scholarly journals Recent Trends in Cardiovascular Complications Among Men and Women With and Without Diabetes

Diabetes Care ◽  
2005 ◽  
Vol 29 (1) ◽  
pp. 32-37 ◽  
Author(s):  
G. L. Booth ◽  
M. K. Kapral ◽  
K. Fung ◽  
J. V. Tu
2019 ◽  
Vol 41 (13) ◽  
pp. 1346-1353 ◽  
Author(s):  
Morten Malmborg ◽  
Michelle D S Schmiegelow ◽  
Caroline H Nørgaard ◽  
Anders Munch ◽  
Thomas Gerds ◽  
...  

Abstract Aims To investigate whether diabetes confers higher relative rates of cardiovascular events in women compared with men using contemporary data, and whether these sex-differences depend on age. Methods and results All Danish residents aged 40–89 years without a history major adverse cardiovascular events, including heart failure, as of 1 January 2012 until 31 December 2016 were categorized by diabetes-status and characterized by individual-level linkage of Danish nationwide administrative registers. We used Poisson regression to calculate overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischaemic stroke, or cardiovascular death (MACE-HF). Among 218 549 (46% women) individuals with diabetes, the absolute rate of MACE-HF was higher in men than in women (24.9 vs. 19.9 per 1000 person-years). Corresponding absolute rates in men and women without diabetes were 10.1 vs. 7.0 per 1000 person-years. Comparing individuals with and without diabetes, women had higher relative rates of MACE-HF than men [2.8 (confidence interval, CI 2.9–2.9) in women vs. 2.5 (CI 2.4–2.5) in men] with a women-to-men ratio of 1.15 (CI 1.11–1.19, P < 0.001). The relative rates of MACE-HF were highest in the youngest and decreased with advancing age for both men and women, but the relative rates were higher in women across all ages, with the highest women-to-men ratio between age 50 and 60 years. Conclusion Although men have higher absolute rates of cardiovascular complications, the relative rates of cardiovascular complications associated with diabetes are higher in women than in men across all ages in the modern era.


1995 ◽  
Vol 27 (1) ◽  
pp. 31-46 ◽  
Author(s):  
M. Murphy

SummaryData on patterns and trends in sterilisation in Britain among women, men and couples are presented using life table approaches with data from a national survey, the General Household Survey. Among couples under age 50, sterilisation is the main method of contraception used, with slightly more women than men being sterilised, although this is reversed if only contraceptive sterilisation is considered. Trends in contraception have remained relatively constant in recent decades. Patterns of sterilisation differ following births of different orders. For example, the resort to sterilisation is much quicker after a third birth than after a second. The proportions of men and women who have been sterilised and then formed a subsequent partnership are very small, so the effect of sterilisation in preventing births in such unions is negligible.


Sexual Health ◽  
2015 ◽  
Vol 12 (1) ◽  
pp. 48 ◽  
Author(s):  
Basil Donovan ◽  
Wayne Dimech ◽  
Hammad Ali ◽  
Rebecca Guy ◽  
Margaret Hellard

Background Gonorrhoea notifications have been increasing in Australia’s cities, in both men and women. We investigated if this could be, at least in part, a result of a testing artefact. Methods: We surveyed 28 laboratories that were known to test for both Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) to determine their testing and reporting practices, and when these practices were instituted. Results: By 2012, 23 (82%) of the laboratories were routinely performing duplex nucleic acid amplification tests for both CT and NG even if a test for only one organism was requested, up from 9 (32%) laboratories before 2007. Although written reports of negative NG tests were not provided if the test was not requested, positive NG tests were always communicated to the attending clinician. Conclusions: The move towards routine duplex testing for CT and NG has probably resulted in more Australians being tested for NG than ever before. While this change has advantages for case-finding and improved public health outcomes, it also brings an increasing potential for false-positive NG tests. Recent trends in NG notifications should be interpreted with caution.


Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Denis Angoulvant ◽  
Pierre Henri Ducluzeau ◽  
Peggy Renoult Pierre ◽  
Gregoire Fauchier ◽  
Julien Herbert ◽  
...  

