Low Anisakis-specific IgE prevalence in dyspeptic patients in Italy – a retrospective study

AbstractThe aims of this case-control study were to determine the prevalence ofAnisakis-specific IgE in patients reporting chronic or acute gastrointestinal (GI) symptoms and to investigate the correlation with raw fish ingestion habits.A group of patients undergoing gastric endoscopy and a control group of healty subjects answered a self-administered questionnaire on their food habits, presence of symptoms (both allergic and not allergic), and general life style. The presence of anti-AnisakisIgE has been evaluated using a serum immunoCAP assay.Our data show a low prevalence of IgE directed againstAnisakisallergens in Italy in dyspeptic patients, despite the high consumption of poorly cooked fish. These findings does not correlate with the results of studies from other Mediterranean countries, such as Spain, for example.The general prevalence ofAnisakisallergens sensitization in Italy could be further investigated through screenings in the allergic population, especially on those patients who claim to have developed a fish allergy and with history of raw fish consumption. Moreover, the attention should be moved on recent allergic reactions associated with fishing ingestion. This could in fact indicate a recent encounter with the parasite. Finally, we must underline that the evaluation ofAnisakis-specific IgG would have probably shown a difference in terms of exposure between the two groups; thus, it might be useful to detect also this antibody class in future population-based studies.

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Low detection rate of advanced neoplasia within 5 years after polypectomy of small serrated adenoma

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2018-136285 ◽

2019 ◽

Vol 95 (1122) ◽

pp. 187-192 ◽

Cited By ~ 3

Author(s):

Duochen Jin ◽

Hailong Cao ◽

Bikash Kumar Shah ◽

Danfeng Chen ◽

Yujie Zhang ◽

...

Keyword(s):

Control Group ◽

Case Group ◽

Surveillance Colonoscopy ◽

Surveillance Period ◽

Serrated Adenoma ◽

Advanced Neoplasia ◽

Significant Difference ◽

Negative Findings ◽

History Of ◽

Low Prevalence

AimPatients with small serrated adenomas (SAs) (<10 mm) often undergo surveillance colonoscopy before the routine recommended time. We aimed to determine the appropriate surveillance intervals following polypectomy of small SAs for symptomatic patients.MethodWe retrospectively reviewed the data of 638 patients, including 122 cases and 516 controls. Subjects in the case group had small SAs at baseline colonoscopy, including sessile SA/polyps and traditional SAs, while subjects in the control group had negative findings. All patients underwent at least one surveillance colonoscopy during the following 5 years.ResultsThere was no significant difference in the incidence rate of advanced neoplasia between the two groups over a 5-year duration (3.6% vs 2.6%, p=0.455). Moreover, both groups also showed a low prevalence of SA formation over 1–5 years (3.6% vs 1.0%, p=0.145). Patients with baseline SA tended to undergo the first surveillance colonoscopy earlier than those without adenoma (≤1 year vs 1 to ≤3 years). Seventy-one (11.1%) of the total included subjects underwent inadequate initial colonoscopy, and 30 (42.3%) underwent early surveillance of adenoma formation within 1 year. Patients with a family history of colorectal cancer (OR 4.69, 95% CI 1.48 to 14.71, p=0.017) or inadequate baseline colonoscopy (OR 3.17, 95% CI 1.202 to 8.409, p=0.035) were at a higher risk of metachronous adenoma formation during the surveillance period.ConclusionPatients with small SAs at baseline gain little benefit from follow-up of colonoscopy within 5 years after complete polypectomy.

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Risk of End-Stage Renal Disease in Psoriatic Patients: Real-World Data from a Nationwide Population-Based Cohort Study

Scientific Reports ◽

10.1038/s41598-019-53017-4 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Eun Lee ◽

Ju Hee Han ◽

Chul Hwan Bang ◽

Seung Ah Yoo ◽

Kyung Do Han ◽

...

