Flora from Fărăgău Area (Mureş County) as Potential Source of Medicinal Plants

2018 ◽  
Vol 1 (1) ◽  
pp. 60-70 ◽  
Author(s):  
Silvia Oroian ◽  
Mihaela Sămărghiţan
Keyword(s):  
Digestive System ◽  
Therapeutic Potential ◽  
National Level ◽  
European Pharmacopoeia ◽  
Volatile Oils ◽  
Potential Source ◽  
Narcissus Poeticus ◽  
Human Disorders ◽  
Dictamnus Albus ◽  
Scientific Value

Abstract The aim of this study was to identify a potential source of medicinal plant from Transylvanian Plain. Also, the paper provides information about the hayfields floral richness, a great scientific value for Romania and Europe. The study of the flora was carried out in several stages: 2005-2008, 2013, 2017-2018. In the studied area, 397 taxa were identified, distributed in 82 families with therapeutic potential, represented by 164 medical taxa, 37 of them being in the European Pharmacopoeia 8.5. The study reveals that most plants contain: volatile oils (13.41%), tannins (12.19%), flavonoids (9.75%), mucilages (8.53%) etc. This plants can be used in the treatment of various human disorders: disorders of the digestive system, respiratory system, skin disorders, muscular and skeletal systems, genitourinary system, in gynaecological disorders, cardiovascular, and central nervous sistem disorders. In the study plants protected by law at European and national level were identified: Echium maculatum, Cephalaria radiata, Crambe tataria, Narcissus poeticus ssp. radiiflorus, Salvia nutans, Iris aphylla, Orchis morio, Orchis tridentata, Adonis vernalis, Dictamnus albus, Hammarbya paludosa etc.

scholarly journals Seaweed as a potential source of dietary fiber

2010 ◽  
Vol 6 (1) ◽  
pp. 9 ◽  
Author(s):  
Dwiyitno Dwiyitno
Keyword(s):  
Colon Cancer ◽  
Dietary Fiber ◽  
Digestive System ◽  
Diabetic Patients ◽  
Fiber Intake ◽  
Food Component ◽  
Dietary Fiber Intake ◽  
Potential Source ◽  
Essential Food

Dietary fiber is one of the most essential food component, mainly used to maintain health andbalance of digestive system. Dietary fiber plays an important role in health, especially in reducingblood cholesterol, improving glucose absorbtion for diabetic patients, preventing colon cancer,and reducing weight. Several studies showed that seaweed is a potential source of dietary fiberwith more advantages compare to that of land-based crops. Contrary to its production, seaweedconsumption in Indonesia is relatively low. To date, dietary fiber intake for the majority of Indonesiansis fulfiled from land-based crops.

scholarly journals Comparative study of the chemical composition, larvicidal, antimicrobial and cytotoxic activities of volatile oils from E. punicifolia leaves from Minas Gerais and Goiás

2021 ◽  
Vol 10 (11) ◽  
pp. e34101119354
Author(s):  
Liliane de Sousa Silva ◽  
Christiane França Martins ◽  
Fernando Yano Abrão ◽  
Camila Aline Romano ◽  
Soraia Ferreira Bezerra ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Comparative Study ◽  
Cytotoxic Activity ◽  
Larvicidal Activity ◽  
Therapeutic Potential ◽  
Volatile Oil ◽  
Minas Gerais ◽  
Cytotoxic Activities ◽  
Volatile Oils ◽  
Murine Fibroblasts