Data are inconsistent regarding sex-differences in the relative rates of cardiovascular events associated with diabetes. We aimed to investigate whether diabetes confers higher relative rates of cardiovascular events in women compared with men using contemporary data, and whether these sex-differences depend on age. Methods: All patients seen in French hospitals in 2013 with at least 5 years or follow-up (or dying earlier) without a history major adverse cardiovascular event, were identified and characterized by individual-level linkage of French nationwide administrative registers. They were categorized by diabetes-status and followed-up until 31 December 2019. Using Cox models, we calculated overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischemic stroke, or cardiovascular death (MACE-HF). Results: The study included 3,381,472 individuals among whom 482,848 (14.3%) had diabetes (88.1% with type 2 diabetes). Among 482,848 (45% women) patients with diabetes, the absolute rate of MACE-HF was higher in men than in women (9.7 vs. 7.4 per 100 person-years). Corresponding absolute rates in men and women without diabetes were 4.9 vs. 3.1 per 100 person-years. Comparing individuals with and without diabetes, women had higher incidence rate ratio (IRR) of MACE-HF than men (IRR 2.42 95% confidence interval [CI] 2.40-2.44) in women vs. 1.99, 95% CI 1.98-2.01 in men) with a women-to-men ratio (WMR) of 1.22 (CI 1.20-1.23, p<0.001). The IRRs of MACE-HF for diabetes vs no diabetes were highest in women aged 45 and in the youngest men and decreased with advancing age for both men and women, but the IRRs were higher in women across all ages, with the highest WMR between age 45 and 70 years. This effect was more apparent for myocardial infarction (women-to-men ratio 1.43, 95%CI 1.39-1.47 after adjustment) than for ischemic stroke (WMR 1.10, 95%CI 1.07-1.13 after adjustment) or overall MACE-HF (WMR 1.16, 95%CI 1.15-1.18 after adjustment). Conclusion: Although men have higher absolute rates of cardiovascular complications, the relative rates of cardiovascular complications associated with diabetes are higher in women than in men across all ages in recent years.


Author(s):  
Marina Zannella ◽  
Andrea Principi ◽  
Davide Lucantoni ◽  
Francesco Barbabella ◽  
Mirko Di Rosa ◽  
...  

While active ageing has emerged as a main strategy to address the challenges of population ageing in Europe, recent research has stressed the need to increase knowledge on within-country differences to promote active ageing through appropriate policy responses. This article draws on the Active Ageing Index (AAI) to capture recent trends in active ageing in Italy with a focus on sub-national diversity. To this end, we compute AAI breakdowns by region separately for men and women for four different years: 2007, 2009, 2012 and 2018. Then, we use linear regression to describe the geographical and sex-specific patterns of change in the AAI over the considered period. The results demonstrate the diversity of regional outcomes and trends in the active ageing of Italian men and women, indicating that the widening geographic gap deserves further consideration by national and regional authorities in designing and implementing active ageing policies. By showing the persistence of disparities in the value of the indicator to the disadvantage of women, results also suggest the need to further integrate both the gender dimension and the life-cycle perspective into active ageing strategies. This article provides an example of how the AAI can be used as a practical tool by policy makers to monitor active ageing trends and outcomes at the sub-national level, and to identify target areas that require further action.


2021 ◽  
Vol 17 (4) ◽  
pp. 293-303
Author(s):  
O.V. Prybyla

Background. According to the latest international clinical guidelines, gliflozins — sodium-glucose cotransporter-2 inhibitors — are indicated as oral antidiabetic drugs of second-third-line therapy in type 2 diabetes mellitus. Due to insulin-independent stimulation of glucosuria, gliflozins have extraglycemic effects such as weight loss, improved adipose tissue distribution, better plasma lipid profile, and decreased uricemia that in generally reduce the risk of cardiovascular complications. The purpose of this study was to evaluate the effectiveness of dapagliflozin in the treatment of men and women with type 2 diabetes mellitus with a metabo­lically unhealthy phenotype. Materials and methods. The study included 17 individuals with diabetes mellitus type 2 (11 men and 6 women), aged 58.0 ± 1.7 years (95% confidence interval 53–62), whose body composition was evaluated by bioelectric impedance using a Tanita analyzer BC-545N (Japan). Patients received therapy with dapagliflozin, antihypertensive and antihyperlipidemic drugs (statins). Results. A three-month use of dapagliflozin in a dose of 10 mg once daily caused a decrease in body mass index, waist circumference, improvement of body composition, in parti­cular a reduction in total body fat (the significance of changes was determined using a paired t-test). No significant changes in muscle and bone mass, body composition, lipid profile, and uricemia level were observed. The group of women, in contrast to men, had a decreased level of visceral fat, which was accompanied by an improvement in the body’s water supply, and a reduction in the estimated metabolic age. Conclusions. Treatment of type 2 diabetes patients with sodium-glucose cotransporter-2 inhibitors for 3 months has reduced the degree of obesity and improved some indices of body composition. Confirmation of this trend can be obtained in further observations.


