The Outer Face:

2020 ◽  
pp. 124-144
Keyword(s):  
2018 ◽  
Vol 6 (3) ◽  
pp. 20-28
Author(s):  
Faisal Al Tabatabaie ◽  
Dhabia Sabeeh Al Waily

The use of cutoffs underneath the hydraulic structures is considered a safe solution to ensure the stability of hydraulic structure against uplift pressure and piping phenomenon in addition to the sliding and overturning forces of the water. These cutoffs are used at critical sections underneath the floor of hydraulic structure to substitute with their depths the horizontal lengths of the creep line of the hydraulic structure base. In this paper, the experimental method- by using electrical analogue model- was carried out to plot the flow net and study the efficiency of the front and rear faces of the cutoffs for dissipating the potential energy of the percolating water underneath the floor of hydraulic structure. An electrical analogue model which was used in this study consists of twenty five models with different depths of upstream and downstream cutoffs. After plotting the flow net for all models, it is concluded that the efficiency of the inner sides are less than that of the outer sides which were investigated before in this topic of this work that both faces reduction values in the uplift pressure are considered the same, where the efficiency of the outer face of upstream cutoff is (70.35) % and for the inner face is (29.64)%, while for the downstream cutoff the efficiency for the outer face is (76.21)% and for the inner face is (23.79)% .


Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1425
Author(s):  
Anabel Guedán ◽  
Eve R. Caroe ◽  
Genevieve C. R. Barr ◽  
Kate N. Bishop

HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration. Hence, nuclear entry is a critical step in the early stages of HIV-1 replication. Following membrane fusion, the viral capsid (CA) lattice, which forms the outer face of the retroviral core, makes numerous interactions with cellular proteins that orchestrate the progress of HIV-1 through the replication cycle. The ability of CA to interact with nuclear pore proteins and other host factors around the nuclear pore determines whether nuclear entry occurs. Uncoating, the process by which the CA lattice opens and/or disassembles, is another critical step that must occur prior to integration. Both early and delayed uncoating have detrimental effects on viral infectivity. How uncoating relates to nuclear entry is currently hotly debated. Recent technological advances have led to intense discussions about the timing, location, and requirements for uncoating and have prompted the field to consider alternative uncoating scenarios that presently focus on uncoating at the nuclear pore and within the nuclear compartment. This review describes recent advances in the study of HIV-1 nuclear entry, outlines the interactions of the retroviral CA protein, and discusses the challenges of investigating HIV-1 uncoating.


Symmetry ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 442 ◽  
Author(s):  
Dongxue Liang ◽  
Kyoungju Park ◽  
Przemyslaw Krompiec

With the advent of the deep learning method, portrait video stylization has become more popular. In this paper, we present a robust method for automatically stylizing portrait videos that contain small human faces. By extending the Mask Regions with Convolutional Neural Network features (R-CNN) with a CNN branch which detects the contour landmarks of the face, we divided the input frame into three regions: the region of facial features, the region of the inner face surrounded by 36 face contour landmarks, and the region of the outer face. Besides keeping the facial features region as it is, we used two different stroke models to render the other two regions. During the non-photorealistic rendering (NPR) of the animation video, we combined the deformable strokes and optical flow estimation between adjacent frames to follow the underlying motion coherently. The experimental results demonstrated that our method could not only effectively reserve the small and distinct facial features, but also follow the underlying motion coherently.


Antiquity ◽  
1954 ◽  
Vol 28 (109) ◽  
pp. 25-31 ◽  
Author(s):  
O. G. S. Crawford

Last summer an archaeologist, Mr R. J. C. Atkinson, taking photographs at Stonehenge, made a most remarkable discovery. He was preparing to photograph a name carved on the inward-facing (northwest) face of Stone 53, one of the Great Horseshoe Trilithons; for this purpose he had remained there after 5 o’clock on July 10th, waiting for the sun to move round and shine on it. Looking not directly at the stone itself but at the image on the glass of his reflex camera, he suddenly saw the dark outline of what appeared to be a dagger, and beside it that of an axe. The carvings were deeply cut and the edges smoothened by the erosive action of more than thirty centuries of British weather (PLATE I). Closer inspection revealed several more axes and some other markings, all probably artificial but now too much weathered for decipherment. Two days later a ten-year-old schoolboy, David Booth, found an axe on the outer face of Stone 4, one of the stones of the Outer Circle, and subsequent search revealed ten more axes on the same face (PLATES II, VI A). Later still, while engaged in making casts of the axes already discovered, Mr R. S. Newall has found many more, bringing the total for Stone 53 up to 12 and for Stone 4 to 25, including on the latter one exceptionally large axe measuring 14 inches in length and 10½ inches across the splayed cutting edge. He has also verified three axes like the others near the bottom left-hand corner of the outer face of Stone 3 (PLATE III B).


1994 ◽  
Vol 126 (2) ◽  
pp. 433-443 ◽  
Author(s):  
A McGough ◽  
M Way ◽  
D DeRosier

The three-dimensional structure of actin filaments decorated with the actin-binding domain of chick smooth muscle alpha-actinin (alpha A1-2) has been determined to 21-A resolution. The shape and location of alpha A1-2 was determined by subtracting maps of F-actin from the reconstruction of decorated filaments. alpha A1-2 resembles a bell that measures approximately 38 A at its base and extends 42 A from its base to its tip. In decorated filaments, the base of alpha A1-2 is centered about the outer face of subdomain 2 of actin and contacts subdomain 1 of two neighboring monomers along the long-pitch (two-start) helical strands. Using the atomic model of F-actin (Lorenz, M., D. Popp, and K. C. Holmes. 1993. J. Mol. Biol. 234:826-836.), we have been able to test directly the likelihood that specific actin residues, which have been previously identified by others, interact with alpha A1-2. Our results indicate that residues 86-117 and 350-375 comprise distinct binding sites for alpha-actinin on adjacent actin monomers.


