scholarly journals Drug Technology in Hunting Practice

2021 ◽  
Vol 68 (1) ◽  
pp. 63-65
Author(s):  
S. Laca Megyesi ◽  
A. Königová ◽  
L. Molnár ◽  
M. Várady ◽  
M. Fedorová ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Particle Shape ◽  
Sem Analysis ◽  
Angle Of Repose ◽  
Flow Properties ◽  
Hausner Ratio ◽  
Compressibility Index ◽  
Drug Technology ◽  
The Right ◽  
Shape And Size

Abstract Antiparasitic therapy in living ratites is based on the right dose and efficacy is only when the drug is pharmaceutically stable and safe. Ivermectin is considered to be the most widely used drug in the treatment of parasitosis in ruminants worlwide. For these reasons, in our study, we focused on the pharmaceutical investigation of ivermectin by SEM analysis of its powder particle shape and size, flow properties of solids (angle of repose, compressibility index, Hausner ratio) and zeta potential.

scholarly journals EXTRACTION OF GUM FROM ABELMOSCHUS ESCULENTUS: PHYSICOCHEMICAL PECULIARITY AND ANTIOXIDANT PREPATENT

2017 ◽  
Vol 10 (9) ◽  
pp. 174 ◽  
Author(s):  
Meenu Nagpal ◽  
Geeta Aggarwal ◽  
Upendrea K Jain ◽  
Jitender Madan
Keyword(s):  
Zeta Potential ◽  
Extraction Yield ◽  
Angle Of Repose ◽  
Abelmoschus Esculentus ◽  
Flow Properties ◽  
Food Ingredients ◽  
Hausner Ratio ◽  
Freeze Dried ◽  
Ultrasonic Assisted ◽  
High Degree

  Objective: This study is aimed to extract gum from Abelmoschus esculentus using ultrasonic assisted method and exploring physicochemical, functional, and antioxidant potential of gum for food and pharmaceuticals.Materials and Methods: The extraction of gum from okra was done employing ultrasound-assisted method to improvise the yield. The extracted gum was further characterized for physical properties including swelling index, solubility, water sorption time, packing and flow properties, electrical properties, zeta potential, scanning electron microscopy, and antioxidant activity.Results: The extraction yield of okra fruit gum (OFG) was found to be 31.52%±0.22% (n=3). The OFG powder obtained after lyophilization showed good flow properties as determined from the results of angle of repose (34.21°), Hausner ratio (1.14), and % compressibility (12.5%). An increase in solubility and swelling index of OFG with increase in pH of buffer from 2.0 to 7.4 was observed. The freeze dried OFG possess rough surface and zeta potential of −9.85 mV. Application of derivatized/interacted OFG gum for modification of drug release profiles is concluded from high degree of esterification of 7.8.Conclusion: The result suggest that the antioxidant activity of OFG was higher compared to corn flour gum. Thus, OFG could be utilized as natural antioxidant food ingredients and also for application in medicine and health-care products.

Effect of particle shape and size on flow properties of lactose powders

Particuology ◽  
2012 ◽  
Vol 10 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Xiaowei Fu ◽  
Deborah Huck ◽  
Lisa Makein ◽  
Brian Armstrong ◽  
Ulf Willen ◽  
...  
Keyword(s):  
Particle Shape ◽  
Flow Properties ◽  
Shape And Size

scholarly journals FORMULATION OF EFFERVESCENT GRANULES FROM RED GINGER (ZINGIBERIS OFFICINALE ROSCOE VAR. RUBRUM) EXTRACT AND ITS ANTIOXIDANT ACTIVITY

2022 ◽  
pp. 112-115
Author(s):  
DIAH LIA AULIFA ◽  
DIKI PRAYUGO WIBOWO ◽  
NENI SAFITRI ◽  
ARIF BUDIMAN
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Physical Stability ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Flow Properties ◽  
Organoleptic Evaluation ◽  
Hausner Ratio ◽  
High Antioxidant Activity ◽  
Red Ginger

Objective: Ginger is one of the Indonesian plants that has been used as traditional medicine. The flavonoids and phenols compounds contained high antioxidant activity. This study aimed to formulate effervescent granules (EG) from red ginger (RG) extract and evaluate its antioxidant activity. Methods: The formulation of EG from RG extract was prepared by the wet granulation method using different concentrations of polyvinylpyrrolidone (PVP). Furthermore, the flowability of granules was evaluated, including flow rate, angle of repose, bulk density, tapped density, Carr's index, Hausner ratio, and effervescent time. The physical stability of granules such as organoleptic evaluation, effervescent time, and pH measurement was also evaluated after 28 d of storage, and the antioxidant activity of EG from RG extract was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Results: The result showed that the EG of RG extract was successfully prepared by wet granulation with a concentration of 15%. In addition, the flowability study showed that all formulas of EG from RG extract have good flow properties, and the granules showed excellent flow properties based on Carr′s index results. The effervescent time of granules remained within the acceptable range according to USP, and the physical stability did not change even after 28 d of storage. The IC50 of EG from RG extract was 283.28±3.6 ppm and has moderate in free radicals scavenging activity. Conclusion: EG from RG extract can be used as food supplements to protect the human body from free radicals and inhibit oxidases.

