scholarly journals model-based radiostereometric analysis (RSA) randomized control trial evaluating the stability of the cementless Taperloc hip stem: the TapHip study

2022 ◽  
pp. 212-221
Author(s):  
Ruben Y Kok ◽  
Lennard A Koster ◽  
Bart L Kaptein ◽  
Marta Fiocco ◽  
Stefan B Keizer
Keyword(s):  
Mixed Model ◽  
Radiostereometric Analysis ◽  
Mixed Model Analysis ◽  
Cementless Total Hip Arthroplasty ◽  
Model Based ◽  
Design Changes ◽  
Full Profile ◽  
Randomized Control ◽  
The Stability

Background and purpose – The Taperloc Complete hip is the successor of the Taperloc hip, aiming to increase range of motion and optimizing femoral fit with intermediate stem sizes. We evaluated whether these design changes affect fixation, and this RSA study compares 2-year migration. Patients and methods – In this prospective, multi-arm study, 100 patients were randomized to cementless total hip arthroplasty (THA) with Taperloc Complete full profile (TCFP), Taperloc Complete reduced distal (TCRD), Taperloc full profile (TFP), or Taperloc reduced distal (TRD). Migration was measured with model-based RSA postoperatively, and after 3, 12, and 24 months. Results – Results based on mixed-model analysis on 2-year postoperative RSA data from 74 patients showed similar subsidence (mm) in the first 3 months (mean [95% CI] TCFP 0.44 [0.20–0.69], TCRD 0.91 [0.40–1.42], TFP 0.71 [0.22–1.19], TRD 1.25 [0.58–1.91]) and stabilization afterwards. The TCFP showed statistically significantly less retroversion (°) at 2-year postoperatively compared with TFP and TCRD (mean [95% CI] TCFP: –0.13 [–0.64 to 0.38], TCRD: 0.84 [0.35–1.33], TFP: 0.56 [0.12–1.00], TRD: 0.37 [–0.35 to 1.09]). Interpretation – As expected in successful cementless THA, RSA shows stabilization after initial subsidence. Based on these results the Taperloc Complete stem is expected to have similar long-term fixation to the Taperloc stems. The reduced distal groups have larger, but statistically non-significant, initial migration compared with the TCFP group, which could be due to implantation in Dorr B, C femur types. It may be important to consider the femur shape for choosing a full profile or reduced distal stem to minimize migration.

scholarly journals Long-term follow-up including extensive complement analysis of a pediatric C3 glomerulopathy cohort

2021 ◽  
Author(s):  
Marloes A. H. M. Michels ◽  
Kioa L. Wijnsma ◽  
Roel A. J. Kurvers ◽  
Dineke Westra ◽  
Michiel F. Schreuder ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Mixed Model ◽  
Immunosuppressive Treatment ◽  
Complement C3 ◽  
C3 Glomerulopathy ◽  
Laboratory Findings ◽  
Mixed Model Analysis ◽  
Long Term Follow Up

Abstract Background C3 glomerulopathy (C3G) is a rare kidney disorder characterized by predominant glomerular depositions of complement C3. C3G can be subdivided into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). This study describes the long-term follow-up with extensive complement analysis of 29 Dutch children with C3G. Methods Twenty-nine C3G patients (19 DDD, 10 C3GN) diagnosed between 1992 and 2014 were included. Clinical and laboratory findings were collected at presentation and during follow-up. Specialized assays were used to detect rare variants in complement genes and measure complement-directed autoantibodies and biomarkers in blood. Results DDD patients presented with lower estimated glomerular filtration rate (eGFR). C3 nephritic factors (C3NeFs) were detected in 20 patients and remained detectable over time despite immunosuppressive treatment. At presentation, low serum C3 levels were detected in 84% of all patients. During follow-up, in about 50% of patients, all of them C3NeF-positive, C3 levels remained low. Linear mixed model analysis showed that C3GN patients had higher soluble C5b-9 (sC5b-9) and lower properdin levels compared to DDD patients. With a median follow-up of 52 months, an overall benign outcome was observed with only six patients with eGFR below 90 ml/min/1.73 m2 at last follow-up. Conclusions We extensively described clinical and laboratory findings including complement features of an exclusively pediatric C3G cohort. Outcome was relatively benign, persistent low C3 correlated with C3NeF presence, and C3GN was associated with higher sC5b-9 and lower properdin levels. Prospective studies are needed to further elucidate the pathogenic mechanisms underlying C3G and guide personalized medicine with complement therapeutics. Graphical abstract

The assessment of the stability of the tibial component of a novel knee arthroplasty system using radiostereometric analysis

