scholarly journals Validasi Metode Analisis Matriks Patch Domperidon Maleat dengan Perbedaan Polimer Menggunakan Spektorfotometri UV-Vis

2021 ◽  
Vol 18 (2) ◽  
pp. 170-176
Author(s):  
Shesanthi Citrariana ◽  
Oktavia Indrati ◽  
Puspa Dwi Pratiwi ◽  
Ita Nurma Sari ◽  
Ari Wibowo

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.

2018 ◽  
Vol 2 (2) ◽  
pp. 178-182
Author(s):  
Sutijo Joko Sudiro ◽  
Muchammad Farid ◽  
Eko Swistoro

ABSTRACT [Relationship between Groundwater Surface Depth with Salinity at the Coast of New Kungkai Beach and its Implementation on Discovery Learning Model]. The aims of this study were 1) to describe the relationship between groundwater surface depth with salinity in the coastal areas of new kungkai beach of Seluma, and 2) to determine the improvement of learning outcomes (cognitive) of high ability students, moderate and low by using discovery learning model on the concept of static fluid in class X computer and network engineering at SMK Negeri 3 Seluma. This research was a quasi experimental research with one groups pretest-posttest design. The results showed: 1) The relationship between depth with salinity has a value of 0.6478 with a significance level of 0.001 (<0.05); 2) Learning with discovery learning model can improve student learning outcomes on cognitive aspects (knowledge). Increased cognitive results can be seen from the average value of the initial test, the final test and the average value of gain in the class x Tkj is high-ability groups are at high criteria with a value of 0.75 gain in the group is in the criteria medium with the value of gain 0,52 and in the low group were in moderate criteria with a gain value of 0.44. There is a difference in learning outcomes between the high, medium and low groups. The difference is shown by Fcount > Ftable (4.04 > 3.35) with a significance level of 5%. Keywords: Groundwater surface depth; salinity; discovery learning model; SMKN 3 Seluma.


2020 ◽  
Vol 3 (3) ◽  
pp. 225-235
Author(s):  
Ongki Okto Beranda ◽  
Bintal Amin ◽  
Sofyan Husein Siregar

The study was conducted in August-October 2019. Aims to determine theconcentration of nitrate, phosphate, uniformity index, diversity and index of dominancy,abundance of epipelic diatoms and know the relationship between nitrate,phosphate and epipelic abundance diatoms in the water area of Sungaitohor DesaMeranti of Riau Islands district. The method used in this research is a surveymethod consisting of 4 research stations. Location of observation and sampling is in the waters of Muara Sungaitohor Kabupaten Meranti Islands. Basedon the results of this study of nitrateconcentrations in the waters of Sungaitohor Bekisar village 0,068-0,092 mg/l, phosphate concentrations ranged0,097-0,220 mg/L. The Epipelic diatom found in the water area of Sungaitohorvillage amounted to 14 types. As for the abundance of type diatomsepipelics ranged from 27,531.72– 40,531.72 ind/cm2. From theCalculation of the community structure diatoms epipelic obtained diversityindex value (H ') which indicates a low index value of h ' has a value of2.7527 and is at a range of 1 ≤ H ' ≤ 3. The uniformity index (E) indicatesthat an epipelic spread is not balanced with an average value of 0.3643uniformity and is at a range of value ≤ 0.5. Meanwhile, the Dominance index (D)shows the value of 0.1704 where the value of the area in the waters ofSungaitohor village does not dominate. The relationship of abundance ofepipelic diatoms with the concentration of nitrate is positive and very weak,with a correlation coefficient of R = 0.0030. While the relationship ofAbundance diatomic epipelic relationship with phosphate concentrations isnegative and weak, with a correlation coefficient r = 0.262. Abundance ofdiatomic epipelics is directly proportional to the concentration of nitrate andinversely proportional to phosphate concentrations


