scholarly journals Formulation and Stability Testing of Microemulsion Griseovulfin

2020 ◽  
Vol 2 (2) ◽  
pp. 32
Author(s):  
Iyan Sopyan ◽  
Dolih Gozali ◽  
Eka Paramudya
Keyword(s):  
Storage Time ◽  
Physical Stability ◽  
Coconut Oil ◽  
The Body ◽  
Test Results ◽  
Virgin Coconut Oil ◽  
Diffusion Test ◽  
Long Term Stability ◽  
Good Penetration

The use of drugs that are less soluble in water will become clinically less efficient, this is caused by the low penetration of the drug into the body. A microemulsion is a dispersion system such as an emulsion that can increase the solubility of drugs that are sometimes difficult to dissolve in water. Microemulsions have long-term stability, clear, transparent, and good penetration capabilities. In this study, a microemulsion formulation with active ingredients griseofulvin and virgin coconut oil was conducted as an oil phase. The resulting microemulsion evaluates physical stability during 35 storage days. The results showed that the microemulsion preparation remained stable during storage time without changes in color, odor, and consistency, while the pH and dosage viscosity experienced less significant changes. The consequences of the centrifugation test at 3700 rpm for 5 hours and freezing tests for 24 days showed stable preparation and cannot be separated. The diffusion test results obtained by FG2 had the largest permeation percentages of 3.6136%, FG3 2.8724%, and the smallest FG1 2.0477%.Keywords: microemulsion, griseofulvin, stability, diffusion test

scholarly journals Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid

2021 ◽  
Vol 11 (18) ◽  
pp. 8591
Author(s):  
Jae Hyuk Choi ◽  
Donghee Son ◽  
Mikyung Shin
Keyword(s):  
Boronic Acid ◽  
Skin Wound ◽  
Body Fluids ◽  
The Body ◽  
Wound Dressings ◽  
Suture Materials ◽  
Wound Site ◽  
Long Term Stability ◽  
State Dependent

Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a component of the hydrogels. However, the weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels necessitates additional suturing at the wound site. In this study, we report on a solid polysaccharide thread reversibly crosslinked with boronic acid-polyphenol complexation and its adhesive gelation for complete tissue sealing without additional suturing. The polysaccharide adhesive suture threads demonstrated long-term stability, which is useful when used for skin wound suturing. Specifically, their robust adhesion property occurred as soon as the threads were soaked, attaining a swollen hydrogel state, dependent on the presence of body fluids after suturing. Moreover, the pH of the body fluids affects the viscoelasticity and adhesiveness of the hydrogels in order to ensure a tight sealing. Therefore, we expect that these pH-responsive adhesive threads would be promising for the development of on-demand functional suture materials.

Modifying Brushite Cement Degradation Using Calcium Alginate Beads

2007 ◽  
Vol 361-363 ◽  
pp. 311-314 ◽  
Author(s):  
Liam M. Grover ◽  
Sarika Patel ◽  
Y. Hu ◽  
Uwe Gbureck ◽  
J.E. Barralet
Keyword(s):  
Calcium Alginate ◽  
Alginate Beads ◽  
The Body ◽  
Cement Matrix ◽  
Calcium Alginate Beads ◽  
Long Term Stability ◽  
The Matrix ◽  
Implant Degradation

The hydrolysis of brushite in calcium phosphate cements to form hydroxyapatite is known to result in the long term stability of the material in the body. It has previously been established that this hydrolysis reaction can be influenced by implant volume, media refreshment rate and media composition. In this study, the effect of macroporosity on the rate of degradation of the material is investigated. Macroporosity was incorporated into the material using calcium alginate beads mixed into the cement paste. The inclusion of the calcium alginate beads did not influence the degree of conversion of the material and allowed the incorporation of porosity at up to maximum of 57%. The macroporosity weakened the cement matrix (from 46.5 to 3.2 MPa). When aged the brushite in the macroporous cement dissolved completely from the matrix resulting in a weight loss of 60wt% in a period of 28 days. This suggests that the controlled incorporation of calcium alginate beads into brushite cements in vivo can be used to control implant degradation rate.