2002 ◽  
Vol 184 (13) ◽  
pp. 3630-3639 ◽  
Author(s):  
David E. Nelson ◽  
Anindya S. Ghosh ◽  
Avery L. Paulson ◽  
Kevin D. Young

ABSTRACT Four low-molecular-weight penicillin binding proteins (LMW PBPs) of Escherichia coli are closely related and have similar dd-carboxypeptidase activities (PBPs 4, 5, and 6 and DacD). However, only one, PBP 5, has a demonstrated physiological function. In its absence, certain mutants of E. coli have altered diameters and lose their uniform outer contour, resulting in morphologically aberrant cells. To determine what differentiates the activities of these LMW PBPs, we constructed fusion proteins combining portions of PBP 5 with fragments of other dd-carboxypeptidases to see which hybrids restored normal morphology to a strain lacking PBP 5. Functional complementation occurred when truncated PBP 5 was combined with the terminal membrane anchor sequences of PBP 6 or DacD. However, complementation was not restored by the putative carboxy-terminal anchor of PBP 4 or by a transmembrane region of the osmosensor protein ProW, even though these hybrids were membrane bound. Site-directed mutagenesis of the carboxy terminus of PBP 5 indicated that complementation required a generalized amphipathic membrane anchor but that no specific residues in this region seemed to be required. A functional fusion protein was produced by combining the N-terminal enzymatic domain of PBP 5 with the C-terminal β-sheet domain of PBP 6. In contrast, the opposite hybrid of PBP 6 to PBP 5 was not functional. The results suggest that the mode of PBP 5 membrane anchoring is important, that the mechanism entails more than a simple mechanical tethering of the enzyme to the outer face of the inner membrane, and that the physiological differences among the LMW PBPs arise from structural differences in the dd-carboxypeptidase enzymatic core.


AJIL Unbound ◽  
2018 ◽  
Vol 112 ◽  
pp. 274-278
Author(s):  
Jean Galbraith

President Trump has done the impossible: he has made the international community enthusiastic about U.S. federalism. Even as they express dismay at Trump's plan to abandon the Paris Agreement, foreign leaders and internationalists have praised the efforts of  U.S. states and cities to combat climate change mitigation in accordance with the Agreement's goals. These leaders are responding to what I will call the outer face of foreign affairs federalism—the direct international engagement undertaken by U.S. states and cities. This outer face has gained visibility in recent years, spurred on not only by the exigencies of climate but also by developments in legal practice. Less noticed internationally but of great practical importance is the inner face of foreign affairs federalism—the ways in which U.S. states and cities interact with the federal government. In this contribution, I first describe these two faces of foreign affairs federalism as they relate to climate and then suggest some ways in which foreign leaders and internationalists could expand the outer face and respond to the inner face.


2019 ◽  
Vol 37 (4) ◽  
pp. 235-248
Author(s):  
Imene Ghezal ◽  
Ali Moussa ◽  
Imed Ben Marzoug ◽  
Ahmida El-Achari ◽  
Christine Campagne ◽  
...  

The purpose of this research was to evaluate mechanical properties of a waterproof breathable fabric. A spacer knit with a cotton inner face and a polyester (PET) outer face was coated in order to obtain a waterproof breathable fabric. The applied coat was a mixture of an acrylic paste and a fluorocarbon resin. The treated fabric has undergone several tests to evaluate its mechanical properties. Tensile strength, flexural strength, abrasion resistance, and wrinkle recovery behavior were measured and discussed. After the coating treatment, the fabric was rigidified by 25% and 19% in wale and course directions, respectively. The coated PET face of the spacer fabric was not altered even after 125,000 abrasion cycles. A stiffer fabric was obtained after the coating treatment. However, fabric recovery behavior was ameliorated by 78% and 72% according to wale and course directions, respectively. The coated fabric can be used to produce raincoats and jackets.


2007 ◽  
Vol 98 (3) ◽  
pp. 1083-1101 ◽  
Author(s):  
Joseph C. Holt ◽  
Shilpa Chatlani ◽  
Anna Lysakowski ◽  
Jay M. Goldberg

Intracellular recordings were made from nerve fibers in the posterior ampullary nerve near the neuroepithelium. Calyx-bearing afferents were identified by their distinctive efferent-mediated responses. Such fibers receive inputs from both type I and type II hair cells. Type II inputs are made by synapses on the outer face of the calyx ending and on the boutons of dimorphic fibers. Quantal activity, consisting of brief mEPSPs, is reduced by lowering the external concentration of Ca2+ and blocked by the AMPA-receptor antagonist CNQX. Poisson statistics govern the timing of mEPSPs, which occur at high rates (250–2,500/s) in the absence of mechanical stimulation. Excitation produced by canal-duct indentation can increase mEPSP rates to nearly 5,000/s. As the rate increases, mEPSPs can change from a monophasic depolarization to a biphasic depolarizing–hyperpolarizing sequence, both of whose components are blocked by CNQX. Blockers of voltage-gated currents affect mEPSP size, which is decreased by TTX and is increased by linopirdine. mEPSP size decreases severalfold after impalement. The size decrease, although it may be triggered by the depolarization occurring during impalement, persists even at hyperpolarized membrane potentials. Nonquantal transmission is indicated by shot-noise calculations and by the presence of voltage modulations after quantal activity is abolished pharmacologically. An ultrastructural study shows that inner-face inputs from type I hair cells outnumber outer-face inputs from type II hair cells by an almost 6:1 ratio.


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