Author(s):  
Michael E. Smith ◽  
Randolph R. Resor ◽  
Pradeep Patel

This analysis presents a methodology for measuring the efficiency of train dispatching as a product of three variables: (a) the type of train control system (measured by latency, defined here as the interval between occurrence of a schedule deviation and initiation of corrective action); (b) the physical capacity of the route (track kilometers per route kilometers); and (c) train minutes per route kilometer (a measure of both capacity and dispatcher competence). A mathematical relationship among these three variables is postulated, and a log-log regression analysis is used to develop coefficients that relate each of the three independent variables to dispatching efficiency. To do this, actual train-movement data and minimum train running times for 28 U.S. Class I railroad line segments are used. Results of the regression analysis indicate a statistically valid relationship among latency, track capacity, traffic volume, and dispatching effectiveness. Dispatching effectiveness, calculated by placing track kilometers per route kilometer, train minutes per route kilometer, and latency at their mean values, was 71.3 percent (the mean latency was about 17 min). At a latency of 3.5 min, average effectiveness is 81.3 percent. Examples of the trade-off between latency and effectiveness and between track capacity and effectiveness also can be calculated. For the average line, when latency is progressively reduced from the current value of 15 min to 3.5 min, dispatching effectiveness increases from 71.3 to 81.3 percent. When track kilometers per route kilometer are increased from the average value of 1.3 to 2.0 (double-tracking the entire railroad, holding all other values constant) dispatching effectiveness can be increased from 71.3 to 89.5 percent—a larger increase than that realized from a reduction in latency, but at much higher cost. To quantify the dollar benefits of such an increase in dispatching effectiveness for U.S. railroads, further analyses were carried out. Based on a previous study of Burlington Northern operations, train delay costs ranged from $163/hr to $266/hr. To simplify calculations, a value of $200/hr is used. According to U.S. railroad statistics, there are about 21 million train hours of traffic each year. Benefits available from installing communications-based train control are calculated in terms of additional train minutes per route kilometer available with an increase in dispatching effectiveness based on this analysis. Based on this analysis, it should be possible to save (1 − 0.713/0.813) or 12.3 percent of total train hours. The benefit of this would be $200 × 0.123 × 21 × 10 or $520 million annually. The Association of American Railroads has estimated the cost of positive train control for the entire U.S. railway network to be between $843 million and $1.1 billion.


2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Sutijo Joko Sudiro ◽  
Muchammad Farid ◽  
Eko Swistoro

ABSTRACT [Relationship between Groundwater Surface Depth with Salinity at the Coast of New Kungkai Beach and its Implementation on Discovery Learning Model]. The aims of this study were 1) to describe the relationship between groundwater surface depth with salinity in the coastal areas of new kungkai beach of Seluma, and 2) to determine the improvement of learning outcomes (cognitive) of high ability students, moderate and low by using discovery learning model on the concept of static fluid in class X computer and network engineering at SMK Negeri 3 Seluma. This research was a quasi experimental research with one groups pretest-posttest design. The results showed: 1) The relationship between depth with salinity has a value of 0.6478 with a significance level of 0.001 (<0.05); 2) Learning with discovery learning model can improve student learning outcomes on cognitive aspects (knowledge). Increased cognitive results can be seen from the average value of the initial test, the final test and the average value of gain in the class x Tkj is high-ability groups are at high criteria with a value of 0.75 gain in the group is in the criteria medium with the value of gain 0,52 and in the low group were in moderate criteria with a gain value of 0.44. There is a difference in learning outcomes between the high, medium and low groups. The difference is shown by Fcount > Ftable (4.04 > 3.35) with a significance level of 5%. Keywords: Groundwater surface depth; salinity; discovery learning model; SMKN 3 Seluma.


Author(s):  
Abd Kholiq ◽  
L. Lamidi

Premature babies who are born alive before 37th week of gestation or babies born with weight criteria of less than 2500 grams need to be treated in an infant incubator because they are very susceptible to viruses in open spaces and will provide protection to newborns by providing premature babies stable temperature and humidity. Stable temperature regulation is needed to prevent hypothermia or hyperthermia that will occur in premature babies. Care of the baby in an infant incubator causes the separation of mother and baby. Mothers who have premature babies are found to lack trust in caring for their babies compared to mothers who have term babies. The purpose of this study was to analysis of temperature on baby incubator control system. In order to get a stable and precise temperature, the temperature sensor is positioned according to the standard of the baby incubator at the hospital. This research uses LM35 and DS18B20 temperature sensors which will be processed using Atmega 328 Microcontroller and will be displayed on a PC (personal computer). Based on the measurement results obtained an average value of min difference for sensor readings on the LM35 has the largest value of 0.22°C and the average max value difference has the largest value of 0.38°C and the average value of the min difference for the sensor readings on the LM35 has a value the largest is 0.39°C and the average difference in the value of max has the largest value that is 0.55°C. It can be concluded that the LM35 sensor is better than the DS18B20 sensor because it has smaller oscillations and also good accuracy. The results of this study can be implemented in infant incubators in accordance with established standards and can be produced at affordable prices in the domestic market.


