Three Hysterical Movement Disorders

1988 ◽  
Vol 62 (3) ◽  
pp. 979-985 ◽  
Author(s):  
Arthur S. Walters ◽  
Doris Wright ◽  
James Boudwin ◽  
Karl Jones
Keyword(s):  
Movement Disorders ◽  
Hemifacial Spasm ◽  
Older Patients ◽  
Life Experiences ◽  
Spontaneous Resolution ◽  
Older Age ◽  
Supportive Psychotherapy ◽  
Involuntary Movements ◽  
Neurological Condition ◽  
The Third

Three hysterical movement disorders are reported: a case of hysterical bilateral blepharospasm which later presented as hysterical hemifacial spasm, a case of hysterical myoclonus, and a case of hysterical parkinsonism. Two patients presented with a relative indifference to preceding life experiences that would normally have evoked considerable emotion. Two of the cases first presented at an older age and one of these older patients was a man. Two of the patients agreed to hypnotherapy and supportive psychotherapy. In both cases the “involuntary” movements disappeared during hypnosis. In the third case, there was a complete spontaneous resolution of symptoms in a neurological condition where resolution would not be expected to occur.

The Nithsdale Schizophrenia Survey V. Follow-up of Tardive Dyskinesia at3-1/2 years

1986 ◽  
Vol 149 (5) ◽  
pp. 621-623 ◽  
Author(s):  
A. D. T. Robinson ◽  
R. G. McCreadie
Keyword(s):  
Tardive Dyskinesia ◽  
Older Patients ◽  
Geographical Area ◽  
Point Prevalence ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Transient Feature

The point-prevalence of tardive dyskinesia in schizophrenics from a discrete geographical area (Nithsdale, in Dumfries and Galloway Region) in 1981, 1982, and 1984 was 31%, 27%, and 30% respectively. This suggests that the prevalence of tardive dyskinesia in a community of schizophrenics has reached a plateau. In 12% of patients there was persistent dyskinesia, i.e. abnormal involuntary movements were present at all three assessments. Persistent dyskinesia was more common in older patients. The severity of tardive dyskinesia fluctuated between assessments in 41 % of patients, indicating that it is only a transient feature in some cases.

scholarly journals Clinical Characteristics, Risk Factors and Predictive Value of COVID-19 Pneumonia: A Retrospective Study of 173 Patients in Wuhan, China

2020 ◽  
Author(s):  
Yang Zhang ◽  
Jun Xue ◽  
Mi Yan ◽  
Jing Chen ◽  
Hai Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Predictive Model ◽  
Disease Severity ◽  
Roc Curve ◽  
Predictive Value ◽  
Older Patients ◽  
Clinical Characteristics ◽  
Lactic Dehydrogenase ◽  
Older Age ◽  
Hospital Outcome

Abstract Background: COVID-19 is a globally emerging infectious disease. As the global epidemic continues to spread, the risk of COVID-19 transmission and diffusion in the world will also remain. Currently, several studies describing its clinical characteristics have focused on the initial outbreak, but rarely to the later stage. Here we described clinical characteristics, risk factors for disease severity and in-hospital outcome in patients with COVID-19 pneumonia from Wuhan. Methods: Patients with COVID-19 pneumonia admitted to Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from February 13 to March 8, 2020, were retrospectively enrolled. Multivariable logistic regression analysis was used to identify risk factors for disease severity and in-hospital outcome and establish predictive models. Receiver operating characteristic (ROC) curve was used to assess the predictive value of above models.Results: 106 (61.3%) of the patients were female. The mean age of study populations was 62.0 years, of whom 73 (42.2%) had underlying comorbidities mainly including hypertension (24.9%). The most common symptoms on admission were fever (67.6%) and cough (60.1%), digestive symptoms (22.0%) was also very common. Older age (OR: 3.420; 95%Cl: 1.415-8.266; P=0.006), diarrhea (OR: 0.143; 95%Cl: 0.033-0.611; P=0.009) and lymphopenia (OR: 4.769; 95%Cl: 2.019-11.266; P=0.000) were associated with severe illness on admission; the area under the ROC curve (AUC) of predictive model were 0.860 (95%CI: 0.802-0.918; P=0.000). Older age (OR: 0.309; 95%Cl: 0.142-0.674; P=0.003), leucopenia (OR: 0.165; 95%Cl: 0.034-0.793; P=0.025), increased lactic dehydrogenase (OR: 0.257; 95%Cl: 0.100-0.659; P=0.005) and interleukins-6 levels (OR: 0.294; 95%Cl: 0.099-0.872; P=0.027) were associated with poor in-hospital outcome; AUC of predictive model were 0.752 (95%CI: 0.681-0.824; P=0.000).Conclusion: Older patients with diarrhea and lymphopenia need early identification and timely intervention to prevent the progression to severe COVID-19 pneumonia. However, older patients with leucopenia, increased lactic dehydrogenase and interleukins-6 levels are at a high risk for poor in-hospital outcome.Trial registration: ChiCTR2000029549

