scholarly journals Examination of the efficacy of various feed additives on the pathomorphological changes in broilers treated with T-2 toxin

2009 ◽  
pp. 49-54 ◽  
Author(s):  
Vladimir Nesic ◽  
Darko Marinkovic ◽  
Ksenija Nesic ◽  
Radmila Resanovic
Keyword(s):  
Small Intestine ◽  
Adverse Effects ◽  
Feed Additives ◽  
Degenerative Changes ◽  
Bursa Of Fabricius ◽  
Broiler Chicks ◽  
Protective Effects ◽  
Negative Consequences ◽  
Intestine Mucosa

A 21-day-long experiment was performed on 160 one-day-old 'Ross' broiler chicks. This research was done with the aim of investigating pathomorphological changes in broilers exposed to a relatively small amount of T-2 toxin (2 ppm) and the possibility of prevention and/or alleviating adverse effects of T-2 toxin using various feed additives. Pathohistological examination showed negative consequences of T-2 toxin in all examined organs as degenerative changes developed in small intestine mucosa, enterocites and hepatocites necroses, as well as lymphocites depletion in bursa of Fabricius. Disparately from inorganic (Minazel-plus, Mz) and organic (Mycosorb, Ms) adsorbents, which did not provoke protective effects, in liver, small intestine and bursa of Fabricius of broilers who were given feed with T-2 toxin and mixed adsorbent (Mycofix-plus, Mf), mostly preserved structure of these organs could be noted.

scholarly journals Efficiency of various feed additives on the performance of broilers treated with T-2 toxin

2011 ◽  
Vol 27 (3) ◽  
pp. 705-711 ◽  
Author(s):  
K. Nesic ◽  
R. Resanovic ◽  
D. Jakic-Dimic ◽  
V. Nesic
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Adverse Effects ◽  
Feed Additives ◽  
Broiler Chicks ◽  
Negative Consequences ◽  
Negative Effects ◽  
Gain Ratio

Experiment was conducted on 160 one-day-old broiler chicks "Ross" proveniention during 21 day. This research was done with the aim to investigate performances of broilers exposed to the relatively small amount of T-2 toxin (2 mg/kg) and the possibility of prevention and/or alleviating its adverse effects by using various feed additives. Results showed negative consequences of T-2 toxin on body weight, weight gain, feed: gain ratio. All used feed additives in the concentration of 0.2% in feed: inorganic (Minazel-plus, Mz) and organic (Mycosorb, Ms) adsorbents, as well as mixed adsorbent (Mycofix-plus, Mf) mostly alleviated negative effects of T-2 toxin.

Some Indian herbs have protective effects against deleterious effects of ochratoxin A in broiler chicks

2021 ◽  
pp. 1-14
Author(s):  
S.D. Stoev ◽  
K. Dimitrov ◽  
I. Zarkov ◽  
T. Mircheva ◽  
D. Zapryanova ◽  
...  
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Ochratoxin A ◽  
Relative Weight ◽  
Fine Powder ◽  
Inhibitory Effect ◽  
Feed Additives ◽  
Tinospora Cordifolia ◽  
Broiler Chicks ◽  
Protective Effects

A protective effect of two herbs, Glycyrrhiza glabra and Tinospora cordifolia, given as feed additives was observed against the growth inhibitory effect of ochratoxin A (OTA) and associated immunosuppression and biochemical or pathomorphological changes. The feed levels of 3 mg/kg OTA and fine powder of one of both herbs were given during a period of 32 days to female broiler chicks divided into 3 experimental and 1 control groups (14 chicks per group). The observed pathological and biochemical changes, the changes in relative organs’ weight and body weight, and the decrease of antibody titer against Newcastle disease were more pronounced in the OTA-treated chicks without herbal supplementation, and less pronounced in the chicks treated additionally with G. glabra or T. cordifolia as was shown by the better feed performance and the higher body weight in the chicks treated with the herbs. The higher relative weight of lymphoid organs of the chicks supplemented with both herbs revealed their beneficial effects on the immune system. The hepatoprotective effect of both herbs was evident, being stronger in the chicks additionally supplemented with G. glabra shown by the pathomorphological findings and by the lower levels of aspartate transaminase (131.1 U/l) compared to chicks given only OTA (156.0 U/l). A protective effect of T. cordifolia on the bone marrow and kidneys was found as was shown by the lower levels of uric acid (382.9 μmol/l) compared to chicks given only OTA (466.9 μmol/l).

