽  
Contact Lenses ◽  
New Era ◽  
Lens Material ◽  
Insight Into

Optimum Infinite is a new GP contact lens material, with an oxygen permeability of 180 barrer and was launched by Contamac at the GSLS 2019. This article provides an insight into the development and characteristics of this breakthrough material.

Diversity, Rationality, and the Division of Cognitive Labor

2017 ◽  
Author(s):  
Ryan Muldoon
Keyword(s):  
Social Structure ◽  
Division Of Labor ◽  
Additional Insight ◽  
Division Of Cognitive Labor ◽  
Social Structure Of Science ◽  
The Social ◽  
Insight Into

Existing models of the division of cognitive labor in science assume that scientists have a particular problem they want to solve and can choose between different approaches to solving the problem. In this essay I invert the approach, supposing that scientists have fixed skills and seek problems to solve. This allows for a better explanation of increasing rates of cooperation in science, as well as flows of scientists between fields of inquiry. By increasing the realism of the model, we gain additional insight into the social structure of science and gain the ability to ask new questions about the optimal division of labor.

scholarly journals Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bimandra A. Djaafara ◽  
Charles Whittaker ◽  
Oliver J. Watson ◽  
Robert Verity ◽  
Nicholas F. Brazeau ◽  
...  
Keyword(s):  
Rural Areas ◽  
Vaccination Campaign ◽  
Control Measures ◽  
Additional Insight ◽  
Short Term ◽  
If Current ◽  
Vaccine Impact ◽  
Potential Impact ◽  
The Impact ◽  
Insight Into

Abstract Background As in many countries, quantifying COVID-19 spread in Indonesia remains challenging due to testing limitations. In Java, non-pharmaceutical interventions (NPIs) were implemented throughout 2020. However, as a vaccination campaign launches, cases and deaths are rising across the island. Methods We used modelling to explore the extent to which data on burials in Jakarta using strict COVID-19 protocols (C19P) provide additional insight into the transmissibility of the disease, epidemic trajectory, and the impact of NPIs. We assess how implementation of NPIs in early 2021 will shape the epidemic during the period of likely vaccine rollout. Results C19P burial data in Jakarta suggest a death toll approximately 3.3 times higher than reported. Transmission estimates using these data suggest earlier, larger, and more sustained impact of NPIs. Measures to reduce sub-national spread, particularly during Ramadan, substantially mitigated spread to more vulnerable rural areas. Given current trajectory, daily cases and deaths are likely to increase in most regions as the vaccine is rolled out. Transmission may peak in early 2021 in Jakarta if current levels of control are maintained. However, relaxation of control measures is likely to lead to a subsequent resurgence in the absence of an effective vaccination campaign. Conclusions Syndromic measures of mortality provide a more complete picture of COVID-19 severity upon which to base decision-making. The high potential impact of the vaccine in Java is attributable to reductions in transmission to date and dependent on these being maintained. Increases in control in the relatively short-term will likely yield large, synergistic increases in vaccine impact.

scholarly journals Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1909
Author(s):  
Joachim T. Siaw ◽  
Jonatan L. Gabre ◽  
Ezgi Uçkun ◽  
Marc Vigny ◽  
Wancun Zhang ◽  
...  
Keyword(s):  
Genome Engineering ◽  
Neuroblastoma Cells ◽  
Gene Signature ◽  
Additional Insight ◽  
Downstream Target ◽  
Anaplastic Lymphoma ◽  
Extracellular Matrix Components ◽  
Transforming Gene ◽  
Insight Into

Aberrant activation of anaplastic lymphoma kinase (ALK) drives neuroblastoma (NB). Previous work identified the RET receptor tyrosine kinase (RTK) as a downstream target of ALK activity in NB models. We show here that ALK activation in response to ALKAL2 ligand results in the rapid phosphorylation of RET in NB cells, providing additional insight into the contribution of RET to the ALK-driven gene signature in NB. To further address the role of RET in NB, RET knockout (KO) SK-N-AS cells were generated by CRISPR/Cas9 genome engineering. Gene expression analysis of RET KO NB cells identified a reprogramming of NB cells to a mesenchymal (MES) phenotype that was characterized by increased migration and upregulation of the AXL and MNNG HOS transforming gene (MET) RTKs, as well as integrins and extracellular matrix components. Strikingly, the upregulation of AXL in the absence of RET reflects the development timeline observed in the neural crest as progenitor cells undergo differentiation during embryonic development. Together, these findings suggest that a MES phenotype is promoted in mesenchymal NB cells in the absence of RET, reflective of a less differentiated developmental status.

Technology in Context: Mediating Factors in the Utilization of Planning Technologies

2005 ◽  
Vol 37 (5) ◽  
pp. 895-907 ◽  
Author(s):  
Ari Goelman
Keyword(s):  
Organizational Structure ◽  
Information Technologies ◽  
Public Access ◽  
Web Gis ◽  
Gis Technology ◽  
Additional Insight ◽  
Mediating Factors ◽  
The Impact ◽  
Insight Into

My research explores the question: how can theorists better understand the ways in which planning technologies are used by municipal planners? In the case-study municipality, a recently introduced web-GIS technology had little demonstrable success in attaining two of its stated goals: enabling increased public access to municipal geographic information and encouraging planners to produce their own maps. My research links these outcomes not only to the technologies themselves, but to organizational structure and human agency. Planners and planning theorists can gain additional insight into the impact of planning technologies through closer attention to the process through which planners come to use information technologies and the way this process both alters and is constrained by existing organizational constraints, including previously adopted technologies.

The impact of tinnitus characteristics and associated variables on tinnitus-related handicap

2015 ◽  
Vol 130 (1) ◽  
pp. 25-31 ◽  
Author(s):  
S Degeest ◽  
P Corthals ◽  
I Dhooge ◽  
H Keppler
Keyword(s):  
Additional Insight ◽  
Tinnitus Handicap Inventory ◽  
Hearing Status ◽  
Questionnaire Score ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship ◽  
Sample Case ◽  
Insight Into ◽  
Associated Variables

AbstractObjective:This study aimed to determine the characteristics of tinnitus and tinnitus-related variables and explore their possible relationship with tinnitus-related handicap.Methods:Eighty-one patients with chronic tinnitus were included. The study protocol measured hearing status, tinnitus pitch, loudness, maskability and loudness discomfort levels. All patients filled in the Tinnitus Sample Case History Questionnaire, the Hyperacusis Questionnaire and the Tinnitus Handicap Inventory. The relationship of each variable with the Tinnitus Handicap Inventory score was evaluated by univariate and multivariate analyses.Results:Five univariables were associated with the Tinnitus Handicap Inventory score: loudness discomfort level, subjective tinnitus loudness, tinnitus awareness, noise intolerance and Hyperacusis Questionnaire score. Multiple regression analysis showed that the Hyperacusis Questionnaire score and tinnitus awareness were independently associated with the Tinnitus Handicap Inventory score.Conclusion:Hyperacusis and tinnitus awareness were independently associated with the Tinnitus Handicap Inventory score. Questionnaires on tinnitus and hyperacusis are especially suited to providing additional insight into tinnitus-related handicap and are therefore useful for evaluating tinnitus patients.

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