Eugenia punicifolia (Kunth) D.C., Myrtaceae, known as “pedra-ume-caá”, is popularly used in the treatment of inflammation, infections, fever, flu, diabetes, and diarrhea. This study aimed to carry out a comparative study of the chemical composition of volatile oil from E. punicifolia leaves collected in Goiás and Minas Gerais, as well as to evaluate the larvicidal activity against Aedes aegypti L3 larvae, the antimicrobial activity against bacteria, pathogenic fungi, and environmental, and cytotoxic activity to Balb 3T3 cells (murine fibroblasts). Volatile oils were obtained by hydrodistillation in a Clevenger apparatus and analyzed by Gas Chromatography Coupled to Mass Spectrometry (CG/MS). A total of 60 compounds were identified, the main components found in the leaves of Goiás being Germacrene D, bicyclogermacrene and β-longipenene and in the leaves collected in Minas Gerais they were (Z)-caryophyllene, γ-cadinene, spathulenol, caryophyllene oxide, and α-cadinol. The larvicidal effect was moderate against Ae. aegypti, with LC50 of 85.53 µg / mL for samples from Goiás and LC50 of 91.52 µg / mL for samples from Minas Gerais. Both oils showed moderate bactericidal activity against K. rhiziphyla (ATCC 9341), M. luteus (ATCC 10240), and S. aureus (ATCC 29737). The oils from Goiás (IC50 706.7 µg / mL) and Minas Gerais (IC50 160.7 µg / mL) had a lower cytotoxic concentration than the toxic action for larvae and bacteria, evidencing a safety profile and an interesting therapeutic potential, mainly concerning to volatile oil from Goiás. Therefore, the volatile oils from E. punicifolia leaves collected in Goiás and Minas Gerais that presented moderate larvicidal activity for Ae. aegypti also presented a bactericide activity and less cytotoxicity against murine fibroblasts. This is the first study of the larvicidal, antimicrobial and cytotoxic activity of volatile oils from E. punicifolia leaves.

scholarly journals Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

2021 ◽  
Vol 11 ◽  
Author(s):  
Mahshad Sarvizadeh ◽  
Omid Hasanpour ◽  
Zari Naderi Ghale-Noie ◽  
Samaneh Mollazadeh ◽  
Mohammad Rezaei ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Digestive System ◽  
Therapeutic Potential ◽  
Diallyl Disulfide ◽  
Enzymatic Reactions ◽  
Diallyl Trisulfide ◽  
Epidemiological Evidence ◽  
Anticancer Efficacy ◽  
Skin Cancers ◽  
Gi Cancers

Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the vast majority of them are colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces the risk of developing malignancies. Among all compounds in garlic, allicin has been most researched, as it contains sulfur and produces many second degradation compounds, such as sulfur dioxide, diallyl sulfide (DAS), diallyl trisulfide (DATS), and diallyl disulfide (DADS) in the presence of enzymatic reactions in gastric juice. These substances have shown anti-inflammatory, antidiabetic, antihypertensive, antifungal, antiviral, antibacterial, and anticancer efficacy, including gastrointestinal (GI) cancers, leukemia, and skin cancers. Herein, we summarize the therapeutic potential of allicin in the treatment of GI cancers.

scholarly journals Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 915 ◽  
Author(s):  
Jamie Nourse ◽  
Stefano Spada ◽  
Sven Danckwardt
Keyword(s):  
Rna Processing ◽  
Therapeutic Potential ◽  
Protein Complexes ◽  
Alternative Polyadenylation ◽  
Rna Motifs ◽  
Physiological Processes ◽  
Human Disorders ◽  
Tightly Coupled ◽  
Cleavage And Polyadenylation ◽  
Health And Disease

A crucial feature of gene expression involves RNA processing to produce 3′ ends through a process termed 3′ end cleavage and polyadenylation (CPA). This ensures the nascent RNA molecule can exit the nucleus and be translated to ultimately give rise to a protein which can execute a function. Further, alternative polyadenylation (APA) can produce distinct transcript isoforms, profoundly expanding the complexity of the transcriptome. CPA is carried out by multi-component protein complexes interacting with multiple RNA motifs and is tightly coupled to transcription, other steps of RNA processing, and even epigenetic modifications. CPA and APA contribute to the maintenance of a multitude of diverse physiological processes. It is therefore not surprising that disruptions of CPA and APA can lead to devastating disorders. Here, we review potential CPA and APA mechanisms involving both loss and gain of function that can have tremendous impacts on health and disease. Ultimately we highlight the emerging diagnostic and therapeutic potential CPA and APA offer.

scholarly journals Therapeutic Potential of Kalanchoe Species: Flavonoids and other Secondary Metabolites

2008 ◽  
Vol 3 (12) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Sônia S. Costa ◽  
Michelle F. Muzitano ◽  
Luiza M. M. Camargo ◽  
Marcela A. S. Coutinho
Keyword(s):  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Point Of View ◽  
Present Review ◽  
Biological Profile ◽  
Research Programs ◽  
Potential Source ◽  
The World