Long-term stability study of drug products and out-of-specification test results

2011 ◽  
Vol 16 (12) ◽  
pp. 615-622 ◽  
Author(s):  
Ilya Kuselman ◽  
Ilana Schumacher ◽  
Francesca Pennecchi ◽  
Cathy Burns ◽  
Aleš Fajgelj ◽  
...  
Keyword(s):  
Stability Study ◽  
Test Results ◽  
Specification Test ◽  
Term Stability ◽  
Drug Products ◽  
Long Term Stability

scholarly journals UJI KEBERADAAN DAN VIABILITAS SEL Lactobacillus bulgaricus PADA PEMBUATAN VCO FERMENTASI YANG BERFUNGSI PROBIOTIK

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Sarkono S a r k on o ◽  
Nur Indah Julisaniah
Keyword(s):  
Storage Time ◽  
Biological Process ◽  
Coconut Oil ◽  
Living Cells ◽  
Lactobacillus Bulgaricus ◽  
Bacterial Cells ◽  
Virgin Coconut Oil ◽  
Bacterial Fermentation ◽  
Fermentation Method ◽  
Coconut Product

Abstrak: Salah satu upaya pengembangan produk kelapa adalah pembuatan minyak kelapa murni atau biasa disebut Virgin coconut oil (VCO). Selain dengan proses sentrifugasi, VCO juga dapat dibuat dengan bantuan mikrobia khususnya bakteri. Dalam penelitian ini dilakukan pembuatan VCO dengan  metode fermentasi mengggunakan bakteri Lactobacillus bulgaricus. Hasil penelitian menunjukkan bahwa bakteri L. bulgaricus dapat digunakan sebagai salah satu alternatif  dalam pembuatan VCO dengan cara fermentasi. Setelah proses fermentasi, sel bakteri L. bulgaricus lebih banyak berada pada lapisan blondo, diikuti lapisan air dan lapisan minyak.  Sedangkan berdasarkan uji viabilitas selama penyimpanan, jumlah sel L. bulgaricus terus mengalami penurunan jumlah sel hidup selama penyimpanan. Waktu penyimpanan maksimal dimana masih terdapat sel L. bulgaricus pada VCO adalah 24 hari.Kata kunci : VCO, Lactobacillus bulgaricus, Viabilitas. Abstract: An effort of coconut product development is making the pure coconut oil or so-called Virgin Coconut Oil (VCO). Besides of centrifugation process, VCO can be also made by biological process, especially using bacteria. Bacterial fermentation method with Lactobacillus bulgaricus was performed to produce VCO. The results showed that the bacterium L. bulgaricus can be used as an alternative in producing VCO by way of fermentation. After the fermentation process, bacterial cells L. bulgaricus mostly present at blondo layer, followed by a layer of water and oil layers. Meanwhile, based on testing the viability during storage, the number of cell L Bulgaricus been steadily declining number of living cells during storage. The maximum storage time for L. bulgaricus on the VCO is 24 days. Keywords: VCO, Lactobacillus bulgaricus, Viability.

Pengaruh Pemberian Virgin Coconut Oil Terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus Norvegicus Jantan

2020 ◽  
Vol 17 (2) ◽  
pp. 181
Author(s):  
NOVIANE ANGRELLA ◽  
ROOSTANTIA INDRAWATI ◽  
LESTARI DEWI
Keyword(s):  
Creatinine Level ◽  
Blood Urea Nitrogen ◽  
Coconut Oil ◽  
The Body ◽  
Virgin Coconut Oil ◽  
Urea Nitrogen ◽  
Waste Products ◽  
Nitrogen Levels ◽  
Functional Product ◽  
Male Wistar Rats

