scholarly journals Use of Aqueous Extract of Wrightia tinctoria Leaves and Coconut Oil in Camel Mange

2021 ◽  
Vol 12 (6) ◽  
pp. 617-620
Author(s):  
N. R. Pandya ◽  
◽  
G. C. Mandali ◽  
K. M. Dave ◽  
S. K. Raval ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Total Protein ◽  
Normal Values ◽  
Coconut Oil ◽  
Weekly Interval ◽  
Therapeutic Trial ◽  
Group A ◽  
Pre Treatment ◽  
Wrightia Tinctoria ◽  
Positive Effect

The present study was carried out during August 2019 to March 2020 for the diagnosis and therapeutic management of mange in camel. A total of fourteen positive cases of mange infestation were selected for the therapeutic trial. The therapeutic trial was carried out with the use of two different treatment viz., aqueous extract of Wrightia tinctoria (20%) and coconut oil in mangy camels. The mite count was performed on weekly interval up to five weeks. The camels had more than twenty Sarcoptic mites on day 0 (pre-treatment). The mite count was gradually decreased on fifth week and the mite reduction was 96.50% and 96.77% in group A & B, respectively. The haematology shows the significantly (p<0.05) increase in Hb, TEC, PCV, Neutrophils and Monocytes whereas, significantly (p<0.05) decreased in TLC, and Lymphocyte. The serological and mineral estimation shows the significant (p<0.05) increase in values of total protein, ALT and Zinc; whereas creatinine, AST and copper were decreased significantly (p<0.05). After treatment of mange infected camels with two different treatments the values of all these hemato-biochemical and micromineral constituents returned nearer to normal values of camels. Thus, aqueous extract of Wrightia tinctoria (20%) and coconut oil gave positive effect on mange infested camels.

Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Akinleye Stephen Akinrinde ◽  
Halimot Olawalarami Hameed
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Therapeutic Index ◽  
Control Treatment ◽  
Control Group ◽  
Protective Effects ◽  
Serum Total Protein ◽  
Significant Amelioration ◽  
Group A ◽  
Group B

Abstract Objectives This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats. Methods Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out. Results DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar. Conclusions The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.

N-Acetyl-β-D-Glucosaminidase Enzymuria in Leukaemia and Myelomatosis: Effect of Treatment in Acute Myeloblastic Leukaemia and Myelomatosis in Adults

1986 ◽  
Vol 23 (6) ◽  
pp. 676-680 ◽  
Author(s):  
P H Whiting ◽  
D J King ◽  
A Ireland ◽  
M A Ratcliffe ◽  
A A Dawson
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Normal Values ◽  
Terminal Phase ◽  
Acute Myeloblastic Leukaemia ◽  
Lysosomal Hydrolase ◽  
Patient Groups ◽  
Effect Of Treatment ◽  
Pre Treatment ◽  
Serum And Urine

The activity of the lysosomal hydrolase N-acetyl-β-d-glucosaminidase (NAG) was measured in the urine of patients with leukaemia or myeloma. Elevated pre-treatment enzymuria was noted in all patient groups with acute myeloblastic leukaemias (AML) FAB type M4 or 5 displaying higher activities than AML patients FAB types M1–3, which in turn were higher than those found in patients with myelomatosis and chronic lymphocytic leukaemia. The ratio of the major isoenzymes of NAG, A/B was reduced significantly only in patients with AML. Following treatment, AML patients who entered remission demonstrated NAG levels which approached normal values. In those AML patients who were either in relapse, in the terminal phase of their illness or treated with aminoglycoside antibiotics, NAG enzymuria was similar to pre-treatment values. A reduction in urinary NAG levels and both serum and urine β2 microglobulin concentrations was also observed following treatment in myeloma patients. The use of enzymuria both as a guide to progress towards remission in AML patients and for assessing prognosis and progress in myeloma patients is discussed.

GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY IN THE SERUM IN MUSCULAR DYSTROPHY AND OTHER NEUROMUSCULAR DISORDERS IN CHILDHOOD

PEDIATRICS ◽  
1958 ◽  
Vol 22 (6) ◽  
pp. 1110-1114
Author(s):  
E. G. Murphy ◽  
Morris M. Cherniak
Keyword(s):  
Muscular Dystrophy ◽  
Normal Values ◽  
Advanced Disease ◽  
Neuromuscular Disorders ◽  
Transaminase Activity ◽  
Older Children ◽  
Younger Child ◽  
Glutamic Oxalacetic Transaminase ◽  
Small Series ◽  
Group A

Serum activities of the enzyme glutamic oxalacetic transaminase were measured in 57 infants and children with various neuromuscular disorders. High values were obtained in 20 out of 32 patients with the Duchenne type of muscular dystrophy. The 12 cases with normal or borderline activities were mainly older children usually with advanced disease. Of the 10 patients with other varieties of muscular dystrophy, all but one had normal values. Normal values were invariably present in primary neuropathies. In the polymyositic group a small series of five cases had normal or borderline activities. The measurement of activity of this enzyme in the serum is a useful diagnostic aid in neuromuscular disorders, particularly in the younger child.