scholarly journals Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

2010 ◽  
Vol 46 (1) ◽  
pp. 115-120
Author(s):  
Vladi Olga Consiglieri ◽  
Samanta Mourão ◽  
Mauricio Sampaio ◽  
Patricia Granizo ◽  
Pedro Garcia ◽  
...  
Keyword(s):  
High Speed ◽  
Angle Of Repose ◽  
Drug Dissolution ◽  
Wet Granulation ◽  
Flow Properties ◽  
Granulation Process ◽  
Index Data ◽  
Compressibility Index ◽  
Dissolution Efficiency

The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies were achieved with Plasdone® K29/32.

scholarly journals The effect of magnesium stearate and sodium starch glycolate on powder flowability

2019 ◽  
pp. 304-310
Author(s):  
Gordana Svonja-Parezanovic ◽  
Mladena Lalic-Popovic ◽  
Svetlana Golocorbin-Kon ◽  
Nemanja Todorovic ◽  
Nebojsa Pavlovic ◽  
...  
Keyword(s):  
Microcrystalline Cellulose ◽  
Magnesium Stearate ◽  
Angle Of Repose ◽  
Flow Properties ◽  
Sodium Starch Glycolate ◽  
Compressibility Index ◽  
Powder Flowability ◽  
The Individual ◽  
Full Factorial ◽  
Spray Dried

The powder flow plays an important role in the manufacture of dosage form such as direct compression tablets. The objective of this research was to investigate the individual and interaction effects of magnesium stearate (MgSt) (Merck Ltd., Germany) as lubricant and sodium starch glycolate (SSG) (Primojel?) as superdesintegrator on powder flowability. Powder formulations were prepared by mixing different concentration of MgSt (0.25% and 5%) and SSG (0.5% and 4%) with microcrystalline cellulose (MCC) (Vivapur?101) or spray-dried lactose (LAC) (Super Tab 21AN) as diluents. Eight powder formulations were prepared using as filler LAC and MCC, as superdesintegrator SSG and as lubricant MgSt in ratios as follows: P1 (LAC : 0.5% SSG : 0.25% MgSt); P2 (LAC : 4% SSG : 5% MgSt); P3 (LAC : 0.5% SSG : 5% MgSt); P4 (LAC : 4% SSG : 5% MgSt); P5 (MCC : 0.5% SSG : 0.25% MgSt); P6 (MCC : 4% SSG : 5% MgSt); P7 (MCC : 0.5% SSG : 5% MgSt); P8 (MCC : 4% SSG : 0.25% MgSt). The powder formulations were evaluated using indirect methods of flowability evaluation according to 9th European Pharmacopoeia: measurement of tapped and bulk density (Ph.Eur.9, 2.9.34) and angle of repose (Ph.Eur. 2.9.36). Also, compressibility index, Hausner?s ratio were calculated. A full factorial design with three factors at two levels and response surface methodology were applied to evaluate the influence of various concentrations of MgSt and SSG on powder flowability. The results indicate that flow properties improved with decrease of SSG content and with increase of MgSt content. Magnesium stearate in powder formulations with microcrystalline cellulose has a greater influence on the improvement of the flow properties than powder formulations with spray-dried lactose.

FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL 90% BUAH LABU AIR (Lagenaria siceraria) SEBAGAI ANTIOKSIDAN DENGAN VARIASI GAS GENERATING AGENT

2020 ◽  
Vol 5 (2) ◽  
pp. 220-229
Author(s):  
Dyera Forestryana ◽  
◽  
Yunitha Hestiarini ◽  
Aristha Novyra Putri
Keyword(s):  
Citric Acid ◽  
Moisture Content ◽  
Sodium Bicarbonate ◽  
Physical Properties ◽  
Tartaric Acid ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Lagenaria Siceraria ◽  
Flow Properties ◽  
Compressibility Index