scholarly journals Somatic mutations in breast and serous ovarian cancer young patients: a systematic review and meta-analysis

2015 ◽  
Vol 61 (5) ◽  
pp. 474-483 ◽  
Author(s):  
Giselly Encinas ◽  
Simone Maistro ◽  
Fátima Solange Pasini ◽  
Maria Lucia Hirata Katayama ◽  
Maria Mitzi Brentani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Ovarian Cancer ◽  
Somatic Mutation ◽  
Early Onset ◽  
Older Patients ◽  
Somatic Mutations ◽  
Age Groups ◽  
Older Age ◽  
Serous Ovarian Cancer

Summary Objective: our aim was to evaluate whether somatic mutations in five genes were associated with an early age at presentation of breast cancer (BC) or serous ovarian cancer (SOC). Methods: COSMIC database was searched for the five most frequent somatic mutations in BC and SOC. A systematic review of PubMed was performed. Young age for BC and SOC patients was set at ≤35 and ≤40 years, respectively. Age groups were also classified in <30years and every 10 years thereafter. Results: twenty six (1,980 patients, 111 younger) and 16 studies (598, 41 younger), were analyzed for BC and SOC, respectively. In BC, PIK3CA wild type tumor was associated with early onset, not confirmed in binary regression with estrogen receptor (ER) status. In HER2-negative tumors, there was increased frequency of PIK3CA somatic mutation in older age groups; in ER-positive tumors, there was a trend towards an increased frequency of PIK3CA somatic mutation in older age groups. TP53 somatic mutation was described in 20% of tumors from both younger and older patients; PTEN, CDH1 and GATA3 somatic mutation was investigated only in 16 patients and PTEN mutation was detected in one of them. In SOC, TP53 somatic mutation was rather common, detected in more than 50% of tumors, however, more frequently in older patients. Conclusion: frequency of somatic mutations in specific genes was not associated with early-onset breast cancer. Although very common in patients with serous ovarian cancer diagnosed at all ages, TP53 mutation was more frequently detected in older women.

Hyperkinetic Movement Disorders

2015 ◽  
Author(s):  
Devin Mackay ◽  
Edison Miyawaki
Keyword(s):  
Computed Tomography ◽  
Clinical Features ◽  
Movement Disorders ◽  
Clinical Presentation ◽  
Genetic Correlations ◽  
Practical Approach ◽  
Involuntary Movements ◽  
Computed Tomography Scans ◽  
Paroxysmal Disorders ◽  
Laboratory Investigations

The hyperkinetic movement disorders include heterogeneous diseases and syndromes, all characterized by one or a variety of excessive, involuntary movements. The hyperkinetic movement disorders are heterogeneous in clinical presentation, but a rational and practical approach to diagnosis exists based on new genetic correlations and targeted laboratory investigations. Treatments informed by a still-developing picture of motor pathophysiology offer significant benefit for these disorders. This chapter discusses choreiform disorders, including patterns in choreiform diagnosis; tremor disorders; paroxysmal disorders, including tics and myoclonus; dystonias, including monogenic primary dystonias; and pathophysiology and treatment in the hyperkinetic movement disorders. Figures include clinical photos, computed tomography scans, and an algorithm representing cortical-subcortical circuitry. Tables delineate definitions, distinguishing clinical features, medications, genetics, protein products, and treatments associated with various disorders.  This review contains 6 figures, 12 tables, and 145 references.