Adverse effects in broiler chickens fed a high lycopene concentration supplemented diet

2013 ◽  
Vol 93 (2) ◽  
pp. 231-241 ◽  
Author(s):  
Luisa Pozzo ◽  
Martina Tarantola ◽  
Elena Biasibetti ◽  
Maria Teresa Capucchio ◽  
Maddalena Pagella ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Adverse Effects ◽  
Broiler Chickens ◽  
Femoral Vein ◽  
Basal Diet ◽  
Bursa Of Fabricius ◽  
Control Group ◽  
Broiler Chicks ◽  
Breast Meat ◽  
Liver And Kidney

Pozzo, L., Tarantola, M., Biasibetti, E., Capucchio, M. T., Pagella, M., Mellia, E., Bergagna, S., Gennero, M. S., Strazzullo, G. and Schiavone, A. 2013. Adverse effects in broiler chickens fed a high lycopene concentration supplemented diet. Can. J. Anim. Sci. 93: 231–241. The present investigation was designed to assess the effects of the administration of a high dietary lycopene dose to broiler chickens on growth and slaughter performances, haemato–biochemical parameters, antioxidant enzymes, histological lesions and lycopene accumulation in the tissues. Thirty-six 1-d-old male Hubbard broiler chicks were examined and divided randomly into two groups (three replicates for each dietary treatment): the Control group, which received a basal diet, and the Lycopene group, which received the basal diet supplemented with 500 mg lycopene kg−1diet. The experimental period lasted 35 d and growth performance was recorded on a weekly basis. At the end of the experiment (day 35), blood samples (n=12) were collected from the femoral vein. Erythrocyte and leukocyte numbers were assessed and the heterophil-to-lymphocyte ratio was determined. The alpha-1-acid glycoprotein, lysozyme, total protein and the electrophoretic patterns were evaluated in serum samples. Nine chickens per group were slaughtered to measure the carcass yields and the weight of the liver, spleen, bursa of Fabricius and thymus. Spleen, liver, and bursa of Fabricius samples were collected for histological examination and fixed in 10% neutral buffered formalin. The lycopene concentration, thiobarbituric acid reactive substances (TBARS) and chemical composition were assayed in breast meat and thigh samples. The TBARS, glutathione content, catalase and superoxide dismutase activity were measured in liver and kidney samples. The high lycopene concentration supplemented diet did not affect the birds’ growth, slaughter performance or antioxidant enzymes in the breast meat, thigh meat, liver and kidney samples. The concentrations of lycopene in the breast and thigh of the lycopene-supplemented group were 0.10±0.05 mg kg−1and 0.42±0.35 mg kg−1, respectively, while no lycopene was found in the Control group. Spleen and bursa of Fabricius of birds fed a diet supplemented with a high level of lycopene showed weight decrease (P<0.05) and degenerative lesions (P<0.05). Moreover, lycopene supplementation reduced the serum protein concentration, albumin, alpha and the gamma globulin serum concentration (P<0.05).

Selected herbal feed additives showing protective effects against ochratoxin A toxicosis in broiler chicks

2019 ◽  
Vol 12 (3) ◽  
pp. 257-268 ◽  
Author(s):  
S.D. Stoev ◽  
P. Njobeh ◽  
I. Zarkov ◽  
T. Mircheva ◽  
D. Zapryanova ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Newcastle Disease ◽  
Relative Weight ◽  
Centella Asiatica ◽  
Serum Levels ◽  
Feed Additives ◽  
Immunosuppressive Effect ◽  
Broiler Chicks ◽  
Protective Effects ◽  
Humoral Immune

The protective effects of herbal feed additives Silybum marianum, Withania somnifera and Centella asiatica against the toxic effects of ochratoxin A (OTA) were studied in 70 broiler chicks aged from 11 to 42 days. OTA was given with the feed at levels 5 mg/kg, whereas S. marianum, W. somnifera and C. asiatica were given at levels of 1,100, 4,000 and 4,600 mg/kg, respectively. All chicks were immunised at the age of 14 days against Newcastle disease. A protective effect of all studied herbal additives against the immunosuppressive effect of OTA and associated biochemical or pathomorphological changes was seen. The intensity of macroscopical and histopathological changes, the deviations in relative organs’ weight or body weight, the biochemical changes and the decrease of antibody titer were strongest in the OTA-exposed chicks without herbal supplementation; followed by chicks treated additionally with C. asiatica, whereas the same changes were significantly slighter or not seen in chicks additionally treated with the herbal additives W. somnifera or S. marianum. The slight increase in the serum levels of uric acid and the enzyme activity of aspartate transaminase and alanine transaminase also supported the protective effects of both herbs on the kidneys and/or liver. The strong immunosuppressive effect of OTA on humoral immune response against Newcastle disease was completely prevented in the chicks taking the herbal additives W. somnifera or S. marianum, which was supported by the higher relative weight of immunocompetent (lymphoid) organs in the same chicks. A hepatoprotective effect was found in OTA-exposed chicks treated additionally with W. somnifera and S. marianum, whereas a nephroprotective effect was only found in the chicks additionally treated with S. marianum as observed from the biochemical and pathomorphological findings. The same herbs could be used as a practical approach for safely utilising of OTA-contaminated feed.

