scholarly journals ACUTE APPENDICITIS: HISTORY AND CURRENT STATE OF THE MEDICAL CARE

2018 ◽  
Vol 25 (3) ◽  
pp. 43-49 ◽  
Author(s):  
I. M. Barsukova ◽  
M. V. Gavshchuk ◽  
A. P. Krivov
Keyword(s):  
Acute Appendicitis ◽  
Postoperative Mortality ◽  
Surgical Pathology ◽  
Laboratory Diagnostics ◽  
Current State ◽  
Abdominal Organs ◽  
High Incidence ◽  
Definition Of ◽  
Operational Activity ◽  
Instrumental Methods

Introduction. The problem of diagnostics and treatment of an acute appendicitis, despite of comprehensive study of this issue, remains extremely actual that is caused by a high incidence of appendicitis, considerable number of various complications of this disease in the pre - and postoperative period. The objective of this study is to assess the current state and dynamics of indicators on acute surgical pathology of abdominal organs in St. Petersburg, scientific justification of the main trends in the development of surgical science and practice. Material and methods.Materials on monitoring of acute surgical pathology of abdominal organs in St. Petersburg are presented to one of 7 nosological forms in the article, – an acute appendicitis. Historical-analytical, standard- legal and statistical methods were used.    Results. A decrease in the proportion of patients with acute appendicitis in the structure of 7 nosological forms of acute surgical pathology of the abdominal organs, united in the concept of «acute abdomen» (by 64.18 %: from 91.93 % in 1953 to 27.75 % in 2016); a decrease in the number of operated patients by 67.9 %; an increase in operational activity to 98.28 % in 2016; an increase in the proportion of patients with hospitalization for less than 24 hours from 58.13 % (1932-1946) to 66.74 % (1953-2016); the rate of late hospitalization (later than 24 hours) remains almost stable for the entire period of observation (more than 60 years), and in recent years has even a slight increase (+8.21%). There is a decrease in postoperative mortality in acute appendicitis in 350 times (from 21.00% in 1910 to 0.06% in 2016).Conclusion. The work demonstrates the success of healthcare in the field of emergency surgery, which are due to many factors to improve organizational approaches related to the development of diagnosis and treatment of acute appendicitis, including – description of characteristic symptoms, introduction of laboratory diagnostics, study of atypical and complicated clinical forms, peculiarities of the disease course in children and elderly people, definition of the terms of surgical intervention, introduction into clinical practice and improvement of instrumental methods of diagnostics and endosurgical methods of appendectomy, etc. 

scholarly journals FEATURES OF DIFFERENTIAL DIAGNOSIS OF URGENT SURGICAL ABDOMINAL PATHOLOGY DURING A PANDEMIC OF CORONAVIRUS INFECTION

2021 ◽  
pp. 5-8
Author(s):  
V. V. Lesnoy ◽  
A. S. Lesna ◽  
V. A. Filonenko
Keyword(s):  
Differential Diagnosis ◽  
Clinical Symptoms ◽  
Diagnostic Algorithm ◽  
Surgical Pathology ◽  
Sonographic Examination ◽  
Advantages And Disadvantages ◽  
Abdominal Organs ◽  
Rapid Tests ◽  
Coronavirus Infection ◽  
Instrumental Methods

Summary. Aim. To analyze the features of differential diagnosis of urgent surgical pathology during a coronavirus infection pandemic. Materials and methods. The work is based on the analysis of the results of additional examination of 28 patients at the admission department, who sought medical help in an urgent manner. Results. The advantages and disadvantages of using instrumental methods for detecting atypical forms of coronavirus infection and acute abdominal pathology are analyzed. Based on this, a diagnostic algorithm was developed using express tests for the determination of COVID-19 and urgent ultrasound protocols, which made it possible to identify lung lesions without clinical symptoms in 8 (28.6 %) patients, and to confirm acute surgical pathology in 5 (17.9 %) patients. Conclusion. Еxamining patients with suspected acute abdominal pathology for the purpose of differential diagnosis with the gastrointestinal form of COVID-19, it is necessary to use rapid tests for detecting antibodies to coronavirus infection and sonographic examination of the abdominal organs (FAST protocol), chest organs (BLUE protocol).

Biomarkers of Acromegaly and Growth Hormone Action

2020 ◽  
Vol 27 (12) ◽  
pp. 1231-1245
Author(s):  
Filippo Maffezzoni ◽  
Teresa Porcelli ◽  
Andrea Delbarba ◽  
Letizia Pezzaioli ◽  
Carlo Cappelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Biological Markers ◽  
Clinical Care ◽  
Hormone Deficiency ◽  
Surrogate Outcomes ◽  
Current State ◽  
Growth Hormone Action ◽  
Igf I ◽  
Definition Of

: Biological markers (biomarkers) play a key role in drug development, regulatory approval and clinical care of patients and are linked to clinical and surrogate outcomes. : Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly, both GH and IGF-I are established biomarkers of disease activity. : However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore, new biological markers for acromegaly and GH replacement therapy are strongly needed. : The aim of this paper is to review and summarize the current state in the field pointing out new potential biomarkers for acromegaly and GH use/abuse.

