Chronic lymphocytic leukemia in a farmer and vegetable seller: Associated with exposure of multiple work-related hazards?

There are several risk factors associated with the incidence of chronic lymphocytic leukaemia (CLL), namely genetic factors, smoking, and occupational exposure to chemicals. We highlight a possible association of a CLL case and the occupational. We reported a case of CLL patient, a 69-year-old man, who had been working as a vegetable seller and a chili farmer since 15 and 4 years ago, respectively. The patient was diagnosed with CLL three months prior to admission and had a history of three times blood transfusions. The patient only complained of paleness and weakness without any specific symptoms. No swelling of the lymph nodes, hepatomegaly, or splenomegaly was found. As a vegetable seller and chili farmer, the patient was exposed to five hazards, physical, chemical, biological, ergonomic to psychosocial. Therefore, it is necessary to analyse whether there was an association between the patient's work and the current CLL. To diagnose occupational diseases, several steps are needed. In this patient, one of the risk factors that could lead to CLL was exposure to chemicals such as pesticides. However, information regarding the content of pesticides used was unclear and there were no results obtained from pesticides biomarker examination that might cause the disease, making it difficult to establish a definitive diagnosis of work-related cause. The patient could be advised to have biomarkers of pesticide substances checked, which requires control of farmers and vegetable sellers who might have been exposed to pesticides. The control mechanism might be started from elimination, substitution, engineering, administration, and use of personal protective equipment. A control mechanism is necessary to prevent the entry of contaminants into the body, especially through inhalation, oral, and dermal pathways. It is recommended to examine for biomarkers of pesticides containing organophosphates, organochlorines, or carbamates to determine the chronic effects on the accumulation of these chemicals that might cause CLL.

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Differential Diagnosis between the Varieties of Vasculitis Forms

International Journal of Business & Technology ◽

10.33107/ijbte.2018.6.2.03 ◽

2018 ◽

Vol 6 (2) ◽

pp. 1-8

Author(s):

Joana Hankollari ◽

Marsida Duli ◽

Qamil Dika ◽

Xhenila Duli ◽

Indrit Bimi ◽

...

Keyword(s):

Risk Factors ◽

Differential Diagnosis ◽

Blood Vessel ◽

Specific Form ◽

The Body ◽

Imaging Studies ◽

Patient Assessment ◽

Diagnostic Difficulties ◽

History Of ◽

Specific Symptoms

Vasculitis is an inflammation of the blood vessels. It can affect any blood vessel in the body by manifesting a variety of systemic, non-specific symptoms that make difficult the diagnosis of this pathology and especially its specific form. In front of any patient suspected of being affected by vasculitis, some questions are asked: Is the vasculitis or other pathology that camouflages, whether it is primary or secondary vasculitis, in which vessels this pathology extends, how can the diagnosis be confirmed and how can it be determined the type of vasculitis?The purpose of this study is to inform about the protocols to be followed to perform differential diagnosis of vasculitis types.This study is a review based on the research of world studies and literature regarding the recommendations for performing differential diagnosis among the variety of vasculitis forms.Primary patient assessment involves taking the history of the medications it uses, risk factors for infectious pathology, history of cardiac valve pathologies, and autoimmune pathologies. Then laboratory and imaging studies are carried out, aiming at setting the diagnosis, determining the affected organ and the degree of disease activity. And recently we refer to algorithms to make differential diagnosis between the varieties of vasculitis forms.Despite the diagnostic difficulties of vasculitis, the variety of its forms, the separation of responsibilities among many specialities, there are protocols that need to be followed rigorously to arrive at a safe diagnosis as well as auxiliary algorithms to distinguish the type of vasculitis.

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Determining the musculoskeletal disorders as the most common work-related injuries, especially in the crafts using the OCRA evaluation method

Occupational Medicine ◽

10.18502/tkj.v10i4.1729 ◽

2019 ◽

Author(s):

Gh Halvani ◽

H Fallah ◽

R Jafari Nodoushan ◽

A Haji hosseini ◽

H Fallah zadeh ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Musculoskeletal Disorders ◽