scholarly journals Weight Test of Broiler Chicks Placed on Probiotic-fortified Composite Feed, Standard Commercial Starter Mash and Cornmeal

2020 ◽  
Vol 9 (3) ◽  
pp. 1102-1104
Keyword(s):  
Adverse Effects ◽  
Growth Performance ◽  
Animal Feed ◽  
Feed Additives ◽  
Broiler Chicks ◽  
Significant Difference ◽  
Weight Test ◽  
Performance Results ◽  
Similar Growth ◽  
Feed Mill

The study was carried out to compare growth performance results among broiler chicks placed on probioticfortified animal feed (G3), Feed Mill of Nigeria starter mash (G1) (conventional feed) and cornmeal (G2) diets. A total of thirty 1-day-old mixed-sex Agricol broiler chicks were randomized into three groups of 10 chicks each and placed on 600g (300g morning, 300g evening) of the respective diets. Feeding test was carried out for the duration of four weeks. The chicks were weighed weekly and data collected was statistically analyzed using a one-way Analysis of variance to check for significant differences in weight among groups. From data analyzed, chicks in groups G3 – probiotic-fortified feed and G1 – Feed Mill of Nigeria starter mash, showed no significant difference in parameters (weight) analyzed (p<0.05) and performed better in comparison to chicks placed on cornmeal diet (G2). This study shows that probiotic-fortified feed can be used as a substitute to conventionally-produced feed and yield similar growth performance without the use of feed additives which have adverse effects on animals being fed.

Model for assigning security objects to a specific risk category in the field of fire safety

2020 ◽  
Vol 90 ◽  
pp. 19-31
Author(s):  
D. V. Zobkov ◽  
◽  
A. A. Poroshin ◽  
A. A. Kondashov ◽  
◽  
...  
Keyword(s):  
Adverse Effects ◽  
Fire Safety ◽  
Economic Activity ◽  
Fire Hazard ◽  
Risk Category ◽  
Negative Consequences ◽  
Acceptable Risk ◽  
Individual Object ◽  
Safety Requirements ◽  
Risk Categories

Introduction. A mathematical model is presented for assigning protection objects to certain risk categories in the field of fire safety. The model is based on the concepts of the probability of adverse effects of fires causing harm (damage) of various extent and severity to the life or health of citizens, and the acceptable risk of harm (damage) from fires. Goals and objectives. The purpose of the study is to develop the procedure for assigning protection objects to a certain category of risk of harm (damage) based on estimates of the probability of fires with the corresponding severity consequences, to determine the acceptable level of risk of harm (damage) due to the fires, to calculate and develop numerical values of criteria for assigning objects of protection to the appropriate risk categories. Methods. The boundaries of the intervals corresponding to certain risk categories are determined by dividing the logarithmic scale of severity of adverse effects of fires into equal segments. Classification methods are used to assign objects of protection to a specific risk category. Results and discussion. Based on the level of severity of potential negative consequences of a fire, risk categories were determined for groups of protection objects that are homogeneous by type of economic activity and by functional fire hazard classes. The risk category for each individual object of protection is proposed to be determined using the so-called index of "identification of a controlled person" within a group of objects that are homogeneous by type of economic activity and class of functional fire hazard. Depending on the risk category, the periodicity of planned control and supervision measures in relation to the specific object of protection under consideration is determined, taking into account its socio-economic characteristics and the state of compliance with fire safety requirements by the controlled person. Conclusions. To develop criteria for classifying protection objects that are homogeneous in terms of economic activity and functional fire hazard classes, the probability of negative consequences of fires, that are causing harm (damage) of various extent and severity to the life or health of citizens, and the acceptable risk of causing harm (damage) as a result of fires, is used. The risk category for each individual object of protection is determined taking into account socio-economic characteristics of the object that affect the level of ensuring its fire safety, as well as the criteriaof integrity of the subordinate person that characterize the probability of non-compliance with mandatory fire safety requirements at the object of protection. Calculations are made and numerical values of criteria for assigning protection objects that are homogeneous in terms of economic activity and functional fire hazard classes to a certain category of risk are proposed. Key words: object of protection, probability of fire, acceptable level of risk, risk category, dangerous factor of fire, death and injury of people.