The Kalanchoe genus (syn. Bryophyllum), family Crassulaceae, comprises 125 species, most of them native to Madagascar. The great importance of several of these species for the traditional medicine in several regions of the World, esspecially India, Africa, China and Brazil, stimulated research programs into these plants from both a pharmacological and chemical point of view. The present review focuses on the main results obtained during the last decade on the secondary metabolites isolated from these species – endowed or not with a specific biological profile – with emphasis on flavonoids. The distribution of these molecules in the genus will be summarized and special attention will be given to K. brasiliensis and K. pinnata, two species well-known for healing inflammatory and infectious processes. Ornamental Kalanchoe species are also discussed as a potential source of bioactive compounds. This review covers the period 1970–2008.

scholarly journals HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers

2018 ◽  
Vol 19 (11) ◽  
pp. 3295 ◽  
Author(s):  
Hongli Zhang ◽  
Qingqing Feng ◽  
Wei-Dong Chen ◽  
Yan-Dong Wang
Keyword(s):  
Clinical Trials ◽  
Adverse Events ◽  
Digestive System ◽  
Therapeutic Potential ◽  
Signaling Networks ◽  
Preclinical Studies ◽  
Current Review ◽  
Promising Therapeutic Target ◽  
Signaling Inhibitors ◽  
Mirna Therapeutics

The HGF/c-MET pathway is active in the development of digestive system cancers, indicating that inhibition of HGF/c-MET signaling may have therapeutic potential. Various HGF/c-MET signaling inhibitors, mainly c-MET inhibitors, have been tested in clinical trials. The observed efficacy and adverse events of some c-MET inhibitors were not very suitable for treating digestive system cancers. The development of new HGF/c-MET inhibitors in preclinical studies may bring promising treatments and synergistic combination (traditional anticancer drugs and c-MET inhibitors) strategies provided anacceptable safety and tolerability. Insights into miRNA biology and miRNA therapeutics have made miRNAs attractive tools to inhibit HGF/c-MET signaling. Recent reports show that several microRNAs participate in inhibiting HGF/c-MET signaling networks through antagonizing c-MET or HGF in digestive system cancers, and the miRNAs-HGF/c-MET axis plays crucial and novel roles for cancer treatment. In the current review, we will discuss recent findings about inhibitors of HGF/c-MET signaling in treating digestive system cancers, and how miRNAs regulate digestive system cancers via mediating HGF/c-MET pathway.

scholarly journals Chemical Characterization of Narcissus poeticus from Sirente –Velino (Apennines - Italy): Galantamine Accumulation and Distribution of Allergenic Compounds in the Flower

2017 ◽  
Vol 12 (1) ◽  
pp. 1934578X1701200
Author(s):  
Donatella Ferri ◽  
Carla Ubaldi ◽  
Giordana Marcozzi ◽  
Paolo Fasciani ◽  
Loretta Bacchetta ◽  
...  
Keyword(s):  
In Vitro Propagation ◽  
Large Scale ◽  
Chemical Characterization ◽  
Potential Source ◽  
Flower Stem ◽  
Narcissus Poeticus ◽  
Extraction Solvents ◽  
Plant Flower

Species of Narcissus (family Amaryllidaceae) are a potential source for large-scale extraction of alkaloids and fragrances. The bulbs typically accumulate a large number of alkaloids, including galantamine, a benzazepine alkaloid proven to be a cholinesterase inhibitor and which is used in the treatment of Alzheimer's disease. The presence of galantamine in N. poeticus L. collected in Abruzzo (Italy) was assessed and several levels of alkaloid were found in all parts of the plant (flower, stem, bulb and root) and not only in the bulb. The amount of galantamine obtained was tested by using two different extraction solvents. Extraction of N. poeticus absolute from the flowers was also performed, as this product is an important floral note in perfumery, and the distribution of allergenic compounds in the coronas and in the tepals was assessed. Moreover, the in vitro propagation of N. poeticus was tested as it may be a valuable resource from which to produce biomolecules, as an alternative to chemical synthetic processes.

scholarly journals From purines to purinergic signalling: molecular functions and human diseases

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhao Huang ◽  
Na Xie ◽  
Peter Illes ◽  
Francesco Di Virgilio ◽  
Henning Ulrich ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Healthy Lifestyle ◽  
Therapeutic Potential ◽  
Purine Metabolism ◽  
Human Diseases ◽  
Proper Function ◽  
Purinergic Signalling ◽  
Nucleotide Synthesis ◽  
Metabolism Disorder ◽  
Human Disorders