2018 ◽  
Vol 100-B (12) ◽  
pp. 1579-1584 ◽  
Author(s):  
T. R. Turgeon ◽  
T. C. Gascoyne ◽  
E. K. Laende ◽  
M. J. Dunbar ◽  
E. R. Bohm ◽  
...  
Keyword(s):  
Knee Arthroplasty ◽  
Tibial Component ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Radiostereometric Analysis ◽  
Patient Reported ◽  
The Mean ◽  
The Stability ◽  
Novel Design

Aims The introduction of a novel design of total knee arthroplasty (TKA) must achieve outcomes at least as good as existing designs. A novel design of TKA with a reducing radius of the femoral component and a modified cam-post articulation has been released and requires assessment of the fixation to bone. Radiostereometric analysis (RSA) of the components within the first two postoperative years has been shown to be predictive of medium- to long-term fixation. The aim of this study was to assess the stability of the tibial component of this system during this period of time using RSA. Patients and Methods A cohort of 30 patients underwent primary, cemented TKA using the novel posterior stabilized fixed-bearing (ATTUNE) design. There was an even distribution of men and women (15:15). The mean age of the patients was 64 years (sd 8) at the time of surgery; their mean body mass index (BMI) was 35.4 kg/m 2 (sd 7.9). RSA was used to assess the stability of the tibial component at 6, 12, and 24 months compared with a six-week baseline examination. Patient-reported outcome measures were also assessed. Results The mean maximum total point motion (MTPM) of the tibial component between 12 and 24 months postoperatively was 0.08 mm (sd 0.08), which is well below the published threshold of 0.2 mm (p < 0.001). Patient-reported outcome measures consistently improved. Conclusion The tibial component of this novel design of TKA showed stability between assessment 12 and 24 months postoperatively, suggesting an acceptably low risk of medium- to long-term failure due to aseptic loosening.

scholarly journals Clinical efficacy of nanohydroxyapatite-containing toothpaste at relieving dentin hypersensitivity: an 8 weeks randomized control trial

BDJ Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Bennett Tochukwu Amaechi ◽  
Kelly C. Lemke ◽  
Shyamali Saha ◽  
Minh N. Luong ◽  
Jonathan Gelfond
Keyword(s):  
Mixed Model ◽  
Potassium Nitrate ◽  
Post Treatment ◽  
Dentin Hypersensitivity ◽  
Double Blind ◽  
Mixed Model Analysis ◽  
Random Intercept ◽  
Parallel Group ◽  
Randomized Control ◽  
Time Point

Abstract Objective The objective of this study was to investigate and compare the effectiveness of several toothpastes containing nanohydroxyapatite (nano-HAP) to relieve dentin hypersensitivity (DHS) with that of a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (CSPS). Materials and methods In this double-blind, randomized, parallel-group clinical trial, patients diagnosed with DHS and qualified to participate were randomized into four groups: toothpaste containing 10% nano-HAP (10%nano-HAP), 15% nano-HAP (15%nano-HAP), 10% nano-HAP supplemented with potassium nitrate (KNO3) (10%nano-HAPKN), or CSPS. Subjects’ baseline and post-treatment sensitivities were assessed using visual analog scale (VAS) after the application of ice-cold and air stimuli. Subjects used their assigned toothpaste for routine toothbrushing twice daily. Post-treatment sensitivity was assessed every 2 or 8 weeks. Mean change in VAS (mm) from baseline at each time point were compared using random-intercept, mixed-model analysis and Duncan test (P < 0.05). Results With either air or cold stimulus, VAS indicated a significant (P < 0.001) reduction from baseline DHS at each time point with all test toothpastes. Among the nano-HAP toothpastes, 15%nano-HAP and 10%nano-HAPKN were consistent in DHS reduction with both stimuli. With either stimuli, the CSPS did not significantly differ from 15%nano-HAP and 10%nano-HAPKN at any time point. Conclusions Toothpaste containing nano-HAP (10 or 15%) alone or supplemented with KNO3 was as effective as CSPS for relief of DHS symptoms when used at least twice daily.