2021 ◽  
Vol 19 (1) ◽  
pp. 73
Author(s):  
Tyas Sari Ratna

 Adolescents 18-21 years of age today have problems related to movement that result in changes to resistance training. Exercise resistance is expressed in VO2max. Body mass index and gender are factors that influence VO2max. The purpose of this study is to analyze the relationship between body mass index and sex on VO2Max and to analyze how closely the relationship is. The type of this study is an observational study with a purposive sampling technique with a point time approach design with a total of 183 samples with criteria for healthy samples aged 18- 21 years. The independent variable in this study was exercise endurance (VO2max), and the dependent variable was body mass index and gender. The data is processed using software for data analysis. From the data normality test using Kolmogorov Smirnov for Body Mass Index data with a value of 0.001, sex data with a value of 0.000, VO2Max data with a value of 0.000 which indicates abnormal data. Test Data analysis using the Spearman rank test resulted in the value of gender and VO2max 0.001 with r value of 0.203 and body mass index value and VO2max -0.015 with r value of 0.766.There is a correlation between body mass index and sex on VO2Max.


Author(s):  
Nurdan Gürkan ◽  
Ahmet Ferda Çakmak

The concept of entrepreneurial orientation, which emerges with the development of strategic management, refers to entrepreneurship orientations of businesses. The businesses need resources in other words organizational slack in order to develop their entrepreneurial trends. The organizational slack consists of three slack type. These slack types are available slack, recoverable slack and potential slack. The purpose of this study is to examine whether organizational slack in the businesses has an effect on entrepreneurial orientation. The relationship between organizational slack and entrepreneurial orientation was investigated through 20 companies that were traded in Borsa Istanbul Corporate Governance Index for 2010-2014 period using panel data analysis method. The results of the study indicate the existence of a statistically significant relationship between and the available slack and the recoverable slack with the entrepreneurial orientation in the businesses. According to findings; there was no statistically significant relationship between potential slack and entrepreneurial orientation.


2019 ◽  
Vol 3 (2) ◽  
pp. 228-244 ◽  
Author(s):  
Muhammad Rezha Pahlawan ◽  
Nurlia Nurlia ◽  
Abdul Rahman Laba ◽  
Erlina Pakki ◽  
Hardiyono Hardiyono

This study aims to determine the effect of Product Quality and Service Quality on Increasing Customer Satisfaction and Loyalty in Makassar Municipal Water Company (PDAM) both directly and through intervening variables or indirect effects. This study uses a quantitative approach conducted with the aim to explain the position of the variables studied and the relationship between one variable with another variable. This research will explain the causal relationship between variables through hypothesis testing. In this study, the analysis method used is path analysis using the SmartPLS program. The results of this study found that directly the product quality had a positive and significant effect on customer satisfaction, service quality had a positive and significant effect on customer satisfaction, product quality had a positive and significant effect on customer loyalty, service quality had a positive and not significant effect on customer loyalty, customer satisfaction positive and significant effect on customer loyalty. The indirect effect of this research is product quality has a positive and significant effect on customer loyalty if mediated by customer satisfaction. Service quality also has a positive and significant effect on customer loyalty if mediated by customer satisfaction.


2021 ◽  
Vol 57 (4) ◽  
pp. 333-342
Author(s):  
Trung Huu Nguyen ◽  
Tran Nguyen Minh An ◽  
Mahboob Alam ◽  
Duc Hoai Tran ◽  
Nghi Tran ◽  
...  

The goal of the research is to develop an experimental mathematical model of pan coating process effect on the biodegradable polymer and to determine optimal process parameters. The polymer solution was conducted with phosphated di-starch phosphate, polyvinyl alcohol, and polyacrylic acid and performed as material coating for the controlled-release urea fertilizer. The image analysis method has been used to determine the particle size distribution, Sauter mean diameter of the particle and layer thickness that is novel. The central composite rotatable design has been selected to determine the regression models of the process, which described the relationship between two objective variables as layer thickness, release time with angle of pan, spray flow, and coating time. The statistical analysis results indicate the fitness of model.


1992 ◽  
Vol 23 (1) ◽  
pp. 13-26 ◽  
Author(s):  
W. H. Hendershot ◽  
L. Mendes ◽  
H. Lalande ◽  
F. Courchesne ◽  
S. Savoie

In order to determine how water flowpath controls stream chemistry, we studied both soil and stream water during spring snowmelt, 1985. Soil solution concentrations of base cations were relatively constant over time indicating that cation exchange was controlling cation concentrations. Similarly SO4 adsorption-desorption or precipitation-dissolution reactions with the matrix were controlling its concentrations. On the other hand, NO3 appeared to be controlled by uptake by plants or microorganisms or by denitrification since their concentrations in the soil fell abruptly as snowmelt proceeded. Dissolved Al and pH varied vertically in the soil profile and their pattern in the stream indicated clearly the importance of water flowpath on stream chemistry. Although Al increased as pH decreased, the relationship does not appear to be controlled by gibbsite. The best fit of calculated dissolved inorganic Al was obtained using AlOHSO4 with a solubility less than that of pure crystalline jurbanite.


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