Keyword(s):

Cohort Study ◽

Renal Disease ◽

End Stage Renal Disease ◽

Treated Group ◽

Population Based ◽

Control Group ◽

Real World Data ◽

History Of ◽

Stage Renal Disease ◽

End Stage

Abstract Psoriasis is a chronic inflammatory skin disorder mediated by the T-cell–related immune response. Psoriatic patients may have a variety of comorbidities, but their risk of end-stage renal disease (ESRD), particularly according to the subtype of psoriasis, is unclear. We investigated the risk of ESRD in patients with psoriasis according to the subtype of psoriasis and history of systemic therapy for psoriasis. A total of 2,121,228 adults (1,590,921 in the control group and 530,307 in the psoriasis group) were enrolled in this nationwide population-based cohort study until 2015. During follow-up, 1,434 of the subjects in the psoriasis group developed ESRD. After adjusting for confounding factors, psoriasis was associated with the risk of ESRD (hazard ratio (HR) 1.58, 95% confidence interval [95% CI] 1.47–1.68). The psoriatic arthritis group (HR 7.60, 95% CI 1.90–30.41) had a higher risk of ESRD than the control group. Interestingly, no such association was detected in the systemically treated group (HR 1.07, 95% CI 0.80–1.41). Moreover, the acitretin-treated group had a lower risk of ESRD (HR 0.658, 95% CI, 0.494–0.875) than the non-systemically treated group. In conclusion, the risk of developing ESRD in patients with psoriasis differed according to the type of treatment and the presence of arthritis.

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Mother-to-Infant Bonding in Women With a Bipolar Spectrum Disorder

Frontiers in Pediatrics ◽

10.3389/fped.2021.646985 ◽

2021 ◽

Vol 9 ◽

Author(s):

Myrthe G. B. M. Boekhorst ◽

Annemerle Beerthuizen ◽

Manon Hillegers ◽

Victor J. M. Pop ◽

Veerle Bergink

Keyword(s):

Bipolar Disorder ◽

Pregnant Women ◽

Population Based ◽

Spectrum Disorder ◽

Control Group ◽

Bipolar Spectrum ◽

Bipolar Spectrum Disorder ◽

Not Otherwise Specified ◽

Increased Risk ◽

History Of

Purpose: Offspring of mothers with a bipolar disorder are at high-risk for impaired developmental outcomes and psychopathology (e. g., mood, anxiety, sleep disorders) later in life. This increased risk of psychopathology is not only because of genetic vulnerability, but environmental factors may play an important role as well. The often long and debilitating mood episodes of mothers with bipolar disorder might hamper their qualities as a caregiver and may impact the child. We examined early mother-to-infant bonding 1 year postpartum in mothers with bipolar spectrum disorder as compared to mothers of the general population. The association between mother-to-infant bonding and the type of bipolar spectrum diagnosis (bipolar I, bipolar II, bipolar Not Otherwise Specified) as well as relapse within 12 months postpartum was also assessed.Methods: In total, 75 pregnant women with a bipolar spectrum disorder participated in the current study. The participants were included in a longitudinal cohort study of women with bipolar spectrum disorder and were prospectively followed from pregnancy until 1 year postpartum. Mother-to-infant bonding was assessed using the Pre- and Postnatal Bonding Scale. A longitudinal population-based cohort of 1,419 pregnant women served as the control group. Multiple linear regression analyses were used to assess the association between bipolar spectrum disorder and mother-to-infant bonding scores, controlling for several confounders.Results: Women with bipolar spectrum disorder perceived the bonding with their child as less positive compared to the control group. The type of bipolar spectrum disorder was not associated with poorer bonding scores. Relapse during the 1st year after delivery also did not affect bonding scores in women with bipolar spectrum disorder.Conclusions: Our findings could imply that women with bipolar spectrum disorder are more vulnerable to impairments in bonding due to the nature of their psychopathology, regardless of the occurrence of postpartum relapse. Careful follow-up including monitoring of mother-to-infant bonding of pregnant women with a history of bipolar spectrum disorder should be a standard to this vulnerable group of women. In addition, regardless of severity and mood episode relapse, an intervention to improve bonding could be beneficial for all mothers with bipolar spectrum disorder and their newborns.

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Multiple sclerosis in the Iranian immigrant population of BC, Canada: prevalence and risk factors

Multiple Sclerosis Journal ◽

10.1177/1352458513519179 ◽

2014 ◽

Vol 20 (9) ◽

pp. 1182-1188 ◽

Cited By ~ 19

Author(s):

Colleen Guimond ◽

Joshua D Lee ◽

Sreeram V Ramagopalan ◽

David A Dyment ◽

Heather Hanwell ◽

...