What Is A Chemical Element?

2020 ◽  
Keyword(s):  
Periodic Table ◽  
Chemical Element ◽  
Abstract Concept ◽  
International Union ◽  
Applied Chemistry ◽  
Educational Levels ◽  
Unique Position ◽  
Current State ◽  
Element Carbon ◽  
Definition Of

The term “element” is typically used in two distinct senses. First it is taken to mean isolated simple substances such as the green gas chlorine or the yellow solid sulphur. In some languages, including English, it is also used to denote an underlying abstract concept that subsumes simple substances but possesses no properties as such. The allotropes and isotopes of carbon, for example, all represent elements in the sense of simple substances. However, the unique position for the element carbon in the periodic table refers to the abstract sense of “element.” The dual definition of elements proposed by the International Union for Pure and Applied Chemistry contrasts an abstract meaning and an operational one. Nevertheless, the philosophical aspects of this notion are not fully captured by the IUPAC definition, despite the fact that they were crucial for the construction of the periodic table. This pivotal chemical notion remains ambiguous and such ambiguity raises problems at the epistemic, logical, and educational levels. These aspects are discussed throughout the book, from different perspectives. This collective book provides an overview of the current state of the debate on the notion of chemical element. Its authors are historians of chemistry, philosophers of chemistry, and chemists with epistemological and educational concerns.

Minority Presidents in a Coalitional World

2018 ◽  
Author(s):  
Paul Chaisty ◽  
Nic Cheeseman ◽  
Timothy J. Power
Keyword(s):  
Coalition Formation ◽  
Cost Minimization ◽  
Analytical Framework ◽  
System Level ◽  
Current State ◽  
Key Concepts ◽  
Definition Of

This chapter summarizes the main parameters of coalitional presidentialism and the key concepts, definitions, explanatory frameworks, indicators, and propositions. It summarizes our understanding of coalitional presidentialism; the distinction between coalition formation and maintenance; the definition of coalitions; the multidimensional understanding of coalition management (the ‘presidential toolbox’); and an analytical framework that emphasizes the motivation of presidents to achieve cost minimization under constraints determined by system-level, coalition-level, and conjunctural factors. It also summarizes our main empirical findings: (1) the characteristics of presidential tools, (2) the substantive patterns of their deployment, (3) the factors that shape the costs of using these tools, (4) the actual (observed) costs of using them, and (5) the potential for imperfect substitutability of these tools. Finally, it concludes with some reflections on the current state of the research on comparative presidentialism.

WoCoVA consensus on the clinical use of in-line filtration during intravenous infusions: Current evidence and recommendations for future research

2021 ◽  
pp. 112972982198916
Author(s):  
Ton Van Boxtel ◽  
Mauro Pittiruti ◽  
Annemarie Arkema ◽  
Patrick Ball ◽  
Giovanni Barone ◽  
...  
Keyword(s):  
Potential Benefit ◽  
Scientific Evidence ◽  
Venous Access ◽  
Current Evidence ◽  
Future Research ◽  
Global Awareness ◽  
Current State ◽  
Intravenous Infusions ◽  
Proper Definition ◽  
Definition Of

The need for filtering intravenous infusions has long been recognized in the field of venous access, though hard scientific evidence about the actual indications for in-line filters has been scarce. In the last few years, several papers and a few clinical studies have raised again this issue, suggesting that the time has come for a proper definition of the type of filtration, of its potential benefit, and of its proper indications in clinical practice. The WoCoVA Foundation, whose goal is to increase the global awareness on the risk of intravenous access and on patients’ safety, developed the project of a consensus on intravenous filtration. A panel of experts in different aspects of intravenous infusion was chosen to express the current state of knowledge about filtration and to indicate the direction of future research in this field. The present document reports the final conclusions of the panel.

scholarly journals The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review

2021 ◽  
Vol 22 (15) ◽  
pp. 7942
Author(s):  
Chiara Agrati ◽  
Alessandra Sacchi ◽  
Eleonora Tartaglia ◽  
Alessandra Vergori ◽  
Roberta Gagliardini ◽  
...  
Keyword(s):  
Endothelial Activation ◽  
Cardiovascular Complications ◽  
Current State ◽  
Activated Platelets ◽  
Blood Clots ◽  
Severe Infections ◽  
Platelet Aggregates ◽  
Definition Of ◽  
Leucocyte Recruitment

In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.

