The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine

Diabetes Care ◽  
2021 ◽  
Vol 45 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Victor S. Harrison ◽  
Mahfuzul H. Khan ◽  
Christine E. Chamberlain ◽  
David M. Harlan
Keyword(s):  
New Technology ◽  
Modern Medicine ◽  
100Th Anniversary ◽  
Therapeutic Use ◽  
Nobel Prizes ◽  
Subsequent Modification

Since diabetes was first described over 3,000 years ago, clinicians and scientists alike have sought ever improving treatments en route to a cure. As we approach the 100th anniversary of insulin’s first therapeutic use, this article will recount the glorious history associated with research surrounding insulin’s isolation, purification, cloning, and subsequent modification. The discovery path we will relate tells the story of many relentless and passionate investigators pursuing ground-breaking research. The fruits of their labor include several Nobel Prizes, new technology, and, more importantly, ever improving treatments for one of humankind’s greatest medical scourges.

scholarly journals Therapeutic use of Adhatoda vasica

2016 ◽  
Vol 2 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Md Tofazzal Hossain ◽  
Md Obydul Hoq
Keyword(s):  
Chronic Bronchitis ◽  
Skin Diseases ◽  
Intestinal Parasites ◽  
Modern Medicine ◽  
Therapeutic Use ◽  
Root Bark ◽  
Active Ingredients ◽  
Adhatoda Vasica ◽  
Beneficial Effects ◽  
The World

Adhatoda vasica Nees belonging to family Acanthaceae, commonly known as Adosa, is found many regions of India and throughout the world, with a multitude of uses in traditional Unani and Ayurvedic systems of medicine. It is also called “Vasaka”. It is a well-known herb in indigenous systems of medicine for its beneficial effects, particularly in bronchitis. Vasaka leaves, bark, the root bark, the fruit and flowers are useful in the removal of intestinal parasites. Vasaka herb is used for treating cold, cough, chronic bronchitis and asthma. In acute stages of bronchitis, vasaka gives unfailing relief, especially where the sputum is thick and sticky. It liquefies the sputum so that it is brought up more easily. For relief in asthma, the dried leaves should be smoked. The juice from its leaves should be given in doses of 2 to 4 grams in treating diarrhea and dysentery. A poultice of its leaves can be applied with beneficial results over fresh wounds, rheumatic joints and inflammatory swellings. A warm decoction of its leaves is useful in treating scabies and other skin diseases. In olden times its leaves were made into a decoction with pepper and dried ginger. But the modern medicine searched its active ingredients and found out that vasicine, oxyvascicine and vasicinone are the alkaloids present in vasaka and in which vasicine is the active ingradient for expelling sputum from the body.Asian J. Med. Biol. Res. June 2016, 2(2): 156-163

scholarly journals VALERIANA JATAMANSI: AN ETHNOBOTANICAL REVIEW

2018 ◽  
Vol 11 ◽  
Author(s):  
Afroz Patan
Keyword(s):  
Molecular Mechanism ◽  
Skin Diseases ◽  
Chemical Constituents ◽  
Modern Medicine ◽  
Therapeutic Use ◽  
Perennial Herb ◽  
Pharmacological Activities ◽  
Valeriana Jatamansi ◽  
The Family ◽  
Medicinal Properties

 Objective: The main objective of review is an effort to give detailed information on Valeriana jatamansi and its multiple medicinal properties. Methods: As per the literature, the plant V. jatamansi is a perennial herb and found at subtemperate Himalayan regions of the Kumaon and Garhwal. The plant most popularly known as “Valerian.” The plant belongs to the family Valerianaceae. The roots and rhizomes of the plants are traditionally used to treat ulcers, jaundice, dry cough, seminal weakness, skin diseases, leprosy, and for sleep enhancement due to the presence of a variety of different chemical constituents such as sesquiterpenes, coumarins, iridoids, lignanoids, alkaloids, and flavonoids. From literature, the reported methods performed for different pharmacological activities have been thoroughly discussed and complied. Results: Most of the studies compiled from literature shown that V. jatamansi possess antimicrobial, antioxidant, anti-inflammatory, cytotoxic, anxiolytic, and neuroprotective activities. Conclusion: The review reveals that continuous research on this plant is needed to know the exact molecular mechanism and further elaborative studies can lead to develop safe therapeutic use in modern medicine.