Keyword(s):

Risk Factors ◽

Multiple Sclerosis ◽

Population Based ◽

Personal History ◽

Canadian Study ◽

Iranian Immigrants ◽

High Prevalence ◽

History Of ◽

Low Prevalence ◽

Crude Prevalence

Background: There is a well-documented increase in the risk of multiple sclerosis (MS) when migrating from a region of low prevalence to one of high prevalence. Objective: We present here an investigation of MS prevalence and candidate environmental and genetic risk factors among Iranian immigrants to British Columbia (BC), Canada. Methods: MS cases of Iranian ancestry were ascertained from a population-based Canadian study. We collected blood samples for genetic and serological analyses, and administered a personal history questionnaire to the cases. Results: The crude prevalence of MS in this population of Iranian ancestry was 287/100,000 (95% CI: 229 – 356/100,000). MS cases were more likely to have a history of infectious mononucleosis (odds ratio (OR) = 7.5; p = 0.005) and smoking (OR = 17.0; p < 0.0001), as compared to healthy controls from previous studies in Iran. Cases were also more likely than controls to have been born between April and September (OR = 2.1; p = 0.019). Conclusion: The prevalence of MS among Iranian immigrants to Canada is greater than the overall prevalence of MS in Iran by a factor of at least four, and is similar to that recently observed among Iranian immigrants in other western nations. No major genetic susceptibility variants were identified, suggesting the environment in Canada may be what is increasing the risk of MS in this population.

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Efavirenz Is Not Associated with an Increased Risk of Depressive Disorders in Patients Living with HIV: An 11-Year Population-Based Study in Taiwan

Healthcare ◽

10.3390/healthcare9121625 ◽

2021 ◽

Vol 9 (12) ◽

pp. 1625

Author(s):

Chia-Wen Li ◽

Yen-Chin Chen ◽

Nan-Yao Lee ◽

Po-Lin Chen ◽

Ming-Chi Li ◽

...

Keyword(s):

Depressive Disorders ◽

Past History ◽

Treated Group ◽

Population Based ◽

Insurance Premium ◽

Control Group ◽

Hazard Ratios ◽

Increased Risk ◽

History Of ◽

Southern Taiwan

(1) Background: This study aimed to determine the association between the use of efavirenz and depressive disorders among human immunodeficiency virus (HIV)-infected patients. (2) Methods: A retrospective cohort study was conducted using Taiwan’s National Health Insurance Database. We identified patients receiving anti-retroviral therapy (ART) between 2000 and 2009; these patients were followed until 2010 for diagnoses of depressive disorders using the Cox proportional hazard model to estimate hazard ratios. (3) Results: After up to 11 years of follow-up, the incidence of depressive disorders for the efavirenz-treated group was estimated at 12.2/1000 person-years (PYs), and the control group was at 12.5/1000 PY (p = 0.822). The independent risk factors for depressive disorders included an insurance premium of less than NTD 17,820 (New Taiwan Dollars—NTD) (adjusted hazard ratio (aHR) 2.59, 95% confidence interval (CI), 1.79–3.76, p < 0.001), and between NTD 17,821 and NTD 26,400 (aHR 1.55, 95% CI, 1.04–2.31, p = 0.030), living in Southern Taiwan (aHR 1.49, 95% CI, 1.21–1.84, p = 0.002), and with a psychiatric history (excluding depressive disorders) (aHR 4.59, 95% CI, 3.51–6.01, p = 0.030). (4) Conclusions: This study concluded that ART-treated patients with a past history of psychiatric disorders, lower insurance premium, and living in Southern Taiwan have an increased risk of depressive disorders, which are not associated with the use of efavirenz.

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Obstructive sleep apnea increases risk of female infertility: A 14-year nationwide population-based study

PLoS ONE ◽

10.1371/journal.pone.0260842 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0260842

Author(s):

Zhu Wei Lim ◽

I-Duo Wang ◽

Panchalli Wang ◽

Chi-Hsiang Chung ◽

Song-Shan Huang ◽

...

Keyword(s):

Study Groups ◽

Population Based ◽

Female Infertility ◽

Control Group ◽

Multivariable Logistic Regression Analysis ◽

Population Based Study ◽

Obstructive Sleep ◽

History Of ◽

The Mean ◽

Control Study

Objectives To determine the risk of having OSA in a cohort of female subjects who are infertile and the odds of being infertile in women with OSA. Patients and methods A nationwide, case-control study of female patients 20 years or older diagnosed with female infertility living in Taiwan, from January 1, 2000, through December 31, 2013 (N = 4,078). We identified women who were infertile and created a 2:1 matched control group with women who were not infertile. We used multivariable logistic regression analysis to further estimate the effects of OSA on female infertility. Results In this 14- year retrospective study, we included 4,078 patients having an initial diagnosis of female infertility. Of those women with infertility, 1.38% had a history of OSA compared with 0.63% of fertile controls (p = 0.002). The mean ages in the study groups were 32.19 ± 6.20 years, whereas the mean ages in the control groups were 32.24 ± 6.37years. Women with OSA had 2.101- times the risk of female infertility compared to women without OSA (p<0.001). Conclusion Our study showed that OSA is more commonly seen in infertile women and increases the odds that a woman will be infertile. More studies need to be done on the whether or not diagnosing and treating OSA can decrease the rate of infertility.

