scholarly journals ESTABLISHMENT OF PERMISSIBLE LIMITS FOR LEACHING SUBSTANCES FROM BONE SUBSTITUTES CONTAINING HYDROXYAPATITE AND BETA-TRICALCIUM PHOSPHATE

2021 ◽  
Vol 82 (1) ◽  
pp. 9-15
Author(s):  
Vadym Chernobrovchenko ◽  
◽  
Kostiantyn Dyadyura ◽  
Mark Balynskyi ◽  
◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Tricalcium Phosphate ◽  
Quantitative Research ◽  
Bone Substitutes ◽  
Biological Materials ◽  
Biological Variation ◽  
The Body ◽  
Quantitative Research Methods ◽  
Beta Tricalcium Phosphate ◽  
Analytical Errors

It has been proven that the main factor in the uncertainty of laboratory results is biological variation, that is, a change in the composition of human biomaterials, reflecting the course of life processes in the body and is characterized by a combination of the constancy of the internal environment and dynamic fluctuations around the homeostasis point. The paper offers objectively substantiated recommendations for the accuracy of laboratory tests, established maximum allowable values of analytical errors of quantitative research methods (measurements) of physical quantities (composition and properties of components of biological materials, analytes) in samples of biological materials. The interpretation of LOD and LOQ for detecting the concentration of leaching micro-impurities in the bioliquid. The identified patterns indicate that the elements of microimpurities have different dissolution rates. The ratio of hydroxyapatite/tricalcium phosphate affects the dissolution rate of the material: the higher the content of β-tricalcium phosphate, the higher the dissolution rate. The results of the research allow establishing recommendations for reducing inaccuracies in determining the composition of bone substitutes based on hydroxyapatite/β-tricalcium phosphate, which is associated with manifestations of biological variation, reflecting the body’s response to various environmental factors and subject to statistical laws.

scholarly journals Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors

2004 ◽  
Vol 72B (1) ◽  
pp. 94-101 ◽  
Author(s):  
Akira Ogose ◽  
Tetsuo Hotta ◽  
Hiroyuki Kawashima ◽  
Naoki Kondo ◽  
Wenguang Gu ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Tumors ◽  
Bone Substitutes ◽  
Beta Tricalcium Phosphate

scholarly journals Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Dajiang Du ◽  
Teruo Asaoka ◽  
Makoto Shinohara ◽  
Tomonori Kageyama ◽  
Takashi Ushida ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Porous Ceramic ◽  
Vital Staining ◽  
Bone Substitutes ◽  
Computer Assisted ◽  
Beta Tricalcium Phosphate ◽  
Ceramic Slurry ◽  
Internal Network ◽  
Rabbit Bone ◽  
Rabbit Femur

Porous ceramic scaffolds with shapes matching the bone defects may result in more efficient grafting and healing than the ones with simple geometries. Using computer-assisted microstereolithography (MSTL), we have developed a novel gelcasting indirect MSTL technology and successfully fabricated two scaffolds according to CT images of rabbit femur. Negative resin molds with outer 3D dimensions conforming to the femur and an internal structure consisting of stacked meshes with uniform interconnecting struts, 0.5 mm in diameter, were fabricated by MSTL. The second mold type was designed for cortical bone formation. A ceramic slurry of beta-tricalcium phosphate (β-TCP) with room temperature vulcanization (RTV) silicone as binder was cast into the molds. After the RTV silicone was completely cured, the composite was sintered at 1500°C for 5 h. Both gross anatomical shape and the interpenetrating internal network were preserved after sintering. Even cortical structure could be introduced into the customized scaffolds, which resulted in enhanced strength. Biocompatibility was confirmed by vital staining of rabbit bone marrow mesenchymal stromal cells cultured on the customized scaffolds for 5 days. This fabrication method could be useful for constructing bone substitutes specifically designed according to local anatomical defects.