EFFECT OF ISOMETRIC AND ISOTONIC EXERCISE TRAINING ON CORE MUSCLE IN SUBJECTS WITH NON SPECIFIC LOW BACK PAIN

2017 ◽  
Vol 10 (6) ◽  
pp. 308
Author(s):  
Bijal Majiwala ◽  
Trupti Warude ◽  
Amrutkuvar Pawar
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Functional Disability ◽  
Isometric Exercise ◽  
Low Back ◽  
Endurance Test ◽  
Isotonic Exercise ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Objective: To compare the effects of isometric (stability) and isotonic training on core muscle in patients with non-specific low back pain on pain, endurance, and functional disability.Methods: Forty participants of both genders aged between 20 and 35 years suffering from non-specific low back pain were taken and equally divided into two groups: Group A isometric exercise and Group B isotonic exercise, both the group received baseline treatment of transcutaneous electrical nerve stimulation and hot moist pack. Outcomes measure visual analog scale, endurance test, and modified Oswestry disability index were used the pre-treatment and at the end of 4 weeks.Results: Experiment of both the groups showed a non-significant improvement in pain, endurance, and functional disability. Except for extensor endurance test which shows significant different in Group A.Conclusion: Both isometric and isotonic exercises are equally effective in reducing pain, increase endurance, and improve functional disability in patients with non-specific low back pain.

scholarly journals Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats

2006 ◽  
Vol 21 (3) ◽  
pp. 168-176 ◽  
Author(s):  
Míriam Elias Cavallini ◽  
Nelson Adami Andreollo ◽  
Konradin Metze ◽  
Marina Raquel Araújo
Keyword(s):  
Gastric Mucosa ◽  
Microscopic Analysis ◽  
Control Group ◽  
Average Weight ◽  
Gastric Cytoprotection ◽  
Microscopic Studies ◽  
Group A ◽  
Ad Libitum ◽  
Pre Treatment ◽  
Group B

PURPOSE: To evaluate and to compare macro and microscopically the intense injuries of the gastric mucosa of rats which were caused by NSAIDS celecoxib and indomethacin and the gastric cytoprotection with omeprazole and misoprostol. METHODS: The sample is formed by one hundred and fifty Wistar rats with average weight 200 g, distributed in four groups, such as: Group A, subdivided in groups A1 and A2 - pre-treatment with omeprazole (20 mg/rat) during seven days and on the 8th day - use of NSAIDS, concerning A1 (20 rats) were given celecoxib (1mg/rat) and A2 (20 rats) were given indomethacin. The Group B, subdivided in group B1 and B2 - pre-treatment with misoprostol (20mg/rat) during seven days and on the 8th day use of NSAIDS, concerning B1 (20 rats) were given celecoxib (1 mg/ rat) and B2 (20 rats) were given indomethacin (12.5 mg/rat). The Group C: were not given cytoprotection during seven days, from the 7th to the 8th day - fast of food and water ad libitum, on the 8th day of NSAIDS use, concerning C1 (20 rats) were given celecoxib, C2 (20 rats) were given indomethacin (12.5 mg/ rat), C3 (20 rats) were given celecoxib (200mg/rato), and Group D - control group, concerning 10 rats were observed during seven days ingesting food and water ad libitum. On the 9th day, the stomachs were taken out and were macro and microscopically evaluated for the identification of the gastric injuries. RESULTS: On the macroscopic studies, the groups A2, B2 and C2 presented a remarkable high number of injuries for cm² /animal, respectively 18.55 injuries for cm² /animal, 16.25 injuries for cm² /animal and 13.55 injuries for cm²/animal. On the microscopic studies, the percentage of the injured mucosa, presented expressive difference among the groups A1, B1, C1 when compared to the groups A2, B2, C2 (p<0.0001). The average of the length/injury and the average of the depth of the injuries did not present expressive statistics differences among the groups A2, B2 and C2. The average of the edema presented expressive statistics difference among the groups A2 and D; B2 and C2 and between C2 and D (p < 0.05). CONCLUSIONS: The indomethacin on the applied concentration causes a great number of macroscopic and microscopic injuries to gastric mucosa of rats when compared to celecoxib which does not cause lesions. Omeprazole and misoprostol on the applied concentrations do not present macroscopic and microscopic effectiveness on the gastric cytoprotection when applying indomethacin. Considering the microscopic analysis of the average of the edema, the group of animals, which was given misoprostol as cytoprotection, presented a lower average compared to the group which was given omeprazole.