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Prevalence and factors associated with age-related macular degeneration in a southwestern island population of Japan: the Kumejima Study

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2016-309980 ◽

2017 ◽

Vol 102 (8) ◽

pp. 1047-1053 ◽

Cited By ~ 2

Author(s):

Ryo Obata ◽

Yasuo Yanagi ◽

Tatsuya Inoue ◽

Miho Yasuda ◽

Yuji Oshima ◽

...

Keyword(s):

Macular Degeneration ◽

Population Based ◽

Cross Sectional Study ◽

Age Related Macular Degeneration ◽

Island Population ◽

Cross Sectional ◽

Factors Associated ◽

Age Related ◽

History Of ◽

Low Prevalence

AimsTo evaluate the prevalence of and factors associated with age-related macular degeneration (AMD) in a rural population of southwestern Japan.MethodsThis population-based cross-sectional study of all residents aged 40 years or older was conducted on the island of Kumejima, Okinawa, Japan. Of 4632 eligible residents, 3762 completed a comprehensive questionnaire and underwent ocular examination (participant rate, 81.2%). A non-mydriatic fundus photograph was used to grade AMD lesions according to the Wisconsin protocol. Prevalence of AMD was calculated and factors associated with AMD were identified by logistic regression.ResultsOf 3068 subjects with gradable photographs, 469 had early AMD and 4 had late AMD. Age-adjusted prevalence was 13.4% for any AMD, 13.3% for early AMD and 0.09% for late AMD. In multivariate analysis, any AMD was positively associated with age (OR 1.04 per year, 95% CI 1.03 to 1.05), male sex (OR 1.42, 95% CI 1.14 to 1.75) and history of cataract surgery (OR 1.35, 95% CI 1.00 to 1.82) and was negatively associated with longer axial length (OR 0.85 per millimetre, 95% CI 0.74 to 0.96). Early AMD similarly showed significant associations with these same factors.ConclusionsPrevalence of early or late AMD in a southwestern island population of Japan was 13.4% or 0.09%. Our data suggest relatively high prevalence for early AMD and low prevalence for late AMD in this sample of rural Japanese population. Significant factors associated with any or early AMD were mostly similar to that of previous studies.

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Assessment of TSLP, IL 25 and IL 33 in patients with shrimp allergy

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-021-00576-9 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Natalia Ukleja-Sokołowska ◽

Magdalena Żbikowska-Gotz ◽

Kinga Lis ◽

Rafał Adamczak ◽

Zbigniew Bartuzi

Keyword(s):

Allergic Diseases ◽

Specific Ige ◽

European Population ◽

House Dust Mites ◽

Control Group ◽

Allergen Components ◽

Sige Level ◽

History Of ◽

And Control ◽

Immunocap Isac

Abstract Background Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response. Methods Thirty-seven patients (18 male and 19 female) with a positive history of symptoms associated with shrimp consumption were selected. All patients had blood samples taken to assess the concentration of allergen-specific IgE (sIgE) to house dust mites (HDM) and shrimp (Singleplex, quantitative method with cut off value > 0,35 kAU/L) as well as the level of allergen components using the ImmunoCap ISAC method (Microarray test, semi-quantitative with cut off value > 0,3 ISU-E). The concentrations of TSLP, IL-25 and IL-33 in the patients’ blood serum was assessed using the ELISA method (Cusabio). Twenty patients with negative allergy history of allergic disease tests were included in the control group. Results Among the 37 shrimp-allergic patients, ImmunoCap ISAC was identified the presence of sIgE to the available shrimp allergen components in only 14 cases (37.8%). TSLP and IL25 levels were significantly higher in the study group. No statistically significant correlation was found between the concentration of analyzed alarmins and the concentration of sIgE level to shrimp or HDM between the study and control groups. No statistically significant correlation was found between poly-sensitization occurring in patients and levels of TSLP, IL-25 and IL-33 . Conclusion In shrimp-allergic patients, the concentrations of TSLP and IL-25 were significantly higher than in the control group (1.33 vs. 0.49 and 157 vs. 39.36, respectively). There was no correlation between the concentrations of TSLP, IL-25 and IL-33 and the concentration of sIgE in the patients or the number of allergen components that the patients were sensitized to. Trial registration: Bioethics Committee 147/2015, 11.03.2015.