Evaluation Method ◽

The Body ◽

Working Environment ◽

Work Related ◽

Demographic Questionnaire ◽

Ergonomic Risk Factors

Introduction: The condition of work in handloom weaving industries cause musculoskeletal (MSDS) disorders which are the most prevailing professional problem among weavers. The aim of this research was to determine ergonomic risk factors in the occurrence of musculoskeletal disorders. Method: The present study was done through descriptive cross-section method to assess the risk factors of work-related musculoskeletal disorders of the weavers. Our data collection tools were: demographic questionnaire, job Nordic questionnaire and body map prevalence of musculoskeletal disorders to decide the rate of symptoms. Then, we took film from handloom weavers while wearing to know the condition of their bodies. After reviewing the films, the posture marks was assigned to each duty using the Ergo Intelligence software. At the end, data were analyzed via one-way ANOVA and T-test using SPSS ver.20. Results: The results showed that the most frequent incidence of pain in different organs of the body during last year belonged to neck and shoulder. The average OCRA was 3.65.This indicated that most of the handloom weavers (64.4%) are at high risk. Conclusion: According to the re According to the results of OCRA indices, weavers are at high risk for musculoskeletal injuries, indicating their poor working environment and working conditions, indicating the need for corrective actions.

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A case report: spontaneous postpartum rupture of unscarred uterus

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183360 ◽

2018 ◽

Vol 7 (8) ◽

pp. 3420

Author(s):

Swati Singh ◽

Ravinder Ahlawat

Keyword(s):

Risk Factors ◽

Differential Diagnosis ◽

Unusual Case ◽

Surgical Intervention ◽

Emergency Laparotomy ◽

Full Thickness ◽

Uterine Incision ◽

History Of ◽

Rupture Of Uterus ◽

Specific Symptoms

Rupture of uterus is characterized by a breach in the wall of the uterus involving its full thickness. An unscarred uterus rupture is uncommon. It has non-specific symptoms and presentation differs according to site and time of rupture. Authors report an unusual case of spontaneous rupture of unscarred uterus. A 32-year-old, pregnant woman, developed postpartum bleeding with no history of prior uterine incision. She was diagnosed as a case of rupture of uterus and emergency laparotomy was done. Early diagnosis and immediate surgical intervention may significantly improve the prognosis. Differential diagnosis of uterine rupture should always be kept in mind in all patients with or without risk factors.

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Occurence of venothromboembolism (VTE) in patients (pts) with acute lymphocytic leukemia (ALL), Burkitt's leukemia/lymphoma (BL), or lymphoblastic leukemia (LL)

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.7059 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 7059-7059

Author(s):

N. V. Luong ◽

H. M. Kantarjian ◽

S. H. Faderl ◽

D. A. Thomas ◽

K. D. Vu

Keyword(s):

Risk Factors ◽

Lymphoblastic Leukemia ◽

Hormone Replacement ◽

Philadelphia Chromosome ◽

Lymphocytic Leukemia ◽

Pulmonary Vasculature ◽

Cancer Center ◽

Public Health Issue ◽

Female Ratio ◽

History Of

7059 Background: Venous thromboembolism (VTE) is a significant public health issue. Although neoplastic diseases are known risk factors for the development of VTE, little is known about the incidence and predisposing factors of VTE among leukemia patients (pts). Methods: We performed a retrospective study to determine the incidence and risk factors associated with development of VTE among pts with ALL, BL, LL at M. D. Anderson Cancer Center between 1999 and 2005. Medical records of 299 ALL pts were reviewed and analyzed. All computations were conducted using Stata 10. Results: Of the 299 pts with a male/female ratio of 182/117 and a median age of 43 yrs (range 15–83 yrs), 18% had VTE. Recurrent VTE occurred in 10 pts. VTE were identified in upper extremities (59%), lower extremities (30%), pulmonary vasculature (7%), and within venous catheters (4%). In a univariate model, pts with baseline platelet (plt) count 50–99 x 109/L were 2.2 times (95% CI: 1.05–4.55) more likely to develop VTE than pts who had plt >100 x 109/L. Pts aged 40–59 yrs were 2.3 times (95% CI: 1.15–4.59) more likely to develop VTE than pts aged 15–39 yrs. Women were 1.8 times (95%CI: 1.04–3.4) more likely than men to have a VTE. Pts with a history of VTE were 15.2 times (95% CI: 2.97–77.51) more likely to develop a VTE than pts who had no prior VTE history. Pts with > 3 comorbidities were 2.6 times (95% CI: 1.19–5.48) more likely to develop VTE than pts without comorbidities. Pts who used oral contraception or hormone replacement therapy (OCP/HRT) were 2 times (95% CI: 1.07–3.92) more likely to develop VTE than non-users. Pts with Philadelphia chromosome (Ph)-positive ALL were 3 times (95%CI: 1.41–6.17) more likely to develop VTE than pts with Ph-negative ALL. In a multivariate model, significant predictors of VTE were age 40–59 yrs, plt count 50–99 x 109/L, diagnosis of Ph-positive ALL, history of VTE, and OCP/HRT use. Conclusions: Pts with ALL have a high VTE rate. In addition to traditional risk factors, disease-specific features may also predispose pts to higher VTE risk. Further studies should be done in other leukemias to establish guidelines in the prevention and management of VTE in pts with leukemia. [Table: see text]