Preparation of Porous Biphasic Tricalcium Phosphate and Its In Vivo Behavior

2005 ◽  
Vol 284-286 ◽  
pp. 281-284 ◽  
Author(s):  
Masanobu Kamitakahara ◽  
Chikara Ohtsuki ◽  
M. Oishi ◽  
Shinichi Ogata ◽  
Toshiki Miyazaki ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Ceramic Body ◽  
Potato Starch ◽  
Bone Substitutes ◽  
The Body ◽  
In Vivo Experiments ◽  
Tcp Phase ◽  
Biphasic Ceramic ◽  
Mg Content

Biphasic ceramic consisting of tricalcium phosphate with α- and β -phases (αβ-TCP) is a candidate as biodegradable bone substitutes since its biodegradability may be controlled by the ratio of the phases. In the present study, preparation of porous αβ-TCP body with continuous pores of 10-50 µm in diameter was attempted using additives of Mg, and its in vivo behavior was examined. Powder of β-TCP was mixed with Mg and potato starch to form slurry, followed by loading in polyurethane foam. The sample was fired at 1400°C for 12 hours for sintering process. α-TCP content of the sample decreased with increasing the Mg content, while β-TCP increased. Ceramic body consisting of β-TCP phase was obtained when 1.0 mass% of Mg was added. Porosity of the body decreased with increasing the content of Mg. The αβ-TCP body with 80% porosity was obtained when the content of Mg was 0.1 mass%. The in vivo experiments showed that the rate of degradation of the obtained αβ-TCP was almost same as α-TCP, and much higher than β-TCP.

scholarly journals Pengaruh latihan kekuatan otot tangan, daya tahan otot dan keseimbangan terhadap ketepatan shooting game petanque di UKM Petanque Upgris

2021 ◽  
Vol 2 (2) ◽  
pp. 274-279
Author(s):  
Wawan Adi Saputro Sukawi ◽  
Osa Maliki ◽  
Fajar Ari Widiyatmoko
Keyword(s):  
Muscle Strength ◽  
Strength Training ◽  
Quantitative Research ◽  
Sampling Technique ◽  
The Body ◽  
Muscle Endurance ◽  
Significance Level ◽  
Quantitative Research Methods ◽  
Paired Sample ◽  
Hand Muscle

This research is motivated by the problem in this study, namely weak hand muscle strength, muscle endurance and balance to shooting games, some UPGRIS students take part in Petanque UKM, some of them are students who have hand muscle strength, muscle endurance in throwing something is lacking and so is the balance of the body. The purpose of this study was to determine the effect of hand muscle strength, muscle endurance and balance on the accuracy of shooting games at UKM Petanque UPGRIS and to determine the causes of the lack of accuracy in the shooting game Petanque. The method used is quantitative research methods with the type of research model True-Experimental Design Pre-test Post-test Two Group design. The population and sample in this study were 10 petanque athletes at the PGRI University of Semarang. This sampling technique uses total sampling. The method of data analysis used paired sample test with a significance level of 5%. The results showed that there was an effect of hand muscle strength training, muscle endurance and balance on the accuracy of shooting game Petanque which was expressed through the results of hypothesis testing with paired sample t-test with count = -7.571 and t-table = 2.777. Then t_count> t-table so that Ho is rejected and Ha is accepted, while based on the significant value because the value is sig. = 0.002 with a confidence level of 95%, then Sig. > ? (0.05). So that Ho was rejected. This study concludes that there is an effect of hand muscle strength training, muscle endurance and balance on the accuracy of the Petanque shooting game at the UKM Petanque UPGRIS club. Suggestion, hand muscle strength training, muscle endurance and balance are used as training media so that they can help athletes improve shooting accuracy.

scholarly journals Alteration of clot architecture using bone substitute biomaterials (beta-tricalcium phosphate) significantly delays the early bone healing process

2018 ◽  
Vol 6 (48) ◽  
pp. 8204-8213 ◽  
Author(s):  
Xin Wang ◽  
Yan Luo ◽  
Yan Yang ◽  
Baoyu Zheng ◽  
Fuhua Yan ◽  
...  
Keyword(s):  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Bone Substitute ◽  
Blood Clot ◽  
Healing Process ◽  
The Body ◽  
Beta Tricalcium Phosphate ◽  
Bone Healing Process

When a bone substitute biomaterial is implanted into the body, the material's surface comes into contact with circulating blood, which results in the formation of a peri-implant hematoma or blood clot.