scholarly journals The Bioinformatics of Integrative Medical Insights: Proposals for an International Psycho-Social and Cultural Bioinformatics Project

2006 ◽  
Vol 1 ◽  
pp. 117863370600100 ◽  
Author(s):  
Ernest Rossi ◽  
Kathryn Rossi ◽  
Garret Yount ◽  
Mauro Cozzolino ◽  
Salvador Iannotti
Keyword(s):  
Gene Expression ◽  
International Collaboration ◽  
Creative Process ◽  
Human Genome Project ◽  
Brain Plasticity ◽  
New Technology ◽  
Modern Medicine ◽  
Genome Project ◽  
The Past ◽  
The Human Genome Project

We propose the formation of an International Psycho-Social and Cultural Bioinformatics Project (IPCBP) to explore the research foundations of Integrative Medical Insights (IMI) on all levels from the molecular-genomic to the psychological, cultural, social, and spiritual. Just as The Human Genome Project identified the molecular foundations of modern medicine with the new technology of sequencing DNA during the past decade, the IPCBP would extend and integrate this neuroscience knowledge base with the technology of gene expression via DNA/proteomic microarray research and brain imaging in development, stress, healing, rehabilitation, and the psychotherapeutic facilitation of existentional wellness. We anticipate that the IPCBP will require a unique international collaboration of, academic institutions, researchers, and clinical practioners for the creation of a new neuroscience of mind-body communication, brain plasticity, memory, learning, and creative processing during optimal experiential states of art, beauty, and truth. We illustrate this emerging integration of bioinformatics with medicine with a videotape of the classical 4-stage creative process in a neuroscience approach to psychotherapy.

A Novel Remote Controllable Drug Delivery System Triggered by Heating From Magnetic Nanoparticles

2009 ◽  
Author(s):  
Xiaoliang Wang ◽  
Hongchen Gu ◽  
Xinyuan Zhu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
New Technology ◽  
Modern Medicine ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Long Time ◽  
Magnetic Filed ◽  
Core Issues

Target drug delivery is one of the core issues in modern medicine. Although both thermo-sensitive and magnetic drug vehicles have been developed for this purpose, reliable drug targeting is yet to achieve, because it’s hard to control local temperature in body for thermo-sensitive drugs, and it’s also difficult to control the colloidal sizes of magnetic vehicles to meet the requirements for both long-time circulation and magnetic responsibility. Here we present a new technology to solve these two problems. The drug (taxel) was combined with hyper-branched thermo-sensitive polymer and magnetic nanoparticles. Magnetic responsibility of the complex can be remotely controlled by applying an alternating magnetic field. The untreated complexes were stable in dispersion, while after exposing to the alternating magnetic filed for 5 minutes, the complexes were destabilized and deposited from dispersion quickly. Unlike the commonly used water bath, the technology present here can heat up the drug vehicles remotely from outside, which must have great potentials in the applications of magnetic or thermo-sensitive drug delivery.

Nobel Prizes Mark 100th Anniversary

Science News ◽  
2001 ◽  
Vol 160 (15) ◽  
pp. 230
Author(s):  
Nathan Seppa ◽  
Peter Weiss ◽  
Jessica Gorman
Keyword(s):  
100Th Anniversary ◽  
Nobel Prizes

Antimicrobial Resistance and Antimicrobial Nanomaterials

2021 ◽  
pp. 1-28
Author(s):  
Muthupandian Saravanan ◽  
Melaku Ashagrie Belete ◽  
Selam Niguse ◽  
Ephrem Tsegay ◽  
Tadele Araya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Resistance ◽  
Drug Delivery Systems ◽  
New Technology ◽  
Modern Medicine ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
Social Burden ◽  
Conventional Drug ◽  
Global Issue