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FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN OSTEOPOROSIS

Indonesian Trust Health Journal ◽

10.37104/ithj.v3i2.57 ◽

2020 ◽

Vol 3 (2) ◽

pp. 337-343

Author(s):

Helfrida Situmorang

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Body Mass Index ◽

Body Mass ◽

Research Design ◽

Univariate Analysis ◽

The Body ◽

Nutritional Deficiencies ◽

Bivariate Analysis ◽

History Of

The irreversible risk factors for osteoporosis are age, gender, race, family / hereditary history, body shape and history of fractures. The risk factors for osteoporosis that can be changed are smoking, vitamin and nutritional deficiencies, lifestyle, eating disorders (anorexia nervosa), early menopause, and the use of certain drugs such as corticosteroids, glucocorticosteroids, and diuretics. The purpose of this study was to determine the factors associated with the incidence of osteoporosis. The research design used was non-experimental, namely a correlational research design, namely research conducted to determine the relationship between two variables. The population in this study were all osteoporosis patients with age. over 45 years old who seek treatment at the Puskesmas Gunting Saga Kec. Kualuh Selatan District of North Labuhan Batu totaling 45 people. The sampling method used was the total sampling technique, which was the same as the population of 45 people. Data collection used is the method of filling out a questionnaire which includes written questions used to obtain data information from the questionnaire. The data analysis conducted was univariate analysis and bivariate analysis. In this study, researchers still adhere to ethical principles. The results illustrate that the respondents are mostly 51-65 years old as many as 27 people (60%). Most of the sex of respondents were women as many as 37 people (82.2 %%). Most of the respondents had no history of osteoporosis as many as 31 people (68.9%). Most of the body mass index of respondents whose body mass index was over 34 people (75.6%). Most of the respondents in the smoking category did not smoke as many as 32 people (71.7%). Most of the respondents' physical activity in the category of independent physical activity was 38 people (84.4%). The conclusion is that there is no relationship between age, sex, family history, body mass index, and smoking with the incidence of osteoporosis. Meanwhile, physical activity has a relationshipwithosteoporosis. Abstrak Faktor-faktor resiko osteoporosis yang tidak dapat diubah yaitu usia, jenis kelamin, ras, riwayat keluarga/keturunan, bentuk tubuh dan sejarah patah tulang. Faktor–faktor resiko osteoporosis yang dapat diubah adalah merokok, defisiensi vitamin dan gizi, gaya hidup, gangguan makan (anoreksia nervosa), menopause dini, serta penggunaan obat-obatan tertentu seperti kortikosteroid, glukokortikosteroid, serta diuretik. Tujuan penelitian ini adalah untuk mengetahui mengetahui faktor-faktor yang berhubungan dengan kejadian osteoporosis Rancangan penelitian yang digunakan adalah non eksperimen yaitu rancangan atau desain penelitian yang bersifat korelasional yaitu penelitian yang dilakukan untuk mengetahui hubungan dua variabel.Populasi dalam penelitian ini adalah semua pasien osteoporosis dengan usia diatas 45 tahun yang berobat di Puskesmas Gunting Saga Kec. Kualuh Selatan Kab Labuhan Batu Utara berjumlah 45 orang.Metode pengambilan sampel yang digunakan dengan teknik total sampling yaitu sama dengan populasi adalah sebanyak 45 orang. Pengumpulan data yang digunakan yaitu metode pengisian kuesioner yang meliputi pertanyaan tertulis yang digunakan untuk memperoleh informasidata dari kuesioner.Analisa data yang dilakukan adalah analisis univariat dan analisis bivariat. Dalam penelitian ini peneliti tetap berpedoman pada prinsip-prinsip etik.Hasil penelitian menggambarkan bahwa responden sebagian besar berumur 51-65 tahun sebanyak 27 orang (60%). Jenis kelamin responden sebagian besar wanita sebanyak 37 orang (82.2%%).Riwayat keluarga responden sebagian besar berstatus tidak ada riwayat osteoporosis sebanyak 31 orang (68.9%).Indeks masa tubuh responden sebagian besar Indeks masa tubuh lebih sebanyak 34 orang (75.6%).Merokok responden sebagian besar kategori tidak merokok sebanyak 32 orang (71.7%).Aktivitas fisik responden sebagian besar kategori aktivitas fisik mandiri sebanyak 38 orang (84.4%).Kesimpulan bahwa tidak ada hubungan umur, jeniskelamin, riwayat keluarga,indeks massa tubuh,dan merokok dengan kejadian osteoporosis. Sedangkan aktivitas fisikada hubungan dengan kejadian osteoporosis.