scholarly journals Time out: should vitamin D dosing be based on patient's body mass index (BMI): a prospective controlled study

2021 ◽  
Vol 10 ◽  
Author(s):  
Mir Sadat-Ali ◽  
Khalid W. AlTabash ◽  
Haifa A. Al-Turki ◽  
Sulaiman A. AlMousa ◽  
Hasan N. AlSayed
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Standard Dose ◽  
Demographic Data ◽  
Controlled Study ◽  
Daily Dose ◽  
Calcium Phosphorus ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Abstract The recommended daily dose of vitamin D is 2000 IU was found to be insufficient in many patients. The objective of the present study is to find whether the daily dose of vitamin D should be based on BMI. Two hundred and thirty patients with an established vitamin D deficiency (serum level of 25 Hydroxy vitamin D3 (25OHD3) of ≤20 ng/ml) and patients with BMI ≥30 kg/m2 were included in the study. Demographic data, comorbidities and BMI were recorded. Pre-treatment and post-treatment serum 25OHD3, calcium, phosphorus and parathyroid hormone (PTH) were tested at 0-, 3- and 6-month periods. Patients were treated with a standard dose of 50 000 IU of vitamin D weekly and 600/1200 mg of calcium a day. Once their level of 25OHD3 reached ≥30 ng/ml, patients were randomised into two groups. Group A received a standard recommended maintenance dose of 2000 IU daily and Group B patients received 125 IU/kg/m2 of vitamin D3. The data were entered in the database and analysed. The mean age of Group A was 50⋅74 ± 7⋅64 years compared to 52⋅32 ± 7⋅21 years in Group B. In both groups, pre-treatment vitamin D level was ≤15 ng/ml and increased to 34⋅6 ± 2⋅6 and 33⋅7 ± 2⋅4 ng/ml at the end of 3 months treatment with a dose 50 000 IU of vitamin D3 and calcium 600/1200 mg once a day for group A and group B, respectively. At 6 months, patients in Group A 25OHD3 level was 22⋅8 ± 3⋅80 and in Group B was 34⋅0 ± 1⋅85 ng/ml (P < 0⋅001). This preliminary study suggests that obese patients need higher dosage of vitamin D than the recommended dose. It is prudent that the dosage should be based on the BMI to maintain normal levels for a healthy musculoskeletal system.

scholarly journals Modulating the Haematological and Cytogenetic Effects of Mitomycin C by Aqueous Extract of Nut Grass (Cyperus rotundus L.)

2007 ◽  
Vol 1 (1) ◽  
pp. 52-54
Author(s):  
Ali H. Ad'hiah ◽  
Mohammed M. F. Al-Halbosiy ◽  
Rakad M. Al-Jumaily
Keyword(s):  
Bone Marrow ◽  
Mitotic Index ◽  
Mitomycin C ◽  
Aqueous Extract ◽  
Leucocyte Count ◽  
Bone Marrow Cells ◽  
Post Treatment ◽  
Cyperus Rotundus ◽  
Micronucleus Formation ◽  
Pre Treatment

The aqueous extract (5, 10 and 15 mg/kg) of nut grass (Cyperus rotundus L.) rhizomes was evaluated orally in albino male mice using some haematological (total leucocyte count) and cytogenetic (mitotic index, micronucleus formation and chromosomal aberrations of bone marrow cells) parameters. The extract interaction with the mutagen mitomycin C (MMC) was also evaluated through two types of treatments (pre- and post-treatments). The results revealed that the dose 15 mg/kg of the extract significantly increased the total count of leucocytes (7634.4 vs. 6783.3 cells/cu.mm. blood), while the mitotic index showed no significant differences, as compared to negative controls. However, the spontaneous formation of micronuclei in the bone marrow cells was significantly decreased in the three investigated doses of the extract (0.30, 0.32 and 0.29, respectively vs. 0.62%), while the chromosomal assay showed similar frequencies in the negative control and nut grass-treated animals. With respect to the interaction with MMC, the pre-treatment (15 mg/kg) enhanced the leucocyte count (10358.6 vs. 3800.2 cells/cu.mm.blood) and mitotic index (11.9 vs. 6.5%), and a similar picture was drawn when the pos-treatment was considered (8884.2 vs. 4292.7 cells/cu.mm.blood; 14.6 vs. 7.6%). However, the doses 5 and 10 mg/kg of the plant extract were much more effective in reducing the MMC-induced micronucleus formation in both types of treatments especially the dose 5 mg/kg (pre-treatment: 4.24 vs. 16.29%; post-treatment: 3.79 vs. 14.34%). With respect to chromosomal aberration assay, the dose 15 mg/kg of the extract was the most effective dose in reducing the MMC-induced aberrations, but the post-treatment was better than pre-treatment in this respect (0.29 vs. 0.79 aberration/cell).