Water pumpkin (Lagenaria siceraria) is a vegetable that contains secondary metabolites that are beneficial to health. Its use as a vegetable is less attractive to the people so that to increase its utilization, dosage forms are made that can attract public interest, one of which is effervescent granules. Effervescent granules are the most popular dosage form because they can serve in fresh drinks. This study aims to determine the effect of variations in the concentration of acids (citric acid-tartaric acid) and base (sodium bicarbonate) on the physical properties of the formula. The water pumpkin effervescent granules made with various ratios of citric acid, tartaric acid, and sodium bicarbonate consisting of FI (2: 1: 2.5); F II (1: 2: 2,5); F III (2: 1: 3,52); F IV (1: 2: 3,44). The granule made by the wet granulation method. The physical properties of the formula included organoleptic, moisture content, flow properties, compressibility index, pH, solubility time, and acceptability test. Based on the results of the evaluation of physical properties, the granule formula of the water pumpkin effervescent meets the standard requirements with a moisture content of 1.26% -2.26%, flow properties from 6.33 to 7.0 seconds, angle of repose 31.14˚-33.69 ˚, compressibility index 13.61% -17.08%, pH 6.1-7.1 and dissolving time 191-223.33 seconds. Variations of citric acid-tartaric acid and sodium bicarbonate affect the physical properties and taste of the effervescent granules. Based on the acceptability test showed that the panelists liked the water pumpkin effervescent granules in FII.

scholarly journals A review: Pharmaceutical excipients of solid dosage forms and characterizations

2020 ◽  
Vol 11 (2) ◽  
pp. 1472-1480
Author(s):  
Iyan Sopyan ◽  
Ni Made Widya Sukma Santi ◽  
Alif Virisy Berlian ◽  
Noer Erin Meilina ◽  
Qisti Fauza ◽  
...  
Keyword(s):  
Particle Size Analysis ◽  
Dosage Forms ◽  
Angle Of Repose ◽  
Size Analysis ◽  
Active Ingredients ◽  
Pharmaceutical Dosage Forms ◽  
Solid Dosage ◽  
Compressibility Index ◽  
The Right ◽  
Different Characteristics

Excipients play an important role in formulating dosage forms. Exertion is empowered to help manufacture, provide, or collect dosage forms. Although considered pharmacological, excipients may consider a drug, due to chemical or physical interactions with the composition of the drug. Excipients have many functions in pharmaceutical dosage forms, including enhancing active ingredients in dosage forms, assisting active ingredients, disintegration, lubricants, binders, and suppliers. Each excipient has different characteristics. In this review, a library of studios is provided relating to the function, function, and content of solid excipients in a solid sedan. Various choices can be used on different compositions; resulting, this difference is also different. In this example, describe the types of excipients that can be used for various components in solid preparations that can be used in the formulation of solid preparations and select the right type of excipient according to the character of the desired solid preparation. In this review also presented a method, combining in and characterizing solid excipients to see the quality. The most commonly used methods for analysis of solid excipients are flow properties, compressibility index, Hausner index ratios, and angle of repose, while the instrumentation commonly used is Fourier transform infrared spectroscopy (FTIR), H and C-Nucleo magnetic resonance (H-CNMR), Scanning electron microscopy (SEM), Particle size analysis (PSA), X-ray diffraction (XRDP) and Differential scanning calorimeter (DSC).

scholarly journals Comparison of the Physicochemical and Pharmacopeial Properties of starches Obtained from Artocarpus odoratissimus Blanco, Nephelium lappaceum l., and Mangifera indica l. seeds with Corn starch

2018 ◽  
Vol 52 (4) ◽  
Author(s):  
Erna C. Arollado ◽  
Joriza Mae M. Pellazar ◽  
Richelle Ann M. Manalo ◽  
Mae Pauline F. Siocson ◽  
Romeo-Luis F. Ramirez
Keyword(s):  
Corn Starch ◽  
Amylose Content ◽  
Mangifera Indica ◽  
The United States ◽  
Angle Of Repose ◽  
Organoleptic Characteristics ◽  
Hausner Ratio ◽  
Compressibility Index ◽  
Nephelium Lappaceum ◽  
High Amylose

Objective. This study was conducted to characterize and compare the physicochemical and pharmacopoeial properties of starches isolated from the seeds of Artocarpus odoratissimus Blanco (marang), Nephelium lappaceum L. (rambutan), and unripe green Mangifera indica L. (mango) with corn starch, as possible sources of pharmaceutical grade starch. Methods. The starch from the seeds of these fruits was isolated and characterized through their physicochemical (organoleptic characteristics, percent yield, amylose-amylopectin ratio, bulk density, tapped density, compressibility index, Hausner ratio, angle of repose, solubility, swelling power, and viscosity) and pharmacopoeial properties (identification test, pH, loss on drying, and limit of iron). Morphology of the granules was also assessed. Results. The physicochemical properties showed that amylose content of the seed starches was significantly lower (p=0.001) and amylopectin content significantly higher (p=0.001) than the native high amylose corn starch. The lower values of bulk and tapped densities, and high values in compressibility index and Hausner ratio of the seed starches compared to corn starch may be due to their smaller particles. The results of the pharmacopoeial characterization showed compliance with the United States Pharmacopeia's (USP) acceptable limits, except for the pH of marang seeds. Conclusion. The starches isolated from the fruit seeds have unique properties, but only rambutan seed starch has the most desirable physicochemical and pharmacopoeial properties that is comparable with corn starch. Rambutan seeds could be utilized as a source of starch for pharmaceutical applications.