Back in the mid-nineties, the discovery of antimicrobials denoted a profound and remarkable achievement in medicine which was capable of saving lives. However, recently, antimicrobial resistance became a major global issue facing modern medicine and significantly increased among bacteria, fungi, and viruses which results in reduced efficacy of many clinically important and lifesaving antimicrobials. The growing rise of antimicrobial resistance inflicts a remarkable economic and social burden on the health care system globally. The replacement of conventional antimicrobials by new technology to counteract and lessen antimicrobial resistance is currently ongoing. Nanotechnology is an advanced approach to overcome challenges of such resisted conventional drug delivery systems mainly based on the development and fabrication of nanoparticulate structures. Numerous forms of nanoparticulate systems have been discovered and tried as prospective drug delivery systems, comprising organic and inorganic nanoparticles.

scholarly journals Editorial: a man and his prizes

2001 ◽  
Vol 9 (4) ◽  
pp. 385-387
Author(s):  
TORE FRÄNGSMYR
Keyword(s):  
100Th Anniversary ◽  
Nobel Prizes ◽  
The World ◽  
Nobel Laureates

This year is the 100th anniversary of the Nobel Prizes. On 10 December 1901, Röntgen received the first prize. Since then, some 700 Nobel Laureates have received the same honour. No prize in the world, at least no prize for science, has reached the same level of glory. How did it come to be so?

Nobel Prizes and a New Technology

2018 ◽  
pp. 361-369
Author(s):  
Anthony S. Travis
Keyword(s):  
New Technology ◽  
Nobel Prizes

Ethical Issues in the Prenatal Diagnosis of Phenylketonuria

PEDIATRICS ◽  
1984 ◽  
Vol 74 (3) ◽  
pp. 424-427
Author(s):  
Neil A. Holtzman
Keyword(s):  
Prenatal Diagnosis ◽  
New Technologies ◽  
Ethical Issues ◽  
New Technology ◽  
Modern Medicine ◽  
Great Cost ◽  
Routine Medical Practice ◽  
Personal Level ◽  
Level I ◽  
Surgical Operations

Clinicians often view ethical dilemmas in terms of individual patients: would couple X, who have a normal 2-year-old child with phenylketonuria (PKU) (due to early treatment), want prenatal diagnosis with subsequent pregnancies? Eventually, the question will be posed on that level, but not yet. At this stage, we are still dealing with a new, unproven technology; a more generic analysis is needed. We must consider whether the technology is ready to be disseminated, and if so, how. Until recently these questions were seldom asked. As a result, modern medicine is replete with examples of technologies—drugs, surgical operations, laboratory tests—whose lack of effectiveness became evident, sometimes at great cost, only after they became part of routine medical practice.1 Lack of "effectiveness" of prenatal diagnosis for PKU could mean the abortion of fetuses unaffected with the disorder, and the unwanted birth of affected infants. The technology introduces a new ethical issue as well: the appropriateness of abortion for treatable conditions. Three issues should be addressed before new technologies are disseminated: validation, acceptance, and proliferation. I will use prenatal diagnosis for PKU to illustrate them. Several items to be discussed under "acceptance" also apply at the personal level. I pose them because they are important in deciding if and how the new technology should be made available, which is a matter of public policy. Lest one think these decisions have all been made for prenatal diagnosis for PKU, consider the following: (1) Research funding must continue to discover other restriction endonuclease sites, develop better probes, and simplify the techniques.

Microfabrication research at the National Submicron Facility

1983 ◽  
Vol 41 ◽  
pp. 86-89
Author(s):  
E.D. Wolf
Keyword(s):  
Integrated Circuits ◽  
Particle Physics ◽  
High Speed ◽  
New Technology ◽  
High Energy ◽  
High Energy Particle ◽  
New Science ◽  
Wide Range ◽  
Intermediate Domain ◽  
Circuit Function

Most microelectronics devices and circuits operate faster, consume less power, execute more functions and cost less per circuit function when the feature-sizes internal to the devices and circuits are made smaller. This is part of the stimulus for the Very High-Speed Integrated Circuits (VHSIC) program. There is also a need for smaller, more sensitive sensors in a wide range of disciplines that includes electrochemistry, neurophysiology and ultra-high pressure solid state research. There is often fundamental new science (and sometimes new technology) to be revealed (and used) when a basic parameter such as size is extended to new dimensions, as is evident at the two extremes of smallness and largeness, high energy particle physics and cosmology, respectively. However, there is also a very important intermediate domain of size that spans from the diameter of a small cluster of atoms up to near one micrometer which may also have just as profound effects on society as “big” physics.

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