2019 ◽  
Vol 2 (14) ◽  
pp. 6-14
Author(s):  
I. V. Kuznetsova

Cardiovascular morbidity remains the leading cause of death in the world, in both men and women. But the programs for the prevention of cardiovascular diseases (CVD), which significantly reduced the incidence of cardiovascular complications among men, proved to be ineffective among the female population. Differences in CVD risk factors in different sexes, different responses of the female and male organism to the same treatment effects induce, on the one hand, the development of gender-oriented cardiological practices and, on the other hand, determine the need to include gynecologists in the development and implementation of cardiovascular reduction measures vascular morbidity and mortality.


2019 ◽  
Vol 91 (1) ◽  
pp. 4-12
Author(s):  
I E Chazova ◽  
A V Aksenova ◽  
E V Oschepkova

Modern clinical guidelines for the diagnosis and treatment of arterial hypertension (AH) do not provide different treatment strategies separately for men and women. The analysis of gender differences in cardiovascular complications and features of AH therapy contributes to the development of an individualized approach to diagnosis and treatment of hypertension. The purpose of this study is to study the effect of sex on the features of therapy of arterial hypertension and the development of cardiovascular complications. Materials and methods. Data from the register of AH from outpatient hospital and cardiology departments of hospitals of 22 regions of the Russian Federation were analyzed. Data of medical documents of 33 564 patients with AH [(36.2%) men and 21 423 (63.8%) women] were entered into the on-line computer program and were analyzed using the statistical software package STATISTICA 10. Results. Cardiovascular and cerebrovascular diseases are more often diagnosed in men: peripheral artery disease, coronary heart disease, acute coronary syndrome, congestive heart failure, ischemic stroke, dissecting aortic aneurysm. The beginning of development cardiovascular disease in men with elevated blood pressure is already observed at age of 25-44 years, which indicates the need for preventive measures already in adolescence and closer monitoring of treatment at a young age. Conclusion. The study confirmed the role of the male sex as a risk factor for the development of cardiovascular disease in hypertensive men and women with comparable figures of blood pressure in. Identified gender features must be considered when diagnosing patients with AH.


1985 ◽  
Vol 37 (1) ◽  
pp. 79-84
Author(s):  
Vilhelm Nielsen

Myths and Word of MouthJens Peter Ægidius: Braga Talks, Norse Myths and Narrative Myths in the Danish Tradition (to 1910). Odense 1985.Reviewed by Vilhelm NielsenThe title Braga Talks is taken from Grundtvig, who in 1843-44 gave 25 lectures under this heading; these are treated in detail by Ægidius. The phrase has since been misunderstood, however, and misused to mean words without content or basis in reality. Braga, the god of poetry, has been forgotten and the emphasis has been transferred to the word talk. The title of this book expresses a slipping from the mythology itself into its narrative reproduction. While working on the preface and the introduction to Norse Mythology (1832) Grundtvig made the discovery (as Thaning has proved) that myths are oral. This was one of the slow discoveries he made, and could have been made the main theme of this book, which says little that is new about Grundtvig’s use of his sources. It does, however, offer a great deal on the narrative tradition in use at the grundtvigian folk high schools, which has been revived in this century by Aage Møller, a clergyman and high school teacher. Unfortunately this phase has not been treated, as the book stops at 1910. Ægidius has, however, included Ludvig Christian Møller, the narrative historian, who was Grundtvig’s disciple and who even before him gave historical talks for both men and women at Borch’s hostel in the 1830s. His narration of myths and legends was only his introduction to narratives from medieval history. The other major characters in Ægidius’ book are Christian Flor and Ludvig Schrøder. Flor was originally Professor of Danish at Kiel but became principal of the first Danish folk high school at Rødding in 1844. Schr.der became principal of Askov folk high school, which from 1864 onwards carried the stamp of his personality. Ægidius claims, and the reviewer underlines this new information, that Schrøder did not give up teaching the myths, even though from 1884 onwards he went on to talk about Denmark’s natural resources. Unfortunately we have only comprehensive notes to the lectures but no myth narratives in written form from his side. His lectures on myth were apparently not the same from year to year, but they were wellprepared and reformulated every time, a necessary precondition for their being both “animated” and mythically “sound”, not in fact lectures but “proper stories”, as Grundtvig says in 1838. The reviewer looks forward to a continuation of the book to include an assessment of Aage Møller’s attempt to revive the tradition — and possibly as a guideline for the most recent trends.


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