Patient-reported quality of life (QoL) of advanced melanoma patients in a Phase 3 study of nivolumab (NIVO) with or without ipilimumab (IPI) versus IPI: CheckMate 067 4-year data.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 9551-9551
Author(s):  
Dirk Schadendorf ◽  
James M.G. Larkin ◽  
Jedd D. Wolchok ◽  
Vanna Chiarion-Sileni ◽  
Fiona Taylor ◽  
...  
Keyword(s):  
Health Status ◽  
Global Health ◽  
Mixed Model ◽  
Advanced Melanoma ◽  
Global Health Status ◽  
Mixed Model Analysis ◽  
Patient Reported ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

9551 Background: Early CheckMate 067 data showed maintenance of QoL in patients with advanced melanoma treated with NIVO with or without IPI based on 1-year data; however, the long-term QoL of these patients has not been evaluated previously. The patient-reported outcomes (PRO) analyses presented here for CheckMate 067 is the first time QoL results have been evaluated in this melanoma population over a 4-year period. Methods: In CheckMate 067, 945 patients were randomized 1:1:1 to receive NIVO (3mg/kg Q2W) + placebo (PBO), NIVO+IPI (1mg/kg+3mg/kg Q3W X 4) followed by NIVO (3mg/kg Q2W), or IPI (3mg/kg Q3W X 4) + PBO. PRO data were collected using the EORTC QLQ-C30 (5 functional domains, 9 symptoms, global health status) and EQ-5D-3L (utility index, VAS) at baseline, weeks 1 and 5 of each 6-week tx cycle, and off-tx follow-up (FU) visits. Mean changes in PRO scores from baseline (randomization) were evaluated descriptively for the PRO analysis population, with conclusions drawn from time points with ≥30 patients completing assessments per tx arm. Least square mean changes from baseline were assessed using a longitudinal mixed model analysis adjusting for repeated measures, including all on-tx data for patients. Results: Completion rates at baseline ranged from 89-92% across tx arms. Of 813 patients included in the PRO analysis population (278 NIVO, 274 NIVO+IPI, 261 IPI), > 200 receiving tx remained for the first year, > 100 receiving tx remained after 2 years, and > 50 receiving tx remained after 3 years. QoL, including assessment of functioning and symptom burden, was maintained for the duration of tx and in FU, with no sustained clinically meaningful deterioration in any tx arm. Global health status (EORTC QLQ-C30) and general QoL (EQ-5D-3L VAS) were also maintained during prolonged tx. Overall, results from the mixed model analysis support the long-term maintenance of QoL over the course of tx. Conclusions: Patient-reported QoL and symptoms in patients with advanced melanoma were maintained from baseline during extended tx with NIVO with or without IPI. Clinical trial information: NCT01844505.

scholarly journals Genotype × Environment Interaction for Resistance to Early Leaf Spot of Groundnut Mini Core Collections in the Savannas of Nigeria

2021 ◽  
Author(s):  
Abdulwahab S. Shaibu ◽  
Zainab L. Miko ◽  
Sanusi G. Mohammed ◽  
Hakeem A. Ajeigbe ◽  
Alhassan Usman ◽  
...  
Keyword(s):  
Leaf Spot ◽  
Mixed Model ◽  
Yield Potential ◽  
Environment Interaction ◽  
Gge Biplot ◽  
Core Collections ◽  
Mixed Model Analysis ◽  
Genotype Environment Interaction ◽  
Arachis Hypogaea L ◽  
The Stability

Background: The genetic yield potential of groundnut (Arachis hypogaea L.) has been continuously challenged by several diseases including early leaf spot (ELS).Methods: In the current study, we evaluated groundnut mini core collections under artificial and natural disease epiphytotics in six environments to identify stable elite sources for ELS resistance and pod yield. Mixed model analysis was done to adequately capture the variance component as a result of genotype (G), environment (E) and G × E interaction (GEI).Result: Highly significant (p less than 0.001) effects for G and GEI on ELS and pod weight were observed. The parametric and non-parametric stability models ranked the genotype differently for their stability to ELS. The GGE biplot identified ICG 1519 as a stable genotype for the ELS resistance. For pod weight, ICG 8896 and ICG 7897 were consistently stable from all the stability models including the GGE biplot. ICG 9449 and ICG 4540 were identified as stable genotypes for both ELS and pod weight. These elite sources of ELS resistance identified in the current study will be useful in the development and deployment of groundnut varieties with resistance to ELS and high pod yielding potentials.

scholarly journals Do Progressive Sensorimotor Training Devices Produce A Graded Increase in Centre of Mass Displacement During Unipedal Balance Exercises in Athletes

2020 ◽  
Vol 10 (11) ◽  
pp. 3893
Author(s):  
Nina Gras ◽  
Torsten Brauner ◽  
Scott Wearing ◽  
Thomas Horstmann
Keyword(s):  
Mixed Model ◽  
Inertial Sensor ◽  
Linear Increase ◽  
Support Surface ◽  
Centre Of Mass ◽  
Sensorimotor Training ◽  
Mixed Model Analysis ◽  
Significant Difference ◽  
Mass Displacement ◽  
The Stability