AbstractPurines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as “purinergic signalling”. Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.

scholarly journals Epidemiological aspects of morbidity in the class of digestive organs in Kazakhstan

2018 ◽  
Vol 90 (2) ◽  
pp. 75-78
Author(s):  
L K Ibraeva ◽  
A U Amanbekova ◽  
N M Zhanbasinova ◽  
L Sh Sexenova ◽  
D H Rybalkina ◽  
...  
Keyword(s):  
Digestive System ◽  
National Level ◽  
National Average ◽  
Significant Excess ◽  
Blood Diseases ◽  
Its Regions ◽  
Survey Results ◽  
West Kazakhstan ◽  
High Level ◽  
Epidemiological Parameters

Aim. To study epidemiological aspects of disease, class of diseases of the digestive system in the region of the relative risk in Kazakhstan. Materials and methods. Studied epidemiological parameters are first identified in the incidence and prevalence of class XI ICD in regions of Kazakhstan with the identification of risk relative to the average national level. In a dysfunctional region Kyzylorda region analyzed the performance of its regions and compared with data from medical examination of the population and the survey. Results. A significant excess of the average national incidence rate between 1990 and 2015, was noted for 3 of the 14 regions of Kazakhstan (West-Kazakhstan, Kyzylorda, Mangystau). According to the dynamics of the unfavorable situation on the high level of incidence currently is in the Kyzylorda region (COA). From the areas of the COA maximum, the incidence of diseases of the digestive system registered in Kazalinsk district which exceeded the level at RK 4.8 times. The data on examination and survey of the complaints of the population exceeded the epidemiological indicators. In the area identified as the leading neoplasms of the digestive system in the structure of cancer incidence and exceeded the national average on the related class of blood diseases. Unfavorable situation on the incidence of the digestive system in Kyzylorda region of Kazakhstan is associated with the cancer and blood diseases, this is partly due to the presence of pollutants in the environment.

scholarly journals The Way of Laryngoscope Disinfection: A Survey of Practice in Various Hospitals and Clinics

2021 ◽  
Vol 9 (1) ◽  
pp. 4-10
Author(s):  
Molla Md Rubaiat ◽  
Kazi Ashkar Lateef ◽  
Abdul Quader ◽  
Husain Md Khurshid
Keyword(s):  
Povidone Iodine ◽  
Soap Solution ◽  
Improve Patient Safety ◽  
Tap Water ◽  
National Level ◽  
Chemical Agent ◽  
Source Of Infection ◽  
Potential Source ◽  
Contact Data ◽  
Improve Patient

Background and Aims: During general anaesthesia, laryngoscope is a common equipment for intubation used by anaesthesiologists. Laryngoscope has been identified as a potential source of cross infection. Though guidelines exist for appropriate disinfection practices, recent reviews suggested that current methods of disinfection areless effective and compliance is poor with the established protocols. We conducted a questionnaire-based survey to study the current disinfection practices being followed by a cross section of anaesthesiologists. Methods: A simple questionnaire containing 14 questions was distributed amongst anaesthesiologists through online as well as direct contact. Data were analyzed with percentage analysis. Results: Out of 150 anaesthesiologists, 120 submitted the completed questionnaires. Residents constituted 41% and 46% were consultants. Eighteen (12%) used only tap water for cleaning and 132 (88%) used a chemical agent after rinsing with water. Out of 132, 76 (51%) used detergent/soap solution, 29 (19%) would wash and then soak in disinfectant or germicidal agents (glutaraldehyde, povidone iodine and chlorhexidine) and 18 (12%) would wipe the blade with an alcohol swab. With respect to disinfection of laryngoscope handles, 70% respondents said they used an alcohol swab, 18% did not use any method, 9% were not aware of the method being used, while 3% did not respond. Conclusion: Our results indicate wide variation in methods of decontamination of laryngoscopes. Awareness regarding laryngoscope as a potential source of infection was high. We need to standardize and implement guidelines on a national level and make available resources which will help to improve patient safety. CBMJ 2020 January: Vol. 09 No. 01 P: 04-10

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