Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits

2007 ◽  
Vol 61 (1) ◽  
Author(s):  
K. Pawłowska-Góral ◽  
M. Wardas ◽  
P. Wardas ◽  
A. Rzepecka-Stojko
Keyword(s):  
Vitamin E ◽  
Antioxidant Status ◽  
Superoxide Radical ◽  
Malonic Dialdehyde ◽  
Total Antioxidant Status ◽  
Protective Effects ◽  
Sod Activity ◽  
Superoxide Radical Anion ◽  
Total Antioxidant ◽  
Reactive Oxygen Forms

AbstractThe influence of CCl4 on the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), the value of the total antioxidant status (TAS), and the concentration of malonic dialdehyde (MDA) and glutathione (GSH) was monitored in plasma or whole blood of rabbits. The administration of CCl4 caused the increase of the SOD activity to approximately 150 % and the decrease in the activity of GPx and GR by about 50 %. These changes were accompanied with the increase in TAS value and MDA concentration and the decrease of GSH concentration. The effect of CCl4 was suppressed by the previous 7 days lasting or simultaneous administration of vitamin E. Oxidative stress caused by CCl4 was accompanied by the development of reactive oxygen forms, especially superoxide radical anion.

Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes

2017 ◽  
Vol 28 (01) ◽  
pp. 096-100
Author(s):  
Leyla Tekin ◽  
Mehmet Erdemli ◽  
Nazile Erturk ◽  
Zeynep Aksungur ◽  
Serdar Aktas ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Hypericum Perforatum ◽  
Ischemia Reperfusion Injury ◽  
Histopathological Examination ◽  
Ischemia Reperfusion ◽  
Total Antioxidant Status ◽  
Albino Rats ◽  
Protective Effects ◽  
Total Antioxidant ◽  
Markers Of Oxidative Stress

Purpose This study aimed to compare the protective effects of Hypericum perforatum (Hp) and quercetin, a flavonoid, against ischemia/reperfusion (I/R) injury in rat testes. Materials and Methods This study included 28 male Wistar albino rats that were divided into four groups. Except for the sham group, torsion was created by rotating both testes at an angle of 720 degrees clockwise for 2 hours. The Hp and quercetin groups received 25 mg/kg Hp and quercetin intraperitoneally 30 minutes before detorsion, respectively. Orchiectomy was performed for the measurement of markers of oxidative stress and histopathological examination. Results In the Hp and quercetin groups, malondialdehyde (MDA) and nitric oxide (NO) levels and total oxidant capacity were significantly lower, the glutathione level and total antioxidant status were significantly higher, and Johnsen's testis biopsy scores were significantly higher than in the torsion/detorsion group (p ˂ 0.001). The markers of oxidative injury were significantly lower (p ˂ 0.001) and total antioxidant status was significantly higher (p ˂ 0.001), except for glutathione (p = 0.62) in the Hp group than in the quercetin group. Johnsen's score between Hp and quercetin groups was not significantly different (p = 0.80). Conclusion Both Hp and quercetin have protective effects against I/R injury of the testes, but the protective effect of Hp was found to be stronger than that of quercetin.

Antioxidant Status Modifications by Topical Administration of Dorzolamide in Primary Open-Angle Glaucoma

2009 ◽  
Vol 19 (4) ◽  
pp. 565-571 ◽  
Author(s):  
Vicente Zanon-Moreno ◽  
Jose J. Garcia-Medina ◽  
Roberto Gallego-Pinazo ◽  
Ignacio Vinuesa-Silva ◽  
Maria A. Moreno-Nadal ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Antioxidant Status ◽  
Open Angle Glaucoma ◽  
Total Antioxidant Status ◽  
Thiobarbituric Acid ◽  
Topical Administration ◽  
Oxidative Activity ◽  
Sod Activity ◽  
Total Antioxidant ◽  
Comparative Group