Characterization of Different Nanostructured Bone Substitute Biomaterials

2014 ◽  
Vol 936 ◽  
pp. 695-700 ◽  
Author(s):  
Nelson Levandowski ◽  
Nelson H.A. Camargo ◽  
Daiara F. Silva ◽  
Gisele M.L. Dalmônico ◽  
Priscila F. Franczak
Keyword(s):  
Tricalcium Phosphate ◽  
Physicochemical Characterization ◽  
Bone Substitutes ◽  
Second Phase ◽  
State University ◽  
Transformation Kinetics ◽  
Beta Tricalcium Phosphate ◽  
Molecular Events ◽  
Kinetics Of

The present research paper centers on physicochemical characterization of six nanostructured alloplastic bone substitutes developed at Santa Catarina State University (UDESC Brazil). In addition to identifying the main phases, the focus was to measure the morphological and microstructural features, which are believed to be crucial for controlling and guiding biological and molecular events. The studied samples exhibited rounded granules measuring 200μm 10(PO4)6(OH)2] was found as main phase for HAp, BCP and HAp/Al2O3 biomaterials. For HAp/TiO2n, HAp/SiO2n and β-TCP, the major phase was beta tricalcium phosphate [Ca3(PO4)2-β]. The results demonstrate that the presence of a second phase of nanometer order, at a hydroxyapatite bioceramic matrix, may modify the surface diffusion of the grains and the phase transformation kinetics of hydroxyapatite and beta tricalcium phosphate at temperatures up to 1100°C.

scholarly journals Osteopontin and Vascular Endothelial Growth Factor-Immunoreactivity in Critical Bone Defects Matrix Production: A Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogeneic Hydroxyapatite Comparison

Minerals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1048
Author(s):  
Ivonete Sena dos Santos ◽  
Igor da Silva Brum ◽  
Victor Hugo Vieira de Oliveira ◽  
Ana Lucia Rosa Nascimento ◽  
Lucio Frigo ◽  
...  
Keyword(s):  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Wistar Rats ◽  
Materials Science ◽  
Bone Matrix ◽  
Bone Substitutes ◽  
Biological Behavior ◽  
Ctrl Group ◽  
Beta Tricalcium Phosphate ◽  
Osteoblast Activity

The development of new bone substitutes has become an area of great interest in materials science. In fact, hydroxyapatite is the most commonly used biomaterial in defects that require bone reconstruction, and that is certainly why the discovery of new products with its formulation has been increasing continuously. The aim of this study was to analyze the biological behavior of a xenogeneic hydroxyapatite widely disclosed in the literature and a synthetic nano-hydroxyapatite/Beta tricalcium phosphate in critical defects in the calvaria of Wistar rats. For this, the groups were divided as follows: 24 adult male Wistar rats were used, weighing between 300 and 350 g, in three groups with eight animals each. In the CTRL group (control), only the clot was kept, without material insertion; in the Bioss group (bovine hydroxyapatite), Bio Oss®—Gleistlich® was introduced; and in the Blue Bone group (REG), the defect was filled in with synthetic nano-hydroxyapatite associated with betatriphosphate of calcium, Blue Bone®—Regener®. According to the results in Goldner’s Trichromics, we can observe a higher percentage of newly formed bone matrix in the REG group than in the CTRL and Bioss groups; in the VEGF, we had a more adequate cell modulation for blood vessel formation in the Blue Bone group (REG) compared to the Bioss and CTRL groups, while in osteopontin, a higher percentage of bone formation was observed in the Blue Bone group (REG) and Bioss group when compared to the CTRL group. We conclude that bone formation, mitosis-inducing cell modulation and main osteoblast activity were higher in the Blue Bone group (REG) than in the CTRL and Bioss groups.