<p><strong>ABSTRACT</strong></p><p><strong>Background:</strong><em> </em><em>Virgin Coconut Oil </em>(VCO) is a functional product that is highly favored and have been widely applied in the everyday lives of society. The increase of the frequencies and duration of VCO consumption is suspected that VCO could negatively impact the target organ. The kidney is a vital organ in the human body, it is responsible for clearing out the residual waste products of metabolism in the body. The evalution of the kidney’s function can be done through the measurement of creatinine and blood urea nitrogen. The purpose of this study is to determine the effect of VCO administration on kidney function.</p><p><strong>Method</strong>: 24 male wistar rats that are divided into 4 groups, which are listed as follows, K(-) or a negative-controlled group, P(1) or the first group of rats that are given VCO with a dose of 2mL/200gr of the rats’ total BW/day, P(2) or the second group of rats that are given VCO with a dose of 3mL/200gr of the rats’ total BW/day,  and P(3) or the third group of rats that are given VCO with a dose of 4mL/200gr of the rats’ total BW/day for 28 day</p><p><strong>Results</strong>: Administrating<strong> </strong>VCO with a dose of 2mL/200gr and 3mL/200gr of the rats’ total BW/day does not affect the blood’s creatinine level while with a dose of 4mL/200gr of the rats’ total BW/day decreases the blood’s creatinine level. Administrating VCO with a dose of 2 mL/200gr, 3 mL/200gr, and 4 mL/200gr of the rats’ total BW/day does not affect the level of blood urea nitrogen.</p><p><strong>Conclusion: </strong>Administration of VCO dose of 4 mL / 200 g BW rat / day significantly decreased blood creatinine levels in experimental animals, while other doses did not affect the creatinine levels or blood urea nitrogen levels<strong></strong></p><p><strong>Keywords</strong><strong>:</strong> <em>Virgin Coconout Oil </em>(VCO), cretinine, blood urea nitrogen.</p>

PEMBERIAN VCO (VIRGIN COCONUT OIL) PADA Tn. M DENGAN DIAGNOSIS MEDIS CVA INFARK DENGAN MASALAH KEPERAWATAN RISIKO KERUSAKAN INTEGRITAS KULIT DI RUANG ICU CENTRAL RUMKITAL dr. RAMELAN SURABAYA

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Eppy Setiyowati
Keyword(s):  
Capillary Pressure ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
The Unconscious ◽  
Inductive Approach ◽  
Skin Problem ◽  
Skin Integrity ◽  
Unconscious Patients

Abstract: Ulcus decubitus is a serious dermal (skin) problem, especially for the unconscious patients with the lack of mobilization hospitalized in the ICU. It appears in the area which is localizedwith the necrotic tissues; it also usually appears on the surface of protruding bones, resulted fromthe long term pressure which increases the capillary pressure. This study was purposed to analyzethe effectiveness of the use of VCO to the patient with the risk of having ulcus decubitus in thecentral ICU of Rumkital Dr. Ramelan Surabaya (Surabaya Navy Hospital). The design used in thisstudy was case study done by investigating a problem through one case comprising of a single unit.The variable used in this study was the use of VCO to the patient with the risk of ulcus decubitus.The data were analyzed descriptively done by using inductive approach. The result of this studyconcludes that the use of VCO to Mr. M who has the risk of impaired skin integrity is effective toprevent decubitus.

Improve Stability of Dicalcium Silicate/Zirconia Composite Coatings by Post-Spraying Heat Treatment

2005 ◽  
Vol 107 ◽  
pp. 141-144 ◽  
Author(s):  
Youtao Xie ◽  
Paul K. Chu ◽  
Xuan Yong Liu ◽  
Chuan Xian Ding
Keyword(s):  
Heat Treatment ◽  
Composite Coatings ◽  
Immersion Test ◽  
Dicalcium Silicate ◽  
Test Results ◽  
Long Term Stability ◽  
The Stability ◽  
Plasma Sprayed ◽  
Sprayed Coatings