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

2011 ◽  
Vol 4 (1) ◽  
pp. 1368-1372
Author(s):  
S. H. Seyed Mohamed Buhary Buhary ◽  
Jaganath S ◽  
Palanichamy S ◽  
Rajesh M ◽  
Prabhu C ◽  
...  
Keyword(s):  
Controlled Release ◽  
Guar Gum ◽  
Hardness Test ◽  
Angle Of Repose ◽  
Natural Polymers ◽  
Powder Blend ◽  
Weight Variation ◽  
Hausner Ratio ◽  
Compressibility Index ◽  
Release Studies

The aim of the study was to formulate and evaluate silymarin controlled release (CR) tablets using natural polymers (xanthan gum and guar gum) CR Tablets of silymarin were prepared by direct compression method at different ratios of 1:0.25, 1:0.5 and 1:0.75 (drug:polymers). The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The powder blend showed satisfactory flow properties. The silymarin tablets are evaluated for general appearance, hardness test, friability test, weight variation and drug content estimation. All the tablets passed the tests. The interactions between the drug with highest proportion of polymers were determined by using FTIR studies. The FTIR study reveals that there is no interaction between drug and polymers. The invitro release study was carried out using 900ml of phosphate buffer pH 7.4 for 10 hours using USP type II dissolution apparatus. The results of invitro release studies of CR tablets of silymarin were compared with control (without polymer).

scholarly journals Physical-chemical properties and microstructural characterization of traditional mexican chili (Capsicum annuum L.) powders

2021 ◽  
Author(s):  
María de J. Perea-Flores ◽  
Miriam F. Fabela-Morón ◽  
Adolfo A. Rayas-Amor ◽  
Rigoberto V. Pérez-Ruíz ◽  
Rafael Ruíz-Hernández ◽  
...  
Keyword(s):  
Moisture Content ◽  
Bulk Density ◽  
Capsicum Annuum ◽  
Chemical Properties ◽  
Laser Scanning Microscopy ◽  
Angle Of Repose ◽  
Flow Properties ◽  
Capsicum Annuum L ◽  
Physical Chemical ◽  
Hausner Ratio

Objective: Evaluate the physical-chemical properties and characterize the microstructure of four varieties of traditional Mexican chili (Capsicum annuum L.) powders: “Arbol”, “Guajillo”, “Piquin” and “Mole ranchero” (Ancho chili). Design/methodology/approach: Physical-chemical properties of chili powders were evaluated by means of moisture content, particle size, aerated and tapped bulk density, Carr index, Hausner ratio, angle of repose (flow properties), capsaicin, and carotenoids content. Microstructure of samples was characterized by Confocal Laser Scanning Microscopy and Scanning Electron Microscopy. ANOVA analysis and Tukey test were performed to evaluate the significant statistical difference between samples at 95% of confidence level. Results: “Arbol”, “Guajillo”, “Piquin” and “Mole Ranchero” chili powders presented a cohesive behavior respect to its flow properties related to aerated and tapped bulk density, angle of repose, Carr Index, and Hausner ratio values under moisture content between 6.59-14.48 gH2O/100g d.s. “Arbol” and “Piquin” chili powders presented the higher capsaicin content, while “Guajillo” and “Mole ranchero” showed the higher carotenoids content. FTIR spectra confirmed the presence of secondary amide, phenolic groups, alkanes, and aliphatic chains that belong to capsaicin structure at specific absorption bands. Microstructure of chili powders presented particles with surface imperfections as cracks and dents, and smooth surface that influence physical-chemical and flowability properties. Limitations on study/implications: Hight moisture content affect the physical-chemical properties, flowability and microstructure of traditional Mexican chili powders. Findings/conclusions: Moisture content between 6.59 and 14.48 gH2O/100g d.s. influences the physical-chemical properties, flowability and microstructure of traditional Mexican chili powders. To improve physical-chemical properties and flowability behavior of chili powders is required that moisture content be lower than 6.59 H2O/100g d.s.

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