scholarly journals Hubungan Body Image dengan Harga Diri pada Remaja Putri Penggemar Kpop di Komunitas A.R.M.Y Medan

2021 ◽  
Vol 3 (3) ◽  
pp. 1365-1371
Author(s):  
Nini Sri Wahyuni ◽  
Anisty Auriella
Keyword(s):  
Body Image ◽  
Data Analysis ◽  
Young Women ◽  
Quantitative Research ◽  
Positive Relationship ◽  
Self Esteem ◽  
The Body ◽  
Research Subjects ◽  
Quantitative Research Methods ◽  
The Relationship

This study aims to determine the relationship between body image and self esteem in Adolescent of K-pop fans in the A.R.M.Y Medan Community. Researchers used quantitative research methods with respondents being Kpop fan girls who joined the A.R.M.Y Medan Community where the number of young women who were taken as research subjects was 100 people. The measuring instrument in this study used a body image scale of 26 items (reliability: 0.918) and a self-esteem scale of 32 items (reliability: 0.918). Methods of data analysis using product moment correlation with the help of SPSS version 25.0 to determine the form of the relationship and the value of the body image variable in explaining the variable self-esteem. The results of the data analysis indicate that there is a positive relationship between body image and self-esteem where rxy = 0.432 with a significant p = 0.000 <0.05. So that the rhit value> rtab (0.432> 0.194) is obtained so that the proposed hypothesis is accepted. This means that the hypothesis proposed is that there is a positive relationship between Body Image and Self-esteem in Kpop fans in the A.R.M.Y Medan Community. Self-esteem is formed by Body Image by 18.7%. From this contribution percentage, it can be seen that there are still 81.3% influence from other factors of Self-esteem. Based on the results of empirical calculations, it shows that young women in the A.R.M.Y community in Medan have moderate self-esteem and body image.

scholarly journals Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Vlad M. Anghelescu ◽  
Ioana Neculae ◽  
Octavian Dincă ◽  
Cristian Vlădan ◽  
Claudiu Socoliuc ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Tricalcium Phosphate ◽  
Bone Substitutes ◽  
Collagen Iv ◽  
Tissue Formation ◽  
Bone Augmentation ◽  
Bioactive Glasses ◽  
Bone Engineering ◽  
Beta Tricalcium Phosphate ◽  
Bovine Hydroxyapatite

Introduction. The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae. There is a lack of in vivo studies of inflammatory-driven angiogenesis in bone engineering using various grafts. Methods. The study was performed in animal experimental model on the standardized monocortical defects in the tibia of 20 New Zealand rabbits. The defects were augmented with three types of bone substituents. The used bone substituents were beta-tricalcium phosphate, bovine hydroxyapatite, and bioactive glasses. After a period of 6 months, bone fragments were harvested for histopathologic examination. Endothelial cell analysis was done by analysing vascularization with PECAM/CD31 and VEGF and fibrosis with collagen IV, laminin, and osteonectin stains. Statistical analysis was realized by descriptive analysis which was completed with the kurtosis and skewness as well as the Kruskal-Wallis and Mann-Whitney statistical tests. Results. The discoveries show that the amount of bone that is formed around beta-tricalcium phosphate and bovine hydroxyapatite is clearly superior to the bioactive glasses. Both the lumen diameter and the number of vessels were slightly increased in favor of beta-tricalcium phosphate. Conclusion. We can conclude that bone substitutes as bovine bone and beta-tricalcium phosphate have significant increased angiogenesis (and subsequent improved osteogenesis) compared to the bioactive glass. In our study, significant angiogenesis is linked with a greater tissue formation, indicating that in bone engineering with the allografts we used, inflammation has more benefic effects, the catabolic action being exceeded by the tissue formation.

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