Progression of the difficulty of agility exercises in sport is often achieved by changing the stability of the support surface via graded sensorimotor training devices. However, little is known about the challenge imposed to postural equilibrium by these graded devices. This study quantified the instability provided by four sensorimotor training devices typically used to enhance athletic performance; three progressively unstable balance pads (ST1–3) and an oscillatory platform (PM). Twenty-five (13 female, 12 male) young adults (age, 26 ± 3 yr; height, 1.76 ± 0.10 m; and weight, 69 ± 12 kg), completed seven unipedal balance conditions involving stable and progressively unstable surfaces that involved four sensorimotor training devices (ST1-3, PM) and their combination (PM-ST1, PM-ST2). An inertial sensor, mounted over the lumbar spine, was used to monitor Centre of Mass (COM) displacement in each condition. Potential differences in COM displacement between conditions were assessed using a mixed-model analysis of variance. COM displacement differed between training devices; with a progressive, though non-linear, increase in COM displacement from the most (ST1) to the least (ST3) stable balance pad. However, there was no significant difference in COM displacement between the least stable balance pad (ST3) and the oscillatory platform used in isolation (PM) or in combination with balance pads (PM-ST1, PM-ST2). These novel findings have important practical implications for the design of progressive sensorimotor training programs in sport.

The Stability of the WHO Reference Thromboplastin NIBS & C 67/40

1979 ◽  
Vol 42 (04) ◽  
pp. 1135-1140 ◽  
Author(s):  
G I C Ingram
Keyword(s):  
Human Brain ◽  
Collaborative Study ◽  
Calibration Constant ◽  
Long Term Stability ◽  
Freeze Dried ◽  
Show Evidence ◽  
Human Material ◽  
Reference Preparation ◽  
The Stability

SummaryThe International Reference Preparation of human brain thromboplastin coded 67/40 has been thought to show evidence of instability. The evidence is discussed and is not thought to be strong; but it is suggested that it would be wise to replace 67/40 with a new preparation of human brain, both for this reason and because 67/40 is in a form (like Thrombotest) in which few workers seem to use human brain. A �plain� preparation would be more appropriate; and a freeze-dried sample of BCT is recommended as the successor preparation. The opportunity should be taken also to replace the corresponding ox and rabbit preparations. In the collaborative study which would be required it would then be desirable to test in parallel the three old and the three new preparations. The relative sensitivities of the old preparations could be compared with those found in earlier studies to obtain further evidence on the stability of 67/40; if stability were confirmed, the new preparations should be calibrated against it, but if not, the new human material should receive a calibration constant of 1.0 and the new ox and rabbit materials calibrated against that.The types of evidence available for monitoring the long-term stability of a thromboplastin are discussed.

Application of the method of mathematical modeling for forecasting channel deformations at the underwater crossing of the main pipeline

2020 ◽  
Vol 10 (6) ◽  
pp. 599-609
Author(s):  
Valery А. Gruzdev ◽  
◽  
Georgy V. Mosolov ◽  
Ekaterina A. Sabayda ◽  
◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Roughness Coefficient ◽  
Computational Domain ◽  
Channel Deformations ◽  
Geological Surveys ◽  
Kuban River ◽  
The Stability ◽  
Protective Structures

In order to determine the possibility of using the method of mathematical modeling for making long-term forecasts of channel deformations of trunk line underwater crossing (TLUC) through water obstacles, a methodology for performing and analyzing the results of mathematical modeling of channel deformations in the TLUC zone across the Kuban River is considered. Within the framework of the work, the following tasks were solved: 1) the format and composition of the initial data necessary for mathematical modeling were determined; 2) the procedure for assigning the boundaries of the computational domain of the model was considered, the computational domain was broken down into the computational grid, the zoning of the computational domain was performed by the value of the roughness coefficient; 3) the analysis of the results of modeling the water flow was carried out without taking the bottom deformations into account, as well as modeling the bottom deformations, the specifics of the verification and calibration calculations were determined to build a reliable mathematical model; 4) considered the possibility of using the method of mathematical modeling to check the stability of the bottom in the area of TLUC in the presence of man-made dumping or protective structure. It has been established that modeling the flow hydraulics and structure of currents, making short-term forecasts of local high-altitude reshaping of the bottom, determining the tendencies of erosion and accumulation of sediments upstream and downstream of protective structures are applicable for predicting channel deformations in the zone of the TLUC. In all these cases, it is mandatory to have materials from engineering-hydro-meteorological and engineering-geological surveys in an amount sufficient to compile a reliable mathematical model.

Sign in / Sign up

Export Citation Format

Share Document