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Profile of Hypospadias Cases in Central Java, Indonesia

Journal of Biomedicine and Translational Research ◽

10.14710/jbtr.v1i1.27 ◽

2015 ◽

Vol 1 (1) ◽

pp. 16

Author(s):

Ziske Maritska ◽

Ardy Santosa ◽

Mahayu Dewi Ariani ◽

Achmad Zulfa Juniarto ◽

Sultana MH Faradz

Keyword(s):

Risk Factors ◽

Family History ◽

Environmental Factors ◽

Observational Study ◽

Maternal Age ◽

Genetic Factors ◽

Multifactorial Disease ◽

Central Java ◽

Birth Characteristics ◽

History Of

Background: Hypospadia is believed to be a multifactorial disease. The risk factors that may induce the formation of hypospadias are environmental factors, endocrine disruptors, and genetic factors. The aim of this study was to describe the profile of hypospadias patients who visited the Center for Biomedical Research (CEBIOR), Faculty of Medicine, Diponegoro University, Semarang, Indonesia.Methods: This study is an observational study, using patients’ medical record in CEBIOR from 2010 to 2012. The hypospadias cases were classified into syndromic, isolated and severe hypospadias based on their phenotype. The history of pregnancy, birth characteristics, and family history of the patients were described.Results: There were 120 cases of hypospadias, consisted of 48.33% severe hypospadias, 41.67% mild isolated hypospadias and 10% syndromic hypospadias. There were 38.33% hypospadias cases whose mothers were being exposed to repellant usage and 39.17% cases whose fathers were smoking. Forty (33.33%) probands’ mothers were aged above 35 years old when they gave birth to their affected son.Conclusion: Majority of hypospadias cases were severe and mild isolated. Environtmental factors including maternal age more than 35 years old, use of repellant, and smoking fathers were found in this study.

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Fatal Mucormycosis and Aspergillosis in an Atypical Host: What Do We Know about Mixed Invasive Mold Infections?

Case Reports in Infectious Diseases ◽

10.1155/2020/8812528 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Maria Tsikala-Vafea ◽

Weibiao Cao ◽

Adam J. Olszewski ◽

John E. Donahue ◽

Dimitrios Farmakiotis

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Chronic Lymphocytic Leukemia ◽

Environmental Exposure ◽

Important Risk Factor ◽

Lymphocytic Leukemia ◽

High Dose ◽

History Of ◽

Invasive Mold Infections

Mixed invasive mold infections (MIMIs) are considered rare. We present a case of fatal aspergillosis and mucormycosis in an elderly host with history of chronic lymphocytic leukemia (CLL) and potential mold exposures. Notably, he had no classic risk factors for IMI other than high-dose corticosteroids, which may be an important risk factor for (M)IMI, based on the current and previous reports. There is an urgent need for studies on the “net state of immunosuppression,” environmental exposure as risk factors for (M)IMIs, and noninvasive fungal diagnostics.

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Better musculoskeletal health for anaesthetists

10.21466/g.bmhfa.2021 ◽

2021 ◽

Author(s):

S.M. Yentis ◽

◽

K. Asanati ◽

C.R. Bailey ◽

R. Hampton ◽

...