The long-term stability of plasma-sprayed dicalcium silicate (C2S) composite coatings is determined by the phase composition, crystallinity, and other properties. Zirconia reinforcement and post-spraying heat treatment are applied to C2S coatings simultaneously in this work. The stability of the coating increases evidently by reinforcement with 70wt% zirconia and heat treatment at 800oC for 4 hours. SEM reveals that the smooth glassy surface of the as-sprayed coatings is replaced by randomly dispersed crystals. Tris-HCl immersion test results show that the dissolution rate of the composite coatings decreases after the heat treatment.

scholarly journals STABILITY OF ZOLEDRONATE GEL EMULSION IN VIRGIN COCONUT OIL

2019 ◽  
pp. 201-206 ◽  
Author(s):  
PRIMA ABIGAIL GAYATRI ◽  
KRISNAWATI . ◽  
MUHAMAD SAHLAN ◽  
DIAH KARTIKA PRATAMI ◽  
RETNO WIDAYATI
Keyword(s):  
Adhesive Strength ◽  
Room Temperature ◽  
Storage Temperature ◽  
Ph Value ◽  
Physical Stability ◽  
Coconut Oil ◽  
Butylated Hydroxytoluene ◽  
Distilled Water ◽  
Virgin Coconut Oil ◽  
Drug Content

Objective: This study aimed to analyze the physical stability and drug content of zoledronate (ZOL) gel emulsion in virgin coconut oil (VCO) as a newpharmaceutical product at 25°C as room temperature and 40°C as an accelerated temperature for a stability physics test.Methods: The ZOL gel emulsion comprises the following ingredients: 0.16% ZOL powder, 2% carboxymethyl cellulose, 5% VCO, 0.44% sodiumbenzoate, and 0.009% antioxidant butylated hydroxytoluene, and distilled water. Samples of this gel emulsion were stored for 1 month at 25°C and40°C, and the parameters used for stability tests were pH, viscosity, spreadability, and adhesive strength. The drug content was also evaluated with aspectrophotometer. The ZOL gel emulsion was evaluated against these metrics on days 1, 7, 14, and 28.Results: The results showed that ZOL pH, viscosity, spreadability, adhesive strength, and drug content gel emulsion were clinically stable over 28 daysof storage at 25°C, whereas it was not stable when stored at 40°C for the same duration. pH value of ZOL gel emulsion significantly decreased at 28 days(p<0.05). Also for viscosity, adhesive strength, and drug content of ZOL gel emulsion showed statistically significant (p<0.05), except for spreadabilityvalue (p>0.05). The spreadability value between ZOL gel emulsion that stored at 25°C and at 40°C showed no significant result at 7 and 14 days (p>0.05).Conclusion: ZOL gel emulsion was stable at 25°C when stored for 28 days, suggesting that this is a suitable storage temperature at which its physicalstability and drug content can be maintained.

DYNA Numerical Experiment on Long-Term Stability of Strip Pillar in Deep Mine

2011 ◽  
Vol 217-218 ◽  
pp. 1520-1524
Author(s):  
Chun Qiu Wang ◽  
Shi Bin Gu ◽  
Zhong Ju Wei ◽  
Bo Li ◽  
Shao Jie Chen
Keyword(s):  
Stable State ◽  
Support Effect ◽  
Test Results ◽  
Deep Mine ◽  
Long Term Stability ◽  
Creep Stress ◽  
Working Face ◽  
Stress And Deformation ◽  
Overlying Strata

The creep test of the No. 3 coal seam of Daizhuang Coal Mine is carried. Based on the experiment results, the creep support effect of deep pillar is analyzed with LS-DYNA. The results show that the circumferential initial creep stress of the tested coal is 3.061MPa and the circumferential initial creep stress is far below the axial initial creep stress which is 7.020MPa. In addition, the creep strength is 9.3266MPa and the creep coefficient is 0.6472. According to the test results, the creep support effect of deep strip pillar can be simulated excellently with LS-DYNA. Stress and deformation in simulated strip pillar show evident rheology. Many changes will take place in the stable situation of pillar after the working face mining. Under the effect of the overlying strata, this pillar turns into steady creep state after 15~16 months, then the pillar is able to maintain long-term stable state.

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