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Risk factors for latex sensitization in young children with myelomeningocele

Journal of Neurosurgery Pediatrics ◽

10.3171/2009.4.peds08364 ◽

2009 ◽

Vol 4 (3) ◽

pp. 285-288 ◽

Cited By ~ 6

Author(s):

Masoud Majed ◽

Farideh Nejat ◽

Mostafa El Khashab ◽

Parvin Tajik ◽

Mohammad Gharagozloo ◽

...

Keyword(s):

Risk Factors ◽

Barium Enema ◽

Univariate Analysis ◽

Young Patients ◽

Diagnostic Procedures ◽

Specific Ige ◽

Increased Risk ◽

History Of ◽

Skin Prick Tests ◽

Low Prevalence

Object Patients with myelomeningoceles (MMCs) are at increased risk of latex allergy and sensitization. Number of surgeries and history of atopy are known risk factors. The object of this study was to evaluate the role of diagnostic procedures and nonsurgical treatments in latex sensitization in young patients with MMC. Methods Seventy-three children with MMC were included in the study. For each child a questionnaire was administered and serum determination of IgE was performed, and 62 children underwent skin prick tests (SPTs), 60 of which had reliable results. Multivariate logistic regression modeling was performed, using latex sensitization as the dependent variable. Results The mean age of the 73 patients was 3.8 years. The SPT results were positive in 30.6%, whereas results of testing for latex-specific IgE were positive in only 8.2%. In univariate analysis, history of untethering, barium enema, and number of clean intermittent catheterizations (CICs) per day were significantly associated with positive results on the SPT. Although the number of surgical procedures was significantly higher in patients who had shunts, no significant relationship between the presence of a shunt and latex sensitization was seen. Conclusions The young age of the patients in this study may account for the low prevalence of latex sensitization that was found. In young patients with MMC, the numbers of CICs per day, a history of untethering, circumcision, and a barium enema performed without latex-free equipment could be risk factors for latex sensitization. The use of latex-free gloves in all procedures performed in these cases, nonlatex polyvinyl chloride catheters in CIC, and ordinary nonballoon tips in barium enemas could decrease the risk of sensitization.

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The association between psoriatic arthritis and venous thromboembolism: a population-based cohort study

Arthritis Research & Therapy ◽

10.1186/s13075-021-02703-8 ◽

2022 ◽

Vol 24 (1) ◽

Author(s):

Tal Gazitt ◽

Jacob Pesachov ◽

Idit Lavi ◽

Muna Elias ◽

Amir Haddad ◽

...

Keyword(s):

Cohort Study ◽

Psoriatic Arthritis ◽

Large Population ◽

Multivariable Analysis ◽

Previous History ◽

Population Based ◽

Janus Kinase ◽

Control Group ◽

Increased Risk ◽

History Of

Abstract Background Although the risk of cardiovascular disease has been discussed extensively in both psoriasis (PsO) and psoriatic arthritis (PsA), very few studies have addressed the occurrence of venous thromboembolic (VTE) events among PsO patients, and even fewer in PsA. Thus, our goal was to assess the association between PsA and VTE events using a large population-based database. Methods This retrospective cohort study includes all 5,275 patients with newly diagnosed PsA from the largest health care provider in Israel between January 2003 and December 2018. Identified PsA patients were matched by age, sex, ethnicity, and index date with 21,011 controls without PsA from the same database. Both groups were followed through June 30, 2019 for the occurrence of VTE event. Cox proportional hazard regression models were used to assess the association between PsA and VTE. Results PsA cohort consisted of 53.2% females with mean age of 51.7±15.4 Sixty-two patients (1.2%) were diagnosed with VTE in the PsA group and 176 patients (0.8%) in the control group (p=0.023, HR=1.40, 95% CI 1.05-1.87). However, there was no increased risk of VTE among PsA patients on multivariable analysis (p=0.16, HR=1.27, 95% CI 0.91-1.80). Within the PsA group, patients with VTE were more often of older age and with history of VTE. Conclusions This study suggests that the increased risk of VTE in PsA patients appears to be related to the underlying comorbidities and not independently associated with PsA. Age and previous history of VTE were the only risk factors associated with increased risk of VTE in patients with PsA. Addressing VTE risk is recommended especially in the era of Janus kinase inhibitors.

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