Immunomodulatory Effect of Andrographis paniculata during Lead Induced Toxicity in Broilers

2016 ◽  
Vol 12 (2) ◽  
Author(s):  
R. S. Ingole ◽  
A. S. Chandewar ◽  
M. V. Joshi ◽  
Madhuri Hedau ◽  
S W Hajare ◽  
...  
Keyword(s):  
Lead Acetate ◽  
Lead Toxicity ◽  
Andrographis Paniculata ◽  
Immunomodulatory Effect ◽  
Bursa Of Fabricius ◽  
Control Group ◽  
Skin Thickness ◽  
Broiler Chicks ◽  
Commercial Diet ◽  
Ameliorative Effect

The effect of dietary lead exposure on immunomodulation of broilers and possible ameliorative effect of Andrographis paniculata were studied. One hundred broiler chicks were randomly divided into five equal groups of 20 each. Group T0 served as control while group T1, T2, T3 and T4 birds were provided commercial diet with lead acetate at the dose of 300 ppm in feed. Powder of dry leaves of Andrographis paniculata was mixed in the feed of group T2, T3 and T4 chicks at the dose of 2 gm, 3 gm and 4 gm/kg of feed respectively and fed for 4 weeks. Significant decrease in HI titres in T1 group and significant increase in T4 group suggested increased haemagglutination titre (HI) response. The maximum skin thickness and diameter on 24th and 48th hours was observed in control group birds (T0) and was comparable with T4 group. Microscopically spleen, thymus and bursa of fabricius revealed increase in lymphoid population in birds fed lead acetate along with Andrographis paniculata compared to T1 group. We concluded that Andrographis paniculata has immunomodulatory effect during lead toxicity in broilers.

scholarly journals The Effects of Turnip (Brassica rapa) Extract on the Growth Performance and Health of Broilers

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 867
Author(s):  
Reza Eghbaldost-Jadid ◽  
Mehran Nosrati ◽  
Behrouz Rasouli ◽  
Alireza Seidavi ◽  
Clive J. C. Phillips
Keyword(s):  
Broiler Chickens ◽  
Growth Promotion ◽  
Antibacterial Properties ◽  
Low Density Lipoproteins ◽  
Feed Additives ◽  
Coliform Bacteria ◽  
Broiler Chicks ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Four Levels

There are concerns about inclusion of antibiotics in the feed of broiler chickens, because of the development of antibiotic resistance, leading to a search for alternative feed additives. Turnip extract is known to have antibacterial properties but has not been tested in the diet of broiler chickens. We allocated 200 broiler chicks to receive one of four levels of turnip extract in their water, 0, 150, 300 or 450 ppm, or a standard antibiotic, Virginiamycin, over a 42-day growing period. Although initially there were detrimental effects of providing 450 ppm, overall the 150 ppm level of supplementation increased weight gain, compared with birds given Virginiamycin, and decreased gizzard weight. Birds given 150 ppm or Virginiamycin had increased low-density lipoproteins (LDLs) and reduced very low-density lipoproteins (VLDLs) in their blood serum and reduced antibody responses to sheep red blood cells, compared to birds in the 450 ppm treatment. Birds given turnip extract at 450 ppm had fewer Gram-negative lactose and coliform bacteria than those provided with no turnip extract, and those provided with 150–300 ppm had the same as those provided with Virginiamycin. Turnip extract could potentially replace antibiotics included in the feed of broiler chickens for growth promotion and the control of bacterial infection of the gastrointestinal tract.

Women's perceptions of the safety of the pill: a survey in eight developing countries

1987 ◽  
Vol 19 (3) ◽  
pp. 313-321 ◽  
Author(s):  
Gary S. Grubb
Keyword(s):  
Developing Countries ◽  
Family Planning ◽  
Adverse Effects ◽  
Birth Defects ◽  
Health Risks ◽  
Scientific Evidence ◽  
Protective Effects ◽  
Gallup Poll ◽  
The Us ◽  
Women’S Perceptions

SummaryIn January 1985, a Gallup poll sponsored by the American College of Obstetrics and Gynecologists reported that 76% of the US women sampled thought that there were substantial risks with using the pill, 31% thought the pill caused cancer and 64% thought the risk of childbearing was equal to or less than that in taking the pill. To assess the perceptions of the pill's safety internationally, a survey of 100–150 urban, middle-class women aged 18–45 years was conducted in each of eight countries in the developing world. There were striking similarities in perceptions of the pill's health effects between countries: (1) taking the pill is considered to have substantial health risks by 50–75% and is thought to be more hazardous than childbearing by over 40% of respondents except those in the African samples; (2) women who had used the pill are as unaware as those who had not of possible serious cardiovascular adverse effects; (3) the protective effects of the pill are virtually unknown; (4) the greatest inconsistency with scientific evidence concerns the risks of sterility and birth defects attributed to pill use. With information from this survey, family planning programmes can rectify almost universal misperceptions of the pill's safety when counselling new and continuing pill users.

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