Normal values of urinary albumin and total protein excretion during pregnancy

1994 ◽  
Vol 171 (4) ◽  
pp. 984-989 ◽  
Author(s):  
Kenneth Higby ◽  
Cheryl R. Suiter ◽  
John Y. Phelps ◽  
Theresa Siler-Khodr ◽  
Oded Langer
Keyword(s):  
Total Protein ◽  
Normal Values ◽  
Urinary Albumin ◽  
Protein Excretion

Variability of Peritoneal Protein Loss in Diabetic and Nondiabetic Patients on Continuous Ambulatory Peritoneal Dialysis

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 242-244 ◽  
Author(s):  
Sophia Spaia ◽  
Fotini Christidou ◽  
Panayotis Pangidis ◽  
Thomas Tsoulkas ◽  
Michalis Pazarloglou ◽  
...  
Keyword(s):  
Body Weight ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Total Protein ◽  
Peritoneal Fluid ◽  
Protein Loss ◽  
Glucose Levels ◽  
Short Period ◽  
Group A ◽  
Group B

In order to evaluate the Influence of diabetes mellitus on peritoneal membrane permeability, we studied the peritoneal protein loss In two groups of patients. Group A consisted of 16 patients (9 nondlabetics and 7 diabetics) who were In the first month of treatment on continuous ambulatory peritoneal dialysis (CAPO). Group B consisted of 13 patients (7 nondlabetics and 6 diabetics) who had been on CAPO for approximately 15 months. In both groups we measured the body weight, serum total protein, albumin, and total protein, urea, and glucose In the peritoneal fluid. We did not find any difference In groups A and B between diabetics and nondlabetics as far as the estimated parameters were concerned. Age, body weight, serum biochemistry, and protein and urea content In peritoneal fluid were similar, when group A was compared to group B. Patients of group B hed on average higher protein losses than those who had been on the method for a short period (mean 7.9 g/dL, vs 6.09 g/dL). Six patients were followed for over 15 months and were found to have significantly Increased protein losses (p=0.02). Glucose levels In peritoneal fluid were significantly lower In patients In group B, p<0.05 (mean 51.8 g/dL vs 37.1 g/dL). Peritoneal protein loss does not seem to differ between diabetic and nondiabetic patients with end-stage renal disease treated with CAPO, at any given time of the treatment. We observed an Increase In protein loss In some patients and a tendency to Increase the protein loss In others. This, along with the fall In glucose levels, might reflect progressive alterations In structure and permeability of the elements Involved In peritoneal transport, and It should receive further evaluation.

scholarly journals Effects of Aqueous Extract of Basella alba L. leaves on Blood Cell Count in Rats

2019 ◽  
Vol 22 (1) ◽  
pp. 73-78
Author(s):  
Farhana Sabrin ◽  
AF Mohammed Shafiqul Alam ◽  
Muhammad Rashedul Islam ◽  
Md Elias Al Mamun ◽  
Jakir Ahmed Chowdhury
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Aqueous Extract ◽  
Control Group ◽  
P Value ◽  
Blood Cell Count ◽  
Basella Alba ◽  
Group A ◽  
Group B ◽  
Group D

The effect of aqueous extract of Basella alba (puishak) leaves on blood cell count of rats was studied. Forty rats of both sexes weighing between 100-150 gm were used. The rats were divided into four groups (7 rats in each group), with group A as the control group and experimental groups were denoted as B, C and D. With all aseptic precautions, aqueous extract of Basella alba (Puishak) leaves was administered into the three different doses (For group B: 60 mg/kg bw, group C: 80 mg/kg bw and group D: 100 mg/kg bw). Control group A also received distilled water as a placebo at the dose of 10 mg/kg bw for 14 days. At day 15, blood samples were collected and sent for haematological analysis. Data analysis of blood count profile of 28 rats revealed that there is an increased number of RBC, WBC and platelet count in experimental groups than in control group. ANOVA test revealed that increased blood cell counts following administration of aqueous leaves extract of keeves of B. alba were statistically significant (p value for each case was .0001<.05) than control group. Paired samples t test was performed to compare between baseline hematological parameters and parameters after 14 days of intervention. Then comparison between Group A & Group B, between Group A & Group C and between Group A & Group D were done. In all cases, probability (p) value < 0.05 was considered as statistically significant.This it is clearly evident that aqueous extract of B.alba has positive stimulant effect on blood cells count of rats. Moreover, it was found that increment of doses also increases the cell count that is positively correlated with the hypothesis. Bangladesh Pharmaceutical Journal 22(1): 73-78, 2019

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