scholarly journals Defining and Quantifying Intermittency in the Power Sector

Energies ◽  
2020 ◽  
Vol 13 (13) ◽  
pp. 3366
Author(s):  
Daniel Suchet ◽  
Adrien Jeantet ◽  
Thomas Elghozi ◽  
Zacharie Jehl
Keyword(s):  
Power Source ◽  
Production Data ◽  
Power Sector ◽  
Predictive Capacity ◽  
The Public ◽  
Current State ◽  
Definition Of ◽  
Quantitative Definition ◽  
The Impact

The lack of a systematic definition of intermittency in the power sector blurs the use of this term in the public debate: the same power source can be described as stable or intermittent, depending on the standpoint of the authors. This work tackles a quantitative definition of intermittency adapted to the power sector, linked to the nature of the source, and not to the current state of the energy mix or the production predictive capacity. A quantitative indicator is devised, discussed and graphically depicted. A case study is illustrated by the analysis of the 2018 production data in France and then developed further to evaluate the impact of two methods often considered to reduce intermittency: aggregation and complementarity between wind and solar productions.

Contemporary psychosurgery and a look to the future

2001 ◽  
Vol 95 (6) ◽  
pp. 944-956 ◽  
Author(s):  
Robert P. Feldman ◽  
Ronald L. Alterman ◽  
James T. Goodrich
Keyword(s):  
Modern Science ◽  
Psychiatric Disease ◽  
Content Type ◽  
Current State ◽  
Mind And Brain ◽  
Patient Selection Criteria ◽  
Definition Of ◽  
Historical Developments ◽  
The Mind ◽  
Fine Print

Object. Despite a long and controversial history, psychosurgery has persisted as a modern treatment option for some severe, medically intractable psychiatric disorders. The goal of this study was to review the current state of psychosurgery. Methods. In this review, the definition of psychosurgery, patient selection criteria, and anatomical and physiological rationales for cingulotomy, subcaudate tractotomy, anterior capsulotomy, and limbic leukotomy are discussed. The historical developments, modern procedures, and results of these four contemporary psychosurgical procedures are also reviewed. Examples of recent advances in neuroscience indicating a future role for neurosurgical intervention for psychiatric disease are also mentioned. Conclusions. A thorough understanding of contemporary psychosurgery will help neurosurgeons and other physicians face the ethical, social, and technical challenges that are sure to lie ahead as modern science continues to unlock the secrets of the mind and brain.

scholarly journals Incidence and Mortality of Anastomotic Dehiscence Requiring Reoperation After Rectal Carcinoma Resection

2014 ◽  
Vol 99 (2) ◽  
pp. 112-119 ◽  
Author(s):  
Zhi-jie Cong ◽  
Liang-hao Hu ◽  
Jun-jie Xing ◽  
Zheng-qian Bian ◽  
Chuan-gang Fu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Carcinoma ◽  
Anterior Resection ◽  
Rectal Resection ◽  
Postoperative Mortality ◽  
Anastomotic Dehiscence ◽  
Systematic Search ◽  
Anterior Rectal Resection ◽  
Incidence And Mortality ◽  
Definition Of

Abstract Anastomotic dehiscence (AD) requiring reoperation is the most severe complication following anterior rectal resection. We performed a systematic review on studies that describe AD requiring reoperation and its subsequent mortality after anterior resection for rectal carcinoma. A systematic search was performed on published literature. Data on the definition and rate of AD, the number of ADs requiring reoperation, the mortality caused by AD, and the overall postoperative mortality were pooled and analyzed. A total of 39 studies with 24,232 patients were analyzed. The studies varied in incidence and definition of AD. Systematic review of the data showed that the overall rate of AD was 8.6%, and the rate of AD requiring reoperation was 5.4%. The postoperative mortality caused by AD was 0.4%, and the overall postoperative mortality was 1.3%. We found considerable risk and mortality for AD requiring reoperation, which largely contributed to the overall postoperative mortality.

Modern imagine methods in diagnostics of acute pancreatitis in clinical practice

2020 ◽  
pp. 14-25
Author(s):  
G. R. Ahunova ◽  
R. R. Ahunova
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Practice ◽  
Mortality Rate ◽  
High Mortality ◽  
Surgical Pathology ◽  
Diagnostic Radiology ◽  
Common Disease ◽  
Review Of The Literature ◽  
Abdominal Organs ◽  
Comprehensive Examination

Acute pancreatitis is one of the most frequent and formidable diseases, and rates as one of the most common disease in the structure of acute surgical pathology of the abdominal organs. In the last decade, there has been an increase in the proportion of necrotic forms of the disease with damage to various departments of the retroperitoneal space and a stably high mortality rate. The diagnostics problem of acute pancreatitis is still relevant due to difficulties that persist despite the possibility of a comprehensive examination of patients upon admission to the hospital and during treatment. This article presents a review of the literature, reflecting the state of the problem and aspects of diagnostic radiology of acute pancreatitis.

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