Keyword(s):

Risk Factors ◽

Musculoskeletal Disorders ◽

Healthcare Workers ◽

Health And Safety ◽

The Body ◽

Musculoskeletal Health ◽

Many Sources ◽

Psychological Risk

3Association of Anaesthetists | Better musculoskeletal health for anaesthetistsSummaryWork-related musculoskeletal disorders are very common amongst healthcare workers, and there is evidence that anaesthetists are at greater risk of upper limb disorders than other groups. This guidance aims to bring together advice and recommendations from a variety of sources in order to inform and support anaesthetists at work, in an attempt to reduce the prevalence and severity of work-related musculoskeletal disorders and the exacerbation of pre-existing disorders. Mechanical and psychosocial risk factors for work-associated musculoskeletal disorders are summarised, along with general principles for achieving better musculoskeletal health and practices specific to areas of the body most at risk. These include recommended exercises and stretches during sedentary work.RecommendationsAttention must be paid by both employers and anaesthetists to the physical and psychological risk factors that may lead to development and/or exacerbation of musculoskeletal disorders. This requires ongoing risk assessments and adherence to published standards of health and safety at work, including training. Such a programme is best achieved as part of a multidisciplinary approach.What other guidelines are available on this topic? There are many sources of guidance on health and safety in the workplace, across many sectors, much of which is of relevance to anaesthetists. There is no readily accessible guidance specifically aimed at the anaesthetic workplace.Why was this guideline developed?This guidance was developed as part of a wider piece of work by the Association of Anaesthetists based around ergonomics of the anaesthetic workplace, as a result of the increased reported incidence of musculoskeletal disorders amongst anaesthetists. It aims to draw on existing guidance and present a summary of advice relevant to anaesthetists and their practice.How and why does this publication differ from existing guidelines?This guidance summarises other advice and recommendations, and focuses on factors relevant to the anaesthetic workplace

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Major Factors Associated with Congenital Malformations in the Agadir Region of Morocco

Journal of Medical Research and Health Sciences ◽

10.15520/jmrhs.v3i8.238 ◽

2020 ◽

Vol 3 (8) ◽

Author(s):

SAID EL MADIDI

Keyword(s):

Risk Factors ◽

Congenital Malformations ◽

International Classification Of Diseases ◽

The Body ◽

Explanatory Variables ◽

Classification Of Diseases ◽

History Of ◽

Major Factors

Introduction: Congenital malformations are a global health problem around the world. MCs is one of the main causes of death and disability of newborns worldwide, but the majority of its risk factors are still poorly understood. Objective: The aim of this study is to determine the main causes that are related to the incidence of congenital malformations (CMs) in the region of Agadir in Morocco. Material and Methods: A prospective cases-control study at regional level was conducted in the pediatrics and neonatology department of Hassan II hospital in Agadir from April 2016 to April 2018. Data on child and maternal variables were recorded for 3701 newborns. The types of congenital malformations have been classified according to the codes of the International Classification of Diseases. Univariate analyzes were performed to identify the variables associated with the etiology of the malformations. Multiple logistic regression was used to characterize the associations between the MC and the determining explanatory variables taken into account simultaneously. Results: The results of these studies showed that there is a significant association between the incidence of the Congenital anomalies and the level of the consanguinity of the child, the prematurity of childbirth, the family history of CMs, the body mass index of the mother and the presence of major trauma during pregnancy. Conclusion: our results have made it possible to highlight the existence of an association between a certain number of risk factors and the occurrence of congenital malformations. Additional studies are needed to confirm and clarify the role of these risk factors.

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Risk Factors of the First Febrile Seizures in Iranian Children

International Journal of Pediatrics ◽

10.1155/2010/862897 ◽

2010 ◽

Vol 2010 ◽

pp. 1-3 ◽

Cited By ~ 7

Author(s):

Abolfazl Mahyar ◽

Parviz Ayazi ◽

Mazdak Fallahi ◽

Amir Javadi

Keyword(s):

Risk Factors ◽

Family History ◽

Body Temperature ◽

Breast Feeding ◽

Febrile Seizures ◽

The Body ◽

Feeding Duration ◽

Significant Difference ◽

History Of ◽

Iranian Children

Objective. Febrile seizures are the most common type of convulsion in children. The identification of influencing factors on incidence of the first febrile seizures is of prime priority. The aim of this study was to identify the risk factors of the first febrile seizures in Iranian children.Methods. In this case-control study 80 children aged 9 month to 5 years with their first febrile seizures were compared with 80 children with fever without seizure based on different risk factors in 2007.Results. There was significant difference between two groups regarding the gender, family history of febrile seizures, breast-feeding duration, and the body temperature (P<.05).Conclusion. Our study showed that factors including the gender, family history of febrile seizures, breast-feeding duration, and the body temperature are among the risk factors in occurrence of the first febrile seizure. Preventive measures to remove such risk factors could lead to lower the incidence of febrile seizures.

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