Classification and Approach to Movement Disorders

2021 ◽  
pp. 571-575
Author(s):  
Paul E. Youssef ◽  
Kenneth J. Mack ◽  
Kelly D. Flemming
Keyword(s):  
Motor Activity ◽  
Movement Disorder ◽  
Movement Disorders ◽  
Normal Flow ◽  
Slow Movement ◽  
Involuntary Movements ◽  
P Movement

Movement disorders are conventionally divided into 2 major categories. Hyperkinetic movement disorders (also called dyskinesias) are excessive, often repetitive, involuntary movements that intrude into the normal flow of motor activity. This category includes chorea, dystonia, myoclonus, stereotypies, tics, and tremor. Hypokinetic movement disorders are akinesia (lack of movement), hypokinesia (reduced amplitude of movement), bradykinesia (slow movement), and rigidity. Parkinsonism is the most common hypokinetic movement disorder. In childhood, hyperkinetic disorders are common, whereas hypokinetic movement disorders are relatively uncommon.

Disorders of cranial nerves

2010 ◽  
pp. 5033-5038
Author(s):  
R.D.M. Hadden ◽  
P.K. Thomas ◽  
R.A.C. Hughes
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Optic Nerve ◽  
Older Patients ◽  
Cranial Nerves ◽  
The Third ◽  
Intracavernous Aneurysm ◽  
System Tract ◽  
Third Nerve ◽  
Sixth Nerve

The 12 cranial nerves are peripheral nerves except for the optic nerve which is a central nervous system tract. Disorders of particular note include the following: Olfactory (I) nerve—anosmia is most commonly encountered as a sequel to head injury. Third, fourth, and sixth cranial nerves—complete lesions lead to the following deficits (1) third nerve—a dilated and unreactive pupil, complete ptosis, and loss of upward, downward and medial movement of the eye; (2) fourth nerve—extorsion of the eye when the patient looks outwards, with diplopia when gaze is directed downwards and medially; (3) sixth nerve—convergent strabismus, with inability to abduct the affected eye and diplopia maximal on lateral gaze to the affected side. The third, fourth, and sixth nerves may be affected singly or in combination: in older patients the commonest cause is vascular disease of the nerves themselves or their nuclei in the brainstem. Other causes of lesions include (1) false localizing signs—third or sixth nerve palsies related to displacement of the brainstem produced by supratentorial space-occupying lesions; (2) intracavernous aneurysm of the internal carotid artery—third, fourth, and sixth nerve lesions. Lesions of these nerves can be mimicked by myasthenia gravis....

Movement Disorders

2009 ◽  
pp. 551-574
Author(s):  
John N. Caviness
Keyword(s):  
Botulinum Toxin ◽  
Movement Disorders ◽  
Surface Emg ◽  
Involuntary Movements ◽  
Botulinum Toxin Injections

Surface EMG, EEG, and elicited response results provide a simple and noninvasive means of studying movement disorders. These techniques are particularly helpful in classifying involuntary movements such as tremor and myoclonus. In addition, EMG can assist with designing and performing botulinum toxin injections.

scholarly journals Psychological and pedagogical aspects of interaction between students and retro-students in the educational process at the Institute of the third age

2019 ◽  
Vol 70 ◽  
pp. 06011
Author(s):  
Anatoly P. Smantser ◽  
Tatiana A. Sidorchuk ◽  
Мaria А. Sidorchuk
Keyword(s):  
Interpersonal Relations ◽  
Life Experiences ◽  
Age Groups ◽  
The Elderly ◽  
Educational Process ◽  
The Third ◽  
Strategic Direction ◽  
The Social ◽  
To Receive ◽  
Intergenerational Interaction