Purpose This study deals with the role of the topical administration of dorzolamide eyedrops on the oxidative/antioxidant status of aqueous humor in patients with primary openangle glaucoma (POAG). Methods A case-control study including 130 patients distributed into three groups was carried out: 1) patients with POAG without dorzolamide instillation administration (GG; n=34); 2) patients with POAG with dorzolamide (DG; n=36); and 3) subjects with cataracts (comparative group, CG; n=60). Oxidative activity was measured in the aqueous humor by malondialdehyde determination by the thiobarbituric acid reactive substances assay. Antioxidant status was assessed in the aqueous humor samples by measuring the superoxide dismutase activity and the total antioxidant status. Results Oxidative activity was significantly higher in both glaucoma groups than in the cataracts group (GG vs CG, p=3.68 E-34; DG vs CG, p=5.11 E-45), and was significantly higher in GG than in DG (p=0.0034). SOD activity was significantly higher in both glaucoma groups than in the cataracts group (GG vs CG, p=1.08 E-14; DG vs CG, p=3.70 E-22), and was significantly higher in GG than in DG (p=0.018). Finally, total antioxidant status was significantly decreased in both glaucoma groups compared with the cataracts group (GG vs CG, p=2.51 E-12; DG vs CG, p=5.06 E-05), and was more significantly decreased in GG than in DG (p=9.23 E-07). Conclusions Topical administration of dorzolamide colirium diminishes oxidative stress in patients with glaucoma.

Plasma vitamin E, total antioxidant status and vascular function in young adults

2002 ◽  
Vol 32 (12) ◽  
pp. 889-894 ◽  
Author(s):  
C. P. M. Leeson ◽  
A. Mann ◽  
M. Kattenhorn ◽  
J. E. Deanfield ◽  
A. Lucas ◽  
...  
Keyword(s):  
Young Adults ◽  
Vitamin E ◽  
Vascular Function ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Plasma Vitamin ◽  
Total Antioxidant ◽  
Plasma Vitamin E

Effect of a high monounsaturated fatty acid diet alone or with combined vitamin E and C, or lycopene intake on oxidative stress in patients with type 2 diabetes mellitus

2012 ◽  
Vol 12 (2) ◽  
pp. 81-86
Author(s):  
Maha Badkook ◽  
Fiona McCullough ◽  
Nessar Ahmed
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Vitamin E ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Total Antioxidant ◽  
Mufa Diet ◽  
Vitamin E And C

The aims of this study were to investigate the effect of a high monounsaturated fatty acid (MUFA) diet alone or with combined vitamin E and C, or lycopene intake on oxidative stress in type 2 diabetes in Saudi Arabia. Forty-eight type 2 diabetic patients consumed a high MUFA diet for 16 weeks. After four weeks of high MUFA diet alone, supplements of vitamins E (400 mg) and C (1,000 mg) were taken for four weeks, followed by a four-week washout period. In the final four weeks, subjects consumed a high MUFA diet with tomato paste (equivalent to 12 mg lycopene). Plasma samples were tested for vitamin E and C, lycopene, malondialdehyde (MDA), total antioxidant status, fasting plasma glucose and glycated haemoglobin A1c (HbA1c). A high-MUFA diet with vitamins E and C or lycopene caused significant elevation of plasma vitamins E, C and lycopene compared to a high-MUFA diet alone. Plasma MDA was reduced with vitamins, but not lycopene supplementation. The total antioxidant status increased significantly following a high-MUFA diet and with vitamin and lycopene supplementations. Fasting glucose was not affected whereas HbA1c decreased significantly after vitamin supplementation compared to baseline. A high-MUFA diet supplemented with vitamin E and C, or lycopene improves antioxidant status in type 2 diabetes.

scholarly journals Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

2021 ◽  
Vol 90 (1) ◽  
pp. 91-98
Author(s):  
Mehmet Ali Temiz ◽  
Atilla Temur ◽  
Yusuf Akgeyik ◽  
Ahmet Uyar
Keyword(s):  
Liver Damage ◽  
Antioxidant Status ◽  
Copper Toxicity ◽  
Total Antioxidant Status ◽  
Oral Exposure ◽  
Albino Rats ◽  
Protective Effects ◽  
Liver Histopathology ◽  
Total Antioxidant ◽  
Antioxidant Parameters