The article deals with the features of intergenerational interaction of students of different ages within a single educational environment and an ambiguous attitude to the social and psychological experience of generations. Empirical research has shown that within the framework of a gerontological unit all age groups of students have an opportunity to receive a qualitatively new social experience on a permanent basis in professional, cultural, leisure and volunteer fields. It should be noted that the younger generation has a positive attitude to retro students; they want to and can become retro students’ mentors, helping the elderly to master modern competencies. Retro students, despite the difficulties of interpersonal relations, are ready as mentors to share their knowledge, social and life experiences with young people. The results presented in the article have shown that the most promising forms of cooperation between students and retro-students are master classes in various areas, and creation of gerontological faculties at universities is the strategic direction of gerontology education.

Positive Development in Africa

2017 ◽  
Author(s):  
Joseph Lah Lo-oh
Keyword(s):  
Life Experiences ◽  
Positive Development ◽  
Growing Up ◽  
Productive Life ◽  
The Third ◽  
African Experience ◽  
African Youth ◽  
Life Courses

This chapter delves into the African experience of positive development in the third decade of life. Despite the formidable challenges and difficulties growing up African, African youth not only flourish during the third decade of life, but also exhibit glaring and giant, but (most often) undocumented, steps toward overcoming their difficulties. Where distressing life experiences seem to stand in their way, they have been raised or brought up in ways to deal with difficult experiences by taking their lives and futures in their own hands. They do not just live life for the sake of it, but also become key actors and agents of their own development. This chapter therefore emphasizes positive and productive life courses often adopted by African youth to navigate the third decade of life so that they eventually flourish and not flounder.

Colorectal cancer characteristics and outcomes in patients less than age 50: A comparison of an urban university hospital with the NCI SEER database.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 3621-3621 ◽  
Author(s):  
Edith P. Mitchell ◽  
Allan Topham ◽  
Pramila R. Anne ◽  
Scott Goldstein ◽  
Gerald Isenberg ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Older Patients ◽  
University Hospital ◽  
Data Sets ◽  
Seer Database ◽  
Pathological Features ◽  
Younger Patients ◽  
The Third ◽  
Colorectal Cancer Patients ◽  
Better Than

3621 Background: Cancer of the colon and rectum is the third most commonly occurring cancer, as well as the third leading cause of cancer deaths in American men and women. Colorectal cancer in younger patients is believed to have worse pathological features and prognosis than in older patients. The objective of this study was to assess pathological features and outcomes of CRC in patients less than age 50 using an institutional sample and comparing to the Surveillance, Epidemiology and End Results (SEER) database. Methods: Included in the study were a total of 4595 cases from the Tumor Registry at Thomas Jefferson University Hospital (TJUH) over a twenty year period from 1988 through 2007 and 290,338 cases from the Surveillance, Epidemiology and End Results (SEER) database from 1988 through 2004. Patients less than age 50 were compared to those age 50 and older. Results: Patients under age 50 with CRC presented with more advanced stage tumors in both data sets (<0.0001) , and had more poorly differentiated tumors than older patients (PTJUH=0.02754; PSEER<0.0001). Patients under 50 also had more mucinous/signet ring cell tumors with 12 percent to 8.1 percent in the TJUH data (p=0.002916) and 13.2 percent to 10.3 percent in the SEER data (p<0.0001), with younger males having the highest prevalence in both data sets. Younger patients had fewer proximal tumors than patients 50 and over, and a higher proportion of rectal tumors (p<0.001). Patients under age 50 were more likely to have positive nodes at all stages (PSEER <0.0001) relative to 50 and over, as well as more likely to develop peritoneal metastases (PTJUH=0.3507),, but less likely to have lung metastases PTJUH=0.05249) than older pts. Despite their poor pathologic features, patients under age 50 had better than or equal survival to those 50 and older. Conclusions: Colorectal cancer patients under age 50 presented with worse histological characteristics and metastasized much sooner, yet the younger patients had better than or equal survival to those ages 50 and older. Ongoing studies will assess differences in treatment and molecular features between younger and older colorectal cancer patients.

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