This study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), Copper + C. tournefortii (Cu+Ct), and C. tournefortii (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, glutathione (GSH) concentration, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) were analysed in the liver tissues. Liver histopathology was also evaluated. Alanine aminotransferase and lactate dehydrogenase significantly decreased in the Cu+Ct group compared with the Cu group. Oxidative stress parameters MDA and TOS significantly increased with copper administration, whereas they decreased with C. tournefortii co-treatment compared to Cu group. GSH concentration and TAS showed significant decreases with copper administration. Celtis tournefortii co-supplementation with copper significantly enhanced antioxidant parameters such as TAS, SOD, and GPx. Celtis tournefortii remarkably attenuated degenerative and necrotic changes caused by the oral exposure of copper in the liver tissue of rats. Celtis tournefortii may provide amelioration of the antioxidant status and moderation of severity of liver damage against copper toxicity. The therapeutic use of C. tournefortii may exhibit protective effects in liver injury treatment.

scholarly journals Tai Chi Exercise Increases SOD Activity and Total Antioxidant Status in Saliva and Is Linked to an Improvement of Periodontal Disease in the Elderly

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Víctor Manuel Mendoza-Núñez ◽  
Beatriz Hernández-Monjaraz ◽  
Edelmiro Santiago-Osorio ◽  
José Miguel Betancourt-Rule ◽  
Mirna Ruiz-Ramos
Keyword(s):  
Older Adults ◽  
Periodontal Disease ◽  
Antioxidant Status ◽  
Tai Chi ◽  
Total Antioxidant Status ◽  
The Elderly ◽  
Control Group ◽  
Sod Activity ◽  
Spectrophotometric Methods ◽  
Total Antioxidant

The aim of this study was to determine the effect of Tai Chi on biological markers of oxidative stress in saliva and its relationship with periodontal disease (PD) in older adults. We carried out a quasi-experimental study with a sample of 71 sedentary volunteers with PD who were divided into a control group of 34 subjects and an experimental group of 37 subjects who performed Tai Chi 5 days a week for a period of 6 months. PD status was characterized using the Periodontal Disease Index (PDI). Superoxide dismutase (SOD), total antioxidant status (TAS), and TBARS levels of both groups were measured by spectrophotometric methods. In addition, inflammation markers (TNF-α, IL-1β, IL-6, IL-8, and IL-10) were measured by flow cytometry. We found a statistically significant increase in SOD activity (P<0.001) and TAS concentration (P<0.05), whereas levels of IL-1βwere significantly lower (P<0.01). Likewise, a statistically significant decrease in the PDI (P<0.05) was observed in subjects who performed Tai Chi during a period of 6 months. Our findings suggest that the practice of Tai Chi has both antioxidant and anti-inflammatory effects that are linked to the improvement of PD in older adults.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Antioxidant status of blood in patients with vibration disease

2019 ◽  
pp. 978-982 ◽  
Author(s):  
N. N. Malyutina ◽  
A. F. Bolotova ◽  
R. B. Eremeev ◽  
A. Zh. Gilmanov ◽  
D. Yu. Sosnin
Keyword(s):  
Antioxidant Activity ◽  
Blood Serum ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Main Group ◽  
Biologically Active ◽  
Antioxidant Systems ◽  
Control Group ◽  
Vibration Disease ◽  
Total Antioxidant

Introduction. The overwhelming number of publications contains only data on the content of individual antioxidants, but not on the overall antioxidant activity of the blood in patients with vibration disease.The aim of the study was to determine the total antioxidant activity of blood serum in patients with vibration disease.Materials and methods. Th e main group consisted of 30 people diagnosed with “Vibration disease” of 1 degree (n=21) and 2 degrees (n=9). Th e control group consisted of 30 clinically healthy men, comparable in age with the main group (p=0.66). Th e total activity of antioxidant systems of blood plasma was evaluated photometrically using the test system “Total antioxidant status-Novo” (“Vector-best”, Russia).Results. The indicator of the total antioxidant status (TAS) was 1,038±0.232 mmol/l in the examined main group, against 1,456±0.225 mmol/l in the examined control group (p<0.000001). Th e coefficient of variation (CV) in patients with vibration disease was 22.35%, 1.45 times higher than in the control group (15.45%). In the main group there was a positive correlation between age and TAS (R=0.525), in the control group there was no such relationship (R=0.095). Th e degree of decrease depended on the severity of vibration disease.Conclusions. 1. The development of vibration disease is accompanied by a decrease in the antioxidant status of blood serum. 2. Th e degree of decrease in the antioxidant status of blood serum correlates with the severity of vibration disease. 3. Reduction of TAS can serve as a pathogenetic justification of the need to include drugs and/or biologically active additives with antioxidant activity in therapy

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